• Journal of applied mathematics & informatics
• /
• v.30 no.5_6
• /
• pp.793-807
• /
• 2012

If G is any connected graph of order p; then the thorn graph $G_p^*$ with code ($n_1$, $n_2$, ${\cdots}$, $n_p$) is obtained by adding $n_i$ pendent vertices to each $i^{th}$ vertex of G. By treating the pendent edge of a thorn graph as $P_2$, $K_2$, $K_{1,1}$, $K_1{\circ}K_1$ or $P_1{\circ}K_1$, we generalize a thorn graph by replacing $P_2$ by $P_m$, $K_2$ by $K_m$, $K_{1,1}$ by $K_{m,n}$, $K_1{\circ}K_1$ by $K_m{\circ}K_1$ and $P_1{\circ}K_1$ by $P_m{\circ}K_1$ and their respective generalized thorn graphs are denoted by $G_P$, $G_K$, $G_B$, $G_{KK}$ and $G_{PK}$ respectively. Many chemical compounds can be treated as $G_P$, $G_K$, $G_B$, $G_{KK}$ and $G_{PK}$ of some graphs in graph theory. In this paper, we obtain the bounds of the wiener index for these generalization of thorn graphs.

• Steel and Composite Structures
• /
• v.3 no.2
• /
• pp.123-140
• /
• 2003

The importance of the research on moment-resistant properties of unstiffened tubular joints and the research background are introduced. The performed experimental research on the bending rigidity and capacity of the joints is reported. The emphasis is put on the discussion of the flexural behavior of the joints including sets of geometrical parameters of the joints and several loading combinations. Procedures and results of loading tests on four full size joints in planar KK and X configuration are described in details at first. Mechanical models are proposed to analyze the joint specimens. Three-dimensional nonlinear FE models are established and verified with the experimental results. By comparing the experimental data with the results of the analysis, it is reported reasonable to carry out the structural analysis under the assumption that the joint is fully rigidly connected, and their bending capacities can assure the strength of the members connected under certain limitation. Furthermore, a parametric formula for inplane bengding rigidity of T and Y type tubular joints is proposed on the basis of FE calculation and regression analysis. Compared with test results, it is shown that the parametric formula developed in this paper has good applicability.

• Korean Journal of Microbiology
• /
• v.40 no.4
• /
• pp.302-306
• /
• 2004

A total of forty strains of pigment-producing halophilic bacteria were isolated from the solar saltern and coastal seawater in Korea. The diversity of those bacteria were determined on the basis of PCR-RFLP and 16S rDNA sequences. The isolated strains were clssified into nine genera: Pseudoalteromonas, Photobacterium, Vibrio, Halobacillus, Bacillus, Paracoccus, Salinicoccus, Tenacilbaculum, and Flavobacterium. While more than $80\%$ of the pigment-producing halophilic bacteria isolated from the coastal seawater were classified as gram-negative Pseudolateromonas, most of the strains isolated from the solar saltern were classified into gram-positive Halo­bacillus. The other strain was KK7, which may be identified as novel species belonging to the genus, Salini­coccus.

• KSBB Journal
• /
• v.13 no.6
• /
• pp.662-668
• /
• 1998

Viruses belonging to the Hantavirus genus cause two acute severe illness in humans, i.e., Haemorrhagic Fever with Renal Syndrome (HFRS) and Hantavirus Pulmonary Syndrome(HPS). Among them, Hantaan virus is one of the most important viruses causing HFRS. Recombinant expression vectors, pKK-NP and pET-NP, with Hantaan viral nucleocapsid gene were constructed, and used to transform Eschericia coli BL21(DE3). Stability of the vectors in the host strain, and effects of some environmental conditions on the expression of nucleocapsid gene were studied. Expression vector, pKK-NP, was very unstable, and the expression level of nucleocapsid gene was very low compared to that of pET-NP. BL21(pET-NP) produced about 100 mg of N protein per liter of culture broth. Induction time did not show any significant difference on the expression level of nucleocapsid gen and cell growth. BL21(pET-NP) culture at 35$^{\circ}C$ showed a little higher expression level than at 30$^{\circ}C$ during growth phase, but reached to the same level at stationary phase. Total expression level was proportional to supplemented glucose concentration of media up to 0.5% along with cell growth, but expression level per unit cell mass was inversely proportional to glucose concentration and maximal when glucose was not supplemented at all.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.8
• /
• pp.4067-4073
• /
• 2012

Obesity is an established risk factor for colorectal cancer. Pioglitazone is a peroxisome proliferator activated receptor$receptor{\gamma}$ ($PPAR{\gamma}$) agonist that induces differentiation in adipocytes and induces growth arrest and/or apoptosis in vitro in several cancer cell lines. In the present study, we investigated the effect of pioglitazone on the development of azoxymethane-induced colon aberrant crypt foci (ACF) in KK-$A^{\mathcal{Y}}$ obesity and diabetes model mice, and tried to clarify mechanisms by which the $PPAR{\gamma}$ ligand inhibits ACF development. Administration of 800 ppm pioglitazone reduced the number of colon ACF/mouse to 30% of those in untreated mice and improved hypertrophic changes of adipocytes in KK-$A^{\mathcal{Y}}$ mice with significant reduction of serum triglyceride and insulin levels. Moreover, mRNA levels of adipocytokines, such as leptin, monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1, in the visceral fat were decreased. PCNA immunohistochemistry revealed that pioglitazone treatment suppressed cell proliferation in the colorectal epithelium with elevation of p27 and p53 gene expression. These results suggest that pioglitazone prevented obesity-associated colon carcinogenesis through improvement of dysregulated adipocytokine levels and high serum levels of triglyceride and insulin, and increase of p27 and p53 mRNA levels in the colorectal mucosa. These data indicate that pioglitazone warrants attention as a potential chemopreventive agent against obesity-associated colorectal cancer.

• Proceedings of the Korean Society of Life Science Conference
• /
• 2000.09a
• /
• pp.28-28
• /
• 2000

• Journal of Radiation Protection and Research
• /
• v.18 no.1
• /
• pp.63-70
• /
• 1993

Double ionization of the K- shell accompanying K- shell electron capture of the 0.035 MeV transition of $^{125}I$ has been studied by counting coincidences between $K_{\alpha}$ hypersatellite X-rays and Ka satellite X-rays emitted when double vacancies are filled. The $^{125}I\;and\;^{125}Te^m$ source materials were used in the measurement. We obtained the coincidence spectrum using two NaI(T1) detectors and a Ge(Li) detector and TAC(Time-to-Amplitude Converter), and then analysed the measured coincidence number $N(K_{\alpha}^{II},\;K_{\alpha}^s)$, the total number $N(K_{\alpha})$ of K X-ray. The probability per K-shell electron capture that a double vacancy is formed, $P_{KK}$ is formed, $P_{KK}$ is found to be $2.15{\times}10^{-4}$.

• Journal of Microbiology and Biotechnology
• /
• v.13 no.5
• /
• pp.809-814
• /
• 2003

${\beta}-amyloid$ ($A{\beta}$) peptides from the proteolytic processing of ${\beta}-amyloid$ precursor protein (${\beta}-APP$) aggregates in the brain to form senile plaques, and their aggregation plays a key role in pathogenesis of Alzheimer's disease (AD). To isolate an active compound that has an $A{\beta}$ aggregation-inhibitory activity, 2,000 microbial metabolite libraries were screened based on their ability to inhibit $A{\beta}$ aggregation by using both Congo red and thioflavin T assays. As a result, a water-soluble fraction of a soil microorganism, KK565, showed a potent $A{\beta}$ aggregation-inhibitory activity. The strain was identified as Streptomyces species, based on the cultural and morphological characteristics, the presence of diaminopimelic acid in the cell wall, and the sugar patterns for the whole-cell extract. In addition, the purification of active principle resulted in identifying a heat-unstable protein responsible for the $A{\beta}$ aggregation-inhibitory activity.

• Proceedings of the Korean Institute of Intelligent Systems Conference
• /
• 1997.10a
• /
• pp.346-349
• /
• 1997

칼만 필터는 피드백 제어의 형태를 사용하는 플랜트를 추정한다. 플랜트의 잡음이나 측정 외란이 발생하더라도 상태를 추정하여 최적의 제어를 행한다. 상태를 추정하기 위하여 칼만 필터의 이득 Kk를 저절하고, 이 이득은 칼만 필터의 파라메터인 측정 오차 공분산 Rk과 프로세서 잡음 오차 공분산 Qk를 조정함으로써 뛰어난 필터 수행을 얻을 수 있다. 그러나 필터 파라메터 Rk, Qk는 필터 연산 이전에 측정되어야 하지만, 현재는 전문가가 전문적인 지식을 바탕으로 파라메터를 조정하여 시스템을 제어하고 있다. 따라서 이러한 비효율적인 작업을 퍼지 논리 제어기를 이용하여 온-라인에서 최적의 파라메터 Rk를 구하고자 한다.

• Proceedings of the Zoological Society Korea Conference
• /
• 2000.10a
• /
• pp.130.2-131
• /
• 2000

No Abstract, See Full Text