YAKHAK HOEJI (약학회지)
- Volume 36 Issue 6
- /
- Pages.529-537
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- 1992
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Effects of Ursolic Acid on Oncogene Expression Detected by In Situ Hybridization in Mice
생쥐에서 종양세포의 암유전자발현에 대한 울솔산의 효과
- Rhew, Tae-Hyong (Dept. of Biology, Pusan National University) ;
- Park, Sung-Mi (Dept. of Biology, Pusan National University) ;
-
Park, Kun-Young
(Dept. of Food Science and Nutrition, Pusan National University)
;
-
Chung, Hae-Young
(Dept. of Pharmacy, Pusan National University)
;
- Hah, Jae-Chung (Dept. of Biology, Pusan National University) ;
-
Lee, Chung-Kyu
(College of Pharmacy, Kyungsung University)
- 류태형 (부산대학교 생물학과) ;
- 박성미 (부산대학교 생물학과) ;
-
박건영
(부산대학교 식품영양학과)
;
-
정해영
(부산대학교 약학과)
;
- 하재청 (부산대학교 생물학과) ;
-
이정규
(경성대학교 약학과)
- Published : 1992.12.29
Abstract
To investigate the effect of ursolic acid on the expression of oncogenes in tumor cells of mice, sarcoma 180 ascites tumor cells were implanted into the left groin of ICR mice and the tumor bearing mice were treated with ursolic acid. The expression of oncogenes were measured by in situ hybridization method. Ursolic acid significantly reduced the expression of oncogenes in the tumor cells. Therefore, it can be said that the prestated anticarcinogenic effect of ursolic acid could be partly ascribed to the mechanism included in the oncogene´s transcription level.