• IMMUNE NETWORK
• /
• v.2 no.1
• /
• pp.25-34
• /
• 2002

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia and joint destruction. The synovial fibroblasts express cell adhesion molecules and have a role in adhesive interation with inflammatory cells in synovial tissue. It has been suggested that hypoxic conditioins are thought to exist in arthritic joints, and several studies indicate that reactive oxygen species (ROS) produced in hypoxic condition can initiate events that lead to pro-adhesive changes via increased expression of adhesion molecules. So, this study wsa designed to examine whether antioxidant can inhibit hypoxia-induced expression of ICAM-1 in cultured human synovial fibroblasts. Methods: Synovial fibroblasts were isolated from synovial tissue in patients with RA and cultured at hypoxic condition. Antioxidant, PDTC (pyrrolidine dithiocarbamate) were pre-treated for an hour before the hypoxic culture and synovial fibroblasts were harvested at 0, 6, 12, 24, 48 hours time points. Cell surface ICAM-1 expression in synovial fibroblasts was examined by the flow cytometric analysis. To analyse the expression of ICAM-1 mRNA, reverse-transcriptase polymerase chain reaction (RT-PCR) was performed. The levels of cytokines in culture supernatants were measured by ELISA, and activation of NF-${\kappa}B$ was analysed by electrophoretic mobility shift assay. The adhesive reaction between synovial fibroblasts and lymphocytes was assayed by measurement of fluorescent intensity of BCECF-AM in lymphocytes. Results: Hypoxic stimuli up-regulated the ICAM-1 expression as well as the adhesive interaction of human synvial fibroblasts to lymphocytes in a time-dependent manner, and PDTC inhibited hpyoxia-induced ICAM-1 expression and cell-cell interaction. PDTC also inhibited the hypoxia-induced activation of intracellular transcription factor, NF-${\kappa}B$. PDTC decreased the amount of hypoxia-induced production of IL-$1{\beta}$ and TNF-${\alpha}$. Conclusion: These studies demonstrate that PDTC inhibit the hypoxia-induced expression of the adhesion molecule, ICAM-1 and activation of NF-${\kappa}B$ in cultured human synovial fibroblasts.

• Journal of Acupuncture Research
• /
• v.29 no.3
• /
• pp.55-65
• /
• 2012

Objectives : The purpose of this study was find out the therapeutic effects of Ulmus davidiana Planch pharmacopuncture(UPP) on the mice with collagen-induced rheumatoid arthritis. Methods : UPP was prepared and tested for therapeutic potential of rhematoid arthritis by measuring the inhibition of cyc1ooxgenase-2(COX-2) and phospholipase A2(PLA2) activities in mice. Results : UPP showed therapeutic effects on collagen-induced rheumatoid arthritis on week 8 and week 9. UPP also inhibited Freund's complete adjuvant induced chronic rheumatoid arthritis in mice. UPP showed significant inhibition of type I and type II PLA2 activities in a dose dependent manner. However, PGE2 Production was not decreased with UPP and lipopolysaccharide-induced COX-2 protein expression was not inhibited by UPP. Conclusions : These results suggest that UPP has an therapeutic effects on drug induced-rheumatoic arthritis by inhibiting PLA2 activity.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.22 no.6
• /
• pp.565-572
• /
• 2009

This work intends to establish the reliability and fracture toughness $K_{IC}$ criterion of welded joints by EGW for high strength EH36-TMCP ultra thick plate. For this, firstly thermo elasto-plastic analysis has been carried out on two pass X-groove butt joint model to clarify the thermal and mechanical behaviour(residual stress, plastic strain, magnitude of stress and their distribution and production mechanism). Moreover, to establish fracture criterion, analysis of fracture toughness $K_{IC}$ has been performed under the notch machined and residual stress with the load condition on EGW welded joints. A quantitative fracture criterion for EGW welded joints is suggested by using $K_{IC}$.

• Korean Journal of Materials Research
• /
• v.19 no.12
• /
• pp.692-698
• /
• 2009

Inconel 718 alloy has excellent mechanical properties at room temperature, high temperature and cryogenic conditions. UTS of base metal is about 900MPa at room temperature; this is increased up to 1300MPa after heat treatment & aging-hardening. Mechanical properties of Inconel 718 Alloy were similar to those shown in the the results for tensile test; mechanical properties of Inconel 718 alloy's GTAW were similar to those of base metal's properties at room temperature. Mechanical properties at cryogenic conditions were better than those at room temperature. Heat-treated Inconel 718, non- filler metal GTAW on Inconel 718 and GTAW used filler metal on Inconel 718's UTS was 1400MPa at cryogenic condition. As a result, the excellent mechanical properties of Inconel 718 alloy under cryogenic conditions was proved through tensile tests under cryogenic conditions. In addition, weldability of Inconel 718 alloy under cryogenic conditions was superior to that of its base-metal. In this case, UTS of hybrid joint (IS-G) at -100$^{\circ}C$ was 900MPa. Consequently, UTS of Inconel 718 alloy is estimated to increase from -100$^{\circ}C$ to a specific temperature below -100$^{\circ}C$. Therefore, Inconel 718 alloy is considered a pertinent material for the production of Lox Pipe under cryogenic conditions.

• Korean Journal of Plant Resources
• /
• v.21 no.4
• /
• pp.336-340
• /
• 2008

Corilagin (CRN) isolated from Euphorbia helioscopia as rheumatoid arthritis drug. CRN was medicated to the abdominal cavity of collagen induced arthritis (CIA) mice that was an animal model for rheumatoid arthritis and its effects on incidence and arthritis index were studied. The results were as folllows; It was exhibited that medicating corilagin inhibited the infiltration of activated T lymphocytes into an inflammatory joint. The production of IgG and IgM that were RF (rheumatoid factor) and inflammatory cytokine, IL-6 and $TNF-{\alpha}$were reduced. After measuring $IFN-{\gamma}$and IL-4, it was found that it was shifted into Th2 immune response as increasing in IL-4. After liver function test, studies on liver poisoning of AST/ALT should be continued.

• Convergence Security Journal
• /
• v.11 no.5
• /
• pp.41-51
• /
• 2011

The objective of this study is to generally check the present situation of private security industry by analyzing the current situation of private security industry in Korea so as to find which policy base is reflected to amend law by analyzing the amendment process of private security law in order to suggest policy direction of private security industry in Korea. Viewing through amendment process of private security law, enhancing publicity and enterprise are not judged to form any definite policy base. They are merely interpreted to partially reflect enterprise under the strong base of publicity. Such policy base may cause overall stagnation of private security industry. For sound development of private security industry, it is required to get out of the existing policy direction so as to change policy base to the direction of enhancing enterprise of private security industry. The power of police for instruction and supervision should be largely transferred to Korea Security Association so as to cultivate autonomous purifying function of private security industry. Police should strive to develop policy in the level of joint production of security service.

• Journal of The Korea Institute of Healthcare Architecture
• /
• v.12 no.1
• /
• pp.49-59
• /
• 2006

According to the increase of demand for human organs such as kidney, heart, pancreas, joint, and cornea for therapeutic transplantation, the production of alternative organs based on Gnotobiotic Pigs gains a lot of concerns all over the world. However, it is not common to design and build Gnotobiotic Pigs' facility, and there are only a few those facilities and planning principles for them. Considering the situation above, this paper tries to develop planning guidelines for space organization and circulation system of standardized Germ Free Pig's facility on the bases of case analysis. The results of this study are as follows. At first, four swine farms including a Gntobiotic Pig's facility has been analysed from the point of space organization and circulation system. Secondly, the space zoning of Gnotobiotic Pigs' facility has been proposed into 5 groups : pigs' area, adminstration area, operating room and laboratory, service area, and mechanical area. Space components of each group have been presented also. Finally, circulation system of Gnotobiotic Pigs' facility has been explored from a operational point of view. This, also, includes human circulation, pig's circulation, and goods' circulation. This study has some limitations because it does not consider the SOPs(standard operational policies) of that facility to the fullest measure and does not suggest space area of each part, either. Despite of some weaknesses, it is expected that this study can give some useful guidelines for the design and planning of Germ Free Pigs' facilities.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 1998.10a
• /
• pp.336-352
• /
• 1998

The horticultural seed industry has made great progress in the last fifty years of its history after the independence of this country. The industry has accomplished self-sufficiency in major vegetable seeds and has even gained international competitive edge in certain crop seeds, particularly in hybrid cultivar development. However, the industry is facing a crisis at present coming from excessive competition among the domestic seed companies as well as the foreign currency crisis of the country. Several major seed companies have already been acquired by multinational corporations. Many people in the country as well as agriculturists are concerned about this situation. Although it is true that the industry is undergoing hard times, this crisis can be turned into a chance for making new progress depending on the joint efforts of the groups responsible, i.e., private companies, public institutions, and policy makers. Therefore, we have to turn this crisis into an opportunity for self-reform and progress. We should not be discouraged or give up. We Propose some ideas for the Progress of the seed industry. Public institutions and policy makers should do such things in cooperation as 1) training human resources for future breeders, 2) securing a wide range of genetic resources and improvement of the management system, 3) basic science research including biotechnology, 4) releasing breeding stocks from germplasm enhancement through use of exotic accessions, 5) support for breeding region- or use-specific cultivars, and 6) collection of foreign agricultural information for breeding cultivars for overseas markets. Eventually the responsible group for the final development of commercial cultivars, production, sales and management is private companies. Therefore, private companies also should have to do their best to develop competitive cultivars with a missionary spirit and endeavor for both domestic and overseas markets in cooperation with public institutions. Management based on competition, professionalism and rationalism is also urged. We are going to conclude with optimism that we can make a new vault of progress once the private and public sectors closely cooperate for the development of Korean horticultural seed industry by overcoming this crisis.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.26 no.7
• /
• pp.958-969
• /
• 2002

No one doubts that textile and apparel industries have contributed to economic miracles of the export-led growth in Korea. However, by the turning of 1990′s, these sectors have encountered many problems such as decreasing of domestic production and exports mainly due to wage rise and shortage. Therefore, foreign direct investment to the low labor cost countries has been enlarged for a way of improving its competitiveness and increasing exports. However, no intensive study has been made exploring current investments and future directions. This study focuses Vietnam as one of the promising overseas investment countries. The purposes of this study are to analyze current investment status of Korean textiles and apparel firms in Vietnam, to explore merits and problems Vietnam has, and to present useful implications and strategies for Korean textiles and apparel companies. Analysis of current secondary data suggests that Korean apparel industry, rather than textiles industry, have invested more in Vietnam, mostly in southern Ho Chi Minh City. Investments of Korean apparel and textile firms have shown steady increase from 1990 but have turned to a decrease from 1995. Findings suggested that Vietnam has merits for attracting foreign investment since it provides relatively cheap labor and outstanding skillful hands suitable for apparel and textiles industries. In addition, because of EU quota increase and the trade agreement between Vietnam and USA it is likely for firms in Vietnam to increase exports to EU and USA Rapid expansion of domestic apparel market and "Korean trend (Han Rue)" in Vietnam resulted from successful star marketing of Korean firms are another merits Vietnam has to the Korean fm. However, regulations of central government, low efficiency of bureaucratic and stiff administrative process, difficulty of making decision in case of joint venture, lack of social overhead capital, high factory construction costs, weak construction condition, and the excessive competition among investment enterprises have found to be problems. Based on pros and cons of investment to Vietnam, marketing strategies, practical implications and future directions were suggested.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.25 no.1
• /
• pp.47-61
• /
• 1997

This study was conducted to grasp the present condition of the name and the related text of the domestic laws (97 statutes, 1 examination, 1 guide, 3 ordinances, 1 leading case) in force which were connected with landscape plant and planting. Examining the general tree-planting system of America, the related foreign laws(1 constitution, 44 statutes, 31 ordinances, 6 leading cases) were arranged in the name and the text and classified by nations of regional groups and it was considered to the mutual relation with lots of laws which are scattered with the various laws. To examine the points at issue of the related domestic laws and to study the related foreign laws, the remedies for the domestic laws being at issue were proposed. That is : A change of the landscape planting concept, the introduction of the landscape planting cost compared with the total construction cost, the unification of the landscape planting ordinances as the unit of city, the clarification of the completion period for the depect of the replaced trees. putting the conservation and production of the top soil under an obligation the adoption of a licence system for the tree planting within the river area, the introduction of the allotment system for landscape architectural expenses, the encouragement of making a hedge, the settlement for the problems of the trees loss compensation, the necessity for the quality test to the landscape planting works, the intensification of the punitive rules to the illegal felling and planting of the trees in the greenzone area, the application of the Labor Standard Act to the landscape planting laborers. The laws relating to landscape plant and planting are prescribed dispersedly in the many other related laws and it is concluded to be impossible for the legislation of the singular law which is applied uniformly to the department of the tree-planting. Hereafter it should be required to analyze concretely in detail the each text of the related laws by means of the joint studies between the professional landscape architects and the lawyers.