• 동의신경정신과학회지
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• 제27권3호
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• pp.169-184
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• 2016

Objectives: To investigate the neurophysiological effect of acupuncture treatment on insomnia patients using quantitative electroencephalography (QEEG) and standardized Low Resolution Brain Electromagnetic Tomography method (sLORETA).Background: Insomnia is one of the commonly encountered symptoms in primary medical care. Recent studies of acupuncture for insomnia reported that the acupuncture groups showed significant improvements compared with the control groups. However, the neurophysiological mechanism of acupuncture in the treatment of insomnia has not been revealed and a few studies have measured the effect of acupuncture treatment using QEEG.Methods: Participants who had some problems in initiating or maintaining sleep, or had non-restorative sleep for more than 3 days a week and ISI scores above 8 and below 21 were treated by acupuncture for 2 weeks (3 times a week, total 6 times). We assessed the effectiveness of acupuncture for insomnia by the PSQI (Pittsburgh Sleep Quality Index) at baseline and at 2 weeks after the end of treatment (4th week). Also, we performed EEG and analysed the EEG data at baseline and at the end of treatment (2nd week) on the linked ears montage using the Neuroguide software program and sLORETA.Results: Thirty-two participants were enrolled and 2 participants dropped out because of personal reasons. Among the 30 participants, EEGs of 12 participants were included in the analysis of QEEG and sLORETA. Total score on the ISI and PSQI was significantly decreased after acupuncture treatment. The number of electrodes exceeding the range of 90% (±1.65) or 95% (±1.96) in the z scored absolute power of beta was significantly decreased after acupuncture treatment. There was no significant change in brain activation between pre- and post-acupuncture using sLORETA.Conclusions: The deviation of absolute power compared to the normative database was significantly decreased after acupuncture treatment in the alpha and beta ranges. Therefore, we suggest that acupuncture treatment for insomnia might be effective through the central nervous system especially in the brain. There are many limitations to drawing any conclusion. Further studies are needed in the future to overcome these limitations.

• Clinical and Experimental Pediatrics
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• 제57권12호
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• pp.526-532
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• 2014

Purpose: Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data on circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) with regard to obesity-related biomarkers in the general adolescent population. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios with obesity-related biomarkers in apparently healthy adolescent boys. Methods: We measured MMP and TIMP concentrations in plasma samples using the enzyme-linked immunosorbent assay and analyzed their associations with obesity-related biomarkers, such as liver enzymes and lipid profiles, in a sample of 91 Korean boys aged 13-14 years who participated in a general health check-up. Results: The mean age of the boys was $13.8{\pm}0.3years$; 72 boys were normal weight and 19 were overweight/obese. The Pearson correlation coefficients revealed a significant correlation between MMP-8 and aspartate aminotransferase (r=0.217, P=0.039) and alanine aminotransferase (r=0.250, P=0.017) and between TIMP-1 and aspartate aminotransferase (r=0.267, P=0.011). In a multivariate linear regression analysis, serum alanine aminotransferase was positively associated with the MMP-8 level. There were no significant differences in the MMP-8, MMP-9, and TIMP-1 levels or MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios between control and overweight/obese subjects. Conclusion: We found a significant association between the MMP-8 level and alanine aminotransferase in the apparently healthy adolescent boys. These findings indicate that there may be a pathophysiological mechanism underlying the relationship between MMP-8 and liver enzymes in young adolescents.

• 한국학교보건학회지
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• 제11권1호
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• pp.27-50
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• 1998

Adolescent health is considered to contribute to health promotion in the home and community in the near future as well as individual health. However, adolescent health has been neglected from education field because of competitive school education focused on the university entrance examination That's why I suggest in this study that we should pay much more attention to adolescent health condition and try to make It better, in terms of man-power development and life-health promotion for nation development The purposes of this study are as follows First, to look into a variety of adolescent health problems Second, to find out the situation and problems of current adolescent health promotion and school health education Third, to make an effort to find, based on the current situation, various developments of adolescent health promotion and school health education in terms of practical, political and environmental change There are used study methods as adolescent-related, school heath-related literature review and anlysis of statistical data The results and suggestions are as follows Teenagers have a great variey of health problems including most Important physical, mental and social developments Recently, chronic diseases, emotional problems, health-risk behaviors linked With adolescents are on increase The complicated disorders of physical, mental, social health rather than paricular aspects of health or health-behavior problems influence adolescent health problems adolescence is regarded as the period when most health-related behaviors are formed. Therefore, adolescent health promotion would he assured by developing the ability of controlling multi-dimensional health determinants in the early stage. Health promotion is a positive concept that each individual, family and community makes real efforts to improve their health To achive this, we need health educational, organizational, political and environmental supports. Adolescent health promotion in Korea has been systematically treated in the category of school health Current school health services have had lots of systemic, constitutional, administrative and educational flaws Accordingly, I'm concerned that we can afford to accept a variety of adolescent health needs However, I would say that if were not to make those flaws better, it's certain that Korean national competitive power and the quality of the lives of most Koreans Will he threatened someday We have to develop Comprehensive School Health Crriculum(CSHC) and set up its standards to Improve adolescent health. CSHC is an organizational and costant process. CSHC means an Important part of overall curriculums. In addition, I could say that it's an Important school health education acivity including current school health services-health care service and school health environment. In conclusion, in order to develop CSHC, we require school nurse's role changes, establishment and management of intergrated subject of health education, striking revision of school health law(or legislation of school health promotion law), reorganization of administration system, big changes in curriculum for school health educators.

• 한국토양비료학회지
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• 제29권1호
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• pp.60-66
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• 1996

콩 근류균(根瘤菌) B. japonicum의 취락형태(聚落形態)에 따라 항생제반응(抗生劑反應)과 혈청형(血淸型) 및 단백질(蛋白質) 전기영동(電氣泳動) 유형(類型)에 차이가 있을지 여부를 구명(究明)코자 우리나라 남부지방에 분포한 토착근류균(土着根瘤菌)을 대상으로 시험한 결과는 다음과 같았다. 1. 분리(分離)한 B. japonicum 120균주(菌株) 취락형태별(聚落形態別) 분포(分布)는 "Dry"형이 47%, "Wet"형이 41%, "Dry/Wet"형이 12%였다. 2. 항생제(抗生劑) 반응(反應)에 있어서 "Dry"형의 균주(菌株)는 chlorampenicole(200ug/ml)과 kanamycin(20ug/ml)에 대하여. "Wet"형은 erythromycin(100ug/ml)과 nalidixic acid(20ug/ml), spectinomycin sulphate(100ug/ml), streptomycin sulphate(10ug/ml), tetracycline(100ug/ml)에 대하여 각각(各各) 높은 내성(耐性)을 보였다. 3. B. japonicum의 취락형태별(聚落形態別)로는 혈청형(血淸型)의 구분(區分)을 보이지 않았으나, 각 혈청형(血淸型)에 속하는 균주중(菌株中)에는 혈청모균주(血淸母菌株)와 동일한 취락형태(聚落形態)를 가진 것이 많았다. 4. B. japonicum의 혈청학적(血淸學的) 분류결과(分類結果)는 단백질전기영동상(蛋白質電氣泳動上)의 밴드유형과 같았으며 특히, 복잡성(複雜性)에 있어서는 가장 복잡하였던 항생제반응(抗生劑反應) 유형(類型)과 지나치게 단순하였던 취락형태적(聚落形態的) 구분이 중간정도(中間程度)를 나타내어 실용성(實用性)을 보였다. 5. B. japonicum의 취락형태별(聚落形態別) 특성은 항생제반응(抗生劑反應)에서는 특이적(特異的)이었으나 혈청학적(血淸學的) 특성(特性) 및 단백질(蛋白質) 전기영동(電氣泳動) 유형(類型)에서는 다양(多樣)한 경향이었다.

• 한국사회복지학
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• 제59권3호
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• pp.175-199
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• 2007

이 연구에서는 부산과 대구 지역의 노인시설에 근무하는 사회복지사, 간호사, 생활지도원 502명을 대상으로, 노인보호 관련 종사자들의 업무특성을 반영하여 고안된 측정도구들을 활용하여 이들의 일반적인 특성과 업무 스트레스, 업무 만족, 치매 및 인간중심 보호와 관련된 인식과 태도를 조사하여 그 결과를 분석하였다. 분석 결과 노인시설 종사자들의 급여수준이 낮고 근무시간이 길며 업무 부담이 과중한 상태인 것으로 나타났다. 치매 및 인간중심 보호와 관련된 종사자들의 인식수준은 높은 편이었으나, 업무 만족 수준이 낮았고 노인에 대한 보호 제공 및 업무환경과 관련된 스트레스가 높게 나타났다. 노인장기요양보험제도 시행을 앞두고 노인에게 사회적 보호를 제공할 전문 인력의 원활한 수급과 전문성 향상, 보호의 질 제고를 위하여 노인시설 종사인력에 대한 처우 개선과 인력 확충, 중장년기 인력 활용, 노인시설 종사인력에 대한 전문적 훈련과 교육 강화, 노인시설에서의 인간중심 보호 방식의 도입과 실천이 필요함을 제시하였다.

• Pediatric Infection and Vaccine
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• 제7권1호
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• pp.113-119
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• 2000

Purpose : Rotavirus is a most common etiologic agent of pediatric gastroenteritis. The standard method to diagnose rotavirus infection was the detection of viral particles in specimens through electron microscopy. But it was complex. Enzyme immunoassay and latex agglutinin are preferred because they are relatively handy, inexpensive and take a short time, in comparison with electron microscopy. However, several reports have shown that the use of ELISA to diagnose rotavirus infection in neonates can result in false positive reactions. The main purpose of this study is to compare ELISA and RT-PCR in the diagnosis of neonatal rotavirus infection. Methods : Data presented in this study were obtained form 123 newborn babies in the nursery of the Fatima Hospital, Masan, Korea, form Jury to December, 1997. We obtained two samples of stool from each of the newborn babies and then performed the Rotazyme test and the RT-PCR. In the Rotazyme test, the results were interpreted according to visual findings. The samples were used for the RT-PCR test after at stock $-30^{\circ}C$ to identify rotavirus group A. The result of the two tests were compared. Results : The informations are divided into 73 males and females. Out of the total informations 15 were transferred from other hospitals. Their average gestational age was $38.5{\pm}1.6$ weeks. The average birth weight was $3134.8{\pm}539gm$. In the Rotazyme test, 75 samples turned out to be positive. Out of them, 55 samples(75.3%) were positive and 18 samples(24.7%) were negative in the RT-PCR. On the other hand, in the Rotazyme test, 50 samples turned out be negative. Out of them, 27 samples(54%) were positive and 23 samples(46%) were negative in the RT-PCR. Conclusion : Rotavirus infection in uncommon in neonates. The diagnosis based on visual findings using Rotazyme test has a disadvantage in the sense that it can result in false positive reactions and false negative reactions in the diagnosis of neonatal rotavirus infection.

• 유통과학연구
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• 제14권7호
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• pp.101-114
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• 2016

Purpose - The aim of this study is to investigate the benefit-sharing activities. They affect contract renewal intention between franchisers and franchisees that are linked through a contract with the intention of building their relationship from the level based on dynamic trust. This study will show a new approach on qualitative growth and consolidation of competitive power and may well be able to suggest practical ways to strengthen directions in the field of franchise industries. Research design, data, and methodology - In this study, based on literature review, we separated logistical-supporting activities and non-logistical-supporting activities from benefit-sharing activities. We modeled how benefit-sharing activities influence contract renewal intention of franchisees by dynamic trust. In particular, considering the possibility of trading concepts and characteristics of trust between providers opportunistic behaviors was defined as variables, depending on the situation and dynamic characters reveal their relationship trust concept. That is, dynamic trust having the possibility of changing depending on opportunistic risks and interdependencies by Lewis & Weigert(1985, 2012) was classified into transitional-based trust, calculated based trust, relational-based trust and balance-based on trust. The total of 104 samples from domestic franchisees being with franchisees were collected by using a structural composed questionnaire. Results - The results are as following. Benefit-sharing activities in logistical supporting activities appeared to affect the multidimensional concept of transitional trust, calculated based on trust, relationship-based trust and balance based on trust dynamic trust with all-defined impact. Non-logistical supporting activities appeared to affect significantly the positive (+) to the dynamic trust concept except transitional trust. Lewis & Weigert(1985; 2012) have proposed a dynamic confidence calculated from relations within-based trust relationship based on trust appears to affect the significant positive (+) to the balance-based confidence transactions confidence mechanism of the system side in the verified relationship. Finally, a relationship based on trust and confidence in the balance based on the Influence of dynamic renewed confidence showed significantly affect the positive(+). In particular, the balance based trust showed the acts as a mediating factors between relational trust and confidence and renew calculated. Conclusion - From the above these results, the significance from this study is as following. First, the proposed activity is to share and validate the approach by identifying the potential in the relationship from the contract with building dynamic trust, and one of the ways from the franchise headquarters and affiliated merchants mutual growth through win-win cooperation in sharing activities. Next, the dynamic segmentation confidence to suggest the possibility can be broken down over the validity and reliability test for each concept. In addition, by identifying the relationship between the dynamic level of confidence granular multi-dimensional concept, to determine the level of trust with a dynamic relationship between risk and interdependencies can be possible in franchise industries. In order to maintain and develop their mutual relationship, franchise industries should propose confidence-building steps to promote their quality improvement.

• 디지털융복합연구
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• 제12권11호
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• pp.329-338
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• 2014

오늘날 각 대학의 취업률은 대학 등급을 결정짓는 중요한 요소 중의 하나이다. 취업예비생은 원하는 취업정보를 얻기 위해서 온라인 또는 오프라인상의 취업지원 사이트들에서 원하는 취업정보들을 이용하고 있다. 웹기반 취업지원업체들과 각 대학교에서 제공해주는 많은 취업지원시스템들이 있지만, 이들은 취업지원관리 위주가 아닌 취업정보를 알리는 데에 더 중심을 두고 있다. 또한, MOU기업, 산업체 현장실습, 취업 멘토교수 등과 관련된 업무 프로세스를 지원해주는 기능과, 각 기업들이 원하는 학생들의 정보(이력서, 자기소개서 등)와 학생들이 원하는 기업들의 정보를 지속적으로 업데이트해주고 관리해주는 기능도 부족하다. 따라서 취업관련 초기 데이터(학생 및 기업정보)의 저장에서부터 취업관리까지 지원해주는 취업지원관리시스템이 요구된다. 본 논문에서는 기존의 취업지원시스템의 기능에 권한별 취업관리 기능을 고려하였고, 스마트 폰에서도 취업정보를 실시간으로 수신할 수 있으며, 학사정보시스템과 연계된 시스템의 설계 및 구축안을 제시하였다.

• Journal of Ginseng Research
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• 제41권1호
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• pp.43-51
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• 2017

Background: BIOGF1K, a compound K-rich fraction prepared from the root of Panax ginseng, is widely used for cosmetic purposes in Korea. We investigated the functional mechanisms of the anti-inflammatory and antioxidative activities of BIOGF1K by discovering target enzymes through various molecular studies. Methods: We explored the inhibitory mechanisms of BIOGF1K using lipopolysaccharide-mediated inflammatory responses, reporter gene assays involving overexpression of toll-like receptor adaptor molecules, and immunoblotting analysis. We used the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay to measure the antioxidative activity. We cotransfected adaptor molecules, including the myeloid differentiation primary response gene 88 (MyD88) and Toll/interleukin-receptor domain containing adaptor molecule-inducing interferon-${\beta}$ (TRIF), to measure the activation of nuclear factor (NF)-${\kappa}B$ and interferon regulatory factor 3 (IRF3). Results: BIOGF1K suppressed lipopolysaccharide-triggered NO release in macrophages as well as DPPH-induced electron-donating activity. It also blocked lipopolysaccharide-induced mRNA levels of interferon-${\beta}$ and inducible nitric oxide synthase. Moreover, BIOGF1K diminished the translocation and activation of IRF3 and NF-${\kappa}B$ (p50 and p65). This extract inhibited the upregulation of NF-${\kappa}B$-linked luciferase activity provoked by phorbal-12-myristate-13 acetate as well as MyD88, TRIF, and inhibitor of ${\kappa}B$ ($I{\kappa}B{\alpha}$) kinase ($IKK{\beta}$), and IRF3-mediated luciferase activity induced by TRIF and TANK-binding kinase 1 (TBK1). Finally, BIOGF1K downregulated the NF-${\kappa}B$ pathway by blocking $IKK{\beta}$ and the IRF3 pathway by inhibiting TBK1, according to reporter gene assays, immunoblotting analysis, and an AKT/$IKK{\beta}$/TBK1 overexpression strategy. Conclusion: Overall, our data suggest that the suppression of $IKK{\beta}$ and TBK1, which mediate transcriptional regulation of NF-${\kappa}B$ and IRF3, respectively, may contribute to the broad-spectrum inhibitory activity of BIOGF1K.

• 한국지구과학회지
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• 제30권2호
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• pp.210-222
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• 2009

최근(2002-2006) 발생한 낙뢰의 빈도, 강도, 지속시간 및 낙뢰율의 시 공간적 특성을 분석하였다. 빈도는 경년변동이 크게 나타났으며, 여름과 겨울에 각각 전체 낙뢰의 75%, 0.6%가 발생하였다. 정극성 낙뢰는 우기(6-9월)에 부극성 낙뢰의 0.15 비율로 발생했으나 동계에는 그 비율이 증가하여 2월경에 부극성 낙뢰의 0.98까지 증가하였다. 낙뢰 지속시간은 여름에 집중되는 계절변동이 크게 나타났으나 낙뢰율의 변동은 이에 비해 작았다. 낙뢰는 새벽(2시, 5-7시)과 오후 중반(15시)에 두 번의 최대 빈도가 나타났으며 5시경에는 낙뢰강도가 강하였으나, 15시를 전후로 하는 오후 중반에는 낙뢰 강도가 약했다. 낙뢰밀도는 남한 서부 내륙 및 서 남해상에 높으며, 영동 및 동해지역은 낮았다. 충남 및 전북지역에서 0.4 이상으로 높게 나타났는데, 구름내 방전일 가능성이 있어 해석의 주의를 요한다. 낙뢰 밀도가 높은 서부내륙에서는 우기 낙뢰 지속시간이 연 평균 15-25시간으로 나타났으나, 서해상에서는 낙뢰 발생 시의 집중도가 높고 강도가 강하였다. 대부분의 내륙에서는 오후 중반에서 저녁 사이에 낙뢰 발생 빈도가 최대였으나 산악 및 해안, 중서부 지역은 각각 오전과 새벽에 최대로 발생하였다.