Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Effects on Kunneotang of Patients with Early Dementia of Alzheimer Type -12 Months Clinical Study-

초기 알츠하이머형 치매환자에 대한 건뇌탕(健腦湯)의 효능 -12 개월 임상 연구-

  • Eom, Hoy-Jin (Dept. of Neuropsychiatry, college of Oriental Medicine, Kyung Hee University) ;
  • Kim, Jong-Woo (Dept. of Neuropsychiatry, college of Oriental Medicine, Kyung Hee University) ;
  • Park, Eun-Hye (Department of psychology, Korea University) ;
  • Kim, Hyun-Taek (Department of psychology, Korea University) ;
  • Whang, Wei-Wan (Dept. of Neuropsychiatry, college of Oriental Medicine, Kyung Hee University)
  • 엄효진 (경희대학교 한의과대학 한방신경정신과학교실) ;
  • 김종우 (경희대학교 한의과대학 한방신경정신과학교실) ;
  • 박은혜 (고려대학교 심리학과) ;
  • 김현택 (고려대학교 심리학과) ;
  • 황의완 (경희대학교 한의과대학 한방신경정신과학교실)
  • Published : 2005.06.30
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Abstract

Object : This study was designed to asses the protective effects of Kunneo tang on cognitive decline of the patients with early DAT. Method : Before administered with Kunneotang, 16 patients with early DAT were measured by auditory ERP, MMSE-K and K-DRS. During 12 months the patients with early DAT were administered with Kunneotang. After 12months the patients were measured by the same examinations again. Result : 1. The total score of MMSE-K decreased but it was not significant. 2. The total score of K-DRS increased but it was not significant. Among the five criteria(attention, memory, initiation/perseveration, construction, conceptualization), Initiation/perseveration score signifcantly decreased and there were no significant differences in the other scores. But, memory mean score had a tendency to increase. 3. The latency of ERP P300 component increased but it was not significant and the amplitude of ERP P300 component showed the significant difference. Conclusion : The results suggest that Kunneotang may have protective effects on cognitive decline in the patients with early DAT.

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