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The Effect of Paljinhangahm-dan on Human Promyelocytic Leukemia Cells(HL-60) Death  

Lee Gun Up (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Moon Seok Jae (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Moon Goo (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Won Jin Hee (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Kim Dong Woung (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Kim Hyung Kuen (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Moon Young Ho (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Lee Jong Bum (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Yoon Jun Chul (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Kim Hong Joon (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.3, 2002 , pp. 514-520 More about this Journal
Abstract
Paljinhangahm-dan is an Oriental herbal formulation for its ability to modulate cancer cell growth and survival. This research was performed to study the anti-cancer effects of Paljinhangahm-dan water extract(PHWE) in human pro myelocytic leukemia(HL-60) cells. After HL-60 cells were routinely cultured, tetrazolium-based colorimetric(MTT) assay was performed for cytotoxicity test. To explore the mechanism of cytotoxicity. I used several measures of apoptosis to determine whether this processes was involved in PHWE-induced cell death in HL-60 cells. In addition, the experiment was practised 1 H-NMR spectroscopy to examine molecular structure of PHWE. This study suggested that PHWE control cancer cell growth through of apoptosis with less cytotoxicity in normal cells.
Keywords
Paljinhangahm-dan(人珍抗癌丹); anti-cancer effects; apoptosis; HL-60;
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