• Journal of Society of Preventive Korean Medicine
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• v.11 no.1
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• pp.1-8
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• 2007

Curcumin and its analogues(Tetrahydrocurcumin THC, demethoxycurcumin ; BDMC and dimethoxycurcumin DiMC) were compared for their ability to inhibit the growth of human leukemia HL-60 cells. The growth of HL-60 cells was inhibited by curcumin, DeMC and DiMC, but not by THC lacking ${\alpha},{\beta}-unsaturated$ carbonyl groups thus suggesting that ${\alpha},{\beta}-unsaturated$ carbonyl groups are crucial for antiproliferative activity. The order of antiproliferative activity was DiMC, curcumin and BDMC indicating that the number of methoxy groups on the aromatic rings of the active compounds plays an important role in enhancing anti-proliferating activity. In comparison with cellular uptake of the active compounds, uptake capacity was found to be highest with DiMC, followed by curcumin and BDMC. Therefore, it is most likely that the differential antiproliferative activities of DiMC, curcumin and BDMC are associated with their capacities of cellular uptake resulting in building up of enough concentration inside the cells.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.2
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• pp.446-452
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• 2008

To evaluate the anti-obesity efficacy of Gamitaeeumjowi-tang consisting of Taeeumjowitang and Daehwang. Eleven male(n=4) and female(n=7), obesity patients were recruited by Tenten Diet Network from November 2005 to February 2006. All the subjects were treated with Gamitaeeumjowi-tang 3 times a day for 12 weeks. Weight, BMI, body fat weight, Total cholesterol, LDL, HDL, Triglycerides, GOT, GPT, and CT results were evaluated before and after the 12 week treatment. Weight, BMI, body fat weight, total cholesterol, triglyceride, and subcutaneous fat in upper and lower abdomen all showed significant decrease after 12 weeks of administration. Also Gamitaeeumjowi-tang showed no toxic effects based on liver function test. Taken together, The potentials of Gamitaeeumjowi-tang as a safe and effective treatment for obesity has been recognized through this study. Further large sample sized and double blinded randomized control trials are needed to fully confirm the findings of this study.

• Journal of Society of Preventive Korean Medicine
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• v.7 no.1
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• pp.87-102
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• 2003

This study was conducted to examine recognition of oriental medical doctors on the quality control of herbal medicine and to provide useful information for the establishment of effective quality control system of herbal medicine. Data were collected from 202 oriental medical doctors working in oriental medical hospitals or clinics in Daegu-Gyungbuk province. Generally, there is a tendency that most respondents have low degree of recognition, trust and satisfaction of the quality control of herbal medicine while they think standardization and complete quality control systems of herbal medicine is needed highly. Thus, in order to increase confidence of consumers in herbal medicine, and to increase the utilization of oriental medical services, both strengthening of quality control systems and standardization and establishment of Oriental KFDA as a new government agency responsible for the work should be required.

• Journal of Society of Preventive Korean Medicine
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• v.8 no.1
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• pp.135-145
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• 2004

This study tried to analyze influencing factors on self-perceived health status(SPHS) of labors in workplace. and suggested the preventive oriental medicine approaches in occupational health care. 914 data for research were collected through the process of oriental health examination with questionnaire in workplace and collected data were analyzed with frequency, homogeneity and correlation statistically. The results were as follows : 1) The distributions of SPHS was 58.4% of healthy group. 41.6% of unhealthy group. 2) For the difference of SPHS by stress, the high level stress group was more included in healthy group(p<0.05). 3. For the difference of SPHS by health behavior. the higher score of health behavior group was more included in healthy group. There was statistically significant difference of SPHS in physical exercise, but not in smoking, drinking, sleeping and body mass index. 4. For the difference of SPHS by the latest health examination results, non-disease group was more included in healthy group, while disease group was more included in unhealthy group. From the above results, SPHS was influenced by stress, health behavior, the latest health examination results. Therefore oriental medical service for occupational health must be interested in the these influencing factors and make an effort to change their perception of health as well as physical improvement.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.3
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• pp.503-509
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• 2011

Jakyaktang(芍藥湯; JYT) exhibits potent anti-inflammatory activity in widely intestinal disease, but its mechanism was undisclosed. To elucidate the molecular mechanisms of JYT on pharmacological and biochemical actions in inflammation, we examined the effect of JYT on pro-inflammatory mediators in phorbol 12-myristate 13-acetate (PMA) plus A23187-induced mast cell and lipopolysaccharide (LPS)-stimulated macrophages. The investigation focused on whether JYT inhibited pro-inflammatory cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) in PMA plus A23187- induced HMC-1 cells and inflammatory madiators such as nitric oxide (NO), TNF-${\alpha}$, IL-6, iNOS, COX-2 in LPS-stimulated RAW 264.7 cells. We found that JYT inhibited LPS-induced NO, TNF-${\alpha}$ and IL-6 productions as well as the expressions of iNOS and COX-2. These results suggest that JYT has inhibitory effects on mast cell-mediated and macropage-mediated inflammation.

• The Journal of the Society of Stroke on Korean Medicine
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• v.12 no.1
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• pp.61-67
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• 2011

Background : Prevalence of spasticity because of stroke are 40% patients after 12 month. Spasticity caused decrease of range of motor, motor function, and active daily living. Electroacupuncture widely used stroke. But it is been studied by systematic review between spasticity and electroacupuncture. This study is aimed to efficacy of electroacupuncture for spasticity because of stroke. Methods : We had used pubmed(www.pubmed.com) and cochrane library(www.thecochranelibrary.com) database. Limits are'human','randomized controlled trial'and'all adult 19+ years'in pubmed. The period was until 15, september, 2011. We used MeSH(Medical Subject Headings terms. The search words were'stroke'[mesh],'muscle spasticity'[mesh and 'electroacupuncture'[mesh]. In cochrane library, we used spasticity and electroacupuncture in cochrane library. We found 19 studies. But only 3 studies were included for inclusion criteria. Results : The appropriate 3 studies were different from subject, acupoint, duration of treatment, endpoint and etc. But these studies were effective for spasticity because of stroke. Conclusion : These studies were not meta analysis because of heterogeneity. But the above results might explain the electroacupuncture were effective for spasticity and further study needed to verify and standard electroacupuncture study for spasticity.

• Journal of Society of Preventive Korean Medicine
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• v.10 no.2
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• pp.63-80
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• 2006

Public health oriental medical doctor has played a great role in providing oriental medical treatment and oriental medical health program with public health medical services, the basic infrastructure, however, is not sufficient. In this study, the researcher surveyed the treatment working or service condition of public health oriental medical doctor. 1. The payment, allowance of doctors are fixed upon the law and guideline according to the financial status of local government. The branch of public health center has more support like an official residence with expenses. 2. The public health center mainly has assitants and ratio of full-timer is more than the branch public health center without any assistants if any, they are temporary employee 3. The public health center has 5.22 beds while the branch has 3.14 beds. The daily average number of patient for public health center is 15.01 while the branch has 8.7 More than half of outpatients are over sixties with musculoskeletal disease. 4. Regarding the traveling clinic, the public health center put into more operation than the branch. The 3rd year serving public doctor gives negative about the traveling clinic much more than 1st and 2nd year serving public doctor. The treatment service condition of public doctor of the public health center is better than the branch doctor, but we are on the point of role-changing as health promotion and preventive treatment to bring up motivation, education and competence strengthening for execution the local-bound health program.

• Journal of Society of Preventive Korean Medicine
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• v.1 no.1
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• pp.55-58
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• 1997

It is well known that Poncirus trifoliata harmonizes the Stomach dissipates the Nodules of Liver and manages Vitality. This herb has been used for stomachache, vomitting, nausea, abdominal distension and swelling of testis in the Oriental Medicine. A major components of Poncirus trifoliata consist of a various flavonoids such as poncirin, naringin, hesperidin, neohesperidin, rhoifolin, poncimarin, poncitrin. Generally pharmacological activities of an oriental medicinal drug may be different due to diverse origin, harvest season and storage Period. In this study, we aimed to measure the contents of poncirin and naringin, major flavonoid of this herb, to determine the quality of Poncirus trifoliata.

• Journal of Society of Preventive Korean Medicine
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• v.18 no.2
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• pp.147-154
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• 2014

Objective : The purpose of this study is to analyze for the patent application tendency in Korean Oriental Pediatric Medicine. Recently, many studies are published in Korean Oriental Pediatric Medicine. However, in the patent area, the research results are few. Method : For patent analysis, we searched the database kipris (http://www.kipris.or.kr) which managed in the Korean Intellectual Property Office by keywords about Korean Oriental Pediatrics. They are technically analysed by year and IPC, patent's contents, main applicant and organization. Results : 1. Patents by year have been on the rise 2 in 1997 to 32 in 2011. 2. Our findings are Section A61;182, A23;46 in IPC analysis 3. In classification of content, 'application-food' is 67 cases, 'application-functional cosmetic' is 18 cases, 'application-clothes' is 5 cases. 4. Korea Institute of Oriental Medicine have 14 patent cases, that is the most patent agency in possession. Main applicants are person > company > university > laboratory > state or local government. Conclusion : This study shows that it has high frequency of daily necessity in patent cases about oriental pediatrics. The results are more distributed 'applied' field than 'treatment' field. The patent information should be connected research achievement results in Korean Oriental Medicine.

• Journal of Society of Preventive Korean Medicine
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• v.12 no.2
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• pp.27-35
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• 2008

Purpose : The experiments was undertaken to evaluate the effects of Ojeoksan-herbal medicine, in rats' fetus Methods : Female Sprague-Dawley rats were orally administered with the Ojeoksan at dose of 5mg/kg/day for 20 days. Pregnant rats were sacrificed at 20th day of gestation, and observed internal and reproductive organs. Approximately live fetuses in the 20th day of gestation were randomly selected and fixed in 95% ethanol. Results : Neonatal body weight and number of fetus of Ojeoksan group were increased to that of control group. The fetuses of dams treated with Ojeoksan didn't showed external malformation. Vertebral and sternal skeletal variations were observed in Ojeoksan administered group, but compared to the control, those skeletal variations were insignificant. There were no significant changes in number of ribs, cervical, thoracic, lumber, sacral and caudal Conclusion : From these results, it can be concluded that Ojeoksan showed no toxicity effects on number of live fetuses. There were no significant changes in skeletal variations were showed in vertebrate and sternum, Ojeoksan weren't shown significant changes in bone malformation. We need more precise study to investigate the mechanism of early or late resorption by the herbal medicines such as Ojeoksan.