• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.294-302
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• 2020

In a genetic algorithm, computer simulations are performed based on the natural evolution process of life, such as selection, crossover, and mutation. The genetic algorithm searches the approximate optimal solution by the parallel arrangement of Schema, which has a short definition length, low order, and high adaptability. This study examined the possibility of improving the efficiency of the optimal solution by considering the characteristics of the building block hypothesis, which are one of the key operating principles of a genetic algorithm. This study evaluated the efficiency of the optimization results according to the gene sequence for the implementation in solving problems. The optimal design problem of the water pipe was selected, and the genetic arrangement order reflected the engineering specificity by dividing into the existing, the network topology-based, and the flowrate-based arrangement. The optimization results with a flowrate-based arrangement were, on average, approximately 2-3% better than the other batches. This means that to increase the efficiency of the actual engineering optimization problem, a methodology that utilizes clear prior knowledge (such as hydraulic properties) to prevent such excellent solution characteristics from disappearing is essential. The proposed method will be considered as a tool to improve the efficiency of large-scale water supply network optimization in the future.

• Journal of Korean Neurosurgical Society
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• v.63 no.2
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• pp.137-152
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• 2020

In spite of the developing endovascular era, large (15-25 mm) and giant (>25 mm) wide-neck cerebral aneurysms remained technically challenging. Intracranial flow-diverting stents (FDS) were developed to address these challenges by targeting aneurysm hemodynamics to promote aneurysm occlusion. In 2011, the first FDS approved for use in the United States market. Shortly thereafter, the Pipeline of Uncoilable or Failed Aneurysms (PUFS) study was published demonstrating high efficacy and a similar complication profile to other intracranial stents. The initial FDA instructions for use (IFU) limited its use to patients 22 years old or older with wide-necked large or giant aneurysms of the internal carotid artery (ICA) from the petrous segment to superior hypophyseal artery/ophthalmic segment. Expanded IFU was tested in the Prospective Study on Embolization of Intracranial Aneurysms with PipelineTM Embolization Device (PREMIER) trial. With further post-approval clinical data, the United States FDA expanded the IFU to include patients with small or medium, wide-necked saccular or fusiform aneurysms from the petrous ICA to the ICA terminus. However, IFU is more restrictive in South Korea than in United States. Several systematic reviews and meta-analyses have sought to evaluate the overall efficacy of FDS for the treatment of cerebral aneurysms and consistently identify FDS as an effective technique for the treatment of aneurysms broadly with complication rates similar to other traditional techniques. A growing body of literature has demonstrated high efficacy of FDS for small aneurysms; distal artery aneurysms; non-saccular aneurysms posterior circulation aneurysms and complication rates similar to traditional techniques. In the short interval since the Pipeline Embolization Device was first introduced, FDS has been firmly entrenched as a powerful tool in the endovascular armamentarium. As new FDS are developed, established FDS are refined, and delivery systems are improved the uses for FDS will only expand further. Researchers continue to work to optimize the mechanical characteristics of the FDS themselves, aiming to optimize deploy ability and efficacy. With expanded use for small to medium aneurysms and posterior circulation aneurysms, FDS technology is firmly entrenched as a powerful tool to treat challenging aneurysms, both primarily and as an adjunct to coil embolization. With the aforementioned advances, the ease of FDS deployment will improve and complication rates will be further minimized. This will only further establish FDS deployment as a key strategy in the treatment of cerebral aneurysms.

• Microbiology and Biotechnology Letters
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• v.45 no.3
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• pp.226-235
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• 2017

Carotenoids such as phytoene, lycopene, and ${\beta}-carotene$ are used as food colorants, animal feed supplements, and for human nutrition and cosmetic purposes. Previously, we reported the isolation of a novel marine bacterium, Kocuria gwangalliensis, which produces a pink-orange pigment. Phytoene desaturase (CrtI), encoded by the gene crtI, catalyzes lycopene formation from phytoene and is an essential enzyme in the early steps of carotenoid biosynthesis. CrtI is one of the key enzymes regulating carotenoid biosynthesis and has been implicated as a rate-limiting enzyme of the pathway in various carotenoid synthesizing organisms. Here, we report the cloning of the crtI gene responsible for lycopene biosynthesis from K. gwangalliensis. The gene consisted of 1,584 bases encoding 527 amino acid residues. The nucleotide sequence of the crtI gene was compared with that of other species, including Kocuria rhizophila and Myxococcus xanthus, and was found to be well conserved during evolution. An expression plasmid containing the crtI gene was constructed (pCcrt1), and Escherichia coli cells were transformed with this plasmid to produce a recombinant protein of approximately 57 kDa, corresponding to the molecular weight of phytoene desaturase. Lycopene biosynthesis was confirmed when the plasmid pCcrtI was co-transformed into E. coli containing the plasmid pRScrtEB carrying the crtE and crtB genes required for lycopene biosynthesis. The results from this study will provide valuable information on the primary structure of K. gwangalliensis CrtI at the molecular level.

• Journal of the Korean Electrochemical Society
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• v.12 no.4
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• pp.342-348
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• 2009

Zn/Air secondary batteries are high energy density type and environment-friendly. Also, they have safer properties than batteries of other type by low manufacturing cost and using the electrolyte solution. But, they have a weak concerning large output discharge. Oxygen evolution reaction(OER) and oxgen reduction reaction(ORR) in aqueous solution make a result of a decrease of cell efficiency and life span. Therefore, to minimize the voltage drop from between OCV and charge/discharge voltage is key point. The problem should be solved through developing catalysts of high efficiency. In this study, we synthesized $Pr_{1-x}(Sr,\;Ca)_x\;CoO_3$ powders by citric method and then measured physical characteristics of each powder by XRD, SEM, TGA etc. We examined its electrochemical properties by the cathodic polarization, anodic polarization and cyclic voltammogram. We achieved results that new catalysts showed better performances than existing $La_{1-x}Sr_xCoO_3$, $La_{1-x}Ca_xCoO_3$, ect. catalysts prepared in our lab.

• International Commerce and Information Review
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• v.19 no.4
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• pp.29-50
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• 2017

In emerging technologies, innovation processes are dynamic in that the government needs to regularly review its policies to resonate with rapid technological advancements, changing public needs, and evolving global trends. In the 1990s, the Internet grew at an explosive rate, but many applications were constrained due to security concerns. Public Key Infrastructure (PKI) seemed to be the fundamental technology to address these concerns by providing security functions. As of 2017, PKI is still one of the best technologies for electronic authentication in an open network, but it is used only in limited areas: for user authentications in closed networks and for server authentications within network security infrastructure like SSL/TLS. The difference between expectation and reality of PKI usage is due to the evolution of the Internet along with the global adoption of new authentication policies under the Internet governance in the early 2000s. The new Internet governance based on the cooperation between multi-stakeholders is changing the way in which a government should act with regard to its technological policies. This paper analyzes different PKI policy approaches in the United States and Korea from the perspective of path-dependence theory. Their different policy results show evidence of the rise of the Internet governance, and may have important implications for policy-makers in the current global Internet society.

• ALGAE
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• v.32 no.4
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• pp.359-377
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• 2017

Pyropia haitanensis (T. J. Chang et B. F. Zheng) N. Kikuchi et M. Miyata is one of the most commercially useful macroalgae cultivated in southeastern China. In red algae, the biosynthesis of terpenoids through 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway can produce a direct influence on the synthesis of many biologically important metabolites. In this study, two genes of cDNAs, 1-deoxy-D-xylulose-5-phosphate synthase (DXS) and 1-deoxy-D-xylulose-5-phosphate reductase (DXR), which encoding the first two rate-limiting enzymes among MEP pathway were cloned from P. haitanensis. The cDNAs of P. haitanensis DXS (PhDXS) and DXR (PhDXR) both contained complete open reading frames encoding polypeptides of 764 and 426 amino acids residues, separately. The expression analysis showed that PhDXS was significant differently expressed between leafy thallus and conchocelis as PhDXR been non-significant. Additionally, expression of PhDXR and its downstream gene geranylgeranyl diphosphate synthase were both inhibited by fosmidomycin significantly. Meanwhile, we constructed types of phylogenetic trees through different algae and higher plants DXS and DXR encoding amino acid sequences, as a result we found tree clustering consequences basically in line with the "Cavalier-Smith endosymbiotic theory." Whereupon, we speculated that in red algae, there existed only complete MEP pathway to meet needs of terpenoids synthesis for themselves; Terpenoids synthesis of red algae derivatives through mevalonate pathway came from two or more times endosymbiosis of heterotrophic eukaryotic parasitifer. This study demonstrated that PhDXS and PhDXR could play significant roles in terpenoids biosynthesis at molecular levels. Meanwhile, as nuclear genes among MEP pathway, PhDXS and PhDXR could provide a new way of thinking to research the problem of chromalveolata biological evolution.

• The Journal of the Korea Contents Association
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• v.12 no.12
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• pp.721-732
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• 2012

Patent information, which is generated under a specific, objective rule for a prolonged period of time, has the properties of technology, right, and management. Because of these characteristics of patents, patent analysis is used to identify R&D capacities and performances, and management strategies of a given nation or enterprise. In this paper, we analyze LTE essential patents which are key IPRs for implementing standardized LTE technology and major weapons in a global patent war. Total of 2,307 LTE essential patents, published and registered applications from European Telecommunications Standards Institute(ETSI)'s online IPR database as of January 2011, are analyzed in quantitative methods. The analysis results present status and statistics of LTE essential patents by major countries, applicant companies and technical fields. And a comparative study is done using 4 patent indices limited to the LTE essential patents issued in the United States. It is expected that results herein are useful for not only figuring out the technological competitiveness of countries and companies in LTE market, but also suggesting a guide to strategic IPR management for related industries.

• Journal of Life Science
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• v.28 no.4
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• pp.488-495
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• 2018

The p53 gene plays a critical role in the transcriptional regulation of cellular response to stress, DNA damage, hypoxia, and tumor development. Keeping in mind the recently discovered manifold physiological functions of p53, its involvement in the regulation of cancer is not surprising. In about 50% of all human cancers, inactivation of p53's protein function occurs either through mutations in the gene itself or defects in the mechanisms that activate it. This disorder plays a crucial role in tumor evolution by allowing the evasion of a p53-dependent response. Many recent studies have focused on directly targeting p53 mutants by identifying selective, small molecular compounds to deplete them or to restore their tumor-suppressive function. These small molecules should effectively regulate various interactions while maintaining good drug-like properties. Among them, the discovery of the key p53-negative regulator, MDM2, has led to the design of new small molecule inhibitors that block the interaction between p53 and MDM2. Some of these small molecule compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, more personalized anti-carcinogenic medicines. Here, we review the structural and functional consequences of wild type and mutant p53 as well as the development of therapeutic agents that directly target this gene, and compounds that inhibit the interaction between it and MDM2.

• Journal of Korea Spatial Information System Society
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• v.4 no.2 s.8
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• pp.5-22
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• 2002

The considerable budgets for the 2nd-phase NGIS projects are allocated to the projects for developments of the GIS applications. Especially, the 78 local governments are major users of GIS application systems. In spite of GIS necessity in local government, whether a GIS is 'good' or bad, depends on its implementation and operation. How to implement GIS in effective wav and how to measure GIS effect for justifying GIS funding can be major concerns. Because it takes minimum 3-4 years to equal the costs and benefits of GIS, the long-terms implementation strategies for GIS project in local government are required. In order to establish a proper implementation model for the GIS application projects and to promote activities in the projects, this study considers several problems in accordance with the phases of GIS evolution and solutions of these problems. Based an the GIS auditing and consulting experience in local governments, this study constructs a GIS implementation and maintenance model in long and comprehensive perspective. This model can be a key to affective and realistic implementation for the future GIS projects.

• Journal of Korean Society of Steel Construction
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• v.27 no.2
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• pp.143-153
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• 2015

In this paper, the standard fire resistance test under load and associated numerical study were carried out to evaluate the fire resistance of unprotected partially encased beams and slimfloor beams. The temperature evolution and the deflection increase of the composite beam specimens were investigated and the effects of the key behavioral parameters including the load ratio, the reinforcement, and the fire exposure were analyzed. The test results showed that the temperature rise of the partially encased beams and slimfloor beams is considerably slow compared to the conventional H-shape composite beams. Up to at least 90 minutes, the reinforcements in the partially encased composite beams maintained below the temperature at which the cold steel strength is sustained. Unprotected partially encased beams and slimfloor beams in the experimental program achieved the fire resistance more than 2 hours according to the limiting deflection criteria. This implies that unprotected partially encased beams and slimfloor beams can be very promising alternatives to enhancing the fire resistance of steel beams. This study also conducted the fully coupled thermal-stress analysis by using the commercial code ABAQUS to the thermal and structural behaviour of composite beams in fire. The numerical predictions provide acceptable correlations with the experimental results.