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The Pharmaceutical Society of Korea (대한약학회)
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Free Radica1 Scavenging and Hepatoprotective Constituents from the Leaves of Juglans sinensis

  • An, Ren-Bo (College of Pharmacy and Phytofermentation Research Center, Wonkwang University, College of Pharmacy, Yanbian University) ;
  • Kim, Hyun-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang University) ;
  • Tian, Yu-Hua (College of Pharmacy and Phytofermentation Research Center, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
  • Published : 2005.01.01
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Abstract

In the course of searching for hepatoprotective agents from natural products, six compounds were isolated from the MeOH extract of the leaves of Juglans sinensis, as guid ed by their DPPH free radical scavenging activity. The structures were determined as juglanoside B (1), quercetin 3-O-${\alpha}$-L-arabinofuranoside (avicularin, 2), quercetin 3-O-${\alpha}$-L-arabinopyranoside (guaijaverin,3), quercetin 3-O-${\alpha}$-L-rhamnopyranoside (quercitrin,4), (+)-catechin (5) and quercetin 3-O-${\beta}$- D-galactopyranoside (hyperin,6). Compounds 2-6 showed significant DPPH free radical scavenging effects. An evaluation for the hepatoprotective activity of the isolated compounds on drug-induced cytotoxicity was conducted, and compounds 1, 2, and 5 showed protective effects against nitrofurantoin-induced cytotoxicity, and compound 5 also exhibited a moderate protective effect on amiodarone-induced cytotoxicity in Hep G2 cells.

Keywords

References

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