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Free Radica1 Scavenging and Hepatoprotective Constituents from the Leaves of Juglans sinensis  

An, Ren-Bo (College of Pharmacy and Phytofermentation Research Center, Wonkwang University, College of Pharmacy, Yanbian University)
Kim, Hyun-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Tian, Yu-Hua (College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Kim, Youn-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Publication Information
Archives of Pharmacal Research / v.28, no.5, 2005 , pp. 529-533 More about this Journal
Abstract
In the course of searching for hepatoprotective agents from natural products, six compounds were isolated from the MeOH extract of the leaves of Juglans sinensis, as guid ed by their DPPH free radical scavenging activity. The structures were determined as juglanoside B (1), quercetin 3-O-${\alpha}$-L-arabinofuranoside (avicularin, 2), quercetin 3-O-${\alpha}$-L-arabinopyranoside (guaijaverin,3), quercetin 3-O-${\alpha}$-L-rhamnopyranoside (quercitrin,4), (+)-catechin (5) and quercetin 3-O-${\beta}$- D-galactopyranoside (hyperin,6). Compounds 2-6 showed significant DPPH free radical scavenging effects. An evaluation for the hepatoprotective activity of the isolated compounds on drug-induced cytotoxicity was conducted, and compounds 1, 2, and 5 showed protective effects against nitrofurantoin-induced cytotoxicity, and compound 5 also exhibited a moderate protective effect on amiodarone-induced cytotoxicity in Hep G2 cells.
Keywords
Juglans sinensis; Juglandaceae; Hepatoprotective; Hep G2 Cells; Free radical scavenging;
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Times Cited By Web Of Science : 8  (Related Records In Web of Science)
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1 Arts, I. C. W., Sesink, A. L. A., Peters, M. F., and Hollman, P. C. H., The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Br. J. Nutr., 91, 841-847 (2004)   DOI   ScienceOn
2 Chin, Y. W., Lim, S. W., Kim, Y. C., Choi, S. Z., Lee, K. R., and Kim, J. W., Hepatoprotective flavonol glycosides from the aerial parts of Rodgersia podophylla. Planta Med., 70, 576- 577 (2004)   DOI   ScienceOn
3 Oh, H., Lee, H. S., Kim, T., Chai, K. Y., Chung, H. T., Kwon, T. O., Jun, J. Y., Jeong, O. S., Kim, Y. C., and Yun, Y. G., Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med., 68, 463-464 (2002b)   DOI   ScienceOn
4 Sanbongi, C., Osakabe, N., Natsume, M., Takizawa, T., Gomi, S., and Osawa, T., Antioxidative polyphenols isolated from Theobroma cacao. J. Agric. Food Chem., 46, 454-457 (1998)   DOI   ScienceOn
5 Oh, H., Kim, D. H., Cho, J. H., and Kim, Y. C., Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense. J. Ethnopharmacol., 95, 421-424 (2004)   DOI   PUBMED   ScienceOn
6 Klee, S., Nurnberger, M. C., and Ungemach, F. R., The consequences of nitrofurantoin-induced oxidative stress in isolated rat hepatocytes: evaluation of pathobiochemical alterations. Chem. Biol. Interact., 93, 91-102 (1994)   DOI   ScienceOn
7 Oh, H., Ko, E. K., Jun, J. Y., Oh, M. H., Park, S. U., Kang, K. H., Lee, H. S., and Kim, Y. C., Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba. Planta Med., 68, 932-934 (2002a)   DOI   ScienceOn
8 Bae, K. H., Medicinal Plants of Korea. Kyo-Hak Publishing Co., Seoul, p. 49 (2000)
9 Agrawal, P. K., Carbon-13 NMR of Flavonoids. Elsevier, Amsterdam, p. 304 (1989)
10 Kim, D. K. and Shin, T. Y., Flavonoids from Sorbaria sorbifolia var. stellipila. Kor. J. Pharmacogn., 29, 254-257 (1998)   과학기술학회마을
11 Singhal, A., Ghosh, P., and Khan, S. A., Low dose amiodarone causing pseudo-alcoholic cirrhosis. Age Ageing, 32, 224-225 (2003)   DOI   ScienceOn
12 Watkins, P. B., Zimmerman, H. J., Knapp, M. J., Gracon, S. I., and Lewis, K. W., Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. J. Am. Med. Assoc., 271, 992-998 (1994)   DOI   ScienceOn
13 Kappus, H., Lipid peroxidation: mechanisms, enzymology & biological relevance. In Sies II (Ed.). Oxidative Stress. Academic Press, London, pp. 273-310, (1985)
14 Halliwell, B., Free radicals, antioxidants and human disease: curiosity, cause or consequence? Lancet, 344, 721-724 (1994)   DOI   ScienceOn
15 Jung, C. M., Hwang, E. J., Kwon, H. C., Kim, S. Y., Bae, K. H., Zee, O. P., and Lee, K. R., Antioxidative flavonoids from Hypericum erectum. Kor. J. Pharmacogn., 30, 196-201 (1999)   과학기술학회마을
16 Lee, M. H., Son, Y. K., and Han, Y. N., Tissue factor inhibitory flavonoids from the fruits of Chaenomeles sinensis. Arch. Pharm. Res., 25, 842-850 (2002)   DOI   ScienceOn
17 Osseni, R. A., Debbasch, C., Christen, M. O., Rat, P., and Warnet, J. M., Tacrine-induced reactive oxygen species in a human liver cell line: the role of anethole dithiolethione as a scavenger. Toxicol. In Vitro, 13, 683-688 (1999)   DOI   ScienceOn
18 Yan, X., Murphy, B. T., Hammond, G. B., Vinson, J. A., and Neto, C. C., Antioxidant activities and antitumor screening of ectracts from cranberry fruit (Vaccinium macrocarpon). J. Agric. Food Chem., 50, 5844-5849 (2002)   DOI   ScienceOn
19 Edoute, Y., Karmon, Y., Roguin, A., and Ben-Ami H., Fatal liver necrosis associated with the use of nitrofurantoin. Isr. Med. Assoc. J., 3, 382-383 (2001)
20 Sarma, J. S., Pei, H., and Venkataraman, K., Role of oxidative stress in amiodarone-induced toxicity. J. Cardiovasc. Pharmacol. Ther., 2, 53-60 (1997)   DOI   ScienceOn
21 Song, E. K., Cho, H., Kim, J. S., Kim, N. Y., An, N. H., Kim, J. A., Lee, S. H., and Kim, Y. C., Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med., 67, 876-877 (2001)   DOI   ScienceOn
22 Thabrew, M. I., Hughes, R. D., and McFarlane, I. G., Screening of hepatoprotective plant constituents using a HepG2 cell cytotoxicity assay. J. Pharm. Pharmacol., 49, 1132-1135 (1997)   DOI   ScienceOn
23 Liu, L., Li, W., Koike, K., Zhang, S., and Kikaido, T., New atetralonyl glucosides from the fruit of Juglans mandshurica. Chem. Pharm. Bull., 52, 566-569 (2004)   DOI   ScienceOn