• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2745-2748
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• 2012

Aims: To study KIT (CD117) expression in thymic epithelial tumors in China, and investigate diagnostic and clinical significance. Material and Methods: Thymic epithelial tumors (TETs) from 102 patients (3 type A, 29 type AB, 5 type B1, 22 type B2, 29 typeB3 and 16 thymic carcinomas) were examined. Immunohistochemical staining with an antic-kit monoclonal antibody was performed on a tissue microarray. Relationships between KIT positive expression and the TET clinical characteristics (WHO histologic classification and Masaoka stage system) were analysed. Results: The KIT positive expression rate was significantly higher in thymic carcinoma (60%, 9/16) than in thymoma (8%, 7/86), a strong correlation being found with the WHO classification, but not the Masaoka tumor stage. The overall survival for patients with KIT positive lesions was significantly worse. Conclusions: KIT is a good molecule marker to differentially diagnose thymic carcinoma from thymoma, while also serving as a predictor of prognosis for TETs. Further research into KIT mutations in Chinese TETs should be conducted to assess the efficacy of targeted therapy.

• Journal of Periodontal and Implant Science
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• 제43권6호
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• pp.308-314
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• 2013

Purpose: The purposes of this study were to assess the dentists' subjective satisfaction with the crestal approach sinus (CAS) kit, a device for maxillary sinus membrane elevation by the crestal approach using a special drilling system and hydraulic pressure, and to summarize the subjective satisfaction of dental implants placed after a sinus lift procedure with the CAS kit. Methods: Thirty dental clinicians who had experience with dental implant placement after a sinus lift procedure with the CAS kit from June 2010 to May 2012 were included in this study. The questionnaire for the evaluation of the dentists' subjective satisfaction with the CAS kit was sent to the respondents and returned. The questionnaire was composed of two main parts. The first part was related to the sinus membrane perforation rate. The second part was related to the dentists' subjective satisfaction with the CAS kit. Results: A total of 28 dentists answered the questionnaire. Among 924 implant cases, sinus membrane perforation occurred in 38 cases (4.1%). Among the 28 dentists, 26 dentists (92.9%) were satisfied or very satisfied with the CAS kit. In particular, 24 dentists (85.7%) reported that safety, cutting performance, and user-friendliness of the CAS drill were advantages of the CAS kit. However, 7 dentists (25%) did not routinely use the hydraulic lifter for sinus membrane elevation. Conclusions: From the survey, it was shown that the respondents were generally satisfied with the CAS kit and that the cutting performance and safety of the drill component were considered strengths of the CAS kit.

• Molecules and Cells
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• 제41권11호
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• pp.971-978
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• 2018

The stem cell factor (SCF)/c-KIT axis plays an important role in the hematopoietic differentiation of human pluripotent stem cells (hPSCs), but its regulatory mechanisms involving microRNAs (miRs) are not fully elucidated. Here, we demonstrated that supplementation with SCF increases the hematopoietic differentiation of hPSCs via the interaction with its receptor tyrosine kinase c-KIT, which is modulated by miR-221 and miR-222. c-KIT is comparably expressed in undifferentiated human embryonic and induced pluripotent stem cells. The inhibition of SCF signaling via treatment with a c-KIT antagonist (imatinib) during hPSC-derived hematopoiesis resulted in reductions in the yield and multi-lineage potential of hematopoietic progenitors. We found that the transcript levels of miR-221 and miR-222 targeting c-KIT were significantly lower in the pluripotent state than they were in terminally differentiated somatic cells. Furthermore, suppression of miR-221 and miR-222 in undifferentiated hPSC cultures induced more hematopoiesis by increasing c-KIT expression. Collectively, our data implied that the modulation of c-KIT by miRs may provide further potential strategies to expedite the generation of functional blood cells for therapeutic approaches and the study of the cellular machinery related to hematologic malignant diseases such as leukemia.

• Parasites, Hosts and Diseases
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• 제47권4호
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• pp.427-429
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• 2009

To establish a definite diagnosis for pulmonary hydatid disease, combination of radiology and serology is useful. In this study, 19 preoperative sera from patients with surgically confirmed pulmonary hydatidosis, 40 sera from patients with other parasitosis and pulmonary diseases, and 20 sera from healthy donors were evaluated using 4 different serological tests, i.e., the commercial ELISA (ELISA-kit) test, the ELISA (ELISA-lab) test prepared in our laboratory, the commercial indirect hemagglutination assay kit (IHA-kit) test, and the IHA test using sensitized sheep red blood cells with tannic acid (IHA-TA). The ELISA-kit was the most sensitive (84.2%) and the most specific test (100.0%). The ELISA-kit also demonstrated the highest positive (100.0%) and negative (95.2%) predictive values. The sensitivity of the ELISA-lab test, that we prepared, was found to be 73.6%, whereas the IHA-kit test and the IHA-TA test were found to be 73.6% and 68.4%, respectively. The specificity of these tests was 96.6%, 98.3%, and 83.3%, respectively. When all 4 tests were assessed together, it was found that the sensitivity had risen to 94.7%. When the ELISA-kit was assessed with the IHA-kit and IHA-TA together, it was found that the sensitivity was 89.5% and 84.2%, respectively. Likewise, the combination of the ELISA-lab and IHA-kit or IHA-TA allowed us to achieve a sensitivity of 84.2% in cases of pulmonary echinococcosis. In conclusion, the diagnosis would be imminent if least 2 tests were applied together.

• 한국수정란이식학회지
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• 제32권3호
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• pp.153-157
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• 2017

This study was conducted to investigate the optimal artificial insemination (AI) time with diagnostic kit at ovulation time. We already applied the patent about the protein in the cow heat mucose in external reproductive tract. And we would examine the accuracy for detection of cow heat by the kit produced with the protein. Evaluation of optimal heat detection was tried two time at 12 hrs and 24 hrs after the heat. And then, AI service also performed two times with no relation to the results of heat diagnosis by heat detection kit and pregnancy rates were checked with rectal palpation on $60^{th}$ day after AI. Heat diagnostic results by kit in natural heat after 12 hrs in Hanwoo cows were showed 31.3~75.0% on positive in first heat detection and 33.3~100.0% on positve in second heat detection. In the $1^{st}$ positive results were significant different (p<0.05), but $2^{nd}$ positive were not. The results of heat detection showed different result on regional influence and individual cow effects. The pregnancy rates of first trial of heat detection were showed 34.4~78.7% on positive and 21.3~68.8% on negative after the diagnosis by heat detection kit. And the pregnancy rates of next trial of heat detection were showed 33.3~85.7% on positive and 14.3~66.6% on negative after the heat diagnosis. Both positive results of first trial and next trial also were showed significant different (p<0.05), but negative results were not. In positive result, first trial of total pregnancy rates was higher than the next trial of pregnancy, but there showed opposite results on negative results. In conclusion, the optimal heat detection kit is suitable to ordinary Hanwoo cows and it suggested that we have to improve the kit's accuracy by detecting the materials like proteins related optimal AI time.

• Journal of Korean Neurosurgical Society
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• 제30권8호
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• pp.981-984
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• 2001

Object : To treat hydrocephalus by ventriculo-peritoneal shunt operation, the correct positioning of the proximal catheter in the ventricle is very important. The purpose of this study was to develop the "shunt guiding kit" for the proper positioning of the proximal shunt catheter to the ventricle in the ventriculo-peritoneal shunt operation. Materials and Methods: The "shunt guiding kit" is made of tungsten alloy and it consists of one frame, two screws and one guider. Through the guider, the proximal shunt catheter operates by mechanically coupling the posterior burr hole to the anterior target point. Results: We have treated three hydrocephalus patients with use of the "shunt guiding kit", and achieved good location of proximal shunt catheters. Conclusion: We developed the "shunt guiding kit" for the proper positioning of the proximal shunt catheter to the ventricle, and this would be very useful for preventing ventriculo-peritoneal shunt malfunction and preventing possible brain injury during the procedures.

• 대한바이러스학회지
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• 제27권2호
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• pp.137-141
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• 1997

We evaluated Immunochromatographic assay kit to screen HBsAg in human serum. When the reference HBsAg was applyed to ICA, HA and EIA kits, the limit of detection for HBsAg were found out to be 4, 2 and 0.25 ng/ml respectively. But ICA kit required 5 minutes to read the result whereas HA and EIA kit more than one hour. The sensitivity was 97% (29 of 30 samples) and the specificity 100% (45 samples) compared with conventional EIA. The ICA kit needs no instrument or machine to perform the test contrary to the conventional methods. Therefore, this rapid and sensitive ICA kit can be used for HBsAg-screening, especially in the emergency room and in the scene of the accident.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2005년도 춘계학술발표대회
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• pp.1351-1354
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• 2005

분산응용을 개발하는데 효율적인 환경을 제공해주는 분산 객체그룹 프레임워크(Distributed Object Group Framework)를 이용한 분산 프로그램 개발 Tool-Kit을 구축하였다. 본 Tool-Kit은 분산응용 개발자들에게 DOGF의 기능을 쉽게 이용할 수 있도록 지원하기 위해 객체그룹 운영자 GUI, 서버 프로그램 개발자 GUI, 클라이언트 프로그램 개발자 GUI등 3가지 GUI로 구축하였다. 분산응용의 개발 시, 서버 프로그램 개발자는 서버 객체들 구현한 후 프레임워크에 등록 및 클라이언트에 대한 접근권한을 부여하고, 클라이언트 프로그램 개발자는 자신에게 접근권한이 부여된 이들 객체 또는 객체그룹을 검색하여 클라이언트 프로그램을 작성할 수 있도록 지원한다. 본 논문에서는 분산응용 개발 시 이용되는 Tool-Kit과 DOGF의 상호동작을 정의하고, 분산 프로그램개발 Tool-Kit을 구축하고, 간단한 분산응용을 이용해 Tool-Kit의 수행성을 보인다.

• 한국어병학회지
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• 제17권2호
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• pp.151-157
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• 2004

수산 혈액학에 시판의 Diff-Quick kit를 사용할 수 있는지의 여부를 검토하였다. 제조사의 지시에 따라 뱀장어의 말초혈액의 도말표본을 염색하였을 때는 핵의 염색성이 불량하여 핵 내에 미염색의 부분도 남아 있고, 또한 세포질의 호염기성도 저하되었으며, 백혈구 과립의 염색도 불량하여 상법으로 사용하는 May-Glunward Giemsa염색에 비해 염색성이 나빴다. 그러나 염색 시간을 변경하여 solution I에 5초, solution II에 10초 염색 후 이온교환수로 세척하였을 때 양호한 결과를 얻었으며, 혈구의 분류도 가능한 것으로 나타났다. 이러한 염색 조건을 다른 어종인 메기를 비롯한 3종의 어류의 말초혈액의 도말표본에 적용해본 결과 이들 어류의 혈액 염색에도 적용 가능한 것으로 나타났다.

• 한국위성정보통신학회논문지
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• 제7권1호
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• pp.48-52
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• 2012

스마트폰의 급속한 보급 확산에 따라 모바일 기기에서 웹 브라우저는 주요한 기능으로 자리 잡고 있으며 사용자는 모바일 기기에서 PC 수준의 고속화된 성능을 기대하는 현실이다. 웹키트(WebKit)는 구글의 안드로이드(Android) 플랫폼에 사용되고 있는 웹 브라우저를 만드는 데 기반을 제공하는 오픈 소스 응용 프로그램 프레임워크이다. 본 논문에서는 WebKit 라이브러리의 연산의 병렬처리를 통한 성능 향상 기법을 제안하였다. 제안된 병렬처리 기법은 JPEG 라이브러리에 적용되었으며, 성능 검증은 PC 기반의 실험을 통하여 이기종 컴퓨팅 기반의 모바일 임베디드 시스템 환경에서의 예측 방법을 사용하였다. 실험 결과는 제안된 병렬화 기법이 이기종 컴퓨팅 환경의 모바일 임베디드 기기로의 적용을 통한 성능 향상 가능성을 보여주었다.