• Title/Summary/Keyword: K&C test

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Bioequivalence Assessment of Roxithromycin Tablets in Healthy Korean Volunteers

  • Kwon Oh-Seung;Kim Hye-Jung;Pyo Hee-Soo;Chung Youn-Bok
    • Biomolecules & Therapeutics
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    • v.14 no.1
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    • pp.50-55
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    • 2006
  • The objective of the study was to evaluate the bioequivalency between the $Rozid^{TM}$ Tablet (Ilhwa Pharm. Co., Ltd.) as a test formulation and the $Rulid^{TM}$ Tablet (Handok Pharm. Co., Ltd) as a reference formulation. Twenty-four healthy male volunteers were administered the formulations by the randomized Latin square crossover design, and the plasma samples were determined by a high performance liquid chromatography (HPLC) with fluorescence detector. $AUC_t,\;C_{max}\;and\;T_{max}$ were obtained from the time-plasma concentration curves, and log-transformed $AUC_t\;and\;C_{max}$ and log-untransformed $T_{max}$ values for two formulations were compared by statistical tests and analysis of variation. $AUC_t$ was determined to be $63.30{\pm}25.57{\mu}g.hr/ml$ for the test formulation and $64.02{\pm}29.27mg.hr/ml$ for the reference formulation. The mean values of $C_{max}$ for the test and reference formulations were $5.07{\pm}2.14\;and\;5.53{\pm}2.60{\mu}g/ml$, respectively. The $AUC_t,\;and\;C_{max}$ ratios of the test $Rozid^{TM}$ Tablet to the reference $Rulid^{TM}$ Tablet were -1.12% and -8.32%, respectively, showing that the mean differences were satisfied the acceptance criteria within 20%. The results from analysis of variance for log-transformed $AUC_t,\;and\;C_{max}$ indicated that sequence effects between groups were not exerted and 90% confidence limits of the mean differences for $AUC_t,\;and\;C_{max}$ were located in ranges from log 0.80 and log 1.25, satisfying the acceptance criteria of the KFDA bioequivalence. The RozidTM Tablet as the test formulation was considered to be bioequivalent to the RulidTM Tablet used as its reference formulation, based on $AUC_t,\;and\;C_{max}$ values.

A Study on The Degradation Characteristics of MLCCs SAC305 Lead-Free Solder Joints and Growth IMCs by Thermal Shock Test (열충격 시험을 통한 MLCCs SAC305 무연 솔더 접합부의 IMCs 성장과 접합특성 저하에 관한 연구)

  • Jung, Sang-Won;Kang, Min-Soo;Jeon, Yu-Jae;Kim, Do-Seok;Shin, Young-Eui
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.29 no.3
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    • pp.152-158
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    • 2016
  • The bonding characteristics of MLCCs (multi layer ceramic capacitor, C1608) lead-free solder (SAC305) joints were evaluated through thermal shock test ($-40^{\circ}C{\sim}125^{\circ}C$, total 1,800 cycle). After the test, IMCs( intermetallic compounds) growth and cracks were verified, also shear strengths were measured for degradation of solder joints. In addition, The thermal stress distributions at solder joints were analyzed to compare the solder joints changes before and after according to thermal shock test by FEA (finite elements analysis). We considered the effects of IMCs growth at solder joints. As results, the bonding characteristics degradation was occurred according to initial crack, crack propagations and thermal stress concentration at solder-IMCs interface, when the IMCs grown to solder inside.

Study of Life Prediction and Failure Mechanisms of Cramic Heater for Home Appliance (가전 제품용 세라믹 히터의 수명 및 고장 원인에 대한 연구)

  • Choi, Hyoungseuk
    • Journal of Applied Reliability
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    • v.17 no.4
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    • pp.355-361
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    • 2017
  • Purpose: The purpose of this research is to establish the life test method for ceramic heater and identify the failure mechanisms. Methods: We do accelerated life test in the condition of thermal shock and failure analysis for failed samples. Conclusion: The main failure mechanisms of ceramic heater are identified as overstress failure mechanisms as results of failure analysis and the shape parameters of weibull distribution by accelerated life test are identified as 0.8, 1.2 and 0.4 each at $400^{\circ}C$, $600^{\circ}C$ and $900^{\circ}C$. At $900^{\circ}C$, the shape parameter 0.4 means that It is exactly initial failure caused that the stress exceeds the strength of ceramic heater highly and the shape parameters 0.8, 1.2 at $400^{\circ}C$, $600^{\circ}C$ means that the shape parameters are around 1.0 so that the main failure mechanism is overstress failure which is same result as failure analysis. It means that the appropriate life test method for ceramic heater is reliability qualification test method rather than accelerated life test.

The Method of Parallel Test Efficiency Improvement using Multi-Clock Mode (멀티클럭 모드를 이용한 병렬 테스트 성능 향상 기법)

  • Hong, Chan Eui;Ahn, Jin-Ho
    • Journal of the Semiconductor & Display Technology
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    • v.18 no.3
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    • pp.42-46
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    • 2019
  • In this paper, we introduce the novel idea to improve parallel test efficiency of semiconductor test. The idea includes the test interface card consisting of NoC structure able to transmitting test data regardless of ATE speed. We called the scheme "Multi-Clock" mode. In the proposed mode, because NoC can spread over the test data in various rates, many semiconductors are tested in the same time. We confirm the proposed idea will be promising through a FPGA board test and it is important to find a saturation point of the Multi-Clock mode due to the number of test chips and ATE channels.

Structural Strength Evaluation of a Carbody by Finite Element Analysis and Tests (구조해석 및 시험에 의한 경량화 차체 구조강도 평가)

  • Yoon S.C.;Kim W.K.;Jun C.S.;Kim M.Y.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2005.10a
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    • pp.49-54
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    • 2005
  • This paper describes the result of structure analysis and load test of body structure. The purpose of the analysis and test is to evaluate an safety which body structure shall be considered fully sufficient rigidity so as to satisfy proper system function under maximum load and operating condition. Material of body structure applied an aluminum alloy. Body structure consist of side frame, under frame, roof frame, end frame. Both FEM analysis and load test are based on 'Performance Test Standard for Electrical Multiple Unit, noticed by Ministry of Construction & Transportation, in 2000' and reference code is JIS E 7105. The test results have been very safety and stable fer design load conditions.

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Critical Pitting Temperature of 2205 Duplex Stainless Steels Using Immersion and Electrochemical Polarization Test Methods (침지시험법 및 전기화학적 분극법에 의한 2205 이상 스테인리스강의 임계공식온도 측정 비교)

  • Shin Jae-Ho;Lee Jae-Bong
    • Journal of the Korean institute of surface engineering
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    • v.39 no.1
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    • pp.18-24
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    • 2006
  • Although stainless steels have the excellent corrosion resistance by passive film, they are susceptible to pitting corrosion in the environment containing halogen elements such as chloride ions. The resistance to pitting corrosion can be evaluated by measuring the critical pitting temperature (CPT). CPT values can be obtained using immersion, potentiodynamic and potentiostatic polarization test methods. Results on duplex 2205 stainless steels showed that CPT values were measured as $50^{\circ}C,\;55^{\circ}C\;and\;61^{\circ}C$, respectively for immersion, potentiodynamic and potentiostatic polarization test methods, depending upon the different test methods, even though the difference between CPT values are not much.

Analysis of Insulation Diagnosis and Failure in Stator Windings of Air-Cooled Gas Turbine Generator

  • Kim, Hee-Dong;Kong, Tae-Sik;Kim, Kyeong-Yeol
    • KEPCO Journal on Electric Power and Energy
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    • v.2 no.3
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    • pp.421-424
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    • 2016
  • In order to evaluate the insulation deterioration in the stator windings of air-cooled gas turbine generators(119.2 MVA, 13.8 kV) which has been operating for more than 15 years, diagnostic test and AC dielectric breakdown test were performed on phases A, B and C. Diagnostic test included measurements of AC current, dissipation factor, partial discharge (PD) magnitude and capacitance. ${\Delta}I$ and ${\Delta}tan{\delta}$ in all three phases (A, B, and C) of generator stator windings showed that they were in good condition but PD magnitude indicated marginally serviceable condition. After the diagnostic test, an AC overvoltage test was performed by gradually increasing the voltage applied to the generator stator windings until electrical insulation failure occurred, in order to determine the breakdown voltage. Although phase A of generator stator windings failed at breakdown voltage of 29.0 kV, phases B and C endured the 29.0 kV. The breakdown voltage in all three phases was higher than that expected for good-quality windings (28.6 kV) in a 13.8 kV class generator.

Effects of Test Temperature on the Reciprocating Wear of Steam Generator Tubes

  • Hong, J.K.;Kim, I.S.
    • Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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    • 2002.10b
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    • pp.379-380
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    • 2002
  • Steam generators (S/G) of pressurized water reactors are large heat exchangers that use the heat from the primary reactor coolant to make steam in the secondary side for driving turbine generators. Reciprocating sliding wear experiments have been performed to examine the wear properties of Incoloy 800 and Inconel 690 steam generator tubes in high temperature water. In present study, the test rig was designed to examine the reciprocating and rolling wear properties in high temperature (room temperature - $300^{\circ}C$) water. The test was performed at constant applied load and sliding distance to investigate the effect of test temperature on wear properties of steam generator tube materials. To investigate the wear mechanism of material, the worn surfaces were observed using scanning electron microscopy. At $290^{\circ}C$, wear rate of Inconel 690 was higher than that of Incoloy 800. It was assumed to be resulted from the oxide layer property difference due to the a\loy composition difference. Between 25 and $150^{\circ}C$ the wear loss increased with increasing temperature. Beyond $150^{\circ}C$, the wear loss decreased with increasing temperature. The wear loss change with temperature were due to the formation of wear protective oxide layer. From the worn surface observation, texture patterns and wear particle layers were found. As test temperature increased, the proportion of particle layer increased.

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Study on bond behavior of steel reinforced high strength concrete after high temperatures

  • Chen, Zongping;Zhou, Ji;Wang, Xinyue
    • Advances in concrete construction
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    • v.10 no.2
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    • pp.113-125
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    • 2020
  • This paper presents experimental results on bond-slip behavior of steel reinforced high-strength concrete (SRHC) after exposure to elevated temperatures. Three parameters were considered in this test: (a) high temperatures (i.e., 20℃, 200℃, 400℃, 600℃, 800℃); (b) concrete strength (i.e., C60, C70, C80); (c) anchorage length (i.e., 250 mm, 400 mm). A total of 17 SRHC specimens subjected to high temperatures were designed for push out test. The load-slip curves at the loading end and free end were obtained, the influence of various variation parameters on the ultimate bond strength and residual bond strength was analyzed, in addition, the influence of elevated temperatures on the invalidation mechanism was researched in details. Test results show that the shapes of load-slip curves at loading ends and free ends are similar. The ultimate bond strength and residual bond strength of SRHC decrease first and then recover partly with the temperature increasing. The bond strength is proportional to the concrete strength, and the bond strength is proportional to the anchoring length when the temperature is low, while the opposite situation occurs when the temperature is high. What's more, the bond damage of specimens with lower temperature develops earlier and faster than the specimens with higher temperature. From these experimental findings, the bond-slip constitutive formula of SRHC subjected to elevated temperatures is proposed, which fills well with test data.

The Acclerated Life Test of Hard Disk In The Environment of PACS (PACS 환경에서 하드디스크의 가속 수명시험)

  • Cho, Euy-Hyun;Park, Jeong-Kyu;Chae, Jong-Gyu
    • Journal of Digital Contents Society
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    • v.16 no.1
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    • pp.63-70
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    • 2015
  • In this paper, we estimate the life cycle from acceleration life test about the hard disk of disk array of image storage of PACS. Webuil distribution was selected by the Anderson-Darling goodness-of-fit test with data of down time at $50^{\circ}C$ and $60^{\circ}C$. The equality test of shape parameter and scale parameter was conducted, so that the probability distribution estimated from data of down time at $50^{\circ}C$ and $60^{\circ}C$ was not statistically significant. The shape parameter was 1.0409, The characteristic life was 24603.5 hours at normal user condition($30^{\circ}C$) by the analysis of weibull-arrhenius modeling which included the acceleration factor of temperature, and The activation energy was 0.5011 eV through arrhenius modeling. The failure analysis of the failure samples of acceleration test and the samples of market return was conducted, so that the share percentage of failure mode was detail difference but the rank of share percentage was almost same. This study suggest the test procedure of acceleration test of hard disk drive in PACS using environment, and help the life estimation at manufacture and use.