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In-silico annotation of the chemical composition of Tibetan tea and its mechanism on antioxidant and lipid-lowering in mice

  • Ning Wang ;Linman Li ;Puyu Zhang;Muhammad Aamer Mehmood ;Chaohua Lan;Tian Gan ;Zaixin Li ;Zhi Zhang ;Kewei Xu ;Shan Mo ;Gang Xia ;Tao Wu ;Hui Zhu
    • Nutrition Research and Practice
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    • v.17 no.4
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    • pp.682-697
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    • 2023
  • BACKGROUND/OBJECTIVES: Tibetan tea is a kind of dark tea, due to the inherent complexity of natural products, the chemical composition and beneficial effects of Tibetan tea are not fully understood. The objective of this study was to unravel the composition of Tibetan tea using knowledge-guided multilayer network (KGMN) techniques and explore its potential antioxidant and hypolipidemic mechanisms in mice. MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH2O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method. RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism. CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.

A Study on the Development of Interior Design Service for Autonomous Vehicles - Focusing on STEEP analysis Techniques - (자율주행차 인테리어 디자인서비스 개발연구 - STEEP 분석 기법을 적용한 사례 중심으로 -)

  • Kang, Taeho;Cho, Jounghyung
    • Journal of Service Research and Studies
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    • v.11 no.3
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    • pp.43-54
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    • 2021
  • This study focused on indoor spaces and convenience devices among vehicle interior designs suitable for the autonomous driving era, and presented an interior design model for future automobiles by applying the STEEP analysis method. The service design methodology is applied to deal with changes in display devices installed for the purpose of rearranging layouts and providing driver-centered information. Changes in types and installation locations of displays for various purposes such as connected and infotainment are expected. In particular, through this analysis, trends and experiences through indoor interior research in future self-driving cars will be studied, and subsequent studies will be used as basic data for actual development and application. Key drivers were extracted after deriving future trends linking the research project conducted in five stages to STEEP and consulting experts through FGI. Through this, it was later presented as a direction for indoor design. Through user-centered participatory design methods, emotional keyword derivation methods were used, summarized the derived drivers in five major trends in the future society, and each derived drivers were grouped to consider the relevant technology fields, and added elements to the autonomous driving level. This is an indoor ray viewed from the perspective of various social issues as well as personal tendencies in the future self-driving car industry.

An Analysis of Customers' Value System Using APT Laddering Technique: Difference Comparison and Strategy Suggestion Among Hair Salon Types (APT 래더링 기법을 적용한 고객의 가치체계 분석: 헤어살롱 유형별 차이 비교 및 전략제시)

  • Miok, Seo
    • Journal of Service Research and Studies
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    • v.11 no.2
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    • pp.21-36
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    • 2021
  • This study investigated the means-end chain theory more concretely through the APT hard laddering technique. This is carrying out a questionnaire survey targeting users by hair salon type, and the items drawn from the qualitative laddering technique are applied. The technique is a comparative analysis of each attribute, consequences, and value item by analyzing each step's questions. The results are as follows. First, hairdresser's ability, acceptance of individual-customized opinions, and cheap price were the most mentioned items in the selection attributes. As for the consequences items, image transformation, neatness, novelty, and psychological stability were drawn in order. The items indicated as important among the value items were satisfaction, followed by happiness, confidence, beauty, and bond. Second, the remarkable selection attributes, irrelevant of hair salon type, was revealed as hairdresser's ability and the key values pursued when using a hair salon were drawn as satisfaction, confidence, and beauty. From this result, it was found that meeting the desire of consumers using hair salons can be linked with ultimately pursued values. It was also verified that partial differences were shown by hair salon type and this meant that consumers' desire and expected benefits were different by hair salon type. Although this study drew value perception through comparison with hair salon types based on the means-end chain theory, it was confirmed that the most important selection attribute was hairdresser's ability and they select and use hair salons to gain satisfaction and confidence.

Detecting Backward Erosion Piping Using a Tracer (추적자를 이용한 후퇴 침식 파이핑 현상 탐지법 개발 연구)

  • Jeong, Won;Kim, Byunguk;Seo, Il Won;Park, Yong Sung
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.43 no.1
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    • pp.55-62
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    • 2023
  • Internal erosion is one of the main causes of levee damage and collapse, and representative of this is backward erosion piping. This type of internal erosion accounts for one-third of the damage to levees, meaning it is important to predict and prevent it. In this work, experiments were conducted with the aim of detecting piping in advance by using a tracer. Experiments were undertaken by changing the head difference, soil diameter, and the installation of the cutoff wall. A tracer was injected twice, once at the beginning of the experiment and once after the piping occurred. A key finding was that the piping process significantly affectedthe concentration variation of the tracer in a soil layer. Hence, a tracer concentration curve monitored at downstream could provide information about piping occurrence. It is expected that the results of this study can be used to prevent levee damage and collapse caused by piping.

Study Visual Characteristics of World Cup Emblems (월드컵 엠블럼에 나타난 시각적 특징 연구)

  • YongFeng Liu
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.3
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    • pp.519-528
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    • 2023
  • The visual characteristics of the World Cup emblem play an important role in conveying culture and identity, highlighting the key elements of the Games, and strengthening the brand image. This study first investigated the visual elements and theoretical background of the emblem through previous studies. Second, the selection of symbolism, shape, and color was the subject of the study. Third, based on the shape-related theory based on the '100 National Cultural Symbols', the analysis was performed using the 'IRI Color Matching Image Scale' as a tool, and a final conclusion was drawn. The World Cup emblem uses a lot of ethnic and living symbols, and the living and ethnic symbols are expressed in a combination. In the beginning, there were many symmetric shapes, but after that it changed to an asymmetric shape. The curved expression form is more used than the straight expression form. And most of the color arrangement image scale distribution shows light, dynamic and modern color arrangement characteristics. In the future, the World Cup emblem design will continue to use national and living symbols. The shape of the emblem should use curves and asymmetric designs, be intuitive, and directly reflect the theme of the competition. In addition, the national flag color should be used as the main color, and other colors should be used as secondary colors. The combination of colors must match the light, dynamic and modern color characteristics of the IRI color scheme image scale.

A Study on North Korea's UAV Threat and Response Stance (북한의 무인기 위협과 대응 자세)

  • Hyeonsik Kim;Chanyoung Park
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.2
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    • pp.227-233
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    • 2023
  • Along with the 4th Industrial Revolution, the impact of "unmanned" is affecting all fields around the world, and in particular, in the military sector, "unmanned" is so important that it occupies a part of the main combat system. Recently, the South Korean military is facing a crisis due to the North Korea's UAV incident that invaded our airspace and descended to Seoul. In response, the South Korea military declared its willingness and countermeasures to capture and destroy North Korea's UAV. However, as the technological development of UAV continues and the utilization plan is expanding, the countermeasures for UAV at the current level can be useless. Also, the threat from North Korea is not just UAV. North Korea has practically a nuclear power and is set to conduct its seventh nuclear test, and its missile technology is also being advanced, with 38 arounds of 67 missile tests conducted in 2022 alone. It is also developing five key strategic weapons that can pose a fatal threat to Korea, and North Korea's strong conventional forces are located around the NLL(Northern Limit Line), and the port of Long Range Artillery is facing the Seoul metropolitan area. It is important to respond to North Korea's UAV threats, which are now receiving much attention, but it will be necessary to comprehensively analyze and clearly prioritize North Korea's threats and use a limited budget to respond to them.

A Study on Tourism Behavior in the New normal Era Using Big Data (빅데이터를 활용한 뉴노멀(New normal)시대의 관광행태 변화에 관한 연구)

  • Kyoung-mi Yoo;Jong-cheon Kang;Youn-hee Choi
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.3
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    • pp.167-181
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    • 2023
  • This study utilized TEXTOM, a social network analysis program to analyze changes in current tourism behavior after travel restrictions were eased after the outbreak of COVID-19. Data on the keywords 'domestic travel' and 'overseas travel' were collected from blogs, cafes, and news provided by Naver, Google, and Daum. The collection period was set from April to December 2022 when social distancing was lifted, and 2019 and 2020 were each set as one year and compared and analyzed with 2022. A total of 80 key words were extracted through text mining and centrality analysis was performed using NetDraw. Finally, through the CONCOR, the correlated keywords were clustered into 4. As a result of the study, tourism behavior in 2022 shows tourism recovery before the outbreak of COVID-19, segmentation of travel based on each person's preferred theme, prioritization of each country's corona mitigation policy, and then selecting a tourist destination. It is expected to provide basic data for the development of tourism marketing strategies and tourism products for the newly emerging tourism ecosystem after COVID-19.

Evaluation of Steel Tube Connection in Precast Concrete Double Wall System (프리캐스트 콘크리트 더블월 시스템의 각형 강관 연결부 성능평가 )

  • Yujae Seo;Hyunjin Ju
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.27 no.2
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    • pp.25-32
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    • 2023
  • In this study, a double wall system is introduced, which was invented to simplify the complicated manufacturing process of the existing precast concrete (PC) double wall systems and to remove defects such as laitance that may occur during the production of concrete panels. An experimental study was conducted to investigate the tensile resisting capacity of the steel tube which is embedded in the precast concrete panel to keep the spacing between PC panels and to prevent damage of the PC panels during transportation and casting concrete onsite. The experiment was planned to determine the detail of effective steel tube connection considering the steel plate treatment method according to the formation of the opening, the presence of embedded concrete, and the reinforcement welding for additional dowel action as key variables. As a result, the ultimate tensile strength increased by 20-30% compared to the control specimen (ST) except for the steel tube specimen (ST_CP) which has steel plates bent inward at the end part of the steel tube. Since the specimen (ST_CON) filled with concrete inside the control specimen has no additional process and cost for the steel tube connections compared to the control specimen during the production of the developed double wall system, it is determined to be the appropriate detail of steel tube connection.

Paradigm of the Transformation of Potential-Forming Space Under the Impact of Intellectual-Innovation Determinants

  • Khanin, Semen;Derhaliuk, Marta;Stavroyany, Serhii;Kudlasevych, Olga;Didkivska, Lesia
    • International Journal of Computer Science & Network Security
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    • v.22 no.1
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    • pp.340-346
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    • 2022
  • The article examines the formation of the scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants. Based on the study of different scientific views on the nature and properties of potential-forming space through the study of approaches to understanding the concept of "space" clarified the complexity and multifaceted nature of the phenomenon and found that its characteristics are relevant to the industrial development model. It is revealed that the leading modern trends related to the spread of globalization and regionalization, rapid development of information and communication technologies, diffusion of innovations accompany the transition from industrial to post-industrial development and its development, which leads to new development: changes production, nature and relations between business entities, etc. It is proved that under such conditions, the region as a key element of the economic system, acquires a leading role in achieving sustainable and balanced development. These processes significantly affect the potential-forming space of the regional economy under the influence of intellectual and innovative determinants, leading to the need for its transformation and change in accordance with modern realities, which is reflected in thorough research on the formation of scientific paradigm based on the formation of its theoretical foundations and methodological basis. This study reveals the essence, role, functions, structure, process of formation of the scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants. It is proved that the formation of the modern scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants occurs in the context of building a post-industrial model of development, accompanied by consideration of the region as a spatial object territories from the physical plane to the spatial environment in which the development of human capital, innovation and self-development of the region. Taking into account the above, the article outlines the prerequisites and factors of formation of the scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants.

A Study on the Perceptions and Current Practices in Estimating Risk Cost of Contractor's Construction Budget - Focused on Building Projects - (종합건설사 실행예산 편성 시 리스크 비용 산정에 관한 인식 및 실태에 관한 연구 - 건축공사를 중심으로 -)

  • Choi, Jeong Won;Kim, Han Soo
    • Korean Journal of Construction Engineering and Management
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    • v.23 no.3
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    • pp.13-24
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    • 2022
  • Construction projects are exposed to various types of risks, which tend to increase. The increasing risks call for contractors' more attentions to forecasting and dealing with these risks. One of the measures to deal with contractors' risks is to forecast or estimate risk cost and include it in the construction budget. Although various researches in relation to risk cost have been observed, little attention has been paid to general contractors' perceptions and current practices in estimating risk cost of construction budget. The objective of the study is to identify and discuss key characteristics and implications based on the survey and analysis of general contractors' perceptions and current practices in estimating risk cost of construction budget. The study shows that there is a gap between the perception and the practice of estimating risk cost, that is, high perception of the importance of risk cost and a relatively low level of practice. It suggests that historical cost data, guidelines and corporate-level standard procedures are required to improve the current practice in addition to sufficient time allocations for risk cost estimating. It discusses that there is a need for using sophisticated estimating techniques including bid data analytics despite a low level of the current adoption, and also proposes that research and development in the field of the sophisticated estimating techniques should be further implemented in order to increase their practicality.