The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지
DOI QR코드

DOI QR Code

The Effect of Mild Cognitive Impairment Management Program on Traditional Korean Medicine in a Public Health Center

일개 보건소 한의약 경도인지장애 관리프로그램의 효과분석

  • Kim, Kyeong Han (Department of Traditional Korean Medicine of Uijeongbu-city Public Health Center) ;
  • Lee, Su-In (Department of Traditional Korean Medicine of Uijeongbu-city Public Health Center)
  • 김경한 (경기도 의정부시 보건소 한의약건강증진실) ;
  • 이수인 (경기도 의정부시 보건소 한의약건강증진실)
  • Received : 2013.07.04
  • Accepted : 2013.09.11
  • Published : 2013.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The aim of this study was to evaluate the effect of a mild cognitive impairment (MCI) management program on traditional Korean medicine in a public health center. Methods: In order to examine the effect of the MCI management program, we investigated MCI patients who participated in the program. MCI patients were treated with Jodeung-san (JDS) or Dangguijagyag-san (DGJYS) for 6 weeks. Mini Mental State Examination-Dementia Screening (MMSE-DS), Geriatric Quality of Life-Dementia (GQOL-D), Geriatric Depression Scale in Korea (GDS-K), and biochemical examination of blood were conducted at intervals of 6 weeks. A satisfaction survey was collected after this program. Results: MMSE-DS mean score increased significantly, by 4.09 (p=0.000) in the JDS group and by 4.15 (p=0.000) in the DGJYS group. GQOL-D mean score also increased significantly, by 5.90 (p=0.000) in the JDS group and by 5.07 (p=0.000) in the DGJYS group. GDS-K mean score decreased significantly, by 10.63 (p=0.000) in the JDS group and by 9.69 (p=0.000) in the DGJYS group. MMSE-DS, GDS-K and GQOL-D scores were not significantly different between the JDS and DGJYS groups. All of the participants were satisfied with the program, and 90% of the participants expressed a high intention to participate in the program again. Conclusions: Both Jodeung-san and Dangguijagyag-san treatment showed improvement on cognitive function, depression and quality of life in this program. Additional studies with more subjects will be required to prove credibility and validity more clearly.

Keywords

References

  1. Statistics Korea. Future Population Projection. Statistics Korea. 2012.
  2. Ministry of Health & Welefare. Survey of Dementia Prevalence Rate. Ministry of Health & Welefare. 2008.
  3. Ku BD, Kim SG, Lee JY, Park KH, Shin JH, Kim KK, et al. Clinical practice guideline for dementia by Clinical Research Center for Dementia of South Korea. J Korean Med Assoc. 2011; 54(8):861-875. https://doi.org/10.5124/jkma.2011.54.8.861
  4. Choi KG. Neuropathology of MCI-View from Relationships with Aging and Alzheimer's Disease-. Dementia and Neurocognitive Disorders. 2003;2:101-107.
  5. Petersen RC, Doody R, Kurz, Mohs RC, Morris JC, Rabins PV, et al. Current Concepts in Mild Cognitive Impairment. Arch Neurol. 2001;58: 1985-1992. https://doi.org/10.1001/archneur.58.12.1985
  6. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Aging, memory, and mild cognitive impairment. Int Psychogeriatr. 1997;9(1): 65-69.
  7. Shah Y, Tangalos EG, Petersen RC. Mild cognitive impairment. When is it a precursor to Alzheimer's disease? Geriatrics. 2000;55:65-68.
  8. Flicker C, Ferris SH, Reisberg B. Mild cognitive impairment in the eldery: predictiors of dementia. Neurology. 1991;41:1006-1009. https://doi.org/10.1212/WNL.41.7.1006
  9. Ministry of Health & Welefare. National Epidemiologic Investigation. Ministry of Health & Welefare. 2008.
  10. Han CS, Lee JY, Lee DW, Ryu SH, Lee KJ, Kim JH, et al. Development of Hybrid Model for Integrating Management of Geriatric Depression and Dementia in Urban Area. J Korean Geriatr So. 2006;10(2):104-114
  11. John KA, Heather BB. The sensitivity of the Beck Depression Inventory to changes of symptomatology. Br J Psychiatry. 1974;125: 184-185. https://doi.org/10.1192/bjp.125.2.184
  12. Peter, R. Ageing and the brain. Postgrad Med J. 2007;82:84-88
  13. Heo EJ, Kang JS, Kang HW, Jeon WK. Evaluation on the Quality of Research Field with Traditional Herbal Prescriptions for Dementia Therapy. J of Oriental Neuropsychiatry. 2012;23 (1):93-114. https://doi.org/10.7231/JON.2012.23.1.093
  14. Murakami Y, Zhao Q, Harada K, Tohda M, Watanabe H, Matsumoto K. Choto-san, a Kampo formula, improves chronic cerebral hypo-perfusion- induced spatial learning deficit via stimulation of myscarinic M1 receptor. Pharmacology Biochemistry and Behavior. 2005;81(3):616-625. https://doi.org/10.1016/j.pbb.2005.05.004
  15. Koichi Y, Yutaka S, Etsuro H, Nobuyasu S, Hirozo G, Owao S, et al. Protective effects of Choto-san and hooks and stems of Uncaria sinesis against delayed neuronal death after transient forebrain ischemia in gerbil. Phytomedicine. 2004;11:478-489. https://doi.org/10.1016/j.phymed.2003.04.001
  16. Watanabe H, Zhao Q, Matsumoto K, Tohda M, Murakami Y, Zhang SH, et al. Pharmacological evidence for antidementia effect of Chotosan( Guteng-san), a traditional Kampo medicine. Pharamacol Biochem Behav. 2003;75(3):635-643. https://doi.org/10.1016/S0091-3057(03)00109-6
  17. Mizushima Y, Kan S, Yoshida S, Irie Y, Urata Y. Effect of Choto-san a Kampo medicine, on impairment of passive avoidance performance in senescence accelerated mouse(SAM). Phytotherapy research. 2003;17:542-545. https://doi.org/10.1002/ptr.1193
  18. Matsuoka T, Narumoto J, Shibata K, Okamura A, Taniguchi S, Kitabayashi Y, et al. Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer''s Disease. Evi-Based Com and Alt Med. 2012.
  19. Inanaga K, Dainoson K, Ninomiya Y, TAkii O, Omaru M, Tanaka T, et al. Effects of Toko-Shakuyaku-San in Patients with Senile Cognitive Disoreders. Progress in Medicine. 1996;16:293-300. 1996.
  20. Iwasaki K, Satoh-Nakaqawa T, Maruyama M, Monma Y, Tomita N, Tanji H, et al. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symtoms and activities of daily living in dementia patients. J Clin Psychiatry. 2005;66(2):248-252. https://doi.org/10.4088/JCP.v66n0214
  21. Folstein MF. Folstein SE. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J of Psych Res. 1975;12:189-198. https://doi.org/10.1016/0022-3956(75)90026-6
  22. Park JH, Kwon YC. Standardization of Korean of the Mini-Mental State Examination (MMSE-K) for Use in the Elderly -Part II. Diagnostic Validity. J Korean NeuroPsychiatric Assoc. 1989;28: 508-513.
  23. Kang YW, Na DY, Han SH. A Validity Study on the Korean Mini-Mental State Examination (K-MMSE) in Dementia Patients. J Korean Neurol Assoc. 1997;15:300-307.
  24. Lee JH, Lee KU, Lee DY, Kim KW, Kim JH, Lee KH, et al. Development of the Korean version of the consortium to establish a registry for alzheimer's disease assessment packet (CERAD -K): clinical and neuro-psychological assessment batteries. J Gerontology Series B: Psychological Sciences and Social Sciences. 2002;57(1):47-53. https://doi.org/10.1093/geronb/57.1.P47
  25. Han JW, Kim TH, Joo JH, Park JH, Kim JR, Yoo SH, et al. A Normative Study of the Mini-Mental State Examination for Dementia Screening (MMSE-DS) and Its Short form (SMMSE-DS) in the Korean Elderly. J Korean Geriatr Psychiatry. 2010;14(1):27-37.
  26. Lee HS, Kim JH, Ko HJ, Ku HM, Kwon EJ, Shin JY, et al. The Standardization of the Geriatric Quality of Life scale-Dementia(GQOL-D). J Korean Geriatr Soc. 2004;8(3):151-164.
  27. Ki BS, Lee CW. A Preliminary Study for the Standardization of Geriatric Depression Scale in Korea. J Korean NeuroPsychiatric Assoc. 1995; 129:1875-1885.
  28. Ministry of Health & Welefare. Direction for Korean Medicine Health Promotion Program in 2013. Ministry of Health & Welefare. 2012.
  29. Gyeonggi Statistical Information Service. Population Statistics. Gyeonggi Statistical Information Service. 2012.
  30. Choi SH, Na DL, Oh KM, Park BJ. A Short form of the Samsung Dementia Questionnaire (S-SDQ): development and cross-validation. J Korean Neurol Assoc. 1997;17(2):253-258.
  31. Galasko D, Kauber MR, Hoftetter R, Salmon DP, Lasker B, Thal LJ. The mini-mental state examination in the elderly diagnosis of Alzheimer' disease. Arch Neurol. 1990;47(1):49-52. https://doi.org/10.1001/archneur.1990.00530010061020
  32. Clark CM, Sheppard L, Fillenbaum GG, Galasko D, Morris, JC, Koss E, et al. Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer's Disease. Arch Neurol. 1999;56(7):857-862. https://doi.org/10.1001/archneur.56.7.857
  33. Lee KS, Jung HK, Oh BH, Hong CH. Comparison of the Validity of Screening Tests for Dementia and Mild Cognitive Impairment of the Elderly in a Community K-MMSE, MMSE-K, MMSE-KC, and K-HDS. J Korean NeuroPsychiatric Assoc. 2009;48(2):61-69.
  34. Nasreddine ZS, Phillips NA, Beirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J American Geriatrics Society. 2005;53(4):695-699. https://doi.org/10.1111/j.1532-5415.2005.53221.x

Cited by

  1. Korean Traditional Medicine in Treating Patients with Mild Cognitive Impairment: A Multicenter Prospective Observational Case Series vol.2020, pp.None, 2013, https://doi.org/10.1155/2020/4323989