Toxicological Research
- Volume 6 Issue 2
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- Pages.167-182
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- 1990
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
MODULATION OF TOXICITY AND CARCINOGENESIS BY CALORIC RESTRICTION
- Allaben, William T. (National Center for Toxicological Research Jefferson) ;
- Chou, Ming W. (National Center for Toxicological Research Jefferson) ;
- Pegram, Rex A. (National Center for Toxicological Research Jefferson) ;
- Leakey, Julian (National Center for Toxicological Research Jefferson) ;
- Feuers, Ritchie J. (National Center for Toxicological Research Jefferson) ;
- Duffy, Peter H. (National Center for Toxicological Research Jefferson) ;
- Turturro, Angelo (National Center for Toxicological Research Jefferson) ;
- Hart, Ronald W. (National Center for Toxicological Research Jefferson)
- Published : 1990.12.01
Abstract
Dietary restriction (caloric restriction) is the only intervention which has been reliably shown to extend the maximum life span of warm-blooded animals and delay the many phenomena associated with aging. It is also one of the most effective modulators of toxicity, especially cancer endpoints. In spite of the known modulator effects of caloric restriction, the biological mechanisms responsible for these effects had not been in vestigated until recently. The National Center for Toxicological Research (NCTR), in a collaborative effort with the National Institute of Aging (NIA), initiated a project whereby nine (9) combinations of rodent species/strains and diets were fed both restricted and ad libitum. The NIA's initiative was to identify biomarkers of aging whereas NCTR's initiative was to identify the biological effects associated with the profound effects caloric restriction has in protecting against both spontaneous (age-related) and chemically-induced toxic endpoints. Independent of sex or species, caloric restriction has similar effects on body temperature, oxygen consumption and
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