• Journal of the Korean Burn Society
• /
• v.24 no.2
• /
• pp.68-73
• /
• 2021

Purpose: A large defect by fourth-degree burns in the upper limb requires flap reconstruction. Since severe vascular damage and decrease in blood circulation after vascular anastomosis can occur in defects caused by fourth-degree burns. Because of the disadvantages, it is difficult to apply free flap surgery to fourth-degree burns. We reconstructed a upper extremity using the pedicled Latissimus Dorsi (LD) flap in two stages. The purpose of our study is to review our experience and suggest two-staged pedicled Latissimus Dorsi (LD) flap in fourth-degree burns of upper extremities. Methods: A retrospective review was performed from 2016 to 2019, on a total of 12 fourth-degree burn patients undergone two-staged pedicled LD flap surgery as reconstruction of upper extremities in our hospital. We reviewed the location of the injury, etiology, TBSA (%), size of burns requiring flap surgery, period from 1st surgery to secondary division surgery, complications. Results: Using two-staged LD flap as a primary reconstruction, the outcome is satisfactory. This flap preserves the elbow joint and maintains the length of the forearm. We obtain low donor-site morbidity, simplicity and a small incision in the donor site. Conclusion: Using two-staged LD flap in fourth-degree burns of upper extremity is effective, such as preserving elbow joint and maintaining the length of the forearm. Successful reconstruction was achieved with excellent cosmetic results with reducing a postoperative scar, donor-site morbidity. Due to these advantages, two-staged pedicled LD flap can be an optimal option for reconstruction of fourth-degree burns in the upper limb.

• Journal of the Korean Applied Science and Technology
• /
• v.38 no.6
• /
• pp.1466-1475
• /
• 2021

Compound K (20-O-β-(_D-glucopyranosyl)-20(S)-protopanaxadiol) is an active ingredient of ginsenosides. Compound K has been known to produce from biotransformation by β-glucosidase action of human intestinal microbes after oral admistration of ginseng. We have investigated the cytotoxicity of compound K obtained from bio-converted ginseng extract. As a result, compound K showed no significant cytotoxicity in the concentration of 0.001 to 1 ㎍/mL and inhibited the production of TNF-α, MCP-1, IL-6 and NO in RAW 264.7 cells induced by LPS inflamation. In the same concentration, HaCaT cells induced by inflammation with TNF-α and IFN-γ decreased IL-8 production due to compound K treatment. In the brine shrimp lethality assay, the LC₅₀ of compound K was 0.37 mg/mL indicating some toxicity, but the bioconverted product containing 35% compound K showed relatively low toxicity with an LC₅₀ of 0.87 mg/mL. These results suggest that the compound K enriched extract is a potential functional material for acne relief cosmetic products.

• Journal of the Korean Orthopaedic Association
• /
• v.54 no.2
• /
• pp.192-196
• /
• 2019

Iatrogenic calcinosis cutis is due to the intravenous administration of calcium gluconate or calcium chloride to treat hypocalcemia. The arthors report three cases of calcinosis cutis with calcifications involving the upper or lower extremities in neonates following the extravasation of calcium gluconate. Three neonates, a 2-week-old girl, 4-week-old boy, and a 4-week-old girl, were consulted for indurated nodules after the intravenous administration of calcium gluconate at the intensive care unit. Complete remission of palpable nodule and calcification was observed on the radiograph at three weeks, four weeks and six months after the initial presentation in each. All three neonates with iatrogenic calcinosis curtis were resolved spontaneously without functional and cosmetic complications. According to enhancement of the patient's cognition about benign disease, a suitable explanation of the disease and avoiding unnecessary treatment through an early diagnosis of iatrogenic calcinosis cutis will reduce a number of potential medical malpractice disputes.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2023.01a
• /
• pp.195-197
• /
• 2023

본 연구의 목적은 청년 대학 졸업자 취업 성공 요인 분석과 수도권과 비수도권의 결정 요인 비교를 통해 대학의 취업 지원을 전략과 방향을 제시하는 것이다. 이를 위해 2019년 대졸자 취업경로이동조사 자료를 활용하여 개인특성, 학교특성, 진로선택 및 취업프로그램 참여, 취업 준비 활동 경험을 독립변수로 하고 취업 성공 여부를 종속변수로 하여 취업 성공 요인을 분석하였다. 그 결과, 서울·수도권 대졸자는 개인특성 중 연령, 부모자산, 어학연수 경험이 취업 성공(+) 요인이었고, 대학특성은 2~3년제 대졸자가 4년제, 교육대 대졸자 보다 취업성공 가능성이 높았다. 진로선택 및 취업프로그램 참여 중 직장체험, 면접·이력서 작성이 취업 성공(+)요인으로 직업심리검사는 취업 성공(-) 요인으로 나타났다. 취업준비활동 경험 중 SSAT 자격증, 공모전 수상, 대외활동, 이력서·면접훈련은 취업 성공(+) 요인으로 졸업 전 구직활동, NCS 준비, 외모관리는 취업 성공(-)요인으로 나타났다. 반면, 비수도권 대졸자는 개인특성 중 연령, 부모자산이 취업 성공(+)요인이었고, 2~3년제 대졸자가 4년제, 교육대 대졸자 보다 취업성공 가능성이 높았다. 진로선택 및 취업프로그램 참여 중 직장체험, 면접·이력서 작성이 취업 성공(+)요인으로, 직업심리검사, 기업채용설명회는 취업 성공(-)요인으로 나타났다. 취업준비활동 경험 중 봉사활동, 공모전 수상, 대외활동, 모의면접은 취업 성공(+)요인이었고, 졸업 전 구직활동, 자격증, 외모관리는 취업 성공(-)요인이었다. 이를 바탕으로 4년제 대학의 비교과 활동 강화, 취업환경과 유사한 실무능력 배양 교육, 면접·이력서 작성 등 실제적 취업지도 프로그램 시행을 제시하였고, 봉사활동, 대외서포터즈, 공모전 등 취업처에 실무능력을 보여줄 수 있는 실무활동 참여를 지원하는 방안 등을 제시하였다.

• The Korean Journal of Applied Statistics
• /
• v.36 no.6
• /
• pp.515-528
• /
• 2023

With the growth of the e-commerce market, consumers increasingly rely on user reviews to make purchasing decisions. Consequently, researchers are actively conducting studies to effectively analyze these reviews. Among the various methods of sentiment analysis, the aspect-based sentiment analysis approach, which examines user reviews from multiple angles rather than solely relying on simple positive or negative sentiments, is gaining widespread attention. Among the various methodologies for aspect-based sentiment analysis, there is an analysis method using a transformer-based model, which is the latest natural language processing technology. In this paper, we conduct an aspect-based sentiment analysis on multilingual user reviews using two real datasets from the latest natural language processing technology model. Specifically, we use restaurant data from the SemEval 2016 public dataset and multilingual user review data from the cosmetic domain. We compare the performance of transformer-based models for aspect-based sentiment analysis and apply various methodologies to improve their performance. Models using multilingual data are expected to be highly useful in that they can analyze multiple languages in one model without building separate models for each language.

• Journal of the Korean Applied Science and Technology
• /
• v.39 no.6
• /
• pp.748-759
• /
• 2022

The purpose of this study is to investigate the mediating effect of job commitment and the moderating effect of job burnout on the relationship between the protean career orientation and subjective career success of hair designers. For this purpose, a survey was conducted on 163 employees working at a representative A brand hair salon in Korea, and statistical analysis was conducted using SPSS 21, and SPSS Process Macro v. 3.3. The results of this study are as follows: First, Protean career orientation affects job commitment to focus on oneself in all aspects related to their job, and as a result, it has a mediating effect on subjective career success that satisfies their career. Second, Through the interaction between protean career orientation and job burnout, the moderating effect on job commitment was confirmed. The significance of this study is to suggest a career success plan for hair salon workers with relatively high turnover rate in the service field by dealing with the understanding of the hair salon organizational culture and the lack of hair designer protean career orientation in terms of the mediating role of job commitment and job burnout in career success.

• Journal of the Korean Applied Science and Technology
• /
• v.40 no.5
• /
• pp.965-976
• /
• 2023

Reynoutria japonica is a perennate plant belonging to Polygonaceae and grows wild in East Asia containing Korea. Roots of Reynoutria japonica (R. japonica), part of roots of Reynoutria japonica, has been used for anti-inflammation and antispasmodics and contains emodin as active compound. Epidermis of skin is crucial roles to defense our body against stimulants, harmful substance and prevent water loss. In this study, we examined the effect of R. japonica and emodin, its active compound, on skin-barrier and moisturizing on HaCaT cells. First, antioxidant effect of R. japonica was prominent by scavenging ABTS⁺ radicals. Next, we conducted real time PCR and expression of filaggrin mRNA which is crucial role in differentiation of keratinocyte increased by R. japonica and emodin dose-dependently. In addition, R. japonica and emodin significantly elevated the expression of HAS-2 mRNA which play a role in hyaluronic acid synthesis on HaCaT cells. Taken together, R. japonica containing emodin, as active compound has potential as a cosmetic material for enhancing the function of skin-barrier and moisturizing in epidermis.

• Journal of the Korean Applied Science and Technology
• /
• v.40 no.4
• /
• pp.856-867
• /
• 2023

Due to the increase in fine dust caused by environmental pollution, oxidative damage and aging of the skin are accelerated. In this study, the antioxidant, hyaluronic acid, filaggrin, MMP-1, and ROS level of selected herbal extracts were evaluated to confirm the protective efficacy of keratinocytes treated PM10. As a result, the antioxidant capacity of 1,1-diphenyl-2-picrylhydrazyl(DPPH), 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid(ABTS), and FRAP assay increased in a concentration-dependent manner. Keratinocytes the group treated with 300 ㎍/ml of PM10, hyaluronic acid and filaggrin decreased by more than 50%, and increased in the group treated with extracts of Alpinia officinarum, Ulmus macrocarpa, and Ulmus macrocarpa but decreased when the extract was treated, which is evaluated as inhibiting the degradation of collagen and elastin. In addition, in the case of ROS measurement using zebrafish embryos, it was confirmed that the extract was reduced when the extract was treated 25 ㎍/ml, the intensity of fluorescence similar to the negative control was shown, confirming that the production of ROS was significantly reduced. Through this study, the selected oriental medicinal materials, Alpinia officinarum, Ulmus macrocarpa, and Ulmus macrocarpa, protect the skin from fine dust. It is thought that it can be used as an anti-aging product for skin improvement as a material that can be improved or improved.

• Journal of the Korean Applied Science and Technology
• /
• v.40 no.4
• /
• pp.825-842
• /
• 2023

This study conducted a survey to analyze the influence of the consumer-brand interaction and the consumer-brand relationship on motivation and satisfaction based on the perceived age of men and women in their teens and 50s who subscribe to cosmetic brands through SNS accounts. For statistical processing of the collected data, frequency analysis, factor analysis, reliability analysis, regression analysis, and multiple regression analysis were performed with SPSS 21.0. The perceived age of the subjects was classified into 'perceived lower group', 'perceived middle group', and 'perceived higher group' according to the difference between the age perceived by others and the age perceived by themselves. In the three groups, the consumer-brand interaction and the consumer-brand relationship showed a meaningful positive relationship with motivation, and the consumer-brand relationship was found to be a major variable explaining 'attractive' among motivation. In the three groups, the consumer-brand interaction and the consumer-brand relationship showed a significant positive relationship with satisfaction, and the consumer-brand relationship appeared as a major variable explaining satisfaction. Therefore, the conclusion of this study is that by perceived age group, the consumer-brand interaction and the consumer-brand relationship have a positive effect on motivation and satisfaction. In particular, it was found that the consumer-brand relationship is a major variable in cosmetics motivation and satisfaction. As this study empirically analyzes the influence of age perceived on SNS on cosmetics brand marketing, it is considered to be a practical implication for establishing cosmetics sales strategy and basic data that can be used for marketing.

• Journal of Life Science
• /
• v.19 no.4
• /
• pp.520-525
• /
• 2009

Early onset of Batten disease (EBD), one of the most lethal neurodegenerative storage disorders of childhood, is caused by inactivating mutations in the Ceroid Lipofuscinosis, Neuronal (CLN1) gene. Neurogranin, a calmodulin-binding protein, is expressed in the brain and participates in the protein kinase C (PKC) signaling pathway. While oxidative stress is the suggested cause of neurodegeneration in EBD, its molecular mechanism(s) remains obscure. In this research, we examined the levels of neurogranin in the brain mRNA of wild-type (WT) mice and EBD knockout (KO) mice, as well as the proteins. We also performed neuronal cultures to measure the expression levels of neurgranin and phosphorylated-neurogranin with or without oxidative stress inducers and anti-oxidants. Results showed that neurogranin in both EBD KO mice brain mRNA and protein extracts decreased in an age dependent manner. However, high amounts of phosphorylated-neurogranin were detected in the 6-month brain. This pattern was also confirmed by cultured neurospheres samples. Moreover, neurospheres treated with $H_2O_2$, an oxidative stress inducer, showed increased phosphorylated-neurogranin patterns. Interestingly, this pattern returned to normal status when treated with N-acetyl-L-cystein, an anti-oxidant, after $H_2O_2$ treatment was performed. Our results suggest that the phosphorylation of neurogranin is affected by oxidative stress status in EBD, and appropriate anti-oxidant treatment will relieve hyper-phosphorylation of neurogranin.