Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

The Effect of Paljinhangahm-dan on Human Promyelocytic Leukemia Cells(HL-60) Death

인진항암단의 인간 전골수성 백혈병 세포 사멸 효과

  • Lee Gun Up (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University) ;
  • Moon Seok Jae (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University) ;
  • Moon Goo (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University) ;
  • Won Jin Hee (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University) ;
  • Kim Dong Woung (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University) ;
  • Kim Hyung Kuen (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University) ;
  • Moon Young Ho (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University) ;
  • Lee Jong Bum (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University) ;
  • Yoon Jun Chul (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University) ;
  • Kim Hong Joon (Department of Internal Medicine, College of Oriental Medicine. Wonkwang University)
  • 이건업 (원광대학교 한의과대학 내과학교실) ;
  • 문석재 (원광대학교 한의과대학 내과학교실) ;
  • 문구원 (광대학교 한의과대학 내과학교실) ;
  • 원진희 (원광대학교 한의과대학 내과학교실) ;
  • 김동웅 (원광대학교 한의과대학 내과학교실) ;
  • 김형균 (원광대학교 한의과대학 내과학교실) ;
  • 문영호 (원광대학교 한의과대학 내과학교실) ;
  • 이종범 (원광대학교 한의과대학 내과학교실) ;
  • 윤준철 (원광대학교 한의과대학 내과학교실) ;
  • 김흥준 (원광대학교 한의과대학 내과학교실)
  • Published : 2002.06.01
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Abstract

Paljinhangahm-dan is an Oriental herbal formulation for its ability to modulate cancer cell growth and survival. This research was performed to study the anti-cancer effects of Paljinhangahm-dan water extract(PHWE) in human pro myelocytic leukemia(HL-60) cells. After HL-60 cells were routinely cultured, tetrazolium-based colorimetric(MTT) assay was performed for cytotoxicity test. To explore the mechanism of cytotoxicity. I used several measures of apoptosis to determine whether this processes was involved in PHWE-induced cell death in HL-60 cells. In addition, the experiment was practised 1 H-NMR spectroscopy to examine molecular structure of PHWE. This study suggested that PHWE control cancer cell growth through of apoptosis with less cytotoxicity in normal cells.

Keywords

References

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