• 척추신경추나의학회지
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• 제6권1호
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• pp.121-127
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• 2011

Objectives : To introduce the Jeongham Therapy which means a mandibul-rectifying treatment. And to show meaningful changes of thoracic kypkosis and lumbar lordosis by the Jeongham Therapy. Methods : We reviewed 8 patients having abnormal thoracic kyphosis and lumbar lordosis who were treated at the JeongHam Korean Medical Clinic. We measured thoracic kyphosis and lumbar lordosis by 3D Body Analyzer 'IBS 2000'. Results : Between before and after the Jeongham Therapy, statically significant differences were found in the thoracic kyphosis and lumbar lordosis. And in these values of measurements, the thoracic kyphosis and lumbar lordosis diminish after the Jeongham Therapy. Conclusion : These results suggest that the Jeongham Therapy is a meaningful therapy to diminish the thoracic kyphosis and lumbar lordosis.

• 대한물리치료과학회지
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• 제27권1호
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• pp.51-55
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• 2020

Background: A typical plank exercise (PE) strengthens the core muscles, stabilizes the spinal column, and provides stability around the pelvis and trunk when the trunk is aligned. However, because PE require that the hip joint be kept straight, they can activate the hamstring (HAM). Excessive HAM activation can induce tightness, which may cause low back pain. Therefore, it is necessary to explore PE methods that can minimize HAM activity while maximizing core muscle activity. Design: Cross-sectional study. Methods: This study included 30 healthy adults as subjects. We measured the activity of the HAM and the erector spinae (ES), rectus abdominis (RA), and external oblique (EO) muscles using surface electromyography during three PEs (typical PE, PE with balance pad, and PE with sling). Results: The RA, EO, and ES showed the highest muscular activity during PE with balance pad and the lowest during PE with sling; however, the differences were not significant. The HAM showed lower activity during PE with sling than during the other two PEs; however, these differences were also not significant. Conclusion: Although HAM activation was not significantly difference among PE positions, we should recognize altering activation of core and hamstring muscle according to PE postures.

• 한국전문물리치료학회지
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• 제21권4호
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• pp.15-22
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• 2014

The purpose of this study was to determine the muscle activities of the erector spinae (ES), gluteus maximus (Gmax), gluteus medius (Gmed), and the hamstring (HAM) and the ratios of Gmax/ES, Gmax/HAM, and Gmed/HAM during the prone heel squeeze (PHS) with different knee flexion angles ($45^{\circ}$, $90^{\circ}$, and $135^{\circ}$). Fifteen young and healthy subjects (8 men, 7 women) were recruited for the study. Surface electromyography signals were collected on ES, Gmax, Gmed, and HAM during PHS. A separate one-way analysis of variance with repeated measures was used to determine the significance of the muscle activities of ES, Gmax, Gmed, and HAM and the ratios of Gmax/ES, Gmax/HAM, and Gmed/HAM with different knee flexion angles during PHS. There was a significant increase in the Gmax activity at the knee flexion of $90^{\circ}$ in comparison with that of the $45^{\circ}$ (p=.016). There were significant increases in the Gmed activity at the knee flexion of $90^{\circ}$ (p=.008) and $135^{\circ}$ (p=.006) in comparison with that of the $45^{\circ}$. There were significant decreases in the HAM activity at the knee flexion of $90^{\circ}$ (p=.009) and $135^{\circ}$ (p=.004) in comparison with that of the $45^{\circ}$. There were significant increases in the Gmax/HAM muscle activity ratio at the knee flexion of $90^{\circ}$ (p=.007) and $135^{\circ}$ (p=.012) in comparison with that of the $45^{\circ}$. There were significant increase in the Gmed/HAM muscle activity ratio at the knee flexion of $135^{\circ}$ in comparison with that of the $45^{\circ}$ (p=.008). The knee flexion of $90^{\circ}$ during PHS can induce decreasing activity of HAM and increasing activity of Gmax, and the knee flexion of $135^{\circ}$ during PHS can induce decreasing activity of HAM and increasing activity of Gmed. Hence, PHS with different knee flexion positions could be considered for the different target muscle.

• 한국전문물리치료학회지
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• 제21권3호
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• pp.38-44
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• 2014

The aim of this study was to investigate the effects of different postural correction in the electromyographic (EMG) activity of the trunk and hip muscles during bridging exercises. Twenty-four healthy subjects volunteered for this study. The muscle activity was recorded with surface electrodes over the erector spinae, multifidus, gluteus maximus (GM), and hamstring (Ham) muscles; it was measured by using surface EMG equipment under the following 3 experimental conditions: manual postural correction, verbal correction, and no correction. The maximal voluntary isometric contraction (MVIC) was determined for each muscle group in order to represent each exercise as a percentage of MVIC and allow for standardized comparison between subjects. A one-way analysis of variance was used to determine significant differences in the EMG activities of each muscle between the 3 experimental groups. During bridging exercises, the manual postural correction on normalized EMG activity of the GM muscle during manual guiding was significantly higher than during verbal guiding and without guiding (p<.05). Furthermore, the GM/Ham ratio was significantly higher during manual guiding than during verbal guiding and without guiding (p<.05). These findings suggest that the activities of the hip and trunk muscles may be favorably modified with manual guiding during bridging exercises.

• 대한물리치료과학회지
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• 제16권3호
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• pp.35-42
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• 2009

Background: The purpose of this study is to measure the amount of influence of taping and a whole body balance upon muscle strength, endurance, and flexibility. Experiments were conducted by two different groups, specially designed for this study. The choice of exercise methods for each group depends on its own idiosyncratic characteristics (or Each group employs its own idiosyncratic exercise method). Methods: The first group, with taping applied, undertook exercises three times a week; second group just took exercises three times a week. These experiments show the following outcomes. Results: The first group showed a considerable amount of difference in terms of muscle strength, endurance, and flexibility. Second group also showed similar outcome. Both the first group and the second group revealed a considerable difference. But the first group showed a bigger difference than the second group. Conclusion: Thus, the result of these experiments strongly indicates that exercise, with taping applied, turns out the most effective in promoting muscle strength, endurance, and flexibility.

• 한국임상약학회지
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• 제28권3호
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• pp.174-180
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• 2018

Objective: Clostridium difficile Infection (CDI) is one of the common nosocomial infections. As elderly population increases, the proper treatment has been emphasized. We investigated the risk factors associated with CDI unimprovement in elderly patients. Furthermore, we performed drug use evaluation of old CDI patients and oldest-old CDI patients. Methods: It was a retrospective study using electronic medical record at Kangbuk Samsung Medical Center (KBSMC) from January 2016 to December 2017. Seventy three patients aged 65 years or older, diagnosed with CDI by Clostridium difficile Toxin B Gene [Xpert] were screened and they were assessed for risk factors regarding unimprovement status. We also evaluated drug use evaluation in old patients ($65{\leq}age$<80) and oldest-old patients ($80{\leq}age$) by assessing the use of initial therapy, severity, dose, route, treatment course, days of use, total days of use and treatment outcome of initial therapy. Results: Out of 73 patients aged over 65 years, four patients were excluded because they did not receive any treatment. There were 31 improved patients and 38 unimproved patients after initial therapy. We were able to find out patients with surgical comorbidity or endocrine comorbidity (especially, diabetes mellitus) had 2.885 more risk of becoming unimproved than those patients without surgical comorbidity or endocrine comorbidity. Drug use evaluation for CDI was generally fair, but vancomycin as initial therapy is more recommended than metronidazole. Conclusion: Although age, antibiotics exposure, use of antacids are all important risk factors for CDI, our result did not show statistical significance for these risk factors. However, the study is meaningful because the number of elderly population keeps increasing and recently updated guideline suggests the use of vancomycin as drug of choice for CDI.

• 수면정신생리
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• 제25권2호
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• pp.58-67
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• 2018

목 적 : 본 연구는 과도한 감정노동에 노출되어 있는 여성 감정노동자들을 대상으로 해양자원을 활용한 심신치유 기법이 효과가 있는지 여부를 알아보는 예비 연구이다. 방 법 : 정상 참고치 이상의 감정노동에 노출되어 있는 신체건강한 여성 감정노동자 12명을 대상으로, 경남 고성 당항포 일대에서 해양자원을 이용한 심신치유 프로그램을 4박 5일간 시행하였다. 피험자들에게 프로그램에 참여하도록 한 뒤 사전, 사후, 추후의 평가를 바탕으로 수면, 기분, 인지기능 영역의 변화를 확인하기 위해 통계분석을 실시하였다. 결 과 : 프로그램에 참가한 뒤 피험자들의 수면의 질이 호전되고 수면 잠복기가 유의하게 감소하였고 우울, 긴장, 분노, 피로 등 기분상태의 호전을 보였으며, 인지기능 또한 향상되었다. 수면의 질, 우울기분을 비롯한 상기 효과는 한 달 반 뒤 실시한 추후 평가에서도 동일하게 확인되었다(PSQI t = 2.63, p = 0.02, HAM-D t = 5.92, p < 0.001). 결 론 : 해양자원을 활용한 심신치유 기법이 긴장을 이완하고 스트레스를 낮추는데 효과적일 수 있음을 시사하며, 이와 관련해 대조군을 포함한 추후연구 및 체계적인 프로그램 개발이 필요하다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권1호
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• pp.7-12
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• 2006

Telomerase activation is detected in most cancerous cells; hence, telomerase is a highly selective target for cancer therapy, which plays an important role in the apoptotic process. We have previously reported that the ginseng saponin metabolite, Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits cell proliferation by inducing apoptosis and cell cycle arrest at the $G_1$ phase. The present study investigated the regulation of telomerase activity in Compound K treated U937 cells. Compound K treatment caused a reduction in telomerase activity and down-regulated the human telomerase reverse transcriptase (hTERT) gene, resulting in the decreased expressions of its protein, and of the c-Myc and Spl proteins (transcription factors of hTERT). These results indicate that the anticancer activity of Compound K could be mediated by inhibition of the telomerase activity.

• 한국의학물리학회지:의학물리
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• 제23권3호
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• pp.199-208
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• 2012

전신에 대해 방사선에 민감한 주요장기가 미리 정의된 인체 전산팬텀(compuational human phantom)은 의료분야에서 방사선 치료에 의한 이차암 위험도 평가 및 진단방사선에 의한 유효선량 평가 등에 유용하게 활용될 수 있다. 본 연구에서는 한국인 여성사체에 대한 고해상도 연속절단면 컬러해부영상을 이용하여 장기 및 조직을 전신에 걸쳐 약 2 mm 간격으로 정밀하게 분할하였고, 이를 이용하여 몬테칼로 전산모사에 사용될 수 있는 VHK-Woman 복셀팬텀을 개발하였다. VKH-Woman 복셀팬텀은 키 160 cm, 몸무게 52.72 kg으로 한국인 여성의 표준체형에 가까우며, 유효선량을 계산할 수 있도록 ICRP 103에 제시된 27개 장기 및 기타 관심장기 12개를 포함한다. VKH-Woman의 복셀 해상도는 $1.976{\times}1.976{\times}2.0619mm^3$이며 복셀행렬의 크기는 $261{\times}109{\times}825$이고, 몬테칼로 코드에 입력하여 사용될 수 있도록 이진파일과 ASCII 파일 형식으로 데이터화되었다.

• Tuberculosis and Respiratory Diseases
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• 제49권3호
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• pp.298-309
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• 2000

연구배경 : 암 유전자치료에서 각광받고 있는 HSV-tk/GCV 전략의 항암효과에는 다음과 같은 장점들이 거론되고 있다 : 1) GCV 처리에 의한 암세포 직접살상효과 2) HSV-tk 이입된 세포에 의해서 HSV-tk 이입되지 않은 주변세포를 살상하는 bystander effect 3) 생체 내 bystander eff ect로 알려 진 anti-tumor immunity. Retrovirus와 adenovirus sequence를 이용할 경우 몇몇 세포주와 마우스에서 이들이 목적유전자의 발현을 억제할 수 있다는 것이 보고되고 있다. 본 연구에서는 retroviral나 adenoviral vector로 HSV-tk 유전자를 이입한 Lewis 폐암세포주와 폐암 마우스 모델을 통하여 HSV-tk/GCV 전략의 장점을 조사하였고 이 viral vector들 사이의 차이를 비교 조사하였다. 또한 Lewis 폐암세포주에서 butyrate를 처리한 후 HSV-tk 유전자의 발현증가를 관찰하였다. 방법 : Lewis retroviral vector와 adenoviral vector로 HSV-tk 유전자를 이입한 후 butyrate로 HSV-tk 유전자의 발현을 유도하고 Western blotting수행하여 분석하였다. 생체 외에서 HSV-tk/GCV에 의한 세포살상효과를 MTT 검사로 수행하였고 생체 내에서 LLC 나 HSV-tk 이입된 LLC 세포주를 이식하여 종양소멸 및 bystander effect를 조사 하였다. 결과 : 1. Butyrate로 HSV-tk adenovirus로 이입된 LLC에서 증가한 반면 retrovirus로 이입된 LLC에서는 증가하지 않았다. 2. 생체 외 그리고 생체 내에서 viral vector로 HSV-tk를 이입한 종양세포에 GCV 투여하는 것은 종양 세포의 살상에 효과적이었으며 LLC와 LLC-tk 세포주를 혼합한 실험에서 bystander effect도 종양세포의 성장을 억제하는 것으로 관찰되었다. 결론 : 향후 생체 외 그리고 생체 내 실험에서 adenoviral vector를 이용한 유전자 전달에 butyrate를 함께 사용하면 유전자발현을 증진시킬 것으로 사료되며 자살 유전자인 HSV-tk을 종양에 이입하여 GCV을 처리 하는 치료가 폐암유전자치료에 효과가 있을 것으로 생각된다.