• Advances in Traditional Medicine
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• 제7권5호
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• pp.501-508
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• 2008

Anti-nociceptive and anti-inflammatory effects of Clematidis Radix (CR)-distillates were investigated in three different pain animal models. Highly purified distillate of CR was injected to Zusanli (ST36) acupoint, called CR herb-acupuncture in the Korean traditional medicine. In tail flick latency test, the CR herb-acupuncture treatment did not show a significant effect of relieving acute phasic pain. To investigate the anti-inflammatory effect of CR herb-acupuncture, inflammatory pain was induced by subcutaneous injection of formalin to the plantar tissue or intra-articular injection of carrageenan to the tibio-tarsal joint in the rats. And the medicinal effect of CR herb-acupuncture was evaluated by analyzing pain behavior such as licking or biting behavior, or by measuring weight distribution ratio between two foot and ankle circumference. In the rat formalin test, the analgesic effect of CR herb-acupuncture was more pronounced in the late phase (for 20 min after the early phase) than in the early phase (for the first 10 min post formalin injection). It also significantly alleviated the carrageenan-induced monoarthritis, in terms of weight distribution ratio and ankle edema. These results revealed that CR herb-acupuncture was effective to treat the inflammatory pain and could be used as an analgesic treatment with an antiinflammatory effect.

• 대한한방내과학회지
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• 제26권3호
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• pp.677-684
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• 2005

Objectives : This study was designed to evaluate the effects of oriental herb medicine therapy on a limited stage small ell lung cancer(SCLS) patient. Methods : The medical record of this case of SCLS was researched. The patient had been treated with oriental herb medicine for five months continuously in OPD. Clinical data was analyzed and the mass of small cell lung cancer before and after oriental herb medicine therapy was compared using X-ray and CT scan of the whole body in order to determine metastasis. Result : After 5 months of oriental herb medical treatment, most of symptoms disappeared or improved. The small cell lung cancer patially receeded and improvements were mainly seen in sputum, coughing, insomnia, diarrhea, and performance status. Conclusion : The study suggests that oriental herb medicine therapy effects the tumor size by causing remission and Improving health and relieving symptoms, and also positively effects the quality of life as a supportive or curative therapy for SCLC patients.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.381-381
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• 2010

2010년 5월 중 서울 약령시와 서울시내 대형마트에서 유통 중인 약용버섯 및 식용버섯류 16품목 92건 대상으로 중금속(비소, 카드뮴, 납, 수은) 모니터링을 실시하였다. 식품의약품안전청에서 고시한 생약의 잔류오염물질 허용기준 및 시험방법에 따라 실험하였으며, 유통 버섯류의 중금속 함유실태를 파악하고, 버섯의 안전성 기준 제정을 위한 기초 자료를 제공하고자 본 실험을 실시하였다. 새송이버섯 등 생버섯 7종 15건에 대한 중금속 검사 결과 비소 0.01~0.26 mg/kg, 카드뮴 0~0.10 mg/kg, 납 0~0.03 mg/kg, 수은 0~0.007 mg/kg 으로 중금속 함유량이 낮았다. 상황버섯 등 11종 77건의 건조되어 식용 및 약용으로 사용되는 버섯류 중 노루궁뎅이버섯은 4건 중 2건(50.0 %)에서 카드뮴이 0.32~0.82 mg/kg으로 한약재 기준 대비 높게 검출되었으며, 상황버섯은 15건 중 5건(33 %)에서 카드뮴 0.58~0.85 mg/kg, 표고버섯은 9건 중 3건에서 카드뮴 0.42~0.74 mg/kg, 운지버섯 5건 중 1건(20.0 %)에서 1.66 mg/kg, 영지버섯 16건 중 2건(12.5%)에서 수은 0.415 mg/kg과 카드뮴 0.66 mg/kg이 분석되었다. 특히 아가리쿠스버섯은 10건 중 10건(100.0 %)에서 카드뮴(10건) 1.49~7.35 mg/kg, 수은(9건) 0.202~0.505 mg/kg으로 높은 유해중금속 함유량을 보이는 것으로 조사되었다.

• 한국한의학연구원논문집
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• 제2권1호
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• pp.129-145
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• 1996

According to the Medical Product Safety Administration Guidelines for safety assessment guinea pigs, mice and rats were used for antigenicity test, rabbits for pyrogenic test and hymolytic test. The results were summarized as follows; 1. The antigenicity test of Red-ginseng radix extract solution for herb-acupuncture did not show any anaphylatic shock but produced IgE in high dose group. 2. The result of the pyrogen test of Red-ginseng radix extract solution for herb-acupuncture was negative. 3. The result of the hemolytic test of Red-ginseng radix extract solution for herb-acupuncture were negative in low and middle dose group but was positive in high dose group.

• 동의생리병리학회지
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• 제22권4호
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• pp.987-992
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• 2008

This study was carried out to understand the macroscopic aspects of the digestive system symptoms occurring after taking oriental herb complex decoction as observing morphological changes in esophagus, stomach and duodenal bulb by endoscopy of upper gastrointestinal tract when these symptoms developed. The subjects of this study were 46 patients (male 22, female 24, mean age : $54.72{\pm}14.26$ years) who were chosen among ones who took oriental herb complex decoction for medical care and developed symptoms related to the gastrointestinal tract while taking an oriental herb decoction, which were assumed that the digestive symptoms were newly developed because of administration. The subjects were given morphological examination by endoscopy of the upper gastrointestinal tract. As a result of the endoscopy operated due to the digestive symptoms developed during the administration of oriental herb decoction, there were 2 cases of esophagitis, 5 cases of acute gastritis, 1 case of chronic gastritis A type, 15 cases of chronic gastritis B type, 1 case of duodenitis, 1 case of gastric ulcer, 1 case of gastric polyp, 2 cases of intestinal metaplasia, 1 case of gastric ptosis and 17 cases of normal findings which didn't have any abnormality macroscopically with endoscopy. With regards to the patients who complained of the digestive symptoms after taking oriental herb decoction, it has been found that the symptoms occurred as the oriental herbal medicine taken by the patients who had the digestive symptoms at ordinary times influenced on the gastrointestinal tract. Especially, many of them were had chronic gastritis and functional dyspepsia in the past. The disease accompanying macroscopic lesions at endoscopy which occurred due to the oriental herb decoction as direct cause, was acute gastritis, and it was the prescription to cure the pains and inflammations of skeletomuscular disease.

• 동의신경정신과학회지
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• 제20권1호
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• pp.89-106
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• 2009

Objectives : The purpose of this study is to analysis of the herb medications corresponded with neuropsychiatry of "Bang-Yak-Hap-Pyun". Methods : The herb medications of "Bang-Yak-Hap-Pyun" Sang.Jung.Ha-Tong(上.中.下統) and "Enlargement side prescriptions" (增補方) are selected by comment on the chief virtue including reference word of corresponded with neuropsychiatry. Results and Conclusion : "Bang-Yak-Hap-Pyun" is a book most people who have a background or career in Han Medicine(韓醫學) would pore over. They corresponded with neuropsychiatry among the herb medications of "Bang-Yak-Hap-Pyun" Sang.Jung.Ha-Tong(上.中.下統) are 55 prescriptions that Sang-Tong(上統) is 8 prescriptions, Jung-Tong(中.統) is 23 prescriptions and Ha-Tong(下統) is 24 prescriptions. And the herb medications corresponded with neuropsychiatry of "Enlargement side prescriptions" (增補方) are 40 prescriptions. And then the herb medications corresponded with neuropsychiatry of "Bang-Yak-Hap-Pyun" received much influence from "Dong-Eui-Bo-Gam". Incidentally the herb medications corresponded with neuropsychiatry of "Bang-Yak-Hap-Pyun" Sang.Jung.Ha-Tong showed the high percentage in Neurosis. And the herb medications corresponded with neuropsychiatry of "Enlargement side prescriptions" showed the high percentage in Psychosis. Besides not only put "Enlargement side prescriptions a premium on "Dong-Eui-Bo-Gam", but also made it the herb medications which were recorded on books flowed after "Dong-Eui-Bo-Gam" known. It was entered up books quoted from "Bang-Yak-Hap-Pyun" Sang.Jung.Ha-Tong but the herb medications were that were not succeeded from "Bang-Yak-Hap-Pyun" Sang.Jung.Ha-Tong. Therefore "Enlargement side prescriptions" shows the efforts for supplement of "Bang-Yak-Hap-Pyun" Sang.Jung.Ha-Tong.

• 대한한의학원전학회지
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• 제27권4호
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• pp.73-84
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• 2014

Objectives : I'd like to mimic JunChenZuoShe Theory as Herb weight ratio grade. And than analyze the characteristics of the prescription based on the Herb weight ratio grade from Taepyeonghyeminhwajegukbang, Somunsunmyungronbang and Nansilbijang. Methods : At first, we have changed herb informations to Herb weight ratio. The second we have decided the ranking of herb weight ratio. The third we have entered herb weight ratio grade. Finally we have counted frequency of first grade herb from the Taepyeonghyeminhwajegukbang, Somunsunmyungronbang and Nansilbijang. Results : We could use a new search function to find prescription by herb weight ratio grade. And than we could find out prescription efficacy rate of the ancient documents. Conclusions : We have entered herb weight ratio grade values by herb weight ratio ranking of top 10%, 30%, 60%. So we could find out that buqi(補氣) efficacy is used most often in the Taepyeonghyeminhwajegukbang, Somunsunmyungronbang and Nansilbijang. In the rate of qingrezaoshi(淸熱燥濕) efficacy, fasanfengre(發散風熱) efficacy, fasanfenghan(發散風寒) efficacy, Nansilbijang is higher than Taepyeonghyeminhwajegukbang. In the rate of qingrezaoshi(淸熱燥濕) efficacy, gongxia(攻下) efficacy, Somunsunmyungronbang is higher than Taepyeonghyeminhwajegukbang.

• 대한한방부인과학회지
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• 제18권3호
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• pp.184-191
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• 2005

Purpose : To evaluate the effect of herb-medicine on seminal parameters in male infertility patients. Methods : 25 patients were enrolled in this study. They were taken herb-medicine three times a day after meals for 2-5months. Semen analysis or CASA were taken on baseline and post-treatment. Results : The result were as follows : (1) No statistical differences in seminal volume were found. (2) The mean${\pm}$SD of sperm concentration was increased from $51.39{\pm}37.80{\times}10^6$ to $75.99{\pm}50.34{\times}10^6/ml$ alter treatment(P<0.05). (3) The mean${\pm}$SD of motility was increased from 20.22${\pm}$10.75% to 34.02${\pm}$21.36% after treatment(p<0.01). Conclusion : Herb-medicine can be effective on male infertility.

• 대한예방한의학회지
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• 제4권2호
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• pp.25-56
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• 2000

Trace element are involved in enzymatic activities, immunological reactions. physiological mechanisms. Deficiency in some trace elements, such as iron and iodine. is still an important health problem, The role of trace elements deficiency is suspected in various clinical situations and is now confirmed by well designed supplementation studies. However, the importance of trace elements as chinese herbal constituents is not sufficiently appreciated by the oriental medical profession, although in recent years a significant increase of new finding on their essential character in chinese herbal medicine occurred. It is well known that herbal medicine contains a variety of trace elements which would show therapeutic effects with active components in herbal medicine . In china, recent work showed some positive correlation between trace element and traditional chinese medicine (TCM) in terms of therapeutic effects even if their role in therapeutic effects is still obscure. In korea, not much attention has been on the therapeutic importance of trace element contained in herbal medicine Here, the therapeutic effects of trace element in TCM were reviewed and summarized. 1. Iron, copper, zinc and manganese are mainly contained in TCM. In addtion, chromium, magnesium, molybdenum, nickel, alminium, cobalt, arsenic and selenium has been studied for their therapeutic effects 2. Zinc, is decreased in patients who have deficiency of kindney(腎虛) and chronic disease. Fe is decreased in patients who have deficiency of blood(血虛). However copper is increased in patients who have chronic disease and hepatic disease.3 Iron concentration is high in herbs used for tonifying and nourishing yin or blood(補陰補血藥) Zinc concentration is high also in herb used for tonifying kidiney and vital essence(補腎補精藥). In addition. copper concentration Is high in herb used for replenishing qi(補氣藥) 4 In herbal drugs, the therapeutic substances in TCM are not only organic but also inorganic. It seems that trace elements would be one of components in herb for its therapeutic effects. This indicates that therapeutic effects of TCM should be extended not only to herb itself, bur also to trace elements contained in herb.

• 동의생리병리학회지
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• 제21권1호
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• pp.285-290
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• 2007

A liver is responsible for drug metabolism in a body. 10% of all medicine side effects lead to liver injury. Herb medicine is not an exception to this rule but all Herb medicines do not lead to liver injury absolutely. As for two times of occurrence of the drug induced liver injury during treatment of a CVA patient, we gave him Herb medicines in conjunction with Western medicines and Western medicines alone for each case. We meet with the result that giving the patient Herb medicines in conjunction with Western medicines reduces the duration of decreasing AST, ALT level as compared with giving him Western medicines alone. So we are now reporting the result.