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Subacute toxicities and toxicokinetics of CJ-10882, a type IV phosphodiesterase inhibitor, after 4-week repeated oral administration in dogs

  • Junghee Han;Cha, Shin-Woo;Im, Doo-Hyun;Chung, Moon-Koo
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.05a
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    • pp.43-44
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    • 2003
  • The subacute toxicity and toxicokinetics of a type IV phosphodiesterase inhibitor, CJ-10882, were evaluated after single (on the 1st day) and 4-week (on the 27th day) oral administration of the drug, in doses of 0 (to serve as a control), 2, 10 and 50 mg/kg/d, to male and female dogs (n = 3 for male and female dogs for each dose). During the test period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, organ weight and histopathology were examined.(omitted)

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Analysis of brightness decrease originated from mixing of flexo printed ONP and OCC in ONP recycling process (플렉소 인쇄 신문지와 OCC 배합에 따른 ONP 탈묵펄프의 백색도 변화)

  • Ryu, Jeong-Yong;Song, Bong-Keun
    • Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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    • 2011.10a
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    • pp.119-123
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    • 2011
  • The application of flexo printed ONP and OCC leads to brightness decrease of deinked stock in ONP recycling system. The largest problems are due to accumulation of flexo ink & introduction of brown fibers. All these are emphasized by variations in the amount of flexo printed ONP and OCC in recovered ONP stock. Most of the brightness problems caused by flexo ink can be helped and solved by applying a proper polyelectrolytes as coagulation agent and flocculation agent. This requires exact evaluation of sedimentation or dissolved air flotation potentials of flexo ink and polyelectrolytes. Effect of bleaching chemical (H2O2) addition level on the increase of brightness of OCC included stock has been investigated by lab scale test.

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Chemically Induced High Pretilt Angle by CN-Containing Polyimide

  • Lee, Myong-Hoon;You, Kwon-Il;Lee, Chang-Jin;Woo, Tae-Ha
    • 한국정보디스플레이학회:학술대회논문집
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    • 2000.01a
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    • pp.191-192
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    • 2000
  • New copolyimides containing nitrile side group were synthesized from copolymerization of pyromellitic dianhydride, m-phenylene diamine and 3,5-diaminobenzonitrile and subsequent thermal imidization of the resulting poly(amic acid). Crystallinity, glass transition temperature and initial decomposition temperature of copolyimides were almost identical to those of homo polyimide prepared from PMDA and m-PDA. Change of pretilt angle induced by the orientation layer of resulting copolyimide was investigated by using a nitrile-containg nematic liquid crystal cell after rubbing. As the content of polar nitrile group was increased in the copolymer, pretilt angle was increased from $3.65^{\circ}$ to $6.49^{\circ}$. The mechanism of this was speculated as the dipolar interaction between the liquid crystal and nitrile groups in copolyimide.

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Functional Inks for Printed Electronics

  • Choi, Young-Min;Jeong, Sun-Ho
    • Proceedings of the Materials Research Society of Korea Conference
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    • 2012.05a
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    • pp.63.1-63.1
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    • 2012
  • In recent years, the functional inks for printed electronics that can be combined with a variety of printing techniques have attracted increasingly significant interest for use in low cost, large area, high performance integrated electronics and microelectronics. In particular, the development of solution-processable conductor, semiconductor and insulator materials is of great importance as such materials have decisive impacts on the electrical performance of various electronic devices, and, therefore, need to meet various requirements including solution processability, high electrical performance, and environmental stability. Semiconductor inks such as IGO, CIGS are synthesized by chemical solution method and microwave reaction method for TFT and solar cell application. Fine circuit pattern with high conductivity, which is valuable for flexible electrode for PCB and TSP devices, can be printed with highly concentrated and stabilized conductor inks such as silver and copper. Solution processed insulator such as polyimide derivatives can be use to all printed TFT device. Our research results of functional inks for printed electronics provide a recent trends and issues on this area.

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Thin Film Transistor fabricated with CIS semiconductor nanoparticle

  • Kim, Bong-Jin;Kim, Hyung-Jun;Jung, Sung-Mok;Yoon, Tae-Sik;Kim, Yong-Sang;Choi, Young-Min;Ryu, Beyong-Hwan;Lee, Hyun-Ho
    • 한국정보디스플레이학회:학술대회논문집
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    • 2009.10a
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    • pp.1494-1495
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    • 2009
  • Thin Film Transistor(TFT) having CIS (CuInSe) semiconductor layer was fabricated and characterized. Heavily doped Si was used as a common gate electrode and PECVD Silicon nitride ($SiN_x$) was used as a gate dielectric material for the TFT. Source and drain electrodes were deposited on the $SiN_x$ layer and CIS layer was formed by a direct patterning method between source and drain electrodes. Nanoparticle of CIS material was used as the ink of the direct patterning method.

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The Synthesis of a High Yield PbSe Quantum Dots by Hot Solution Method

  • Baek, In-Chan;Seok, Sang-Il;Chung, Yong-Chae
    • Bulletin of the Korean Chemical Society
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    • v.29 no.9
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    • pp.1729-1731
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    • 2008
  • Colloidal solutions of crystalline PbSe nanoparticles have been synthesized by hot solution chemical process using PbO in oleic acid and tributylphosphine (TBP) bonded selenium. The use of TBP as a capping agent along with oleic acid gives a very good yield (around 10% at 180 ${^{\circ}C}$) with an average diameter of particle of about < 6.6 nm. The effects of temperature on size and production yield of PbSe quantum dots are studied. Xray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM) and UV/VIS/NIR absorption spectroscopy were used to characterize the samples.

Luminescence properties of $ZnGa_{2}O_{4}$ based phosphors

  • Singh Binod Kumar;Ryu Hojin;Chang Ho-Jung
    • Proceedings of the Korean Society Of Semiconductor Equipment Technology
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    • 2005.09a
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    • pp.35-39
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    • 2005
  • Phosphor powders of zinc gal late added with Mg and rare-earth elements were prepared by sol id state reaction to improve luminescent properties. Green emitting $ZnMnGa_{2}O_{4}$ reached maximum intensity at Mn=0,005 mole$\%$ and further improvement was achieved by addition of $Mg^{2+}$. Tm, Mg-added zinc gallate phosphor exhibited a strong blue band emission, peaking at about 420 nm with the maximum intensity at the concentration of 0.003 mole$\%$ Mg and 0.015 mole$\%$ Tm. Deepening of the potential wells of the ground and excited states was suggested to be the cause for the enhancement in emission intensity at optimal doping of Mg and Tm.

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Preparation of isotropic pitch precursor for pitch-based carbon fiber through the co-carbonization of ethylene bottom oil and polyvinyl chloride

  • Liu, Jinchang;Shimanoe, Hiroki;Nakabayashi, Koji;Miyawaki, Jin;Ko, Seunghyun;Jeon, Young-Pyo;Yoon, Seong-Ho
    • Journal of Industrial and Engineering Chemistry
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    • v.67
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    • pp.276-283
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    • 2018
  • For the first time, polyvinyl chloride (PVC) was used as an easily-handled chlorine source for preparation of isotropic pitch-based carbon fiber (IPCF) incorporating ethylene bottom oil (EO) as a raw material. Pitch precursors were prepared by the chlorination-dehydrochlorination triggered by chlorine radicals originated from PVC; aromatization and poly-condensation reactions occurred by polyene-type radicals from PVC. Radical production and co-carbonization were facilitated by pretreatments of EO through vacuum distillation, bromination, and additional heat treatment. Pitches were prepared by the co-carbonization of pretreated EO and EO containing 20 wt% PVC, and had higher yields and better spinnability than those by simple distillation.

Effects of DW-286a, a fluoroquinolone antibiotic agent, on hERG channel currents expressed in CHO cells

  • Kim, Eun-Joo;Kim, Ki-Suk;Shin, Won-Ho;Seo, Joung-Wook;Choi, Gyu-Kap;Park, Eun-Kyung;Hwang, Ji-Yoon;Han, Sang-Seop
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.77.1-77.1
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    • 2003
  • Prolongation of the QT interval may result in a potentially dangerous arrhythmia. The most commonly proposed mechanism for QT interval prolongation(LQT) by pharmaceuticals is inhibition of the rapid delayed rectifier potassium channel (I$\sub$Kr). The LQT potency of pharmaceuticals can be effectively evaluated by examining the effect on human ether-a go-go-related gene (hERG) channels expressed in CHO cells, known to be equal to I$\sub$kr/. We have transfected JERG into CHO cell lines transiently to express high levels of functional hERG channels. (omitted)

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Long-term measurement of physiological cardiovascular parameters using telemetry system in dosgs.

  • Kim, Eun-Joo;Seo, Joung-Wook;Choi, Gyu-Kap;Park, Eun-Kyung;Kim, Ki-Suk;Shin, Won-Ho;Han, Sang-Seop
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.87.1-87.1
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    • 2003
  • With the issuance of the ICH “Guidance for industry S7A Safety Pharmacology Studies For Human Pharmaceuticals” in July 2001 came the preference for the use of unanesthetized animals when evaluation the safety profile of new pharmaceutical agents. Telemetry provides a means of obtaining measurements of physiological functions in conscious animals without the problems associated with classical cardiovascular measuring methods. The Korea Institute of Toxicology (KIT) established the telemetric measurement of cardiovascular parameters, such as Blood pressure, Heart rate, ECG (PR, RR, QRS, QT and QTcB interval) under GLP conditions. (omitted)

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