• Toxicological Research
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• 제6권2호
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• pp.167-182
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• 1990

Dietary restriction (caloric restriction) is the only intervention which has been reliably shown to extend the maximum life span of warm-blooded animals and delay the many phenomena associated with aging. It is also one of the most effective modulators of toxicity, especially cancer endpoints. In spite of the known modulator effects of caloric restriction, the biological mechanisms responsible for these effects had not been in vestigated until recently. The National Center for Toxicological Research (NCTR), in a collaborative effort with the National Institute of Aging (NIA), initiated a project whereby nine (9) combinations of rodent species/strains and diets were fed both restricted and ad libitum. The NIA's initiative was to identify biomarkers of aging whereas NCTR's initiative was to identify the biological effects associated with the profound effects caloric restriction has in protecting against both spontaneous (age-related) and chemically-induced toxic endpoints. Independent of sex or species, caloric restriction has similar effects on body temperature, oxygen consumption and $CO_2$production. Caloric restriction also decreased lipid glycolysis and metabolism in rats and mice, which suggest decreased production of metabolites which could lead to fatty acid epoxide formation. The age-associated loss of ciradian regulation of intermediate enzymes is also significantly reduced. Moreover, caloric restriction reduced the age-associated feminization of sexually dimorphic liver isozymes, increased several glucocorticoid responsive isozymes, elevated glucagon/insulin ratios, produced less microsomal superoxide and enhanced the capacity for utilzing detoxicating metabolic pathways. Calorically restricted rats have less than half the number of aflatoxin ($AFB_1$)-DNA adducts than ad libitum animals and urinary excretion of $AFB_1$ was increased significantly. Finally, DNA repair mechanisms are enhanced and oncogene expression is decreased in calorically restricted animals.

• Bulletin of the Korean Chemical Society
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• 제10권2호
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• pp.201-202
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• 1989

• 대한핵의학회지
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• 제31권4호
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• pp.459-463
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• 1997

핵의학적 유방영상법은 오랜동안 시범되어 왔지만 임상에서 큰 역할을 못했고, 근래에 핵의약품과 핵의학기기 사용방법의 발전으로 scintimammogram(SM)이 다시 각광을 받게 되었다. 유방암 진단에 대한 핵의학영상법의 특이도와 예민도가 방사선 유방촬영법보다 높다고 보고되었으나 1cm보다 작은 유방암은 SM에 용이하게 발견되지 않는다. 본 보고에서는 1cm보다 작은 유방암이 발견된 두 증례를 발표한다. 한증례는 $^{99m}Tc$ MDP를 수술전 골영상을 위해서 사용하였고, 두 번째 증례는 비촉지 유방종괴를 $^{99m}Tc$ MIBI로 유방촬영 하였다.

• Clinics in Shoulder and Elbow
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• 제27권1호
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• pp.26-31
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• 2024

Background: The coracoacromial ligament (CAL) is frequently observed to be damaged during arthroscopy and it is unclear how demographic, anatomic, and radiographic factors are related to CAL degeneration in full-thickness rotator cuff tears. Methods: A prospective study was conducted of patients at a single institution undergoing shoulder arthroscopy for first-time, full-thickness rotator cuff tears. We evaluated preoperative anteroposterior radiographs to obtain critical shoulder angle, glenoid inclination, acromial index, acromiohumeral distance, lateral acromial angle, and acromial morphology. We documented CAL quality, rotator cuff tear size and pattern during arthroscopy. Multiple logistic regression was used to identify predictive factors for encountering severe CAL fraying during arthroscopy. Results: Shoulders had mild CAL degeneration in 58.1% of cases, whereas severe CAL degeneration was present in 41.9% of shoulders. Patients with severe CAL attrition were significantly older (62.0 years vs. 58.0 years, P=0.042). Shoulders with severe CAL attrition had large rotator cuff tears in 54.1% of cases (P<0.001), and tears involving the infraspinatus (63.2% vs. 29.6%, P=0.003). The severe degeneration group was more likely to have a larger critical shoulder angle measurement on preoperative radiographs than those in the mild attrition group (36.1°±3.6° [range, 30°-45°] vs. 34.1°±3.8° [range, 26°-45°], P=0.037). Conclusions: While the clinical impact of CAL degeneration remains uncertain, increased severity of CAL degeneration is associated with older age, larger rotator cuff tear size, presence of infraspinatus tearing, and increased preoperative critical shoulder angle. Level of evidence: III.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1987년도 제26차 춘계학술대회
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• pp.119.1-119.1
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• 1987

• 한국조경학회지
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• 제40권1호
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• pp.69-80
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• 2012

대체로 정원은 인간의 자연과 문화에 대한 생각, 그리고 그 둘 간의 영향관계로 설명되어 왔다(Francis and Hester, 1990). 이 글은 정원을 인간의 꿈과 이상이 구축된 표상으로 간주하고 그 구체적인 면모를 토마스 제퍼슨의 정원을 사례로 하여 고찰해 보려고 한 것이다. 정치가로서의 면모가 더 많이 알려져 있는 토머스 제퍼슨은 직접 여러 정원을 설계하여 조성한 후 몸소 가꾼 정원가이기도 하였다. 그가 직접 설계하고 완성시킨 몬티첼로, 아카데미컬 빌리지, 포플러 포레스트 등에는 그의 국가적 이념으로서 자유와 민주주의, 중농주의 등의 이념적 가치와 함께, 전원에 대한 지향 그리고 고등교육에 대한 이상이 숨김없이 표상되어 있다. 정치가이자 신생국의 선각자로서의 이상과 함께 그의 개인적인 꿈과 신념이 공간적으로 표출되어 있는 것이다. 추구하고자 하는 상징적 의미를 은유적으로 표현하거나 그것을 공간적 도식으로 재현함으로써 제퍼슨의 이상은 자신은 물론 그 곳을 찾는 이들에게 재음미되고 공유되어졌다고 할 수가 있다. 그런 점에서 제퍼슨에게 있어서 정원은 이념과 이상을 공간적으로 드러낼 수 있는 무대였다고 할 수가 있다.

• Clinics in Shoulder and Elbow
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• 제27권1호
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• pp.39-44
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• 2024

Background: Displaced olecranon fractures constitute a challenging problem for elbow surgeons. The purpose of this study is to evaluate the role of suture anchor fixation for treating patients with displaced olecranon fractures. Methods: A retrospective review was performed for all consecutive patients with displaced olecranon fractures treated with suture anchor fixation with at least 2 years of clinical follow-up. Surgical repair was performed acutely in all cases with nonmetallic suture anchors in a double-row configuration utilizing suture augmentation via the triceps tendon. Osseous union and perioperative complications were uniformly assessed. Results: Suture anchor fixation was performed on 17 patients with displaced olecranon fractures. Functional outcome scores were collected from 12 patients (70.6%). The mean age at the time of surgery was 65.6 years, and the mean follow-up was 5.6 years. Sixteen of 17 patients (94%) achieved osseous union in an acceptable position. No hardware-related complications or fixation failure occurred. Mean postoperative shortened disabilities of the arm, shoulder, and hand (QuickDASH) score was 3.8±6.9, and mean Oxford Elbow Score was 47.5±1.0, with nine patients (75%) achieving a perfect score. Conclusions: Suture anchor fixation of displaced olecranon fractures resulted in excellent midterm functional outcomes. Additionally, this technique resulted in high rates of osseous union without any hardware-related complications or fixation failures.

• Journal of Korean Neurosurgical Society
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• 제38권2호
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• pp.89-95
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• 2005

Objective : The purpose of this study is to analyze aneurysm morphology and define limitations and feasibility in endovascular Gugliemi detachable coil[GDC] embolization for anterior communicating artery [ACoA] aneurysms. Methods : From January 2000 through October 2003, 123patients were treated with endovascular coil embolization for ACoA aneurysms. There were 75women and 48men, with a mean age of 63years. All ruptured aneurysms were treated within 15days of rupture. Aneurysm morphology was classified according to neck size and projection of aneurysm dome as follows-A : neck of aneurysm <4mm & anterior projection, B : neck of aneurysm [4mm & anterior projection, C : neck of aneurysm<4mm & posterior [superior] projection, D : neck of aneurysm [4mm & posterior [superior] projection, E : neck of aneurysm<4mm & inferior projection, and F : neck of aneurysm [4mm & inferior projection. Endovascular procedures were categorized as either "successful" or "unsuccessful". Clinical follow-up was estimated at discharge and at 6months, post treatment results were classified according to Glasgow Outcome Scale[GOS]. Results : Successful embolization for ACoA was performed in 86patients of 123patients [69.9%]. Complete or near complete aneurysm occlusion was observed in 102patients [82.9%]; a neck remnant was observed in 6patients [4.9%]; partial embolization was done in 3patients [2.4%]; and embolization was attempted in 12patients [9.8%]. Among 55patients with follow-up angiographic results, 18patients [32.7%] were defined as recanalization of the aneurysm sac. Morphological analysis demonstrated that anterior projecting aneurysms and morphological classifications [morphological classifications worsens [A - D] chances of successful coil occlusion significantly decrease] were major factors in successful embolization, and, inferiorly projecting and wide neck [${\ge}4mm$] aneurysms are highly related to recanalization of aneurysms. Conclusion : Endovascular coil embolization of ACoA aneurysms shows good outcome in our study. Nevertheless, there is a limitation in the endovascular approach to ACoA, even though advanced modern techniques evolve rapidly. Compensatory surgical approach with the endovascular approach is required for successful treatment of ACoA aneurysms.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1986년도 제25차 춘계학술대회
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• pp.124.1-124.1
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• 1986

• 융합정보논문지
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• 제9권11호
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• pp.180-188
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• 2019

본 연구의 목적은 윌리엄 포크너의 작품 세계를 관통하는 남부 신화에 대한 재고라는 측면에서 그 신화의 실체 혹은 신화라는 허상에 대한 주제의식을 가지고 타자에 대한 폭력, 혹은 작가로서의 고뇌를 다 아우를 수 있는 공통점을 찾고자한다. 특히 "팔월의 빛"에 나타난 제퍼슨 사회가 미셸 푸코가 말한 판옵티콘 메커니즘과 평행을 이루며 타자에 대한 폭력을 정당화하는 과정을 살펴본다. 푸코는 인간 본성의 기저에 깔려있는 감시와 처벌의 담론을 문학 작품의 장으로 옮겨 적용할 수 있는 메커니즘을 제공하고 있다. 이를 통하여 남부신화를 구성하는 감옥의 체계와 법체계를 초월하는 린치의 문제까지 한 사회가 저지르는 집단적인 반도덕적 행위에 대한 고발은 작가로서의 그의 양심과 도덕성에 대한 고뇌의 산물인 점을 파악한다.