• The Korean journal of sports medicine
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• v.36 no.4
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• pp.214-220
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• 2018

Purpose: The purpose of this research is to study changes in pituitary hormone in anterior lobe and thyroid hormone before, after, and during recovery time in severe 100 km ultramarathon. Methods: Healthy middle-aged runners (age, $52.0{\pm}4.8$ years) participated in the test. Grade exercise test is done, and then blood is taken from those participants before and after completing 100 km ultramarathon at the intervals of 24 hours (1 day), 72 hours (3 days), and 120 hours (5 days) to analyze their luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and free thyroxine (Free T4). Results: For LH, it decreased more significantly at 100 km than pre-race. However, after 1 day result increased more than that of 100 km. At 3 days, it was significantly higher than pre-race and 100 km, recovering at 5 days. In terms of FSH, it decreased at 100 km, 1 day, and 3 days more than pre-race but recovered at 5 days. TSH was higher at 1 day and 5 days compared to pre-race. T3 was only higher at 100 km than pre-race. T4 was higher till 5 days at 100 km than pre-race. Free T4 increased more significantly at 100 km than pre-race. Conclusion: In terms of severe long distance running, LH and FSH which belong to hormone from anterior lobe as well as T3, T4, and Free T4 which belong to thyroid hormone showed their variation within the standard range. However, TSH showed abnormal increase from enhanced concentration of blood after marathon becoming hyper-activation even during the recovery period.

• Journal of Forest and Environmental Science
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• v.24 no.2
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• pp.99-109
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• 2008

This study conducted 6 times of roadkill investigations in national road 121 km (about 10%) of Chungcheongnam-do. As a result of the investigation, 94 individuals were found dead on the road. The roadkill statuses by construction of road were 44 times (1.13 times/km) at two traffic lanes, 1 time (1.90 times/km) at three lanes, and 23 times (0.35 times/km) at four traffic lanes. Also, land use on the frequency of roadkill were 26 times between mountain region and cultivated land, 25 times between cultivated land and cultivated land, and 20 times between mountain region and mountain region. So, particular attention is needed at the construction and facilities of road to reduce roadkill.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.142-146
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• 2016

최근 저해상도 기상자료를 바탕으로 한 단기간에 내린 폭우나 극심한 가뭄 등과 같은 국지적인 기상 예보는 한계가 있기 때문에 고해상도 기상자료에 대한 수요가 증대되고 있으며, 특히 지형이 복잡한 한반도의 경우 지형적인 영향을 고려한 고해상도 기상자료가 요구되고 있다. 하지만 현재 기상청에서 제공하는 남한 지역의 지상 관측 자료는 약 10km의 불규칙한 간격으로 분포하고 있으며 이는 복잡한 남한지역의 지형 특성을 고려하기에는 해상도가 낮아 상세한 기상 현상을 예측하기 힘들다. 또한, 북한의 경우 사용가능한 관측 자료가 부족하여 한반도 전체를 대상으로 한 기상 예보 및 기후 특성 분석에는 한계가 있다. 따라서 본 연구에서는 정량적 강수 예측 모형인 QPM(Quantitative Precipitation Model)을 이용하여 3시간 간격의 현재기후(2000-2014년)에 대한 한반도 지역의 1km 강우 자료를 복원하였다. 관측 자료가 부족한 북한의 경우 재분석 자료를 이용하여 1km 해상도의 강우 자료를 복원하였다. 이를 위해 몇 가지 특정한 강우 Case를 선별하였고, QPM 수행 시 필요한 강수, 상대습도, 지위고도, 연직 기온, 연직 바람장 등의 변수에 대하여 남한 지역에 해당하는 지점의 여러 재분석 자료와 실제 남한 지역의 지상/고층 관측 자료와의 비교 및 Correlation 분석을 통해 가장 적절하다고 판단되는 재분석 자료인 NASA에서 제공하는 MERRA Reanalysis data를 선정하였다. 또한, 소규모 지형효과를 고려하기 위한 상세 지형자료로 고해상도 지형 자료인 DEM(*Digital Elevation Model) 1km 자료를 사용하였다. 한반도의 강우를 복원하기 위하여 Barnes 기법을 이용하여 불규칙적으로 분포해 있는 강수량 데이터를 규칙적인 자료로 격자화 하였고, 격자화 한 10km 해상도의 자료를 QPM을 통해 복잡한 지형 특성을 고려한 1km 해상도의 강우 자료로 복원하였다. 또한, QPM의 모의 성능을 검증하기 위하여, 위에서 선별한 특정 강우 Case에 대하여 복원한 1km 강우자료와 200m 이내의 거리에서 겹치는 지상관측자료와의 비교를 통하여 모의 성능을 검증하였다. 본 연구를 통해 복원된 한반도 상세 강우 자료를 통해 통일을 대비한 기상, 농 수산업, 수자원 등 다양한 분야에서 활용 될 수 있으며, 국지적인 폭우 및 가뭄 등의 이상 기상 현상을 분석하는 데 참고 기초 자료로써 활용 될 수 있을 것으로 기대된다.

• Journal of Wetlands Research
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• v.17 no.4
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• pp.391-401
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• 2015

In this study, divided into small category groups for the residential area it was carried out monitoring for the runoff during precipitation. Based on the results analyzed according to the nonpoint sources Housing leakage characteristics. Analysis of the rainfall runoff and concentration of each type of exclusive detached house with apartments, in the majority of precipitation types runoff concentrations were higher in early. In the case of a difference of two points per runoff rate rainfall it was largely investigation. The average runoff is estimated loadings of BOD $101.1kg/km^2$, SS $232.2kg/km^2$, T-N $18.2kg/km^2$, T-P $2.0kg/km^2$ detached house case, if the apartment was estimated at point BOD $108.82kg/km^2$, SS $329.18kg/km^2$, T-N $57.67kg/km^2$, T-P $4.21kg/km^2$. The average EMCs is BOD BOD 6.6 mg/L, SS 12.8 mg/L, T-N 1.518 mg/L, T-P 0.099 mg/L detached house case, if the apartment was estimated at point BOD 6.3 mg/L, COD 11.2mg/L, SS 14.5 mg/L, T-N 3.1 mg/L, T-P 0.2 mg/L. The initial 30 percentage calculated based on the initial results, the total flow of 30% if the outflow of detached house showed a net percentage difference to T-P 1.04 > T-N 0.97 > BOD 0.90 > SS 0.80. The apartment area showed the percentage difference in the water quality in the order of BOD 1.49 > T-P 1.40 > SS 1.30 > T-N 0.96 per item.

• Journal of Life Science
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• v.33 no.2
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• pp.149-157
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• 2023

Transforming growth factor-β (TGF-β) is a multifunctional cytokine that affects not only the survival and growth of cancer cells but also the activity of immune cells. Although it has been generally accepted that cancer cell-derived TGF-β could promote the survival and growth of early cancer cells and have immunosuppressive roles, it has been known that TGF-β has differential effects according to the type or stage of cancer cells. Therefore, it is hard to clearly define its role in cancer progression and immune responses. This study investigated the effects of TGF-β signaling on the expression of five NKG2D ligands and the NK cell-mediated anticancer immune response in the primary colon cancer cell line KM12C and its two metastatic cell lines, KM12SM and KM12L4A. At the surface protein level, exogenous TGF-β decreased the expression of MICA, MICB, ULBP1, and ULBP2, and galunisertib increased the expression of MICA, MIAB, ULBP1, ULBP2, and ULBP3 in KM12C. However, KM12SM and KM12L4A showed no significant changes in the expression of NKG2DLs after treatment with TGF-β or galunisertib. TGF-β signaling inhibition via galunisertib improved the NK cell-mediated anticancer immune response against KM12C but did not show a significant response to KM12SM and KM12L4A. Therefore, the suppression of TGF-β signaling could improve the NK cell-mediated anticancer immune response against KM12C. However, an increase in NKG2DLs expression and an enhanced NK cell-mediated cancer immune response is hard to expect due to the alteration of TGF-β signaling in KM12SM and KM12L4A.

• Korean Journal of Microbiology
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• v.44 no.1
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• pp.56-62
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• 2008

Two hundred and sixty-eight bacterial strains were isolated from pine mushroom (Tricholoma matsutake) basal soil. In the course of screening for antifungal activity against seven plant pathogenic fungi (Alternaria panax, Botrytis cinerea, Colletotrichum gloeosprioides, Fusarium oxysporum, Phytopthora capsici, Pythium ultimum, Rizoctonia solani) of isolates, strain KM1-15 showed strong antibiotic activity against Alternaria panax and Colletotrichum gloeosprioides. In determining its relationship on the basis of 16S rDNA sequence, KM1-15 strain was most closely related to Bacillus $koguryoae^T$ (AY904033) (99.62%). When assayed with the API 50CHE Kit, unlike Bacillus koguryoae, it is positive for utilization of L-arabinose, cellobiose, inulin, and D-turanose. Results of cellular fatty acid analysis showed that major cellular fatty acids were 15:0 anteiso (35.78%) and 17:0 anteiso (17.97%). In particular, hydroxyl fatty acids such as 13:0 iso 3-OH, 14:0 iso 3-OH, 15:0 iso 3-OH, and 17:0 iso 3-OH were only restricted to strain KM1-15. DNA G+C content was 43.7 mol% and quinone system was MK-7 (100%) in strain KM1-15.

• Journal of Korean Society for Atmospheric Environment
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• v.16 no.2
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• pp.121-128
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• 2000

To identify the effects of air pollution on several physiological characteristics of Styrax japonica in Yeochon industrial comples soil properties photosynthetic capacity and chorophyll contents were investigated. All of these measurements were taken on Styrax japonica stand at 1. 3 and 7km from an industrial complex which is an air pollution source. In addition a Styrax japonica stand in Sang-ju city was selected as a control Each physiological measurement was in leaves of east-, west- south- and north-facing branches. The results obtained were as follows: 1) Al contents of soil in Yeochon industrial complex were higher than those of Sang-ju city a non-polluted area. higheral contents contributed to decrease in soil pH. 2) Chlorophyll contents of leaves at 1km from the industrial complex closest from the air pollution source were lower than those of 3 and 7km/ 3) Photosynthetic capacity of Styrax japonica at 1km from the air pollution source was lower than those at 3 and 7km.

• Journal of Korean Society of Transportation
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• v.35 no.6
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• pp.499-510
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• 2017

Traffic accident fatalities in Korea in 2016 was 4,292 and 1,732 cases were deaths of elderly people. In spite of this, the researches on behaviors of the elderly when crossing roads, are rather limited. The purpose of this study is to investigate and analyze road crossing behavior characteristics of the elderly, when crossing roads, especially focusing on the characteristics of pedestrians and vehicles. Cross-sectional data was collected from six different sites in two regions and the following results was identified. First, at road crossings, 528 cases(84.3%) out of 626 conflict situations of the elderly and 303 cases(63.3%) out of 478 conflict situations of the non-elderly pedestrians were found to be dangerous, respectively. The elderly tend to face a statistically significant risk of 3.11 times higher than that of non-elderly people. Second, 519 cases(82.9%) of jaywalking occurred in 626 conflict cases of the elderly and 375 cases(78.5%) of jaywalking in 478 conflict events of non-elderly persons, which indicates the elderly's 1.34 times higher trend compared with the non-elderly's. Third, the pedestrian safety margin (PSM) analysis showed that the PSM of the elderly and the non-elderly were 3.33 seconds and 4.04 seconds respectively, which is 17.5% high. Fourth, the difference in pedestrian safety interval was examined by dividing the speed of approaching vehicle into less than 30km/h, above 30km/h and less than 50km/h, and over 50km/h. There was no significant difference between the PSM of coming vehicles with the speed less than 30km/h and the PSM of approaching with the speed 30km/h~50km/h, but the conflicts with vehicle of the speed above 50km/h show significantly lower PSM than with vehicle speed of 30km/h~50km/h. Finally, when the risk threshold is set to less than 2.5 seconds, the analysis shows that older pedestrians tend to cross roads dangerously 1.59~2.53 times than younger pedestrians. The results set forth here can be used as a basis for constructing the elderly safety measures at present and a potential basis for autonomous vehicle safety application in the future for solving the issue of the difference in crossing behavior between elderly and non-elderly pedestrians.

• Korean Journal Plant Pathology
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• v.11 no.3
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• pp.265-270
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• 1995

Transposon mutation of Xanthomonas campestris pv. vesicatoria (Xcv) was induced by using transposon omegon ($\Omega$)-Km (Tn $\Omega$Km), which was confirmed by resistance to kanamycin (KMr), and nonpathogenic mutants were selected through the inoculation test on pepper plants. The mutagenesis frequency was about 6$\times$10-8, and 53 out of 2,000 Kmr bacterial colonies tested were nonpathogenic to the pepper cultivar Cheung-Hong. Optimum conditions for the Tn $\Omega$Km mutagenesis of Xcv were Luria Bertani (LB) broth medium for culture of Xcv, yeast extract-dextrose-CaCO3 (YDC) agar medium for selection of Tn $\Omega$Km-mediated mutants, and over 1 to 2 in the ratio of the donor (Escherichia coli S17-1 with the plasmid pJFF350 $\Omega$Km) and the recipient (Xcv) in the culture for the mutagenesis. One of the 4 nonpathogenic mutants (WNP1, WNP3, WNP4 and WNP5), which had been reconfirmed through the inoculation on pepper cv. Dabokgun, showed no differences in the production of exoenzymes such as protease and polygalacturonase and extracellular polysaccharides in vitro and the bacterial growth rate from those of the wild type of Xcv.

• Journal of KIISE:Software and Applications
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• v.27 no.12
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• pp.1174-1182
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• 2000

본 논문은 주행중인 자동차 환경에서 운전자의 안전성 및 편의성의 동시 확보를 위하여, 보조적인 스위치 조작 없이 상시 음성의 입, 출력이 가능한 시스템을 제안하였다. 이대 잡음에 강인한 threshold 값을 구하기 위하여, 1.5초마다 기준 에너지와 영 교차율을 변경하였으며 대역 통과 여과기를 이용하여 1차, 2차로 나누어 실시간 상태에서 자동으로, 정확하게 끝점 검출을 처리하였다. 또한 남성, 여성을 피치검출로 구분하여 모델을 선택하게 하였고, 주행중인 자동차 속도에 따라 가장 적합한 모델을 사용하기 위하여 Idle-40km, 40-80km, 80-100km로 구분하여 남성, 여성 모델을 각각 구분하여 인식할 수 있게 하였다. 그리고, 음성의 특징 벡터와 인식 알고리즘은 PLP 13차와 OSDP(one-Stage Dynamic Programming)을 사용하였다. 본 실험은 서울시내 도로 및 내부 순환도로에서 각각 속도별로 구분하여 화자독립 인식 실험을 한 결과 40-80km 상태에서 남자는 96.8%, 여자는 95.1%, 80-100km 상태에서는 남자 91.6%, 여자는 90.6%의 인식결과를 얻을 수 있었고, 화자종속 인식실험 결과 40-80km 상태에서 남자는 98%, 여자는 96%, 80-100km 상태에서는 남자는 96%, 여자는 94%의 높은 인식률을 얻었으므로, system의 유효성을 입증하였다.