• Title/Summary/Keyword: Ki-67 index

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Erection Penogram with Papaverine and 99m Tc-HSA (파파베린과 테크니시움을 이용한 음경발기촬영술)

  • Choi, Hyung-Ki;Chung, Byung-Ha
    • Clinical and Experimental Reproductive Medicine
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    • v.13 no.2
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    • pp.181-185
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    • 1986
  • To estimate the penile blood flow changes during artificial with erection intracorporeal papaverine injection, we injected 99 m Technitium-Human Serum Albumin via antecubital vein simultaneously and calculate the radioisotope activity of the penis using computerized Gamma Camera. We classified the results into 3 groups according to the transit time, erection persistent time and venous index in 67 impotence patients. We defined the arteriogenic impotence with the delayed transit time (more than 600 seconds) in 13 patients and venogenic with the shortened erection persistant time (less than 200 seconds) and decreased venous index (less than 0.8) in 11 patients. The rest of them (43 patients) were regarded as equivocal impotence, probably nonvasculogenic or psychogenic.

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The Research on the Optical Reliability of Spectacle Lens in Korea (국내 안경렌즈 광학적 요소 신뢰성 조사)

  • Kim, Tae-Hun;Ye, Ki-Hun;Sung, A-Young
    • Journal of Korean Ophthalmic Optics Society
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    • v.13 no.1
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    • pp.43-48
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    • 2008
  • Purpose: This study is to evaluate reliability of geometrical optics properties of spectacle lenses by using ISO and the medical instrument standard of KFDA, which are being sold in Korea. Methods: We used samples of three hundred and ninety eight spectacle lenses of eight company in total. Refractive indices of each samples which were used in experiment were classified into three groups of medium index (1.55~1.56), high index (1.60~1.61) and extra high index (1.67). Results: Conformity of refractive power was 81.61% in total spectacle lenses. The results showed that thickness conformity 90%, appearance conformity 85.18%, size conformity 96.23% and optical center point conformity 99.50% in total. Conclusions: We found that they deviated from the permitting value in many spectacle lenses on refractive power. The results of errors on prism power, surface inspection and optical center point showed small values in total products. In experiment of lens size and thickness, the bulk of indication rates and conformities of samples deviated from the permitting errors.

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Seasonal Variation in Biomass and Community Structure of Intertidal Seaweeds at Heuksando and Hongdo, Southwestern Coast of Korea (한국 남서해안 흑산도와 홍도의 조간대 해조류 생물량과 군집구조의 계절적 변동)

  • Oh, Ji Chul;Park, Seo Kyoung;Choi, Han Gil;Nam, Ki Wan
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.46 no.6
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    • pp.878-885
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    • 2013
  • Seasonal variation in marine macroalgal community structure was examined at the intertidal zones of Heuksando and Hongdo, Shinan, Korea, from July 2008 to May 2009. In total, 86 macroalgal species were identified, including 12 green, 19 brown, and 55 red algae; 67 species at Heuksando and 70 species at Hongdo, were observed. Annual seaweed biomass was 252.44 g dry $wt/m^2$ at Heuksando and 217.67 g dry $wt/m^2$ at Hongdo. The dominant seaweed in importance value (IV > 15) differed between the sites: Sargassum thunbergii at Heuksando and Corallina pilulifera at Hongdo. The vertical distribution pattern of seaweeds from the upper to lower intertidal zones at Heuksando was Gloiopeltis spp., Ulva spp. - S. thunbergii, S. fusiforme, Hildenbrandia rubra - S. thunbergii, C. pilulifera. On the rocky shore of Hongdo, seaweed zonation was distinct: Porphyra yezoensis, Gloiopeltis spp., Ulva spp. - C. pilulifera, S. fusiforme, Myelophycus simplex - Chondrus ocellatus, C. pilulifera, and Carpopeltis affinis. Annual seaweed coverage, richness index (R), evenness index (J'), and diversity index (H') values were greater at Hongdo (41.35%, 12.82, 0.59, and 2.50 respectively) than at Heuksando (31.54%, 11.93, 0.44, and 1.87 respectively), which may indicate that the seaweed community at Hongdo is more stable relative to the one at Heuksando.

Breast Cancer in Tunisia: Association of Body Mass Index with Histopathological Aspects of Tumors

  • Bouguerra, Hichem;Guissouma, Hajer;Labidi, Soumaya;Stambouli, Nejla;Marrakchi, Raja;Chouaib, Salem;Elgaaied, Amel Ben Ammar;Boussen, Hammouda;Gati, Asma
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.16
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    • pp.6805-6810
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    • 2014
  • Background: Previous studies have suggested a link between obesity and breast cancer (BC). However, there is no universal consensus, especially in population based studies. Because only few studies have been conducted on African women, we aimed here to assess the relationship between BMI at time of diagnosis and the BC histopathological features among Tunisian patients according to menopausal status using a hospital-based prospective cohort study. Materials and Methods: Clinical and pathological data were collected from 262 patients stratified on four groups according to their BMI. The relationship between BMI and histopathological features at diagnosis was analysed using univariate and multivariate analysis. Receiver-operating characteristic (ROC) curves were used to evaluate the performance of BMI in predicting of high tumor grade, in comparison to ki-67 index of proliferation. Results: Obesity was correlated with larger tumors, advanced grade and with ER-PR-Her2+ BC subtype. An association of BMI with tumor size and tumor grade was observed in both premenopausal and postmenopausal women. Additionally, a significant association between BMI and ER+, ER+PR+Her2+ and ER-PR-Her2+ status was revealed for premenopausal patients, while only ER+PR+Her2+ was associated with BMI for postmenopausal women. Finally, our results showed that compared to Ki67 proliferation index, BMI is a useful prognostic marker of high grade BC tumors. Conclusions: These data are the first to show that in Tunisia obese women suffering from BC have significantly larger tumors and advanced tumor grade and that higher BMI might influence tumor characteristics and behavior.

Maximum Modulation Index of VSC HVDC based on MMC Considering Compensation Signals and AC Network Conditions (전력계통 전압 변동과 순환 전류 보상 성분을 고려한 MMC 기반 VSC-HVDC의 최대 변조 지수 선정에 관한 연구)

  • Kim, Chan-Ki;Belayneh, Negesse Belete;Park, Chang-Hwan;Kim, Jang-Mok
    • The Transactions of the Korean Institute of Power Electronics
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    • v.25 no.1
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    • pp.61-67
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    • 2020
  • This study deals with the modulation index (MI) of a voltage source converter (VSC) HVDC system based on a modular multilevel converter (MMC). In the two-level converter, the purpose of the MI is to maximize the achievable AC voltage of the converter from a fixed DC voltage. Unlike that in a two-level converter, the MI in the MMC topology plays a role in making the converter a voltage source using a capacitor. The circulating current in the MMC distorts the AC voltage reference, and the distortion affects the MI. In addition, the AC network conditions, such as AC voltage variation and reactive power, affect the MI. Therefore, the MI should be optimized with consideration of internal and external factors. This study proposes a method to optimize the MI of an MMC HVDC system.

Expression of Hypoxia-inducible Factor-$1{\alpha}$ in Non-small Cell Lung Cancer: Relationship to Prognosis and Tumor Biomarkers (비소세포 폐암에서 HIF-$1{\alpha}$의 발현: 예후 및 종양표지자와의 관련성)

  • Cho, Sung-Rae;Byun, Joung-Hun;Kim, Jong-In;Lee, Bong-Geun;Chun, Bong-Kwon
    • Journal of Chest Surgery
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    • v.39 no.11 s.268
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    • pp.828-837
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    • 2006
  • Background: Tissue hypoxia is characteristic of many human malignant neoplasm, and hypoxia inducible factor-1(HIF-1) plays a pivotal role in essential adaptive response to hypoxia, and activates a signal pathway for the expression of the hypoxia-regulated genes, resulting in increasing $O_2$ delivery or facilitating metabolic adaptation to hypoxia. Increased level of HIF-$1{\alpha}$ has been reported in many human malignancies, but in non-small cell lung carcinoma the influence of HIF-$1{\alpha}$ on tumor biology, including neovascularization, is not still defined. In present study the relationship of HIF-$1{\alpha}$ expression on angiogenetic factors, relationship between the tumor proliferation and HIF-$1{\alpha}$ expression, interaction of HIF-$1{\alpha}$ expression and p53, and relationship between HIF-$1{\alpha}$ expression and clinico-pathological prognostic parameters were investigated. Material and Method: Archival tissue blocks recruited in this study were retrieved from fifty-nine patients with primary non-small cell lung carcinoma, who underwent pneumonectomy or lobectomy from 1997 to 1999. HIF-$1{\alpha}$, VEGF(vascular endothelial growth factor), and p53 protein expression and Ki-67 labeling index in tumor tissues were evaluated, using a standard avidin-biotin-peroxidase complex(ABC) immunohistochemistry. Relationship between the HIF-$1{\alpha}$ expression and VEGF, p53 overexpression and correlation between the HIF-$1{\alpha}$ expresseion and Ki-67 index were analyzed. Clinico-pathologic prognostic parameters were also analyzed. Result: HIF-$1{\alpha}$ expression in cancer cells was found in 24 of 59 cases of non-small cell lung carcinoma(40.7%). High HIF-$1{\alpha}$ expression was significantly associated with several pathological parameters, such as pathological TMN stage(p=0.004), pT stage(p=0.020), pN stage (p=0.029), and lymphovascular invasion(p=0.019). High HIF-$1{\alpha}$ expression was also significantly associated with VEGF immunoreactivity(p<0.001), and aberrant p53 expression(p=0.040). but was marginally associated with Ki-67 labeling index(p=0.092). The overall 5-year survival rate was 42.3%. The survival curve of patients with a high HIF-$1{\alpha}$ expression was worse than that of patients with low-expression(p=0.002). High HIF-$1{\alpha}$ expression was independent unfavorable factors with a marginal significance in multivariate analysis performed by Cox regression. Conclusion: It is suggested that high HIF-$1{\alpha}$ expression may be associated with intratumoral neovascularization possibly through HIF-VEGF pathway, and high HIF-$1{\alpha}$ expression could be associated with lymph node metastasis and post operative poor prognosis in patients with non-small cell lung carcinoma.

Determination of Thermal Cracking Index of Internal Restricted Mass Concrete Using a Numerical Analysis (수치분석을 통한 내부구속 매스콘크리트의 온도균열지수 결정)

  • Seo, Ki-Young;Kim, Hee-Sung;Jin, Chi-Sub
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.11 no.1
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    • pp.57-67
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    • 2007
  • The service life of concrete structure is to a great extent influenced by crack developed at early ages of concrete material. Especially, hydration heat is a main cause of thermal cracking at mass concrete structures. The thermal cracking of massive structure is analyzed of the thermal cracking index which was presented Concrete Standard Specifications. The thesis analyzed the thermal cracking index which considered various variable (cement type, height of casting, curing condition, concrete mixing temperature, the unit cement content) at internal restricted mass concrete. The analysis result is denoted increase and decrease rate of thermal cracking index whenever the variables change. The results is helped to understand thermal cracking every time structures is designed and constructed. And I think that it is useful economic and stable design of mass concrete structures.

Comparison between FDG Uptake and Clinicopathologic and Immunohistochemical Parameters in Pre-operative PET/CT Scan of Primary Gastric Carcinoma (원발성 위암 환자의 치료 전 PET/CT 스캔에서 FDG 섭취 정도와 임상병리학적 및 면역조직화학적 지표들과의 비교)

  • Han, Eun-Ji;Choi, Woo-Hee;Chung, Yong-An;Kim, Ki-Jun;Maeng, Lee-So;Sohn, Kyung-Myung;Jung, Hyun-Suk;Sohn, Hyung-Sun;Chung, Soo-Kyo
    • Nuclear Medicine and Molecular Imaging
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    • v.43 no.1
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    • pp.26-34
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    • 2009
  • Purpose: The purpose of this study was to find out what clinicopathologic or immunohistochemical parameter that may affect FDG uptake of primary tumor in PET/CT scan of the gastric carcinoma patient. Materials and Methods: Eighty-nine patients with stomach cancer who underwent pre-operative FDG PET/CT scans were included. In cases with perceptible FDG uptake in primary tumor, the maximum standardized uptake value (SUVmax) was calculated. The clinicopathologic results such as depth of invasion (T stage), tumor size, lymph node metastasis, tumor differentiation and Lauren's classification and immunohistochemical markers such as Ki-67 index, expression of p53, EGFR, Cathepsin D, c-erb-B2 and COX-2 were reviewed. Results: Nineteen out of 89 gastric carcinomas showed imperceptible FDG uptake on PET/CT images. In cases with perceptible FDG uptake in primary tumor, SUVmax was significantly higher in T2, T3 and T4 tumors than T1 tumors ($5.8{\pm}3.1$ vs. $3.7{\pm}2.1$, p=0.002). SUVmax of large tumors (above or equal to 3 cm) was also significantly higher than SUVmax of small ones (less than 3 cm) ($5.7{\pm}3.2$ vs. $3.7{\pm}2.0$, p=0.002). The intestinal types of gastric carcinomas according to Lauren showed higher FDG uptake compared to the non-intestinal types ($5.4{\pm}2.8$ vs. $3.7{\pm}1.3$, p=0.003). SUVmax between p53 positive group and negative group was significantly different ($6.0{\pm}2.8$ vs. $4.4{\pm}3.0$, p=0.035). No significant difference was found in presence of LN metastasis, tumor differentiation, Ki-67 index, and expression of EGFR, Cathepsin D, c-erb-B2 and COX-2. Conclusion: T stage of gastric carcinoma influenced the detectability of gastric cancer on FDG PET PET/CT scan. When gastric carcinoma was perceptible on PET/CT scan, T stage, size of primary tumor, Lauren's classification and p53 expression were related to degree of FDG uptake in primary tumor.

Study on the Labeling Items and Reliability of Spectacle Lens (안경렌즈의 표시사항 및 신뢰성에 관한 연구)

  • Ye, Ki-Hun;Kim, Tae-Hun;Kwon, Young-Seok;Sung, A-Young
    • Journal of Korean Ophthalmic Optics Society
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    • v.11 no.4
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    • pp.323-327
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    • 2006
  • For this study we research investigated the current situation of packing on the labeling items of domestic spectacle lens and reliability of spectacle lens. We use sample which is three hundred and ninety six spectacle lenses of eight company total. Refractive index of each sample in experiment is 1.55~1.56, 1.60~1.61 and 1.67. The percentage of labeling of A company and B company indicated the percentage of labeling of 80%, but The percentage of labeling of two companies indicated only 52.1% and 56.9% seperately. The most companies indicated comparatively a low marking ratio about packing on the labeling items. The results of difference the value of power which is recorded with the value of power which is measurement showed only small value.

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Aquatic Plant Restoration by Mattress/Filter System in Stagnant Stream Channel (정체수역에서의 Mattress/Filter에 의한 수생식물 복원)

  • Yeo Woon-Ki;Heo Chang-Hwan;Lee Seung-Yun;Jee Hong-Kee
    • Journal of Environmental Science International
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    • v.15 no.1
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    • pp.21-31
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    • 2006
  • Aquatic plants grow in water with photosynthesis and purify water quality as taking organic and inorganic matter in water. Polluted water in stagnant stream channel where nutritive salts load is great can be purified by activities of aquatic plants. Aquatic plants should be fixed to bed easily to plant and sustainable environment is needed. So in this study, Mattress/Filter system is suggested to plant aquatic plant in stagnant stream channel. In the result of study, coverage of Phragmites australis, Zizania latifolia and Typha angustifolia which planted in mattress was $78\%,\;62\%\;and\;82\%$ and numbers of species in each mattress system were 7, 11, 3. The evenness index of each mattress system was 0.86, 0.91 and 0.79 and diversity index of each mattress system was 1.67. 2.18 and 0.87. Removal rates of phosphorus at Phragmites australis, Zizania latifolia and Typha angustifolia which planted in mattress were $68.7\%,\;62.7\%,\;55.3\%$ and removal rates of nitrogen of them were $79.8\%,\;74.7\%,\;64.9\%$. The removal rate of nitrogen was greater than phosphorus at all system and both removal rates were greater at Phragmites australis than at Zirania latifolia and at Typha angustifolia the rate was the least. Removal rates of $PO_4^{-3},\;NH_4-N,\;NO_{3-}N$ at Phragmites australis were $57.4\%,\;52.8\%,\;47.8\%$ and at Zizania latifolia were $82.6\%,\;77.2\%,\;67.5\%$ and at Typha angustifolia were $80.6\%,\;73.7\%,\;64.3\%$. It seems that removal effect is great by the planted mattress system.