• Journal of Acupuncture Research
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• v.25 no.1
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• pp.73-87
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• 2008

Objectives : The purpose of this study was to observe the anti-oxidative effects of electroacupuncture at Pungyung($ST_{40}$) in rats. Methods : The author performed several experiments, including measurements of body weightrelative liver weightslevels of albumin, total bilirubin, LDL-cholesterol, LDH, GOT and GPT in serum levels of SOD, glutathione, catalase, NO and MDA in the liver and histological analysis of the liver. Results : 1. Liver index was decreased in the $ST_{40}-EA$ group compared with the holder group and the control group. 2. LDL-cholesterol was significantly decreased in the $ST_{40}-EA$ group compared with the group. 3. SOD activity was significantly increased in the $ST_{40}-EA$ group and $ST_{40}-NR$ group compared with the control group. Glutathione activity was significantly increased in the $ST_{40}-EA$ group compared with the control group, the holder group, and the Sham-EA group. Catalase activity was significantly increased in the $ST_{40}-EA$ group compared with the control group and the holder group. Conclusions : These results suggest that electroacupuncture at $ST_{40}$ has an antioxidant effect in rats.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.6
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• pp.601-606
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• 2014

The purpose of this study is to research the effects of acupuncturing BL40 and ST36 and to determine the mechanism of action of acupuncturing BL40 and ST36 by measuring the changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats. To determine the mechanism of action of acupuncturing BL40 and ST36, pretreatment with indomethacine and methylene blue was performed. Acupuncturing BL40 and ST36 significantly increased rCBF, and the increased rCBF by acupuncturing BL40 and ST36 was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase, and methylene blue($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. Acupuncturing BL40 and ST36 decreased MABP, and decreased MABP by acupuncturing BL40 and ST36 was not changed by pretreatment with indomethacin and methylene blue. This result suggested that acupuncturing BL40 and ST36 might significantly increase rCBF by dilating arterial diameter and mechanism of acupuncturing BL40 and ST36 might be mediated by cyclooxygenase and guanylate cyclase.

• Proceedings of the Korean Magnestics Society Conference
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• 2012.05a
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• pp.70-71
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• 2012

In summary, the BLS experiments was applied to investigate the magnetic properties of $Co_{40}Fe_{40}B_{20}$ thin films. We find that the exchange stiffness constant decrease with increasing Ar gas pressure.

• Journal of Animal Science and Technology
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• v.47 no.6
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• pp.1001-1008
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• 2005

This study examined the effect of corn processing with varying rumen undegradable protein (RUP) on feed intake, milk yield, its composition and, blood characteristics in Holstein cows during the transitional period (21 days pre partum to 21 days post partum). Twenty Holstein cows were randomly assigned to four diets (five cows/diet), ground corn with 30 % RUP (GCR30), ground corn with 40 % RUP (GCR40), flaked corn with 30 % RUP (FCR30), and flaked corn with 40 % RUP (FCR40). The processed corn with varying RUP was fed in total mixed rations (TMR) to cows. Dry matter intake (DMI) was higher with 40 % RUP diet than with 30 % RUP diet, resulting in higher protein and energy intake by cows during pre and post partum (p＜0.05). However, it was not affected by corn processing during pre and post partum. Similarly milk yield was higher with 40 % RUP diet than with 30 % RUP diet. and milk yield was affected by corn processing at RUP 30 % level. Corn processing did not affected the milk fat and protein contents in dairy cows. The concentration of blood non esterified fatty acid (NEFA) were effected by RUP level with flaked corn, however, it was non-significant with RUP levels when given with ground corn. It is concluded that increasing RUP from 30 % to 40 % in iso-nitrogenous diet could increase milk yield in dairy cows during the transitional phase.

• Proceedings of the KIPE Conference
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• 2019.07a
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• pp.177-179
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• 2019

본 논문은 리튬폴리머 배터리를 기반으로 한 40 kV 펄스전원장치의 설계를 다룬다. 기존에 설계된 펄스전원장치는 삼상 380 V AC 입력 전원을 통해 구동되었으나, 이를 배터리 기반 2 kW 용량의 고전압 충전기를 통해 구동하도록 설계한다. 이 고전압 충전기는 44 V 리튬 폴리머 배터리를 기반으로 2 kW의 출력 용량을 갖도록 삼상 델타-와이 변압기 구조의 LCC 공진형 컨버터로 제작된다. 이를 통해 설계된 펄스전원장치는 최대 전압 40 kV, 펄스 폭 1.5 us - 5 us, 최대 펄스 반복율 3 kHz의 사양을 갖는다. 본 논문을 통해 2 kW급 고전압 충전기의 설계 및 분석을 하고 시뮬레이션 결과, 실험 결과를 분석한다. 또한 배터리 기반 40 kV 펄스 전원 장치의 시스템을 설명하며, 저항부하 실험을 통해 안정적인 동작과 성능을 검증한다.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2005.11a
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• pp.191-196
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• 2005

A low-cost, high-performance 40 Gb/s clock recovery module using a phase-locked loop(PLL) for a 40 Gb/s optical receiver has been designed and implemented. It consists of a clock recovery circuit, a RF mixer and frequency discriminator for phase/frequency detection, a DR-VCO, a phase shifter, and a hold circuit. The recovered 40 GHz clock is synchronized with a stable 10 GHz DR-VCO. The clock stability and jitter characteristics of the implemented PLL-based clock recovery module has shown to significantly improve the performance of the conventional open-loop type clock recovery module with DR filter. The measured peak-to-peak RMS jitter is about 230 fs. When input signal is dropped, the 40 GHz clock is generated continuously by hold circuit. The implemented clock recovery module can be used as a low-cost and high-performance receiver module for 40 Gb/s commercial optical network.

• Korean Journal of Soil Science and Fertilizer
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• v.43 no.5
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• pp.540-545
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• 2010

This study was conducted to investigate effects of irrigation points on cucumber growth and water saving under greenhouse. Automatic irrigation system and tensiometers were installed at four plots to measure soil water tension and properties of irrigated water. Each plot was irrigated at different irrigation points; soil water tension of 15, 20, 30, and 40 kPa, respectively. Conventional irrigation plot without tensiometer was also investigated. The total yield and sugar contents of cucumber had no significant differences between plots. However, irrigated water volumes were saved most when irrigation points were 30, and 40 kPa. The two plots of 30, and 40 kPa treatments used about 60% less of irrigated water than the plot of conventional practice did. In conclusion, this research suggested that the optimum irrigation point for cucumber cultivation in greenhouse can be soil water tension of 30 kPa based on the results of overall cucumber quality, and Greenhouse water usage.

• ETRI Journal
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• v.30 no.2
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• pp.261-267
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• 2008

In this paper, we propose and demonstrate a cost-effective technique to upgrade the capacity of dense wavelength division multiplexing (DWDM) networks to a 40 Gb/s line rate using the existing 10 Gb/s-based infrastructure. To accommodate 40 Gb/s over the link optimized for 10 Gb/s, we propose applying a combination of super-FEC, carrier-suppressed return-to-zero, and pre-emphasis to the 40 Gb/s transponder. The transmission of 40 Gb/s DWDM channels over existing 10 Gb/s line-rate long-haul DWDM links, including $40{\times}40$ Gb/s transmission over KT's standard single-mode fiber optimized for 10 Gb/s achieves successful results. The proposed upgrading technique allows the Q-value margin for a 40 Gb/s line rate to be compatible with that of 10 Gb/s.

• Biomolecules & Therapeutics
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• v.26 no.6
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• pp.599-607
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• 2018

Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical trials, unexpected liver toxicity resulted in premature termination of its development. Here, we investigated whether TAK-875 directly inflicts toxicity on hepatocytes and explored its underlying mechanism of toxicity. TAK-875 decreased viability of 2D and 3D cultures of HepG2, a human hepatocarcinoma cell line, in concentration-(>$50{\mu}M$) and time-dependent manners, both of which corresponded with ROS generation. An antioxidant, N-acetylcysteine, attenuated TAK-875-mediated hepatotoxicity, which confirmed the role of ROS generation. Of note, knockdown of GPR40 using siRNA abolished the hepatotoxicity of TAK-875 and attenuated ROS generation. In contrast, TAK-875 induced no cytotoxicity in fibroblasts up to $500{\mu}M$. Supporting the hepatotoxic potential of TAK-875, exposure to TAK-875 resulted in increased mortality of zebrafish larvae at$25{\mu}M$. Histopathological examination of zebrafish exposed to TAK-875 revealed severe hepatotoxicity as manifested by degenerated hypertrophic hepatocytes with cytoplasmic vacuolation and acentric nuclei, confirming that TAK-875 may induce direct hepatotoxicity and that ROS generation may be involved in a GPR40-dependent manner.

• Fisheries and Aquatic Sciences
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• v.23 no.1
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• pp.2.1-2.6
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• 2020

Background: As the cost of fishmeal continues to rise, there will be a need to optimize the diet by minimizing dietary fishmeal inclusion in aquafeed. In this study, a 7-week experiment was conducted to evaluate soybean meal, fermented soybean meal (soytide), and sesame meal as fishmeal replacers in whiteleg shrimp, Litopenaeus vannamei. Methods: A 30%-based fishmeal diet was considered as control (CON), six other diets were prepared by replacing 20% or 40% of fishmeal with soybean meal (SB₂₀ and SB₄₀), fermented soybean meal (ST₂₀ and ST₄₀), or sesame meal (SM₂₀ and SM₄₀) from the CON diet. Twenty shrimp with average initial weight of 0.65 ± 0.05 g (mean ± SD) were randomly distributed into 21 tanks (45 L) and fed four times a day. Water temperature was controlled at 28 ± 1 ℃ and aeration was provided by air stones. Results: Weight gain, specific growth rate, feed efficiency, and protein efficiency ratio of shrimp fed CON showed no significant differences compared to shrimp fed all the other diets. However, growth performance of shrimp fed ST₂₀ diet was significantly higher than those of shrimp fed the SM₂₀ and SM₄₀ diets (P < 0.05). Superoxide dismutase activity (SOD) of shrimp fed CON, ST₂₀, and ST₄₀ diets was significantly higher than those of shrimp fed the SB₄₀ and SM₄₀ diets. But there were no significant differences among shrimp fed CON, SB₂₀, ST₂₀, ST₄₀, and SM₂₀ diets. Also, lysozyme activity of shrimp fed ST₂₀ diet was significantly higher than those of shrimp fed the SB₄₀ and SM₄₀ diets. Although, lysozyme activity of shrimp fed the CON diet was not significantly different compared to shrimp fed all the other experimental diets. Conclusions: Therefore, SB, ST, and SM could replace 40% of fishmeal based on growth performance and lysozyme. According to the SOD activity, SB and SM could replace 20% of fishmeal and ST could replace 40% of fishmeal in juvenile whiteleg shrimp Litopenaeus vannamei.