• BMB Reports
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• 제56권9호
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• pp.520-525
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• 2023

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline. Several recent studies demonstrated that impaired adult neurogenesis could contribute to AD-related cognitive impairment. Adult subventricular zone (SVZ) neurogenesis, which occurs in the lateral ventricles, plays a crucial role in structural plasticity and neural circuit maintenance. Alterations in adult SVZ neurogenesis are early events in AD, and impaired adult neurogenesis is influenced by the accumulation of intracellular Aβ. Although Aβ-overexpressing transgenic 5XFAD mice are an AD animal model well representative of Aβ-related pathologies in the brain, the characterization of altered adult SVZ neurogenesis following AD progression in 5XFAD mice has not been thoroughly examined. Therefore, we validated the characterization of adult SVZ neurogenesis changes with AD progression in 2-, 4-, 8-, and 11-monthold male 5XFAD mice. We first investigated the Aβ accumulation in the SVZ using the 4G8 antibody. We observed intracellular Aβ accumulation in the SVZ of 2-month-old 5XFAD mice. In addition, 5XFAD mice exhibited significantly increased Aβ deposition in the SVZ with age. Next, we performed a histological analysis to investigate changes in various phases of adult neurogenesis, such as quiescence, proliferation, and differentiation, in SVZ. Compared to age-matched wild-type (WT) mice, quiescent neural stem cells were reduced in 5XFAD mice from 2-11 months of age. Moreover, proliferative neural stem cells were decreased in 5XFAD mice from 2 to 8 months of age. Furthermore, differentiations of neuroblasts were diminished in 5XFAD mice from 2-11 months of age. Intriguingly, we found that adult SVZ neurogenesis was reduced with aging in healthy mice. Taken together, our results revealed that impairment of adult SVZ neurogenesis appears with aging or AD progression.

• 한국비블리아학회지
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• 제33권1호
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• pp.95-122
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• 2022

이 연구는 부산·울산·경남지역 내 공공도서관을 중심으로 청소년서비스 현황을 조사하고 문제점을 파악한 다음 서비스 활성화를 위한 과제를 제안하고자 하였다. 2021년 기준 국가도서관통계시스템과 부산광역시 도서관포털에 등록된 부산·울산·경남지역 공공도서관 93개관을 대상으로 청소년서비스 현황과 청소년서비스에 대한 사서의 인식을 조사하였다. 조사결과, 부산·울산·경남 지역 공공도서관에 청소년 공간이 있는 곳이 24%이며, 공간이 있는 경우 공간 내부에 청소년 서가가 가장 많이 설치되어 있는 것으로 나타났다. 청소년 서비스를 제공하는 도서관은 76%로 나타났으며, 서비스 대상의 연령대는 만13~18세로 설정하고 있었다. 청소년들의 저조한 이용과 소극적인 참여, 전용 공간의 부족, 프로그램 운영을 위한 인력 부족, 예산 부족 등 문제점이 복합적으로 작용하여 서비스 제공이 쉽지 않은 상황으로 나타났으나, 대부분의 사서들이 청소년 전용 공간과 청소년 서비스 제공의 필요성에 동의하는 것으로 나타났다. 이에 공공도서관 청소년 서비스 활성화를 위한 과제로 공간조성과 서비스 기획/운영 단계에서 청소년의 참여 확대, 청소년 전용 공간 조성, 청소년 봉사활동 내용의 다양화, 담당사서의 전문성 확보와 지역인적자원 활용, 서비스에 대한 홍보 확대 등을 제안하였다.

• 가정과삶의질연구
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• 제20권4호
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• pp.13-26
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• 2002

The purpose of this study was to understand the adult day care as a place for the elders and adults and to develop an initial understanding of the programs and their participants for adult day care for the cognitively-impaired in the U.S.A. The data was collected from 13 Adult Day Care Centers(ADC), and 318 participants from six Adult Day Care Centers from 2001 to 2002 by personal interview and the documents about the participants and their family and caregivers. Participants used ADC program average 8.15 hours In weekdays, 3 days per week. ADC programs provided primarily lunch and snack, transportation, personal care, professional health care, occupational.speech physical therapies, rehabilitation, and respite care. Participants'caregivers were mainly daughters and wives. It is the hope of this study to provide design and care professionals with a first draft of a ″sense-making″template by which they may understand adult day care in a systemic manner and engage in meaningful results as to what this place type could and should be.

• 식품보건융합연구
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• 제6권3호
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• pp.1-4
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• 2020

This study analyzed in nutrient contents changes of adult's favorite foods between March 2019 and July 2020 after policy implementation nutrient-poor foods based on special act on safety control of adult's dietary life in Korea. Among adult's favorite foods manufactured or sold in 2020 as well as 2019, calories and key nutrients in breads, ice creams and pizzas were improved in comparison to those in the other food groups. However, most of the changes in calories or key nutrient contents exist. The newly introduced candies, breads showed slightly greater improvements in calories and key nutrient contents than in 2019. On the other hand, some negative changes were found in newly introduced chocolates in comparison to previous ones. Overall, policy implementation on foods seemed to induce changes in nutrient contents of adult's favorite foods. In particular, nutrition education is reported to have a positive impact on adult's frequency and preference for processed foods, and more systematic and continuous nutrition education measures should be devised to help adult as consumers selectively purchase healthy foods. This research is meaningful in that it is the first study to analyze the quality changes of adult's favorite foods since the high-calorie and low-nutrient food management policy.

• 대한수의학회지
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• 제34권1호
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• pp.195-212
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• 1994

For the purpose to increase productivities of livestock the present investigations were undertaken in order to clarify the clinical and suclinical status of Korean native cattle, dairy cattle(holstein) and Korean native goat. Blood, feces and urine samples were collected from 247 Korean native cattle(222 adult and 25 calf), 224 dairy cattle(211 adult and 13 calf) and 142 Korean native goat rearing at Chonbuk area and analyzed for clinical, serum chemical, hematological and urinary findings. In addition, we were examined the infection rate of theileriosis, internal parasite and ring worm. The mean value for each component was calculated by statistical analysis using Excel computer program. From these investigations the following results were obtained. The mean values for RBC, PCV and etc in 433 adult cow(Korean native cattle and dairy cattle) were similar with other reports. But the mean values for MCHC of all species were lower than normal. Adult Korean native cattle and adult dairy cattle which showed hematologically normal levels were only 9.01% and 9.48%, respectively. Abnormally high values for PCV, RBC and Hb were recorded in 7.66% of adult Korean native cattle, 20% of korean native calf, 15.38% of dairy calf and 13.36% of Korean native goat. Adult Korean native cattle and adult dairy cattle which showed hematologically anemia were 4.95% and 19.43% respectively, but Korean native calf and dairy calf showed normal. Adult Korean native cattle, adult dairy cattle, Korean native calf and dairy calf which showed normal serum protein level 84.0%, 90.8%, 50% and 44.4%, respectively. In present investigations, 50% of Korean native calf and 55.6% of dairy calf were decreased serum protein values under range. These abnormally decreased serum protein values mean the shortage of antibody, and these have a possibility to occurs to pneumonia and diarrhea. From these results, the economical loss caused by pneumonia was calculated as 124,038,833 won in the KNC and 742,703,430 won in the dairy calf rearing in Chonbuk area. Calculated economical loss caused by enteritis was 56,658,690 won in Korean native cattle, 476,775,799 won in dairy calf, and the total loss amount of 533,434,488 won in Chonbuk area. Abnormally high values$(21.7{\pm}4.0mg/dl)$ for serum calcium were recorded 49.6% in dairy cattle. The mean values for serum total cholesterol were $170.8{\pm}99.8mg/dl$ in Korean native cattle, $196.0{\pm}40.6mg/dl$ in Korean native calf, $202.9{\pm}86.0mg/dl$ in adult dairy cattle and $289.4{\pm}97.5mg/dl$ in dairy calf. The infection rate of internal parsite were as follows; adult Korean native cattle: 21.2%, Korean native calf: 8.0%, adult dairy cattle: 67.8% and Korean native goat: 81.5%. The estimated economical loss caused by internal parasites infection were 1,120,855,837 won in Korean native calf, 4,994,959,405 won in adult Korean native cattle, 3,334,751,066 won in adult holstein, and the total loss amount to 9,450,566,308 won. The infection rate of theileriosis were 1.4% in Korean native cattle and 6.6% in dairy cattle. The presumed economical loss by T. sergenti infection were 154,408,482 won in Korean native cattle and 171,577,237 won in dairy cattle rearing at Chonbuk area. The infection rate of ringworm were 0.5% in Korean native cattle, 0.9% adult dairy cattle and 7.7% in dairy calf. The presumed economical loss by dermatomycophyte were 12,061,532 won in Korean native cattle, 16,895,403 won in dairy cattle, and the total estimated loss amount to 28,955,935 won a year in Chonbuk area.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2006년도 가을 학술발표논문집 Vol.33 No.2 (C)
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• pp.218-221
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• 2006

본 논문은 인터넷의 대표적인 문제점중의 하나인 Adult Image 분류 연구에 대해 기술한다. 특히 우리는 이러한 Adult Image를 분류하기 위한 Data Set을 5가지 타입으로 구성한다. 이러한 각 Image에 대해 Color, Gradient, Edge Direction 특성의 Feature들을 추출하고 이를 Histogram으로 구성한다. 이렇게 구성된 Histogram을 Support Vector Machine에 적용하여 Adult Image를 분류한다. 그 결과, 우리는 8250개의 Test Set에 대하여 Recall(96.53%), Precision(97.33%), False Positive(2.96%), F-Measure(96.93%)의 성능 결과를 보여준다.

• 대한가정학회지
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• 제43권7호
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• pp.37-51
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• 2005

The purpose of this study was to determine the level of caregiving behaviors of adult children and the main factors influencing the caregiving behaviors of adult children. This research was based on a survey conducted with 620 adults, from 30 to 59 years old, living in the Seoul metropolitan area, with at least one living parent. Statistical analysis was carried out using SPSS/WIN including frequencies, t-test, one-way ANOVA and regression analysis. no results were as follows. First, the level of caregiving behaviors of adult children varied with background variables, such as birth ranking and job for the children-related variables, and age of mother, income level and type of living for the parents-related variables. Second, the level of caregiving behaviors of adult children varied with the degree of emotional solidarity between the adult children and their parents. Third, the caregiving behaviors were significantly different according to gender as gender played an important role in differentiating the motives for caregiving behaviors.

• 한국연초학회지
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• 제31권1호
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• pp.1-8
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• 2009

This study was conducted to determine the effects of processed tobacco leaves on the development, adult emergence and body weight of the cigarette beetle, Lasioderma serricorne Fabricius) (Coleoptera: Anobiidae) is serious insect pest of tobacco leaves and cigarette during storage. Developmental time, adult emergence rate and adult weight of the cigarette beetle, were evaluated on the cured tobacco and burley tobacco leaves at $30{\pm}1^{\circ}C$ with $70{\pm}5$ % RH under 12L:12D. The developmental time on all of the flue-cured tobacco leaves was about 61 days, but in the only CD3W and CD4TR grade burley tobacco, the developmental times ranged from 70 days to 74 days. Among the flue-cured tobacco leaves, the highest beetle emergence rate was 123 % on the CD3L grade, and the lowest was on the AB4OR grade. Adult body weights of the cigarette beetle reared on flue-cured tobacco were about 2.11~2.46 mg, and on the only CD3W and CD4TR grade burley tobacco were about 1.86~1.96 mg. Among the flue-cured tobacco leaves, the highest adult body weight(2.46 mg) of cigarette beetle was observed on the B1O grade flue-cured tobacco, whereas the lowest adult weight(2.11 mg) was observed on the CD4L grade flue-cured tobacco. The adult weight of cigarette beetle reared on whole meal was 2.04mg.

• 치과방사선
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• 제25권2호
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• pp.437-445
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• 1995

The purpose of this study was to evaluate the equivalent and effective dose, and estimate radiation risk to the critical organs of head and neck region from the use of adult and child mode in panoramic radiography. The results were as follows. 1. The salivary glands showed the highest equivalent and effective dose in adult and child mode. the equivalent and effective dose in adult mode were 837μSv and 20.93μSv, those in child mode were 462μSv and 11.54μSv, respectively. 2. Total effective doses to the critical head and neck organs were estimated 34.21μSv in adult mode, 20.14μSv in child mode. From these datas, the probabilities of stochastic effect from adult and child mode were 2.50x10/sup -6/ and 1.47x10/sup -6/. 3. The other remainder showed the greatest risk of fatal cancer. The risk estimate were 4.5 and 2.7 fatal malignancies in adult and child mode from million panoramic examinations. The bone marrow and thyroid gland showed about 0.1 fatal cancer in adult and child mode from these examinations.

• 대한가정학회지
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• 제40권7호
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• pp.193-210
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• 2002

The purpose of this study is to identify the characteristics of physical setting of adult day care as a place for the elders and adult and to develop an basic understanding of the architectural program and physical setting for adult day care for the cognitively-impaired in the U.S.A. The data was collected from 13 Adult Day Care Centers(ADCC) from 2001 to 2002 by interview and the documents about those facilities. Physical environment should be viewed as an element in the care of individuals with dementia, and that the principles used to plan and design environment should be consistent with the principles used in providing other aspects of care. The results of the study provided the information about the best condition of physical setting of ADCC for the elderly with dementia. Memory Loss Adult Day Center and St. Ann Center for Intergenerational Care have better architectural program than other facilities. It is the hope of this study to provide guideline for design and care professionals with a first draft of a "sense-making" template and to slow own the progression of the disease by the appropriate physical environment.