개에서 발생한 양성 전립선 비대증의 약물 치료 1례

Medication for Benign Prostatic Hyperplasin in a Dog

  • 임영환 (충남대학교 수의과대학 동물의과학연구소) ;
  • 용환율 (서울대학교 치과대학 치학연구소 BK21 치의학생명과학사업단) ;
  • 손정민 (충남대학교 수의과대학 동물의과학연구소) ;
  • 송근호 (충남대학교 수의과대학 동물의과학연구소) ;
  • 최호정 (충남대학교 수의과대학 동물의과학연구소) ;
  • 박성준 (충남대학교 수의과대학 동물의과학연구소) ;
  • 정성목 (충남대학교 수의과대학 동물의과학연구소) ;
  • 이영원 (충남대학교 수의과대학 동물의과학연구소) ;
  • 신상태 (충남대학교 수의과대학 동물의과학연구소) ;
  • 조종기 (충남대학교 수의과대학 동물의과학연구소)
  • Lim, Young-Hwan (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Yong, Hwan-Yul (Craniomaxillofacial Life Science BK 21, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Son, Jung-Min (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-Ho (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Choi, Ho-Jung (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Park, Seong-Jun (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Jeong, Seong-Mok (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Lee, Young-Won (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Shin, Sang-Tae (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Cho, Jong-Ki (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University)
  • 발행 : 2007.03.30

초록

An 8-year-old, male Shih-tzu dog with clinical signs of hemorrhage from penile orifice and pain on lifting hindlimb was brought to the Veterinary Medicine Teaching Hospital, Chungnam National University. The patient was shown polyuria/polydipsia (PU/PD), more than 10 times per day, and gasterointestinal signs such as intermittent vomiting and melena. On laboratory examination, BUN, creatinine and amylase level were all highly increased. Radiographic and ultrasonographic findings included that both kidneys were abnormal, and both prostates were hyperplastic bilaterally and cysts were presented in parenchyma. Additionally, hyperechoic pancreas and intact urinary bladder were observed from ultrasonographic examination. The dog was diagnosed as pancreatitis, acute renal failure and benign prostatic hyperplasia (BPH). After the appropriate treatment for pancreatitis and acute renal failure, He dog was treated with administration of azasteroid for BPH. On day 71 after azasteroid treatment, good response to the treatment was defined by ultrasonography and clinical signs cured completely.

키워드

참고문헌

  1. Barsanti JA, Finco DRL Canine prostatic diseases. In Morrow DA(ed): Current Therapy in Theriogenolgy. Philadelphia: WB Saunders company, 1986: 553-560
  2. Berry SJ, Strandberg JD, Saunders WJ, Coffey DS. Development of canine benign prostatic hyperplasia with age. Prostate 1986; 9: 363-373 https://doi.org/10.1002/pros.2990090406
  3. Brendler CB, Berry SJ, Ewing LL, McCullough AR, Cochran RC, Strandberg JD, Zirkin BR, Coffey DS, Wheaton LG, Hiler ML, Bordy MJ, Niswender GD, Scott WW, Walsh PC. Spontaneous benign prostatic hyperplasia in the beagle: Ageassociated changes in serum hormone levels, and the morphology and secretary function of the canine prostate. J Clin Invest 1983; 71: 1114-1123 https://doi.org/10.1172/JCI110861
  4. Bruengger A, Bartsch G, Hollinger BE, Holly B, Rohr HP. Smooth muscle cell of the canine prostate in spontaneous benign hyperplasia, steroid induced hyperplasia and estrogen or tamoxifen treated dogs. J Urol 1983; 130: 1208-1210 https://doi.org/10.1016/S0022-5347(17)51762-0
  5. Ewing LL, Berry SJ, Higginbottom EG Dihydrotestosterone concentration of beagle prostatic tissue: effect of age and hyperplasia. Endocrinology 1983; 113: 2004-2009 https://doi.org/10.1210/endo-113-6-2004
  6. Feeney DA, Johnston GR, Klausner JS, Perman V, Leininger JR, Tomlinson MJ. Canine prostatic disease--comparison of radiographic appearance with morphologic and microbiologic findings: 30 cases (1981-1985). J Am Vet Med Assoc 1987; 190: 1018-1026
  7. Funke PJ, Tunn UW, Senge T, Neumann F. Effects of the antioestrogen tamoxifen on steroid induced morphological and biochemical changes in the castrated dog prostate. Acta Endocrinol 1982; 100: 462-472
  8. Glassman DT, Chon JK; Borkowski A, Jacobs SC, Kyprianou N. Combined effect of terazosin and finasteride on apoptosis, cell proliferation, and transforming growth factor-${\beta}$ expression in benign prostatic hyperplasia. The Prostate 2001; 46: 45-51 https://doi.org/10.1002/1097-0045(200101)46:1<45::AID-PROS1007>3.0.CO;2-U
  9. Hedlund PO. Side effects of endocrine treatment and their mechanisms: Castration, antiandrogens, and estrogens. The prostate supplement 2000; 10: 32-37
  10. Iguer-Ouada M, Verstegen JP. Effect of finasteride (proscar MSD) on seminal composition, prostate function and fertility in male dogs. J Reprod Fertil Suppl 1997; 51: 139-149
  11. Imperato-McGinley J, Binienda Z, Arthur A, Mininberg DT, Vaughan ED Jr, Quimby FW. The development of a male pseudohermaphroditic rat using an inhibitor of the enzyme 5 alpha-reductase. Endocrinology 1985; 116: 807-812 https://doi.org/10.1210/endo-116-2-807
  12. Johnson CA. Disorders of the prostate gland. In Nelson RW, Couto CG (ed): Small animal internal medicine, 3rd ed. St. Louis: Mosby, 2003: 927-933
  13. Johnston SD, Kamolpatana K, Root-Kustritz MV, Johnston GR. Prostatic disorders in the dog. Anim Reprod Sci 2000; 60: 405-415 https://doi.org/10.1016/S0378-4320(00)00101-9
  14. Johnston SD, Kustritz MVR, Olson PNS. Disorders of the canine prostate. In: Canine and feline theriogenolgy, 1st ed. Philadelphia: WB Saunders company, 2001: 337-355
  15. Krawiec DR, Heflin D. Study of prostatic disease in dogs: 177 cases (1981-1986). J Am Vet Med Assoc 1992; 200: 1119-1122
  16. Kutzler MA, Yeager A. Prostatic disease. In Ettinger SJ, Feldman EC (ed): Textbook of veterinary internal medicine, 6th ed. St. Louis: WB Saunders company, 2005: 1809-1819
  17. Leav I, Schelling KH, Adams JY, Merk FB, Alroy J. Role of canine basal cells in postnatal prostatic development, induction of hyperplasia, and sex hormone-stimulated growth, and the ductal origin of carcinoma. Prostate 2001; 48: 210-224 https://doi.org/10.1002/pros.1100
  18. Merk FB, Warhol MJ, Kwan PW, Leav I, Alroy J, Ofner P, Pinkus GS. Multiple phenotypes of prostatic glandular cells in castrated dogs after individual or combined treatment with androgen and estrogen. Morphometric, ultrastructural, and cytochemical distinctions. Lab Invest 1986; 54: 442-456
  19. Read RA, Bryden S. Urethral bleeding as a presenting sign of benign prostatic hyperplasia in the dog: a retrospective study (1979-1993). J Am Anim Hosp Assoc 1995; 31: 261-267 https://doi.org/10.5326/15473317-31-3-261
  20. Suzuki K, Okazaki H, Ono Y, Kurokawa K, Suzuki T, Onuma E, Takanashi H, Mamiya Y, Yamanaka H. Effect of dual inhibition of 5-alpha-reductase and aromase on spontaneously developed canine prostatic hypertrophy. The prostate 1998; 37: 70-76 https://doi.org/10.1002/(SICI)1097-0045(19981001)37:2<70::AID-PROS2>3.0.CO;2-P
  21. Trachtenberg J, Hicks LL, Walsh PC. Androgen- and estrogen-receptor content in spontaneous and experimentally induced canine prostatic hyperplasia J Clin Invest 1980; 65: 1051-1059 https://doi.org/10.1172/JCI109757
  22. Winter ML, Liehr JG Possible mechanism of induction of benign prostatic hyperplasia by estradiol and dihydrotestosterone in dogs. Toxicol Appl Pharmacol 1996; 136: 211-219 https://doi.org/10.1006/taap.1996.0027