• 대한기계학회논문집A
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• 제24권1호
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• pp.206-214
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• 2000

The pressure tube is a major component of the CANDU reactor, which supports nuclear fuel bundle and it's containment vessel. If a flaw is found during the periodic inspection from the pressure tube s. the integrity evaluation must be carried out. and the safety requirements must be satisfied for continued service. In order to complete the integrity evaluation, complicated and iterative calculation procedures are required. Besides, a lot of data and knowledge for the evaluation are required for the entire: integrity evaluation process. For this reason. an integrity evaluation system, which provides efficient of evaluation with the help of attached databases, was developed. The developed system was built on the basis of ASME Sec. XI and FFSG(Fitness For Service Guidelines for zirconium alloy pressure tubes in operating CANDU reactors) issued by the AECL, and covers the delayed hydride cracking(DHC). This system does not only provide various databases including the 3-D finite element analysis results on pressure tubes, inspection data and design specifications but also is compatible with other commercial database software. In order to verify the developed system, several case studies have been performed and the results were compared with those from AECL. A good agreement was observed between those two results.

• 보건행정학회지
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• 제11권3호
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• pp.46-70
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• 2001

Medical Aid expenditure Increased rapidly at a higher rate than that of Medical Insurance during the period 1992-1999. To establish an effective cost containment strategy, knowledge of the cause and the nature of the increase of Medical Aid expenditure is required. The purpose of this study was to analyze increasing rates of Medical Aid expenditure by the components of medical expenses. Data were collected using the Medical Aid Statistical Yearbook during the period of 1992-1999. The major findings were as follows: 1. The annual mean increasing rate of Medical Aid expenditure between 1992 and 1999 was 22.8%, which exceeding that of Medical Insurance expenditure (17.5%) between 1992 and 1999. Since 1998, Medical Aid expenditure increased even more rapidly than in previous years, with the increase in number of Medical Aid beneficiaries. 2. Of Medical Aid expenditure, that of inpatient and outpatient annually increased 24.2% and 22.8% respectively and that of type 1 and type 2 increased annually 28.8% (outpatient) ∼29.9% (inpatient), 14.3% (outpatient) ∼ 15.5% (inpatient). Therefore, Medical Aid expenditure of inpatient and type 1 led the increase of Medical Aid expenditure. 3. Between 1992 and 1997, the frequencies of utilization per beneficiary and the charges per case positively contributed to the increase of Medical Aid expenditure while the number of beneficiaries contributed negatively, but since 1998, the number of beneficiaries increased and positively contributed to the increase of Medical Aid expenditure. 4. According to the analysis of the charges per case, the increase of the price index led to the increase of the charges per case but the days of medication and service intensity also contributed to the increase of the charges per case variably by year. Considering the above findings, factors associated with the Medical Aid system affected the increase of Medical Aid expenditure in addition to the general factors of the increase in medical expenditure. In conclusion, it appears that a more intensive cost containment strategy is required to control rapidly increasing Medical Aid expenditure. For this, more precise analysis and development of policy considering the effect of the number of beneficiaries and the increase of price index is needed.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제32권5호
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• pp.473-477
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• 2010

Organized hematoma of the maxillary sinus is a rare, nonneoplastic benign lesion with locally destructive behavior that may mimic a malignancy. Clinically, symptoms do not usually occur while the lesion remains localized to the maxillary sinus. Because there is gradual enlargement of the lesion causing erosion and displacement of the adjacent bony structures, symptoms such as epistaxis, cheek swelling, nasal obstruc-tion, headache, and exophthalmos become manifest. Radiologically, unilateral cases are much more fre-quent than bilateral, and Waters' view shows complete opacity of the expanded maxillary sinus and some masses. CT scan shows a large heterogeneous enhancing mass causing considerable expansion of the max-illary sinus with bony erosion. On MR imaging, the mass usually has a variable signal intensity on T1- and T2- weighted images, ranging from low to high. After contrast administration, discrete areas of enhance-ment are present within the mass. Although the disease is essentially benign and nonneoplastic, differen-tial diagnosis from neoplastic disease including malignancy both clinically and radiologically has been always problematic. Accurate preoperative diagnosis of organized hematoma of the maxillary sinus is important to avoid unnecessary extensive surgery, because this condition is curative with a simple, conservative surgical approach and rarely recur. Organized hematoma of the maxillary sinus should be included in the differential diagnosis when patients have recurrent epistaxis, slow-growing mass of the cheek, nasal obstruction, and expansile mass in the maxillary sinus. A 33-year-old man was referred to the department of oral and maxillofacial surgery with a three-month history of slowly growing painful swelling of the left cheek. The mass of the maxillary sinus was resected by a Caldwell-Luc approach. Histopahtoly showed only a fibous encapsulated organized hematoma. To our knowledge, organized hematoma of the maxillary sinus has not been previously described in the Korean literature of the oral and maxillofacial surgery. We report a case of organized hematoma of the maxillary sinus presenting with an enlarging maxillary sinus mass.

• 대한한방소아과학회지
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• 제27권4호
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• pp.99-107
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• 2013

Objectives The purpose of this study is to obtain knowledge and views on treatment of acupuncture and acupressure for myopia. Methods The key words such as 'myopia, acupuncture', 'myopia, acupressure', 'refractive errors, acupuncture', 'refractive errors, acupressure' are used for the research through PubMed. Total 13 studies among the searched 66 were analyzed, except duplicated studies and have little relation to myopia or acupuncture and acupressure. Results Total 13 studies were selected: RCT (5), NRCT (3), UCT (3), Review (2). RCT had two studies on treatment by stimulating auricular acupoints, one study on a treatment by stimulating auricular acupoints and meridian acupoints, one study on a treatment to stimulate auricular acupoints with medication, and one study on electroacupuncture. In NRCT, two studies were on treatment to stimulate auricular acupoints with medication and only one study was on analysis of effect according to intensity of acupuncture. UCT had two studies on acupuncture, and one study on treatment to stimulate auricular acupoints. In Review, there were one study on introduction of Chinese eye exercises, and one study on systematic review for effectiveness and safety of acupuncture. Conclusions The effect on treatment of acupuncture and acupressure for myopia had mostly positive results. However, still not many researches were done to conclude this found. Also, the design of the experiment should be more accurate with systematically designed experimental group and control group.

• Journal of Microbiology and Biotechnology
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• 제17권6호
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• pp.945-951
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• 2007

DNA-DNA hybridization has been established as an important technology in bacterial species taxonomy and phylogenetic analysis. In this study, we analyzed how the efficiency with which the genomic DNA from one species hybridizes to the genomic DNA of another species (DNA-DNA hybridization) in microarray analysis relates to the similarity between two genomes. We found that the predicted DNA-DNA hybridization based on genome sequence similarity correlated well with the experimentally determined microarray hybridization. Between closely related strains, significant numbers of highly divergent genes (>55% identity) and/or the accumulation of mismatches between conserved genes lowered the DNA-DNA hybridization signal, and this reduced the hybridization signals to below 70% for even bacterial strains with over 97% 16S rRNA gene identity. In addition, our results also suggest that a DNA-DNA hybridization signal intensity of over 40% indicates that two genomes at least shared 30% conserved genes (>60% gene identity). This study may expand our knowledge of DNA-DNA hybridization based on genomic sequence similarity comparison and further provide insights for bacterial phylogeny analyses.

• The Korean Journal of Pain
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• 제31권4호
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• pp.253-260
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• 2018

Background: One of the most frequent problems caused by diabetes is the so called painful diabetic neuropathy. This condition can be treated through numerous types of therapy. The purpose of this study was to analyze, as a meta-analysis, different treatments used to alleviate painful diabetic neuropathy, with the aim of generating results that help making decisions when applying such treatments to tackle this pathology. Methods: A search was conducted in the main databases for Health Sciences, such as PUBMED, Web of Science (WOS), and IME biomedicina (Spanish Medical Reports in Biomedicine), to gather randomized controlled trials about treatments used for painful diabetic neuropathy. The analyzed studies were required to meet the inclusion criteria selected, especially those results related to pain intensity. Results: Nine randomized controlled trials were chosen. The meta-analysis shows significant positive effects for those treatments based on tapentadol [g: -1.333, 95% CI (-1.594; -1.072), P < 0.05], duloxetine [g: -1.622, 95 % CI (-1.650; -1.594), P < 0.05], pregabalin [g: -0.607, 95% CI (-0.980; -0.325), P < 0.05], and clonidine [g: -0.242, 95 % CI (-0.543; -0.058), P < 0.05]. Conclusions: This meta-analysis indicates the effectiveness of the treatments based on duloxetine, gabapentin and pregabalin, as well as other drugs, such as tapentadol and topic clonidine, whose use is better prescribed in more specific situations. The results provided can help increase the knowledge about the treatment of painful diabetic neuropathy and also in the making of clinical practice guidelines for healthcare professionals.

• 전자공학회논문지S
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• 제35S권9호
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• pp.53-62
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• 1998

본 논문에서는 유전 알고리즘을 이용한 스테레오 정합 방법을 제안한다. 스테레오 정합은 2차원 영상으로부터 물체의 3차원 구조를 복원하기 필수적인 과정이다. 제안된 2차원 구조의 염색체는 각 요소가 변이값들로 이루어진다. 이때, 각 염새체의 비용함수는 두 장의 영상의 휘도값의 차이와 변이값의 평활성에 기초하여 구성된다. 또한, 2차원 염색체에서 주변 화소의 변이값에 영향을 받는 교차와 돌연변이 연산자가 제안된다. 이러한 지식 기반의 연산자를 이용함으로써 보다 빠른 수렴성과 안정된 결과를 보장받을 수 있다. 제안된 유전 알고리즘기반의 스테레오 정합 방법을 합성 영상과 실 영상에 적용한 결과. 제안한 방법이 특징값이 너무 많거나 적은 영상, 잡음이 많이 섞인 영상, 또는 반복적인 형태의 영상에 대해서도 좋은 결과를 얻을 수 있음을 알 수 있다.

• Nuclear Engineering and Technology
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• 제52권8호
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• pp.1871-1880
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• 2020

Round robin analyses for vessel failure probabilities due to PTS events are proposed for plant-specific analyses of all types of reactors developed in Korea. Four organizations, that are responsible for regulation, operation, research and design of the nuclear power plant in Korea, participated in the round robin analysis. The vessel failure probabilities from the probabilistic fracture mechanics analyses are calculated to assure the structural integrity of the reactor pressure vessel during transients that are expected to initiate PTS events. The failure probabilities due to various parameters are compared with each other. All results are obtained based on several assumptions about material properties, flaw distribution data, and transient data such as pressure, temperature, and heat transfer coefficient. The realistic input data can be used to obtain more realistic failure probabilities. The various results presented in this study will be helpful not only for benchmark calculations, result comparisons, and verification of PFM codes developed but also as a contribution to knowledge management for the future generation.

• 대한기계학회논문집B
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• 제36권5호
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• pp.533-538
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• 2012

본 논문에서는 산소 민감 발광 염료를 이용하여 마이크로 채널 내에서 세포가 배양되고 있을 때 산소농도를 측정하였다. 현재까지 알려진 여러 산소 민감 발광 염료 중 본 논문에서는 물에 잘 녹으며 장 시간 동안 사용하여도 독성이 없는 것으로 알려진 $[Ru(bpy)_3]^{2+}$를 사용하였으며 이와 더불어 산소 민감 염료 측정법의 단점을 보완하기 위하여 칼세인 염료를 이용하여 두 염료의 밝기 비율을 구하여 농도를 측정하였다. SCOMS 카메라와 마이크로 채널을 이용하여 캘리브레이션을 실시하고 농도와 밝기와의 관계를 구하였으며 이 관계를 이용하여 세포가 배양되는 조건에서의 배양액의 산소농도를 측정하였다. 실험 결과 채널입구에서 점점 멀어질수록 마이크로 채널 내에서 산소농도는 점점 낮아진다는 것을 관찰 할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4679-4683
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• 2013

Background: ERCC1 is considered as a promising molecular marker that may predict platinum based chemotherapy response in non small cell lung cancer patients. We therefore investigated whether its expression is indeed associated with clinical outcomes in advanced stage NSCLC patients. Materials and Methods: Pretreatment tumor biopsy samples of 83 stage 3B and 4 non-small cell lung cancer patients treated with platinum based chemotherapy were retrospectively analyzed for immunohistochemical ERCC1 expression. None of the patients received curative surgery or radiotherapy. Results: By calculating H- scores regarding the extent and intensity of immunohistochemical staining of tumor biopsy samples, ERCC1 expression was found to be positive in 50 patients (60.2%). ERCC1 positive and negative groups had no statistically significant differences regarding treatment response, progression free survival and overall survival (respectively p=0.161; p=0.412; p=0.823). Conclusions: In our study we found no association between ERCC1 expression and survival or treatment response. The study has some limitations, such as small sample size and retrospective analysis method. There is need of more knowledge for use of ERCC1 guided chemotherapy regimens in advanced stage NSCLC.