• 생명과학회지
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• 제26권12호
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• pp.1383-1391
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• 2016

타목시펜과 같은 항에스트로젠은 ER 양성의 초기 유방암 환자에게 사용되고 있다. 그러나 대부분의 환자에서 이 항에스트로젠에 대한 내성 발현은 불가피하게 발생한다. BCAR3 유전자는 사람의 에스트로젠 의존성 유방암에서 tamoxifen 내성유도를 야기하는 단백질로 발견되었다. 우리들은 이전에 이 BCAR3 유전자가 세포주기 진행과 EGF와 인슐린에 의한 DNA 합성 신호전달경로를 조절한다고 보고하였다. 본 연구에서는, 비종양성 정상적인 인간유방상피세포인 MCF-12A세포에서 c-Jun 전자의 조절에 대한 BCAR3유전자의 기능적인 역할을 조사하였다. BCAR3의 일시적인 발현 또는 지속적인 발현이 c-Jun mRNA와 단백질의 발현을 증가하는 것을 발견하였다. 또한 BCAR3 발현 유전자의 미세주사에 의해 세포 증식이 증가하였다. 이 c-Jun의 발현 증가는 promoter의 활성화를 통해 일어난다. 또한 BCAR3에 의한 c-Jun 발현 유도가 억제성 Ras, Rac, Rho에 의해 억제되었다. 다음으로 EGF 성장인자에 의한 c-Jun 발현 유도에 대한 BCAR3의 영향을 단일 세포 미세주사법에 의해 조사하였다. BCAR3 항체, BCAR3의 siRNA와 같은 BCAR3의 기능을 억제할 수 있는 물질들을 세포로 미세주사하면 EGF에 의한 c-Jun의 발현을 억제하였지만, IGF-1 성장인자에 의한 c-Jun 발현은 억제하지 않았다. 이러한 결과들로부터 BCAR3는 c-Jun 단백질 발현 유도와 세포 증식에 중요한 역할을 하며, 여기에는 Ras, Rac, Rho와 같은 GTPase들이 필요하다는 것을 발견하였다.

• 대한전자공학회논문지TC
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• 제43권5호
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• pp.113-120
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• 2006

이 논문은 휴대인터넷 통신 네트워크 구조 변경으로 커버리지 확대 및 음영지역 해소, 그리고 핸드오버 성능 향상에 관한 논문이다. 마이크로 셀 내의 RAS(Radio Access Station)를 중심으로 SS(Subscriber Station)와의 거리가 멀어질수록 전파감쇄로 인하여 통신환경의 질이 64QAM, 16QAM 그리고 QPSK로 떨어지게 된다. 그 결과 Throughput의 저하는 물론이고, 여러면에서 통신 품질의 질도 떨어지게 된다. 실제로 휴대인터넷의 대부분의 지역은 환경이 좋지 않은 QPSK 지역으로 사용자 대부분은 이러한 지역에서 휴대인터넷을 사용하게 된다. 그 결과 사용자들은 많은 불만을 가지게 될 것이다. 이런 셀 내의 통신환경으로 인한 문제점을 해결하기 위하여 RS(Relay Station)를 적용하여 셀의 커버리지 확대는 물론이고, 통신환경을 향상시켜 핸드오버 호 블록킹 성능 향상을 시키는데 그 목적이 있다.

• Fisheries and Aquatic Sciences
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• 제13권2호
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• pp.150-156
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• 2010

The separation performance of a low-pressure hydrocyclone (LPH) was evaluated for suspended-solids removal in a recirculating aquaculture system (RAS). The dimensions of the LPH were 335 mm cylinder diameter, 575 mm cylinder height, 60 mm overflow diameter, 50 mm underflow diameter, and $68^{\circ}$ cone angle. The inflow rate varied (400, 600, 800, and 1,000 mL $s^{-1}$) with 25%, 25%, 20%, and 10% of bypass ($R_f$), respectively. The maximum total separation efficiency (Et) and reduced separation efficiency (E't) for suspended solids from the effluent of the second settlement tank (before biofiltration) were 58.9% and 45.2%, respectively, at an inflow rate of 600 mL $s^{-1}$ and 25% of $R_f$. The maximum Et and E't for suspended solids from the water supply channel (after biofiltration) were 24.4% and 16%, respectively, at an inflow rate of 1,000 mL $s^{-1}$ and 10% of $R_f$. The maximum grade efficiency (Ei) was 51.6% for a 300 ${\mu}m$ particle size at an inflow rate of 600 mL $s^{-1}$ with 23% of $R_f$. The maximum reduced grade efficiency (E'i) was 37.6% for a 300 ${\mu}m$ particle size at an inflow rate of 1,000 mL $s^{-1}$ with 11% of $R_f$. The results indicate that the separation performance of the LPH for suspended solids removal was size selective and that maximum removal occurred at particle sizes ranging from 300 to 500 ${\mu}m$.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권2호
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• pp.137-145
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• 2000

Carcinogenesis is a multi-stage process that generally consists of at least three steps; initiation, promotion, and progression. If one of these carcinogenic steps were suppressed or delayed, the cancer could be prevented. Cancer chemoprevention is defined to be inhibition or reversal of the carcinogenic process by the specific chemical agents and is a novel approach to cancer management alternative to conventional chemotherapy. Chlorophylln(CHL), a water-soluble derivative of chlorophyll, containing sodium and copper, has been known to be strong antimutagen in several test systems, but its mechanism of antimutagenic action is unknown. In the present experiment, the possibility of CHL as chemopreventive drugs on 7,12-dimethylbenz[a]anthracene(DMBA)-induced hamster buccal pouch carcinogenesis was investigated by mutagenicity test, carcinogenicity test, and frequency or spectrum of H-ras mutations in the both of DMBA-induced and chlorophylln-pretreated-DMBA induced tumor by polymerase chain reaction and non-isotopic restriction fragment length polymorphism. The treatment of CHL reduced the yields and multiplicity of the 0.5% DMBA-induced tumor, 86% to 62.5% and $3.7{\pm}0.6$ to $1.4{\pm}0.3$, respectively. The occurrence of histidine revertant by $20{\mu}mole$ DMBA was inhibited 25.6 to 81.7% by 1 to $5{\mu}M$ CHL in a dose-dependent manner. The mutation rates of H-ras gene in DMBA-induced and CHL-pretreated-DMBA induced tumor were 96%, 94% of which the most mutations were in codon 12/13. These results suggest that CHL inhibits the carcinogenic action of DMBA by the formation of complex between CHL and DMBA or the inhibition of the activation of DMBA in vivo. But CHL did not affect the mutation rates or its spectrum in already formed tumor.

• 한국분말재료학회지
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• 제12권3호
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• pp.167-173
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• 2005

Production of weakly agglomerated nanopowders with the characteristic size of about 10 nm and a narrow particle size distribution is still a topical problem especially if the matter is an acceptable output (>50 g/hour), a high purity of the final product, and a low (energy consumption. The available experience and literature data show that the most promising approach to production of such powders is the evaporation-condensation method, which has a set of means for heating of the target. From this viewpoint the use of pulsed electron accelerators for production of nanopowders is preferable since they allow a relatively simple adjustment of the energy, the pulse length, and the pulse repetition rate. The use of a pulsed electron accelerator provides the following opportunities: a high-purity product; only the target and the working gas will interact and their purity can be controlled; evaporation products will be removed from the irradiation zone between pulses; as a result, the electron energy will be used more efficiently; adjustment of the particle size distribution and the characteristic size of particles by changing the pulse energy and the irradiated area. Considering the obtained results, we developed a design and made an installation for production of nanopowders, which is based on a hollow-cathode pulsed gas-filled diode. The use of a hollow-cathode gas-filled diode allows producing and utilizing an electron beam in a single chamber. The emission modulation in the hollow cathode will allow forming an electron beam 5 to 100 ms long. This will ensure an exact selection of the beam energy. By now we have completed the design work, manufactured units, equipped the installation, and began putting the installation into operation. A small amount of nanopowders has been produced.

• 지역연구
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• 제32권4호
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• pp.51-73
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• 2016

본 연구는 한 중 일 간 경제교류의 증대에 따른 한국 서비스업의 중국 및 일본 산업과의 연계 심화를 고려하여 한국 서비스업과 한 중 일 전 산업 간의 네트워크 변화를 실증적으로 분석하는데 목적을 두고 있다. 이를 통해, 한국 서비스업의 산업 간 네트워크가 한 중 일의 공간적 범위에서 설명될 수 있는지를 확인하고, 향후 한국 도시지역의 산업 정책 방향 설정에 도움이 될 수 있는 기초자료를 제공하고자 하였다. 구체적으로, 본 연구는 한국 서비스업이 집중되어 있는 수도권에 연구의 초점을 맞추어, 한국 수도권 서비스업이 지난 1995년~2010년 동안 한 중 일 20개 도시지역의 10개 산업부문과 어떠한 연관관계를 가져왔는지를 단위구조를 활용한 생산연계 분석 및 네트워크 분석을 통해 실증하였다. 분석 결과, 한 중 일 내에 형성되어 있는 한국 수도권 서비스업의 산업 간 네트워크는 아직 많은 부분을 국내 산업, 특히 제조업에 의존하고 있었다. 동시에 중국 및 일본 도시지역 산업들과의 연계 정도가 강하지 못한 것으로 분석되어 한 중 일 간에 산업 연계가 증가하였다고는 하나, 한국 수도권 서비스업과 관련한 산업 연계는 한 중 일 내에 크게 발달해 있지 않은 것으로 판단된다.

• 한국수산과학회지
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• 제52권5호
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• pp.482-495
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• 2019

This study compared the productivity of fish and vegetables grown using the hybrid biofloc technology-aquaponics (HBFT-AP), a semi-recirculating aquaculture system (SRAS), and hydroponics (HP). For the study of fish productivity (HBFT-AP vs. SRAS), fish were provided feed containing 3.0% monobasic potassium phosphate (MKP) for 18 weeks. After the 18-week feeding trial, the average weight of the sampled population (n=100) was not significantly different (P>0.05), while hematocrit (PCV, %), hemoglobin (Hb, g/dL), and plasma K (mEq/L) were significantly different (P<0.05) between the two groups (HBFT-AP: 47.83%, 15.48 g/dL, and 1.39 mEq/L; SRAS 34.83%, 11.81 g/dL, and 2.48 mEq/L). Leaf vegetable productivity (HBFT-AP vs. HP) was compared in three experiments (EXP 1-3), and slower growth was observed in both groups in EXP 2, in which pH was maintained at 5.0 or less throughout the experiment. During the 18-week feeding trial, total ammonia nitrogen (TAN), $NO_3-N$, and $PO_4-P$ levels increased with time in the HBFT-AP system, while the concentration of $NO_2-N$ remained below 0.1 mg/L throughout the study.

• 한국물환경학회지
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• 제29권6호
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• pp.799-807
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• 2013

Reservoir sedimentation is one of the major concerns for sustainable reservoir operation. Since sediment concentration of the rivers in the Himalayan Mountain is very high, a proper sediment management scheme is necessary. This paper presents long-term reservoir sedimentation and sediment flushing based on the gate operation. Focused on the reservoir to be constructed for the Patrind hydropower project in Pakistan, 4 different flushing scenarios were proposed in this study to prevent successive sedimentation. By extending flushing period and by increasing the flushing discharge for 2 times, the flushing rate increases up to 53.2% and 43.6% in proportion to flushing period and discharge, respectively. Based on the simulation presented in this paper, it is expected to establish efficient sediment management plan to increase hydro power generation and sediment flushing simultaneously.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 G
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• pp.3206-3208
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• 1999

This paper describes the remote fault monitoring system for tower parking facilities. This system consists of central station, remote monitoring equipments and communication equipments. The central station is developed under client-server architecture which composed a DB server, a fault detection client, a status collection client and a A/S client. And the remote monitoring systems are connected to central station by LAN using RAS(Remote Access Service) which is constructed PSTN(Public Switched Telephone Network). This system offers real-time fault detection and status data acquisition of tower parking system.

• 약학회지
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• 제36권6호
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• pp.529-537
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• 1992

To investigate the effect of ursolic acid on the expression of oncogenes in tumor cells of mice, sarcoma 180 ascites tumor cells were implanted into the left groin of ICR mice and the tumor bearing mice were treated with ursolic acid. The expression of oncogenes were measured by in situ hybridization method. Ursolic acid significantly reduced the expression of oncogenes in the tumor cells. Therefore, it can be said that the prestated anticarcinogenic effect of ursolic acid could be partly ascribed to the mechanism included in the oncogene´s transcription level.