• IMMUNE NETWORK
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• v.14 no.1
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• pp.45-53
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• 2014

Osteoarthritis (OA) is a degenerative joint disease characterized by a progressive loss of cartilage. And, increased oxidative stress plays a relevant role in the pathogenesis of OA. Ursodeoxycholic acid (UDCA) is a used drug for liver diseases known for its free radical-scavenging property. The objectives of this study were to investigate the in vivo effects of UDCA on pain severity and cartilage degeneration using an experimental OA model and to explore its mode of actions. OA was induced in rats by intra-articular injection of monosodium iodoacetate (MIA) to the knee. Oral administration UDCA was initiated on the day of MIA injection. Limb nociception was assessed by measuring the paw withdrawal latency and threshold. Samples were analyzed macroscopically and histologically. Immunohistochemistry was used to investigate the expression of interleukin-$1{\beta}$ (IL-$1{\beta}$), IL-6, nitrotyrosine and inducible nitric oxide synthase (iNOS) in knee joints. UDCA showed an antinociceptive property and attenuated cartilage degeneration. OA rats given oral UDCA significantly exhibited a decreased number of osteoclasts in subchondral bone legion compared with the vehicle-treated OA group. UDCA reduced the expression of IL-$1{\beta}$, IL-6, nitrotyrosine and iNOS in articular cartilage. UDCA treatment significantly attenuated the mRNA expression of matrix metalloproteinase-3 (MMP-3), -13, and ADAMTS5 in IL-$1{\beta}$-stimulated human OA chondrocytes. These results show the inhibitory effects of UDCA on pain production and cartilage degeneration in experimentally induced OA. The chondroprotective properties of UDCA were achieved by suppressing oxidative damage and inhibiting catabolic factors that are implicated in the pathogenesis of cartilage damage in OA.

• Journal of Korea Technology Innovation Society
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• v.14 no.4
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• pp.833-859
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• 2011

This study aims to draw the characteristics of the regional operation system of the shared research instrument service, which contributes to the R&D investment efficiency by the avoidance of duplicated research instrument investment and the enhancement of the network collaboration. So from the perspective of technology infrastructure policy and regional innovation system, Gyeonggi region of Korean metropolitan area has been analyzed for the case study. The case study has been conducted by 2 step process of within-case analysis and cross-case analysis. Firstly, the characteristics of operation system of the shared research instrument have been examined through various research methods. Secondly, in the cross-case analysis, the examined issues and problems have been organized by the matrix of 3 organizational governance characteristics and 4 issues to facilitate the regional policy approach. The issues deducted by the cross-case analysis have been deducted as (1) 'usage fee charge system', 'relevant method for the performance index and measurement of the instrument service management' for the regional policy led case, (2) 'performance management issue', 'financial and managerial accounting system for the instrument operating division', and 'change of budget support scheme' for the joint operation case and lastly (3) 'usage facilitation after the expiration of research lab support project' for the university led case.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.1
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• pp.59-69
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• 2018

In this paper, we present a robust beamforming design to tackle the weighted sum-rate maximization (WSRM) problem in a multicell multiple-input multiple-output (MIMO) - non-orthogonal multipleaccess (NOMA) downlink system for 5G wireless communications. This work consider the imperfectchannel state information (CSI) at the base station (BS) by adding uncertainties to channel estimation matrices as the worst-case model i.e., singular value uncertainty model (SVUM). With this observation, the WSRM problem is formulated subject to the transmit power constraints at the BS. The objective problem is known as on-deterministic polynomial (NP) problem which is difficult to solve. We propose an robust beam forming design which establishes on majorization minimization (MM) technique to find the optimal transmit beam forming matrix, as well as efficiently solve the objective problem. In addition, we also propose a joint user clustering and power allocation (JUCPA) algorithm in which the best user pair is selected as a cluster to attain a higher sum-rate. Extensive numerical results are provided to show that the proposed robust beamforming design together with the proposed JUCPA algorithm significantly increases the performance in term of sum-rate as compared with the existing NOMA schemes and the conventional orthogonal multiple access (OMA) scheme.

• Journal of the Microelectronics and Packaging Society
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• v.24 no.1
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• pp.45-50
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• 2017

We investigated effect of Zn content on shear strengh of Sn-0.7Cu-xZn and OSP surface finished solder joints. Five pastes of Sn-0.7Cu-xZn (x=0, 0.5, 1.0, 1.5, 2.0 wt.%) solders were fabricated by mixing of solder powder and flux using planatary mixer. $180{\mu}m$ diameter solder balls were formed on OSP surface finished Cu electrodes by screen print method, and the reflow process was performed. The shear strength was evaluated with two high shear speeds; 0.01 and 0.1 m/s. The thickness of the intermetallic compound(IMC) layer was decreased with increasing Zn content in Sn-0.7Cu-xZn solder. The highest shear strength was 3.47 N at the Zn content of 0.5 wt.%. As a whole, the shear strength at condition of 0.1 m/s was higher than that of 0.01 m/s because of impact stress. Fracture energies were calculated by F-x (Force-displacement) curve during high speed shear test and the tendency of fracture energy and that of shear strength were good agreement each other. Fracture took place within solder matrix at lower Zn content, and fracture occured near the interface of OSP surface finished Cu electrode and solder at higher Zn content.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.47 no.1
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• pp.128-138
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• 2010

In this paper, we propose a new bit assignment scheme for Wyner-Ziv video coding. Distributed video coding (DVC) is a new video coding paradigm which enables greatly low complexity encoding because it does not have any motion prediction module at encoder. Therefore, it is very well suited for many applications such as video communication, video surveillance, extremely low power consumption video coding, and other portable applications. Theoretically, the Wyner-Ziv video coding is proved to achieve the same rate-distortion (RD) performance comparable to that of the joint video coding. However, its RD performance has much gap compared to MC-DCT-based video coding such as H.264/AVC. Moreover, Transform Domain Wyner-Ziv (TDWZ) video coding which is a kind of DVC with transform module has difficulty of exact bit assignment because the entire image is treated as a same message. In this paper, we propose a feasible bit assignment algorithm using adaptive quantization matrix selection for the TDWZ video coding. The proposed method can calculate suitable bit amount for each region using the local characteristics of image. Simulation results show that the proposed method can enhance coding performance.

• Journal of Korean Society of Steel Construction
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• v.23 no.5
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• pp.535-546
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• 2011

In this paper, semi-rigid elasto-plastic post-buckling analysis of a space frame was performed using various explicit arc-length methods. Various explicit arc-length methodsand a large-deformation and small-strain elasto-plastic 3D space frame element with semi-rigid connections and plastic hinges were developed. This element can be appliedto both explicit and implicit numerical algorithms. In this study, the Dynamic Relaxation method was adopted in the predictor and corrector processesto formulate an explicit arc-length algorithm. The developed "explicit-predictor" or "explicit-corrector" were used in the elasto-plastic post-buckling analysis. The Eulerian equations for a beam-column with finite rotation, which considers the bowing effects, were adopted for the elastic system and extended to theinelastic system with a plastic hinge concept. The derived tangent stiffness matrix was asymmetrical due to the finite rotation. The joint connection elements were introduced for semi-rigidity using a static condensation technique. Semi-rigid elasto-plastic post-buckling analyses were carried out to demonstrate the potential of the developed explicit arc-length method and advanced space frame element in terms of accuracy and efficiency.

• The Journal of the Korean bone and joint tumor society
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• v.13 no.2
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• pp.88-95
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• 2007

Purpose: The purpose of this study was to compare the proapoptotic effects of matrix metal-loproteinase inhibitor (MMPI) and doxorubicin on wild-type p53 osteosarcoma cell line, socalled U2OS cell line. Materials and Methods: U2OS cells were treated with MMP inhibitor III (MMPI III) and doxorubicin, either respectively or simultaneously. In cells treated with doxorubicin, Fas-neutralizing antibody so called ZB4 was additionally treated to examine whether the doxorubicin played a role through the Fas/FasL pathway. Cells were analysed regarding to apoptosis and cell death by flow cytometry. Results: U2OS cells incubated with doxorubicin showed significant amount of cell death in dose-dependent manner. However, those incubated with MMPI III mostly remained viable state. In addition, there is no relationship between two drugs. Cells treated with doxorubicin and ZB4 at the same time did not show down regulation of apoptosis through inhibition of Fas/FasL pathway. Conclusion: It is important to re-examine MMP inhibitor's effect on other osteosarcoma cell line with wild-type p14 as well as wild-type p53 to evaluate its proapoptotic effect.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.3
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• pp.64-77
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• 2015

An effective method for produce munitions effectiveness data is to calculate weapon effectiveness indices in the US military's Joint Munitions Effectiveness Manuals (JMEM) and take advantage of the damage evaluation model (GFSM) and weapon Effectiveness Evaluation Model (Matrix Evaluator). However, a study about the Range Safety that can be applied in the live firing exercises is very insufficient in the case of ROK military. The Range Safety program is an element of the US Army Safety Program, and is the program responsible for developing policies and guidance to ensure the safe operation of live-fire ranges. The methodology of Weapon Danger Zone (WDZ) program is based on a combination of weapon modeling/simulation data and actual impact data. Also, each WDZ incorporates a probability distribution function which provides the information necessary to perform a quantitative risk assessment to evaluate the relative risk of an identified profile. A study of method to establish for K-Range Safety data is to develop manuals (pamphlet) will be a standard to ensure the effective and safe fire training at the ROK military education and training and environmental conditions. For example, WDZs are generated with the WDZ tool as part of the RMTK (Range Managers Tool Kit) package. The WDZ tool is a Geographic Information System-based application that is available to operational planners and range safety manager of Army and Marine Corps in both desktop and web-based versions. K-Range Safety Program based on US data is reflected in the Korean terrain by operating environments and training doctrine etc, and the range safety data are made. Thus, verification process on modified variables data is required. K-Range Safety rather than being produced by a single program, is an package safety activities and measures through weapon danger zone tool, SRP (The Sustainable Range Program), manuals, doctrine, terrain, climate, military defence M&S, weapon system development/operational test evaluation and analysis to continuously improving range safety zone. Distribution of this K-range safety pamphlet is available to Army users in electronic media only and is intended for the standing army and army reserve. Also publication and distribution to authorized users for marine corps commands are indicated in the table of allowances for publications. Therefore, this study proposes an efficient K-Range Safety Manual producing to calculate the danger zones that can be applied to the ROK military's live fire training by introducing of US Army weapons danger zone program and Range Safety Manual

• Journal of Veterinary Clinics
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• v.20 no.4
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• pp.443-448
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• 2003

To determine whether localization of tartrate-resistant acid phosphatase (TRAP) and cathepsin K was associated with rupture of the cranial cruciate ligament (CCL) in dogs. Tissue specimens were obtained from 30 dogs with CCL rupture during surgical treatment, 8 aged normal dogs, and 9 young normal dogs that were necropsied for reasons unrelated to this study and unrelated to musculoskeletal disease. The cranial cruciate ligament was examined histologically. $TRAP^+$ cells and cathepsin $K^+$ cells were identified by histochemical staining and immunohistochemical staining respectively. TRAP and cathepsin $K^+$ were co-localized within the same cells principally located within the epiligamentous region and to a lesser extent in the core region of ruptured CCL. Localization of $TRAP^+$ cells (P < 0.05) and cathepsin $K^+$ cells (P =0.05) within CCL tissue was significantly increased in dogs with CCL rupture, compared with aged-normal dogs, and young normal dogs (P < 0.05 - TRAP, P < 0.001 - cathepsin K). Localization of $TRAP^+$ cells and cathepsin $K^+$ cells within the CCL tissue of aged-normal dogs was also increased compared with young normal dogs (P < 0.05). Small numbers of $TRAP^+$ cells and cathepsin $K^+$ cells were seen in the intact ligaments of aged-normal dogs, which were associated with ligament fasicles in which there was chondroid transformation of ligament fibroblasts and disruption of the organized hierarchical structure of the extracellular matrix. $TRAP^+$ cells and cathepsin $K^+$ cells were not seen in CCL tissue from young-normal dogs. Localization of the proteinases $TRAP^+$ and cathepsin $K^+$ in CCL tissue was significantly associated with CCL rupture. Small numbers of proteinase positive cells were also localized in the CCL of agednormal dogs without CCL rupture, but were not detected in CCL from young-normal dogs. Taken together, these findings suggest that the cell signaling pathways that regulate expression of these proteinases in CCL tissue may form part of the mechanism that leads to upregulation of collagenolytic ligament remodeling and progressive structural failure of the CCL over time.

• Journal of Broadcast Engineering
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• v.26 no.3
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• pp.247-257
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• 2021

This paper proposes a new technique for calibrating a multi-view RGB-D camera using a 3D (dimensional) skeleton. In order to calibrate a multi-view camera, consistent feature points are required. In addition, it is necessary to acquire accurate feature points in order to obtain a high-accuracy calibration result. We use the human skeleton as a feature point to calibrate a multi-view camera. The human skeleton can be easily obtained using state-of-the-art pose estimation algorithms. We propose an RGB-D-based calibration algorithm that uses the joint coordinates of the 3D skeleton obtained through the posture estimation algorithm as a feature point. Since the human body information captured by the multi-view camera may be incomplete, the skeleton predicted based on the image information acquired through it may be incomplete. After efficiently integrating a large number of incomplete skeletons into one skeleton, multi-view cameras can be calibrated by using the integrated skeleton to obtain a camera transformation matrix. In order to increase the accuracy of the calibration, multiple skeletons are used for optimization through temporal iterations. We demonstrate through experiments that a multi-view camera can be calibrated using a large number of incomplete skeletons.