• Journal of Environmental Health Sciences
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• v.46 no.3
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• pp.267-275
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• 2020

Objectives: The causes of dementia have been reported in various ways, but there has been little research on the interrelationship between heavy metals and dementia, and the results also show little consistency. Therefore, it is imperative to compare the levels of heavy metal exposure between the dementia-suffering group and a control group to confirm the correlation between the level of heavy metal exposure and the likelihood of dementia. Methods: In order to assess the dementia level of the elderly, the Global Deterioration Scale (GDS) and Mini Mental State Examination (MMSE) were applied. To analyze the concentration of heavy metals in the blood, blood was collected from the veins of study subjects and measured using Inductively Coupled Plasma-mass spectrometry (ICP-MS). Results: There was a statistically significant correlation between lead and manganese concentrations in the blood and the MMSE and GDS. It was found that there was a statistically significant correlation between cadmium concentration in the blood and the GDS, but the MMSE was less relevant. It was found that the blood mercury concentration and the MMSE and GDS were less relevant. The lead concentration in the blood was 0.95±0.74 ㎍/dL in the dementia patient group and 0.33±0.22 ㎍/dL in the normal group, while cadmium was 0.69±0.37 ㎍/L in the dementia group and 0.18±0.10 ㎍/L in the normal group. Mercury was 0.81±0.31 ㎍/L in the dementia group and 1.16±0.80 ㎍/L in the normal group. Manganese was 6.83±2.01 ㎍/L in the dementia group and 4.78±1.59 ㎍/L in the normal group. All of these show statistically significant differences. Conclusions: As the concentration of lead, cadmium and manganese in the blood increases, the MMSE scores and GDS scores were found to worsen, and it was confirmed that there is a correlation between heavy metal exposure and cognitive degradation.

• Journal of Oriental Neuropsychiatry
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• v.16 no.1
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• pp.43-66
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• 2005

Object : This study was designed to asses the protective effects of Kunneo tang on cognitive decline of the patients with early DAT. Method : Before administered with Kunneotang, 16 patients with early DAT were measured by auditory ERP, MMSE-K and K-DRS. During 12 months the patients with early DAT were administered with Kunneotang. After 12months the patients were measured by the same examinations again. Result : 1. The total score of MMSE-K decreased but it was not significant. 2. The total score of K-DRS increased but it was not significant. Among the five criteria(attention, memory, initiation/perseveration, construction, conceptualization), Initiation/perseveration score signifcantly decreased and there were no significant differences in the other scores. But, memory mean score had a tendency to increase. 3. The latency of ERP P300 component increased but it was not significant and the amplitude of ERP P300 component showed the significant difference. Conclusion : The results suggest that Kunneotang may have protective effects on cognitive decline in the patients with early DAT.

• CELLMED
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• v.7 no.3
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• pp.13.1-13.10
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• 2017

Nutrition is one of the factors influencing cognitive functions. But, the role of nutrition on cognitive functions within the elderly is recognized to a lesser degree. The aim of this academic endeavor was to analyze the affiliation between nutritional status and cognitive functions of the elderly in Korea. 316 subjects, of 114 male and 201 female aged above 65 years, were gathered from university hospital clinics, Elderly Welfare Centers, and Health Welfare Centers located in the district of Seoul, Gyeonggi province, and Incheon in Korea. The cognitive function was tested by the Korean-Mini Mental State Examination (K-MMSE) questionnaire. Nutrition intake was assessed by a 24-hour recall, a food frequency questionnaire (FFQ). Nutrition adequacy and quality were assessed by the Nutrition Screening Initiative (NSI) checklist, the nutritional adequacy ratio (NAR), and the mean adequacy ratio (MAR). The elderly with normal cognitive function status displayed significantly higher levels of calcium, riboflavin, thiamin, folate, vitamin C, vitamin E, vitamin B6, phosphorous, potassium, iron, niacin, zinc, animal fat, animal protein, polyunsaturated fatty acids, total protein, vegetable oil, vegetable protein, fiber than levels of the elderly with moderate cognitive impairment. The K-MMSE score positively correlated with of high consumption of pork, white radish, sea mustard, tomato, tangerine, grape, apple, and ice cream, and K-MMSE was negatively associated with high intake of potato, anchovy, fish cake, and mushroom. The findings suggest that nutritional status is affiliated with cognitive function within the elderly of Korea. The consumption of variety of foods and nutrients ensures adequate cognitive function in the Korean elderly.

• The Journal of the Acoustical Society of Korea
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• v.35 no.1
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• pp.49-54
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• 2016

In this paper, we propose a vocal separation method using weighted ${\beta}$-order minimum mean wquare error estimation (WbE) based on kernel back-fitting algorithm. In spoken speech enhancement, it is well-known that the WbE outperforms the existing Bayesian estimators such as the minimum mean square error (MMSE) of the short-time spectral amplitude (STSA) and the MMSE of the logarithm of the STSA (LSA), in terms of both objective and subjective measures. In the proposed method, WbE is applied to a basic iterative kernel back-fitting algorithm for improving the vocal separation performance from monaural music signal. The experimental results show that the proposed method achieves better separation performance than other existing methods.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39B no.12
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• pp.864-869
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• 2014

In this paper, we propose an OFDM system with a pre-equalizer which pre-distorting a transmission signal to compensate for the degradation of the system by the intersymbol interference and multi-path fading at the high-speed multimedia communications. We model an OFDM system by using C language, a simulation was performed. As a result, there was a performance of BER is about 7dB at $10^{-3}$, improved to $10^{-4}$ on the MMSE property also $10^{-3}$.

• Journal of Satellite, Information and Communications
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• v.12 no.2
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• pp.65-70
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• 2017

The structure of MMSE receiver front-ended by CMA(Constant Modulus Array) array working in CDMA forward link which is applicable to LEO spread spectrum satellite communication system is proposed. By using the despreaded pilot signal of forward link as a reference signal, the CMA array can capture multi-path signals securely even in severely faded LEO satellite channel. The remaining MAI (Multiple Access Interference) is cancelled by the cascaded MMSE receiver. Besides theoretical development, through relevant computer simulation, it is proved that the proposed system shows much better BER performance than any other possible candidate systems. As a spatio-temporal receiver mounted on a mobile vehicle, the proposed system also reduces implemental cost and complexity by adopting the simplest algorithm for its spatial and temporal domain processing.

• The Journal of Korean Medicine
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• v.34 no.3
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• pp.106-118
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• 2013

Objectives: The aim of this study was to evaluate the effect of a mild cognitive impairment (MCI) management program on traditional Korean medicine in a public health center. Methods: In order to examine the effect of the MCI management program, we investigated MCI patients who participated in the program. MCI patients were treated with Jodeung-san (JDS) or Dangguijagyag-san (DGJYS) for 6 weeks. Mini Mental State Examination-Dementia Screening (MMSE-DS), Geriatric Quality of Life-Dementia (GQOL-D), Geriatric Depression Scale in Korea (GDS-K), and biochemical examination of blood were conducted at intervals of 6 weeks. A satisfaction survey was collected after this program. Results: MMSE-DS mean score increased significantly, by 4.09 (p=0.000) in the JDS group and by 4.15 (p=0.000) in the DGJYS group. GQOL-D mean score also increased significantly, by 5.90 (p=0.000) in the JDS group and by 5.07 (p=0.000) in the DGJYS group. GDS-K mean score decreased significantly, by 10.63 (p=0.000) in the JDS group and by 9.69 (p=0.000) in the DGJYS group. MMSE-DS, GDS-K and GQOL-D scores were not significantly different between the JDS and DGJYS groups. All of the participants were satisfied with the program, and 90% of the participants expressed a high intention to participate in the program again. Conclusions: Both Jodeung-san and Dangguijagyag-san treatment showed improvement on cognitive function, depression and quality of life in this program. Additional studies with more subjects will be required to prove credibility and validity more clearly.

• The Journal of Korean society of community based occupational therapy
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• v.2 no.1
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• pp.37-47
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• 2012

Objective : The purpose of this study was to identify Effects of the ROM dance on cognitive function, neuropsychiatric in using wheelchair senior in nursing home. Methods : The subjects of the experimental group were 15 seniors using wheelchair who attended an ROM dance program in a nursing home. It was carried out for 18 weeks from Mar. 2010. to August. 2010. The evaluation tools used for the presented study were the Mini-Mental Status Exam-Korean(MMSE-K) and Neuropsychiatric Inventory-Questionaire (NPI-Q). Results : In the terms of cognitive function there was no significant defference between the mean pre/post test. but the factor(orientation of time) of MMSE-K and the factors 2 (sleep/nighttime behavios, apathy/indefference) of NPI-Q was significant improvement. Conclusion : In this study, the ROM dance program was effective in improving cognitive function and neuropsychiatric in seniors using wheelchair. also ROM dance program was decreasing and regression delay effect in cognitive and neuropsychiatric.

• Journal of Sasang Constitutional Medicine
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• v.23 no.3
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• pp.402-411
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• 2011

1. Objectives: This study is about three vascular dementia patients with disorientation, memory impairment and cognitive disorder. In this study, we evaluated the effects of Sasang constitutional treatment and suggested using the Mini Mental Status Examination - Korea (MMSE-K), Global Deterioration Scale (GDS). 2. Methods: These three patients were treated by Sasang constitutional herbal medications based on "Donguisusebowon". Acupuncture and west medications were limited as much as possible. We evaluated the symptoms through the Mini Mental Status Examination - Korea (MMSE-K), GDS (Global Deterioration Scale). 3. Results and Conclusions: Disorientation, memory impairment and cognitive disorder that were these three patients chief complaints were improved. This case study shows that Sasang constitutional herbal medications are an effective treatment for vascular dementia patients.

• Journal of Haehwa Medicine
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• v.15 no.1
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• pp.1-9
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• 2006

For this study, we carried out dementia assessment examination of 74 patients with memory disturbance who have come to Cheongju oriental hospital of Daejeon university from April 2005 to February 2006. This study classified the patients as none-dementia(ND), questionable dementia(QD), and dementia(DA) groups and analyzed the result of examination. As a result, the following conclusion was drawn. 1. Among the 3 groups, there was no significant differences in the sex distribution. But according to age distribution, the age of QD and DA groups showed significant difference from that of ND group. 2. MMSE-K and HDS-K scores showed the significant differences among all groups, and 7 MS result showed the significant difference between ND and the other groups. 3. The DA group significantly got lower scores than ND group in the items of the MMSE-K, Orientation, Registration, Recall, Attention, Copy two pentagons and Comprehension. Especially, significant difference also was shown in the orientation item between QD and DA groups. 4. The scores in the items of 7 MS, Benton temporal orientation, Enhanced cued recall and Clock drawing showed significant difference among all groups. Category fluency score showed significant difference between ND and the other groups. 5. The results of Brain CT and clinical chemistry test didn't show significant difference among all groups.