• The Journal of Internal Korean Medicine
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• v.22 no.4
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• pp.639-645
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• 2001

Angiogenesis is a fundamental process in reproduction and wound healing. Under these condition, neovascularization is tightly regulated. Unregulated angiogenesis may lead to several angiogenic diseases, and is thought to be indispensible for solid tumor growth and metastsis. The construction of new vascular network is a multistep cascade involving basement membrane degradation, endothelial cell proliferation, endothelial cell migration, and tube formation. Newly reported anti-angiogenic agents in oriental medical field have targeted both specific and multistep stages in the angiogenic process. From recent approach in oriental medical field with several herb medicines including activating blood flow and removing blood stasis medicine(活血化瘀藥), it may be possible in the future to develope specific anti-angiogenic agents that offer a less toxic potential therapy for cancer and angiogenic disease.

• The Journal of Korean Medicine
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• v.30 no.2
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• pp.145-151
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• 2009

Objectives: The purpose of this study was to investigate distribution of pattern identification by age in stroke patients. Methods: From 1 April, 2007 to 29 September, 2008, 903 patients within a month after onset of stroke were included. Stroke patients were interviewed by oriental medicine doctors who used standard operation procedures for this study. A questionnaire was completed by a question-and-answer form between patients and doctors after explanation of details to patients and patients' agreement given. Results: Distributions of pattern identification in stroke patients differed by age groups. Dampness-Phlegm pattern was more common in the younger group aged under 80 years, while Yin-Deficiency pattern was more common in the older group aged over 80 years. Conclusions: In this study, we found a character of distribution of pattern identification by age in stroke patients within one month after stroke onset. We have concluded that these differences should be considered in the management and treatment of stroke patients.

• Journal of Pharmacopuncture
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• v.9 no.1
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• pp.59-67
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• 2006

Objectives : This study planed to evaluate effect of oriental medicine therapy treatment method of dyspnea that happen from cancer of the pancreas patient who accompany Multiple metasis Methods : Patient complained dyspnoea during admission into dept. Of internal medicine, college of oriental medicine, Dong-eui Univ, was appealed patient treated by Oriental medicine therapy that is of use Herb Medication and Herbal -acupuncture Treatment being diagnosed in lung asthenia including deficiency of Eum and insufficiency of Gi of the lung(肺虛), the fire due to deficiency(虛火), and loving warfare of symptoms evaluated through VAS (visual analog scales). Results & Conclusion : Patient's difficulty in breathing symptoms took a favorable turn after treatment. This study means that Oriental medicine therapy that is difficulty in breathing symptoms that happen from patient surely has effectiveness.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.13 no.1
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• pp.47-54
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• 2007

Cough is not only serves to maintain normal function of respiratory tract, but also many diseases may lead to this symptom. In Korean medicine, Zhudanxi(朱丹溪), was the first to classify cough according to the different stages of time. In this research, I investigated the stage of Nocturnal Cough(夜嗽) through 26 oriental medical books. As a result, deficiency of Yin(陰虛) was the most common causes of Nocturnal Cough and indigestion(食積) is the next. Liuweidihuang-tang(六味地黃湯) prescribed as the treatment for Yin Xu(陰虛) and Xeibaisan-jiawei(瀉白散加味) prescribed as the treatment for indigestion(食積).

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.3
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• pp.514-520
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• 2002

Paljinhangahm-dan is an Oriental herbal formulation for its ability to modulate cancer cell growth and survival. This research was performed to study the anti-cancer effects of Paljinhangahm-dan water extract(PHWE) in human pro myelocytic leukemia(HL-60) cells. After HL-60 cells were routinely cultured, tetrazolium-based colorimetric(MTT) assay was performed for cytotoxicity test. To explore the mechanism of cytotoxicity. I used several measures of apoptosis to determine whether this processes was involved in PHWE-induced cell death in HL-60 cells. In addition, the experiment was practised 1 H-NMR spectroscopy to examine molecular structure of PHWE. This study suggested that PHWE control cancer cell growth through of apoptosis with less cytotoxicity in normal cells.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1933-1937
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• 2004

Gastroesophageal reflux disease(GERD) refers to the varied clinical manifestations of reflux of stomach and duodenal contents into the esophagus and is preferable to the 'reflux esophagitis'. Clinical symptoms of reflux esophagitis are heartburn, dysphagia, blood loss, abdominal pain, nocturnal wheezing, coughing, hoarseness. We applied oriental medicines to patient who had reflux esophagitis. we treated them with herb-medication, acupuncture, moxa therapy and aroma therapy for about 2 months. During this period, we observed that symptoms had been improved.

• The Journal of Internal Korean Medicine
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• v.27 no.4
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• pp.1027-1034
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• 2006

Objectives: This study was to examine diagnosis of dyskinesia by criteria of oriental medicine and to evaluate the effect of oriental medical treatment on the symptoms. Methods: After the patient was treated with Yonggyedeunggyo-tang, the changes in dyskinetic symptoms were evaluated for treatment efficacy every hospital day. Results: The dyskinesia symptoms disappeared. Conclusions: Herbal medicine and Saam Acupuncture therapy is useful for the treatment of Hemiballism- Hemichorea-Orofacial dyskinesia patients.

• The Journal of Internal Korean Medicine
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• v.34 no.3
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• pp.240-255
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• 2013

Objectives : This study was performed to research trends in Korean medicine treatment of diabetes mellitus (DM). Methods : We reviewed 73 studies about diabetes mellitus, which had been published from 2008 to 2013. The article search was performed on the Korean institute of oriental medicine (KIOM) database. Results : 1. Patterns of study design were as follows : 14 review studies, 44 experimental studies, 7 clinical studies, 8 case reports. 2. From the 14 review studies, we noted that literature studies about definition, pathologic mechanism, treatment, pathologic pattern identification of DM and previous study analyses were done. 3. From the 44 experimental studies that are the most common type of DM studies, various Korean medicine treatments such as single medicinal herbs, herbal complexes, diets and pharmacopuncture were used. Anti-diabetic effects were demonstrated in most of the studies. 4. 7 clinical studies about acupuncture, electroacupuncture, herbal medicine, etc. were reported. 5. 8 cases about DM complications and comorbidities were reported. Clinical symptoms improved in all of studies, blood sugar level decreased in four studies. Conclusions : Further clinical and case study based on experimental researches should be performed.

• Journal of Korean Medical classics
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• v.21 no.4
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• pp.161-177
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• 2008

The oriental medicine is not static knowledge. Since the publication of "Hwangjenaegyeong(黃帝內經)", it has unceasingly changed and developed, that changes and developments ate the reflex of culture and civil progression, and they also are active acceptance of the time's demand. when we look back into the history of the Oriental medicine, angle of understanding disease can be classified into two concepts ; internal-external and Eumyang. Internal-external is whether we find the source of disease internal or external. Eumyang is deciding which is more important between yin-essence and yang-gi which are components of the essence-gi of body. This thesis view course of development of theory of the oriental medicine since publication of "Hwangjenaegyeong(黃帝內經)" at certain point of internal-external and Eumyang and with those as background, will inquire into sameness and difference between the Korean medicine and the Chinese medicine, and provide an advanced course for the oriental medicine.

• The Journal of Internal Korean Medicine
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• v.25 no.4
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• pp.177-185
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• 2004

This study was designed to analyze the effectiveness of the diagnosis and treatments of hemorrhagic infarction patients in oriental medicine. In this study the clinical symptoms of two hemorrhagic infarction patients improved after diagnosis and treatment of oriental medicine. Though improvement was seen after diagnosis and treatment of both hemorrhagic infarction patients, the early stage of hemorrhagic infarction required western fluid therapy treatments. Study of more cases will be needed in order to varify efficacy for these oriental treatments to be generally applied.