• 한국임상수의학회지
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• 제26권6호
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• pp.603-605
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• 2009

7연령의 암컷 미니어처 슈나우저견이 갑작스런 발작과 근육 떨림 증상을 주증으로 내원하였다. 내원 당시 발열과 헐떡임이 두드러졌으며, 신체검사 상에서 현저한 앞다리 근육 강직증상, 근육부분수축과 뻣뻣한 걸음걸이가 관찰되었다. 실험실 검사에서 심각한 저칼슘혈증과 함께 고인혈증이 특징적으로 관찰되었다. 이와 더불어 관찰된 낮은 농도의 부갑상선 호르몬과 이온화된 칼슘농도, 뇨중 칼슘과 인의 배설 량 측정을 통하여 원발성 부갑상선기능저하증이 진단되었다. 이 환축은 10% 글루콘산칼슘 투여를 통한 초기 치료에 반응이 좋았으며, 비타민 D 유사체와 칼슘 보조제를 통한 유지 치료에 의해 잘 관리 되고 있다. 부작용으로 일시적인 고인혈증이 나타났으나, 이 역시 경구용인 흡착제인 sevelamer hydrochloride를 이용한 치료에 의해 안정화 되었다. 결론적으로 본 증례의 경우 개에서 나타나는 원발성 부갑상선기능저하증의 임상증상과 특징적인 실험실 검사 결과 그리고, 치료 반응에 대한 국내 첫 증례보고이다.

• 한국임상수의학회지
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• 제31권5호
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• pp.439-444
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• 2014

체중 2.7 kg의 5세령 암컷 말티즈 견이 양측 슬개골 탈구와 후지 파행으로 지역동물병원에 내원하였다. 도르레절제술과 슬개골의 외측 보강 봉합법을 이용하여 슬개골 탈구 정복술을 실시하였으나, 수술 3주 후 등을 굽힌 자세의 보행과 후지의 운동실조, 흉요추부의 압통, 간헐적인 경련증상으로 재 내원하였다. 자기공명영상 촬영 결과, 우측 전두엽의 종괴와 경수에서부터 3번 요수까지의 공동성 변화가 확인되었다. 병리조직학적 소견으로 뇌종양은 느슨한 망상구조 또는 레이스 모양의 수막세포들로 구성되었으며, 세포 외부에 다양한 크기와 형태의 많은 낭포성 공간이 관찰되었다. 면역조직화학염색 결과 종양세포들은 vimentin 양성, 신경원 특이 에놀라제 및 신경교 섬유질 산성 단백질에는 음성을 나타내었다. 경수와 흉수 부위에는 부정형의 확장된 중심관 유사 동공이 관찰되었다. 이 증례는 개에서 특이적인 두개강 내 소낭성 뇌수막종과 연관되어 2차적으로 발생한 척수공동증의 임상소견과 영상학적 및 병리조직학적 특징을 보여주고 있다.

• 한국임상수의학회지
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• 제22권3호
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• pp.284-287
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• 2005

A 18-month-old, male Maltese dog with acute seizure was referred to Veterinary Medical Teaching Hospital, Kyungpook National University. Abnormal neurologic findings included a tendency to fall to the left, turn and circle to the right, negative bilateral menace responses and pupillary light reflexes, and diminished responses to facial sensation testing on both sides. Radiographic signs were normal, except for occipital dysplasia. Magnetic resonance imaging of the brain revealed bilateral asymmetric ventriculomegaly, which is more on left side. Cerebral edema was also suspected. The dog died after 9 days from the onset of seizure, and a necropsy was performed. Histopathologically, the brain lesions in the meninges and the cerebral cortex of this dog was presented. There was severe diffuse nonsuppurative inflammation in perivascular area of the meninges and the cerebral white matter. Based on the results, this case was diagnosed as necrotizing meningoencephalitis in Maltese dog.

• 한국임상수의학회지
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• 제24권1호
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• pp.68-72
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• 2007

An 8-year-old, male Shih-tzu dog with clinical signs of hemorrhage from penile orifice and pain on lifting hindlimb was brought to the Veterinary Medicine Teaching Hospital, Chungnam National University. The patient was shown polyuria/polydipsia (PU/PD), more than 10 times per day, and gasterointestinal signs such as intermittent vomiting and melena. On laboratory examination, BUN, creatinine and amylase level were all highly increased. Radiographic and ultrasonographic findings included that both kidneys were abnormal, and both prostates were hyperplastic bilaterally and cysts were presented in parenchyma. Additionally, hyperechoic pancreas and intact urinary bladder were observed from ultrasonographic examination. The dog was diagnosed as pancreatitis, acute renal failure and benign prostatic hyperplasia (BPH). After the appropriate treatment for pancreatitis and acute renal failure, He dog was treated with administration of azasteroid for BPH. On day 71 after azasteroid treatment, good response to the treatment was defined by ultrasonography and clinical signs cured completely.

• 한국임상수의학회지
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• 제25권5호
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• pp.391-395
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• 2008

8세령 수컷 요크셔테리어 잡종견(몸무게: 7.5kg)이 운동불내성과 실신을 주증상으로 강원대학교 동물병원에 내원하였다. 초기 심장 검사에서 경미한 이첨판 역류증이외에 특별한 이상소편은 관찰되지 않았다. 운동내성검사에서 환자는 심각한 chronotrophic incompetence소견을 보였고, 1시간-디지털 심전도 검사에서 돌발적으로 발생하여 종료되는 발작성 동성 빈맥소견(심박수: 156-172회)을 보였다. 추가적인 미주신경 자극시험과 verapamil 반응시험에서 빈맥이 종료되는 소견을 보였다. 이러한 소견을 토대로 본 증례는 동방회귀성 빈맥증으로 진단내렸다. 환자는 diltiarem과 enalapril로 치료하였고, 한달 후 재검사에서 운동 불내성 소견은 지속적으로 보였지만, 추가적인 실신소견은 관찰되지 않았다.

• 한국임상수의학회지
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• 제26권3호
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• pp.263-267
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• 2009

A 9-year-old, female, Maltese Dog(2.15 kg of body weight) was referred to the Veterinary Medical Teaching Hospital, Chungnam National University with cervical masses, abdominal masses and petechia. Physical examination showed masses in mandibular, prescapular, inguinal, popliteal lymph node and abdominal subcutaneous hemorrhage. This case was diagnosed as the multicentric lymphoma by physical examination, laboratory examination, radiography, ultrasonography, CT, fine needle aspiration and histopathologic examination. This dog was treated by low-budget protocol with lomustine and prednisolone. The dog show that response duration and survival time is 143days and 263 days, respectively.

• Environmental Analysis Health and Toxicology
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• 제20권1호
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• pp.87-95
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• 2005

Cadmium is well known as a toxic metal and has insulin mimicking effects in rat adipose tissue. This study was undertaken to investigate the effect of CdCl₂ on glucose transport and its mechanism in 3T3 - L1 adipocytes. CdCl₂ exhibits respectively 2.2 and 2.8 fold increases in the 2-deoxyglucose uptake when exposed to 10 and 25 μM of CdCl₂ for 12 hr. To investigate the stimulating mechanism of glucose transport induced by CdCl₂. Wortmannin and PD98059 were used respectively as PI3K inhibitor and MAPK inhibitor, which did not affect 2-DOG uptake. This results suggest that induced 2-deoxy-(l-3H)-D-glucose (2-DOG) uptake by CdCl₂ may not be concerned with the insulin signalling pathway. Whereas nifedipine, a calcium channel blocker inhibited the 2- DOG uptake stimulated by CdCl₂. In addition, we also measured the increased production of Reactive oxygen substances (ROS) and glutathione (GSH) level in 3T3-L1 adipocytes to investigate correlation between the glucose uptake and increased production of ROS with H2DCFDA. CdCl₂ increased production of ROS. Induced 2-DOG uptake and increased production of ROS by CdCl₂ were decreased by N-acetylcystein (NAC). And L-buthionine sulfoximine (BSO) a potent inhibitor of γ-GCS, decreased of 2-DOG uptake. Also NAC and BSO changed the cellular GSH level, but GSH/GSSG ratio remained unchanged at 10, 25 μM of CdCl₂.

• 한국자원식물학회지
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• 제18권1호
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• pp.198-206
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• 2005

애완견의 털에 부착되어 있는 세균을 분리 동정한 후, 이 분리 세균들에 대한 항세균효과가 있는 생약재 추출물을 탐색하였다. 애완견의 털에서 76개의 세균을 분리한 결과, Staphylococcus속이 41균주로 가장 많았으며 그 다음으로 Micrococcus속이 21균 주, Enterococcus속이 8균주, Bacillus속이 3균주, Exiguobacterium속 of 2균주, Shigella속과 Zoogloea속이 각각 1균주씩으로 동정되었다. 이러한 결과는 개의 털에 존재하는 세균들이 사람에게 감염을 일으킬 수 있는 원인이 될 수 있음을 시사한다. 분리균주들에 대한 항생제 저항성과 생약재 추출물의 항세균 활성은 디스크 확산법으로 확인하였다. 황금의 추출물이 애완견의 털로부터 분리한 세균들에 대해 높은 항세균 활성을 나타내어 항생제 저항성이 있는 세균들에 대한 새로운 항미생물제로 사용학 수 있을 것으로 기대된다.

• 한국임상수의학회지
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• 제36권6호
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• pp.297-300
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• 2019

Wii^® balance board (WBB) is a device that can measure and record body sway. This study was conducted to evaluate the reliability of WBB in small sized dog as inexpensive, portable and convenient tool. The center of pressure path length (CPPL) and 95% confidence ellipse area (Area 95) were evaluated with only two plates of WBB. The parameters were evaluated between no load (0 kg) and mass group (0.25-4 kg on each one plate). 23 dogs (2.3-7.3 kg) were evaluated for with hindlimb standing for 10 seconds. The mass group showed a significant value in comparison to the no load during the measurement. And intra-class correlation coefficients (ICCs) between CPPL and Area 95 revealed very high both mass and dog group. In the evaluation of medial patellar luxation (MPL) as a diagnostic tool, 80 dogs with MPL and 23 non-affected dogs were used. In studies of CPPL and Area 95, significant differences were found between non-affected and MPL groups for 10 and 30 seconds, respectively. The WBB can be used as a valid tool for evaluating hind limb standing balance and can be useful as an objective tool to present clinical results in small sized dog with MPL.

• 한국미생물·생명공학회지
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• 제49권1호
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• pp.57-64
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• 2021

Lactic acid bacteria (LAB), belonging to the Firmicutes phylum, lack heme biosynthesis and, thus, are characterized as fermentative and catalase-negative organisms. To verify the hypothesis that heme-rich-nutrients might compensate the heme-biosynthesis incapability of non-respiratory LAB in animal gut, a heme-rich-nutrient was fed to a dog and its fecal microbiome was analyzed. Firmicutes abundance in the feces from the heme-rich-nutrient-fed dog was 99%, compared to 92% in the control dog. To clarify the reason of increased Firmicutes abundance in the feces from the heme-rich-nutrient-fed dog, Lacobacillus gasseri were used as model anerobic LAB to study a purified heme (hemin). The anaerobic growth of L. gasseri in the medium with 25 µM hemin supplementation was faster than that in the medium without hemin, while the growth in the 50 µM hemin-supplemented medium did not vary. Cellular activities of the cytochrome bd complex were 1.55 ± 0.19, 2.11 ± 0.14, and 2.20 ± 0.08 U/gcell in the cells from 0, 25, and 50 µM hemin-supplemented medium, while intracellular ATP concentrations were 7.90 ± 1.12, 11.95 ± 0.68, and 12.56 ± 0.58 µmol_ATP/g_cell, respectively. The ROS-scavenging activities of the L. gasseri cytosol from 25 µM and 50 µM hemin-supplemented medium were 68% and 82% greater than those of the cytosol from no hemin supplemented-medium, respectively. These findings indicate that external hemin could compensate the heme-biosynthesis incapability of L. gasseri by increasing the cytosolic ROS-scavenging and extra ATP generation, possibly through increasing the electron transfer. Increase in the number of anaerobic bacteria in heme-rich-nutrient-fed animal gut is discussed based on the results.