• Journal of Internet Computing and Services
• /
• v.4 no.3
• /
• pp.15-22
• /
• 2003

Many information storage systems, such as database system, were needed to integrate much informations into one system and to provide mare voluminous lump of informations. But as the size of information system becomes larger, the responded result size of existing keyword based searching system might be too large and couldn't do the exact search which the user intends to. In this study, we proposed a paper searching method which uses RDF semantic. For this, we analyzed the structural forms of the tit1e of research papers and reconstructed them into RDF/XML. When we use these RDF descriptions of the titles to search papers, we could get more precise and accurate results than keyword based searching method.

• BMB Reports
• /
• v.42 no.7
• /
• pp.450-455
• /
• 2009

The "stage albinism line of winter wheat" FA85 was a specific natural mutant strain on leaf color. This physiological mutation was controlled by cytogene. In order to reveal the genetic and biochemical mechanism of albinism, 2-DE was used to investigate the difference of chloroplast protein expression pattern between FA85 and its parent wheat Aibian 1. From the results of 2-DE gels analysis, approximately 683 spots were detected on each gel, and 57 spots were expressed differently at least two-fold. Using MALDI-TOF/TOF MS, 14 of 57 spots were identified, which could be categorized into four classes: carbon metabolism, energy metabolism, defense/stress response and signal transduction. Compared with the parent wheat, the expression of ATPase-$\gamma$ and GP1-$\alpha$ was up-regulated in FA85, and of other proteins was down-regulated. Together, we concluded that the expression of chloroplast proteins had changed obviously in FA85, which might be related to the leaf color mutant.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
• /
• 2001.06a
• /
• pp.1172-1172
• /
• 2001

Compact Near Infrared Diode Array Spectrometers offer new possibilities for on line quality assurance in the agricultural sector. Due to their speed and complete robustness towards temperature fluctuations and mechanical shock Diode Array Spectrometers are suitable for the use on Agricultural Harvest Machines. The growing consumer consciousness of food quality in combination with falling manufacturing prices demands procedures for an effective quality control system. The various conventional types of NIR instruments which have so far been used in laboratories are unsuitable for mobile applications under the rough conditions of field cropping not only because of their slow speed of measurement but also because of their shock sensitive filter wheels and monochromators necessary for fractionating polychromatic light. Another advantage of the on line use is the reduction of the sampling error because of the continuously measurement of the whole product. Considering the large economic importance of the dry matter content on agricultural products it is of particular advantage that water belongs to those constituents which are most easily assessed in the near infrared. While other constituents of economic importance such as starch, oil and protein in grains and seeds have a much lesser effect on NIR signals, their contents can nonetheless be assessed with high analytical precision on freshly harvested grains and seeds. In the last years several applications for on line quality assessment on harvesting machines were developed and tested. The talk will give an overview and outlook on existing and future possibilities of this new field of NIR applications.

• Proceedings of the Korean Operations and Management Science Society Conference
• /
• 2005.05a
• /
• pp.1-9
• /
• 2005

Today, according to tremendous development of B2B e-commerce, B2B e-marketplaces which accomplish various types of transactions through a number of buyers and sellers on online are embossed importantly. However, buyers are unable to search correct products because of inconsistency of product information between buyers and sellers. This paper solved this problem as semantic web technology. Semantic Web is an extension of current Web in which information is given well-defined meaning, better enabling computers and people to work in cooperation. The Semantic Web aims at machine-processable information. Its underlying technologies are RDF, RDF Schema, and ontology as the shared formal conceptualization of particular domains. In this paper, we present an implementation of Semantic Web enabled search system for B2B E-Marketplace domains. The system exploits OWL as the standard ontology language proposed by W3C and the Jena which is a Semantic Web toolkit, namely a Java framework writing Semantic Web applications. Finally, we summarize our experiences and discuss future research topics.

• Journal of the Institute of Electronics Engineers of Korea CI
• /
• v.47 no.4
• /
• pp.96-101
• /
• 2010

The core study of semantic web is the efficiency of ontology parsing. The ontology parsing and inference is based on the significant information retrieval which is the ultimate purpose of semantic web. However, most existing ontology writing tools were not processing the efficient ontology parsing. Therefore, we design the two steps ontology parser for extracting the all facts, are included in the ontology, more fast in this study. In the first step, the token extractor collects the all tokens of ontology and the triple extractor extracts the statements in the collected tokens. In conclusion, we confirm that which is designed in this study, processes the ontology parsing more faster than the existing ontology parsers.

• Advances in concrete construction
• /
• v.6 no.1
• /
• pp.47-68
• /
• 2018

This article reports the utilization of fly ash (FA) waste product from industry and silpozz which is an agro-waste from agriculture as an environmental friendly material in construction industry. The evaluation of strength and durability study was observed using FA and silpozz as a partial replacement of Ordinary Portland Cement (OPC). The studied parameters are compressive strength, flexural strength, split tensile strength and bond strength as well as the durability study involves the acid soluble chloride (ASC), water soluble chloride (WSC), water absorption and sorptivity. Scanning electron microscopy (SEM) and XRD of selected samples are also done. It reveals from the test results that the deterioration factor (DF) in compressive strength is 4% at 365 days. The DF of split tensile strength and flexural strength is 0.96% and 0.6% at 90 days respectively. The minimum slip is 1mm and 1.1mm after 28 days of testing bond strength for NWC and SWC sample respectively. The percentage decrease in bond strength is 10.35% for 28 days SWC samples. The pre-cast blended concrete samples performed better to chloride diffusion. Modulus of elasticity of SWC samples are also studied.The water absorption and sorptivity tests are conducted after 28 days of curing.

• Proceedings of the Korean Information Science Society Conference
• /
• 2007.10c
• /
• pp.17-22
• /
• 2007

이 논문에서는 관계형 데이터베이스 모델 기반의 OWL 웹 온톨로지 모델을 보이고 이에 대한 실험 및 비교 평가 결과에 대하여 기술한다. OWL은 W3C에 의해 2004년 12월에 권고안으로 채택된 이후에 많은 연구가 진행되고 있다. 편집 도구 개발, 저장소 개발로 OWL 기반의 추론 엔진까지 이와 관련된 다양한 연구가 진행 중이다. 특히 OWL 온톨로지의 영구적인 저장 및 관리를 위해 관계형 데이터베이스 모델을 이용한 많은 연구 결과들이 발표되고 있다. 이 논문에서는 널리 알려진 관계형 모델 기반의 저장소 보다 나은 성능을 제공하기 위해 제안한 모델에 대한 평가 결과에 대하여 기술한다. 기존 유사 연구의 경우, 비교 평가를 위한 평가 항목으로 온톨로지 로드 시간을 고려하기도 하지만 이 논문에서는 질의응답 시간에만 초점을 둔다. 이는 매우 특수한 상황을 제외한 대부분의 상황에서 질의 처리 시간이 가장 중요한 요소이며 실질적인 활용성 측면에서 핵심적으로 다루어야 하는 평가 항목이기 때문이다. 실험을 위한 데이터로서는 많은 연구에서 활용하고 있는 LUBM 데이터 셋을 이용하며 실험 대상으로는 오픈 소스이며 널리 알려진 시스템인 Jena의 저장소와 Sesame를 이용한다. 실험 및 비교 평가 결과, 제안 시스템이 비교 대상 시스템들에 비해 나은 성능을 보임을 알 수 있다.

• Genomics & Informatics
• /
• v.12 no.4
• /
• pp.276-282
• /
• 2014

The disease tuberculosis, caused by Mycobacterium tuberculosis (MTB), remains a major cause of morbidity and mortality in developing countries. The evolution of drug-resistant tuberculosis causes a foremost threat to global health. Most drug-resistant MTB clinical strains are showing resistance to isoniazid and rifampicin (RIF), the frontline anti-tuberculosis drugs. Mutation in rpoB, the beta subunit of DNA-directed RNA polymerase of MTB, is reported to be a major cause of RIF resistance. Amongst mutations in the well-defined 81-base-pair central region of the rpoB gene, mutation at codon 450 (S450L) and 445 (H445Y) is mainly associated with RIF resistance. In this study, we modeled two resistant mutants of rpoB (S450L and H445Y) using Modeller9v10 and performed a docking analysis with RIF using AutoDock4.2 and compared the docking results of these mutants with the wild-type rpoB. The docking results revealed that RIF more effectively inhibited the wild-type rpoB with low binding energy than rpoB mutants. The rpoB mutants interacted with RIF with positive binding energy, revealing the incapableness of RIF inhibition and thus showing resistance. Subsequently, this was verified by molecular dynamics simulations. This in silico evidence may help us understand RIF resistance in rpoB mutant strains.

• Genomics & Informatics
• /
• v.12 no.2
• /
• pp.64-70
• /
• 2014

Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The life-threatening infection caused by HPV demands the need for designing anticancerous drugs. In the recent years, different compounds from natural origins, such as carrageenan, curcumin, epigallocatechin gallate, indole-3-carbinol, jaceosidin, and withaferin, have been used as a hopeful source of anticancer therapy. These compounds have been shown to suppress HPV infection by different researchers. In the present study, we explored these natural inhibitors against E6 oncoprotein of high-risk HPV-16, which is known to inactivate the p53 tumor suppressor protein. A robust homology model of HPV-16 E6 was built to anticipate the interaction mechanism of E6 oncoprotein with natural inhibitory molecules using a structure-based drug designing approach. Docking analysis showed the interaction of these natural compounds with the p53-binding site of E6 protein residues 113-122 (CQKPLCPEEK) and helped the restoration of p53 functioning. Docking analysis, besides helping in silico validation of natural compounds, also helps understand molecular mechanisms of protein-ligand interactions.

• Genomics & Informatics
• /
• v.13 no.2
• /
• pp.60-67
• /
• 2015

The leading cause of cancer mortality globally amongst the women is due to human papillomavirus (HPV) infection. There is need to explore anti-cancerous drugs against this life-threatening infection. Traditionally, different natural compounds such as withaferin A, artemisinin, ursolic acid, ferulic acid, (-)-epigallocatechin-3-gallate, berberin, resveratrol, jaceosidin, curcumin, gingerol, indol-3-carbinol, and silymarin have been used as hopeful source of cancer treatment. These natural inhibitors have been shown to block HPV infection by different researchers. In the present study, we explored these natural compounds against E6 oncoprotein of high risk HPV18, which is known to inactivate tumor suppressor p53 protein. E6, a high throughput protein model of HPV18, was predicted to anticipate the interaction mechanism of E6 oncoprotein with these natural inhibitors using structure-based drug designing approach. Docking analysis showed the interaction of these natural inhibitors with p53 binding site of E6 protein residues 108-117 (CQKPLNPAEK) and help reinstatement of normal p53 functioning. Further, docking analysis besides helping in silico validations of natural compounds also helped elucidating the molecular mechanism of inhibition of HPV oncoproteins.