• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.5
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• pp.1264-1269
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• 2003

The inhibitory effects of the Juglans sinensis walnut ethanol extract (JSWE) on carbon tetrachloide (CCl₄)-induced fibrosis, serum transaminases (GOT and GTP), hepatic glutathione (GSH), serum pro-inflammatory cytokines (IL-1β and IL-6) were investigated in rats. JSWE significantly inhibited on CCl₄-induced fibrosis in dose-dependent manner. Moreover, JSWE significantly inhibited on the serum levels of GOT, GTP, IL-1β, and IL-6 in dose-dependent manner in CCl₄-induced fibrosis rat. However, JSWE markedly increased the production of hepatic GSH in a dose-dependent manner. These results show that JSWE may explain some known biological activities of Juglans sinensis walnut including their anti-fibrotic and anti-inflammatory effects, and is of considerable benefit in the treatment for live diseases.

• Archives of Pharmacal Research
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• v.28 no.5
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• pp.529-533
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• 2005

In the course of searching for hepatoprotective agents from natural products, six compounds were isolated from the MeOH extract of the leaves of Juglans sinensis, as guid ed by their DPPH free radical scavenging activity. The structures were determined as juglanoside B (1), quercetin 3-O-${\alpha}$-L-arabinofuranoside (avicularin, 2), quercetin 3-O-${\alpha}$-L-arabinopyranoside (guaijaverin,3), quercetin 3-O-${\alpha}$-L-rhamnopyranoside (quercitrin,4), (+)-catechin (5) and quercetin 3-O-${\beta}$- D-galactopyranoside (hyperin,6). Compounds 2-6 showed significant DPPH free radical scavenging effects. An evaluation for the hepatoprotective activity of the isolated compounds on drug-induced cytotoxicity was conducted, and compounds 1, 2, and 5 showed protective effects against nitrofurantoin-induced cytotoxicity, and compound 5 also exhibited a moderate protective effect on amiodarone-induced cytotoxicity in Hep G2 cells.

• The Korea Journal of Herbology
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• v.24 no.2
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• pp.39-48
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• 2009

Objectives : To clarify the possible effect of JS (Juglans sinensis), PCF (Psoralea corylifolia L.), and J+P(JS+PCF), we examined their influence on the development of pulmonary eosinophilic inflammation in the asthmatic murine model. Methods : All mice were immunized on two different days (21 days and 7 days before inhalational exposure) by intraperitonial injections of 0.2 ml alum-precipitated Ag containing 100 ${\mu}$g of OVA bound to 4 mg of aluminum hydroxide in PBS. Seven days after the second sensitization, mice were exposed to aerosolized ovalbumin for 30 minutes/day on 3 days/week for 8 weeks (at a flow rate of 250 L/min, 2.5% ovalbumin in normal saline) and, JS, PCF and J+P (200 mg/kg, 400 mg/kg) were orally administered 3 times per week for 8 weeks. Results : The suppressive effects of JS, PCF, and J+P were demonstrated by the accumulation of eosinophils into airways, with the reduction of eosinophils and lung leukocytes. These were correlated with the marked reduction of IL-4, IL-5, IL-13 levels in the BALF and serum. OVA-specific IgE levels were also decreased in serum and BAL from these mice. And also JS, PCF, and J+P decreased eosinophilic CCR3 and CD11b expression in lung tissue. Conclusions : These results indicate that JS, PCF, and J+P have deep inhibitory effects on airway inflammation and hyper-responsiveness in the asthmatic murine model. The suppression of IL-5, IgE, and eosinophilils and the increase of IFN-${\gamma}$ production in BALF seem to contribute to these effects. Specially, esosinophils and TNF-a in J+P combination group were significantly reduced in BALF and lung tissue. Hence, the results indicated that JS, PCF, and J+P could act as an immuno-modulator which possesses anti-inflammatory and anti-asthmatic property by modulating the imbalance between Th1 and Th2 cytokines.

• Journal of Acupuncture Research
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• v.20 no.6
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• pp.128-139
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• 2003

Juglans sinensis Dode has been reported to have antioxidant activity. However, the effect of Juglans sinensis Dode aquacupuncture(JS) on reactive oxygen species(ROS)-induced alterations in membrane transport function in renal tubular cells. This study was performed to evaluate the effect of JS on the organic hydroperoxide t-butylhydroperoxide(tBHP)-induced inhibition of $Na^+$-dependent phosphate($Na^+$-Pi) uptake in opossum kidney (OK) cells, an established renal proximal epithelial cell line. tBHP inhibited $Na^+$-Pi uptake in a time-dependent manner. The inhibitory effect of tBHP was prevented by JS over concentration range of 0.05-1mg/100ml in a dose-dependent manner. Kinetic studies showed that tBHP caused an decrease in Vmax for $Na^+$-Pi uptake without any a significant change in Km. $Na^+$-dependent phosphonoformic acid binding, a irreversible inhibitor of renal $Na^+$-Pi uptake, was decreased by tBHP treatment. The reduction in Vmax and phosphonoformic acid binding by tBHP was prevented by JS. tBHP induced lipid peroxidation and its effect was completely inhibited by JS and antioxidant N,N'-diphenyl-p-phenylenediamine. These data suggest that the oxidant inhibits phosphate uptake by a reduction in the number of active carrier across the membrane. JS may prevent oxidant-induced inhibition of membrane transport function by a mechanism similar to antioxidants in renal epithelial cells. Although the precise constituents remain to be explored, JS may be employed as a useful candidate herb for drug development to prevent and treat oxidant-mediated renal failure.

• Korean journal of applied entomology
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• v.36 no.2
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• pp.156-165
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• 1997

Host plants and host preference of brown chafer, Adoretus tenuimaculatus Waterhouse (Coleoptera: Scarabaeidae) were investigated in fields and laboratory. 66 kinds of plants in 25 fanlilies were recorded as host during the field survey and 14 kinds in 5 families were verified to be eaten by artificial plant supply. Thus, host plants of A. tertuimaculatus were 186 kinds in 42 families in total including 136 kinds of plants in 32 families from literatures. 50 plants in 19 families were newly recorded as host of A. tenuimaculatus in this study. A. tenuimaculatus was the most frequently visited to J14glans sinensis and Caztanea crenata was the highest damaged plant. C. crenata, Robinia pseudoacasia, Malus sieboldii, J. sinensis, Quercus mongolica, and Q. aliena were considerably highly preferered host plant. However, A. tenuimaculatus never visited to Diospyros lotus, J. nigra, Fraxinus mandshurica, F. rhynchophylla, Pyracantha angustqolia, Paulownia coreana, and Celtis sinensis. Even the same host plant of A. tenuimaculatus. preference was different according to observed place and damage level was also different depending on observed place and time.

• Journal of Forest and Environmental Science
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• v.36 no.4
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• pp.326-327
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• 2020

• Journal of Pharmacopuncture
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• v.9 no.3 s.21
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• pp.79-88
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• 2006

Objectives : This systematic review summarizes the existing evidence on anti-tumor herbal acupuncture in South Korea. Methods : Literature searches were conducted in four databases. All studies of anti-tumor herbal acupuncture which has been published in South Korea until May, 2006 were included. Data were extracted according to pre-defined criteria by two independent reviewers. Results : We found 73 papers related to anti-tumor herbal acupuncture in South Korea. Seventy of seventy-three papers are trial research and only three papers are clinical research. Herb materials which were used in those papers are Bee-venom, Wild-ginseng, Ginseng, Houttuynia cordata Thunb, Lonicerae Flos, Carthami Tinctorii Juglans sinensis, Euphorbiae Radix, Ecliptae Herba, Crotonis Semen, Juglans sinensis, Armeniaceae Amarum, so on. From those papers, Anti-tumor herbal acupunctures are effective to tumor cell line and tumor in vivo. Clinical research papers reported that Anti-tumor herbal acupunctures are useful to improve cancer related symptoms and quality of life(QOL) of cancer patients. Conclusions : From the above results, we make sure of that anti-tumor herbal acupuncture is useful therapeutics for cancer patients. If we conceive complex-herb materials and carry out more advanced research, Anti-tumor Herbal Acupuncture is one of those major therapeutics to improve clinical symptoms and quality of life(QOL) of cancer patients.

• Journal of Korean Society of Forest Science
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• v.78 no.2
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• pp.189-197
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• 1989

This study was carried out to produce the grafts of Juglans sinensis by juvenile grafting method which epicotyl of newly germinated seeds were used as stocks and juvenile fresh shoots were used as scion. The results obtained were as follows ; 1. When plastic tube installed covering up seed with soil up to 6cm height for diameter increment of epicotyl, the epicotyl can be grown up to thickness of 10mm. 2. When the soft fruit branches and the soft water sprout with the terminal bud 8cm to 12cm long were used as scions, the survival rates showed 90 Percent. 3. The optimum date for making juvenile grafts was around the 20th of May, and the survival rates of grafted seedlings showed 86 percent in average. 4. The grafted seedlings showed first sprouting the 15th of June, that is 25 days after making graft, and the sprouting rate was 72 percent. 5. The height-growth of grafted seedlings finished at the end of July, and diameter growth lasted into the end of October. 6. There was positive correlation between the height of grafted seedlings and the diameter at root collar. 7. In general, it takes two years to make plantable graft seedlings from hardwood scion and stock, but the juvenile graft seedlings can be easily obtained in a year and so it seems to be economic.

• Journal of Korean Society of Forest Science
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• v.66 no.1
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• pp.95-108
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• 1984

In order to see the effect of various factors on the success of grafting of walnut, a modified cleft grafting experiment has been conducted with Juglans sinensis Dode, J. regia (persian walnut), J. regiu (carpathian walnut), J. mandshurica, J. nigra and five cultivars of Carpathian walnut as "HANSEN", "METCALFE" "SCHOOL", "ILL CRATH", "LAKE" in a large green house equipped with automatic environmental control system in which temperature of the grafting bed at $28^{\circ}C$ and 85-100% for humidity during the period of January 1981-June 1983. As results of the experiments, the following facts were observed. 1) Hteroplastic grafting was proved to be more successful than homoplastic grafting with all five species tested among the J. regia (carpathian walnut), J. regia (persian walnut), J. sinensis, J. mondshurica, J. nigra. 2) It was interesting to notice that results hight survival of graft high as 99.33-100% with heteroplastic grafting when "Persian Walnut" and "Carpathian Walnut" was grafted on the stock of J. mandshurica and J. nigra. 3) A statistical significance of 5% Level was recognized in the above stocks among five species of homoplastic grafting with heteroplastic grafting and no significance among the scions. 4) The heteroplastic grafting when five cultivars of Carpathian Walnut as above as was grafted on the stock of Juglans nigra and J. mandshurica resulting high survival of graft as high as 85.33-100%. 5) As conclusion, the heteroplastic grafts of Carpathian Walnut and Persian Walnut was grafted on the stock of Juglans nigra and Jugdans mandshurica, the graft union, between stock and scion completed, in short period and was followed by a vigorous growth as well as "Cross Breeding", or hybrization, became apparent, with different desirable traits which could he used to cultivate a Later generation that combined these characteristics.

• Korean Journal of Plant Resources
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• v.27 no.2
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• pp.188-193
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• 2014

The sap outflow characteristics of Juglans sinensis and J. mandshurica were investigated to evaluate the optimum pruning period of walnut tree that there is a sap spill on dormant. The total period of sap outflow were 34 days for both J. sinensis and J. mandshurica. Total amount of sap outflow per tree in J. sinensis and J. mandshurica were 2,922 mL/tree and 3,135 mL/tree, respectively and the period of sap outflow and non sap outflow between two species were similar. ANOVA analysis showed that the amount of sap outflow was significant differences with day of sap outflow but there were no significant differences between species. From the correlation analysis between air-temperature and sap outflow, daily minimum temperature showed a positive correlation at the 1% level of significance (r=0.56 and r=0.46) for both J. sinensis and J. mandshurica. When branch of walnut tree that diameter is 5 cm cut on the period of sap outflow, the sap flowed down the longest period (48 days) but the sap outflow was not observed after budburst. Therefore, our study supported that the pruning have to avoid the period of sap outflow to reduce sap outflow of walnut tree.