• Journal of Pharmacopuncture
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• v.15 no.3
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• pp.19-30
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• 2012

Objectives: Many efforts have shown multi-oncologic roles of galectin-3 for cell proliferation, angiogenesis, and apoptosis. However, the mechanisms by which galectin-3 is involved in cell proliferation are not yet fully understood, especially in human colon cancer cells. Methods: To cluster genes showing positively or negatively correlated expression with galectin-3, we employed human colon cancer cell lines, SNU-61, SNU-81, SNU-769B, SNU-C4 and SNU-C5 in high-throughput gene expression profiling. Gene and protein expression levels were determined by using real-time quantitative polymerase chain reaction (PCR) and western blot analysis, respectively. The proliferation rate of human colon cancer cells was measured by using a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results: Expression of ${\gamma}$-aminobutyric acid B receptor 1 (GABABR1) showed a positive correlation with galectin-3 at both the transcriptional and the translational levels. Down-regulation of galectin-3 decreased not only GABABR1 expression but also the proliferation rate of human colon cancer cells. However, Korean herbal extract, HangAmDan-B (HAD-B), decreased expression of GABABR1 without any expressional change of galectin-3, and offset ${\gamma}$-aminobutyric acid (GABA)-enhanced human colon cancer cell proliferation. Conclusions: Our present study confirmed that GABABR1 expression was regulated by galectin-3. HAD-B induced galectin-3-independent down-regulation of GABABR1, which resulted in a decreased proliferation of human colon cancer cells. The therapeutic effect of HAD-B for the treatment of human colon cancer needs to be further validated.

• Journal of the Korean Society of Costume
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• v.57 no.9
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• pp.1-15
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• 2007

The purpose of this study is to classify the types of and to examine the characteristics of the golden decoration technique used for expressing patterns on the costumes from Dang dynasty to Cheong dynasty era. In order to classify the types of the golden decoration technique and to examine its characteristics, literature review, focusing on documents and records of China, and investigation on the relics from Dang to Cheong Dynasty era were conducted. The types of decoration technique using gold include china JigGeum (brocade technique), InGeum (attaching gold powder and flake technique), GeumSaJaSu (embroidery technique), GeumSaTapestry, mixed technique. Interestingly, it was newly found in this study that embroidery with golden thread was used in the GeumSaTapestry technique and that there were some cases of the mixture of 2-3 gold decoration technique. The GeumSajaSu technique was used the most frequently from Dang dynasty to Yo dynasty era. However, its use had decreased enormously while the use of JigGeum had increased a lot since Geum dynasty era. The mixture of 2-5 techniques was used frequently in JigGeum, GeumSaJaSu, and GeumSaTapestry, but not used in InGeum. Particularly, the mixture technique was the most frequently used in the GeumSaTapestry, which expresses by composition of paintings. All four methods were used the mostly frequently in costumes, while GeumSaJaSu and GeumSaTapestry were generally used for home accessories. InGeum and GeumSaJaSu were used a lot for gaze and leno fabrics such as Sa or Ra, while JigGeum was mostly used for satin weaved fabrics like Dan.

• The Journal of Korean Medical History
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• v.16 no.1
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• pp.3-16
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• 2003

In researches done previously, the characteristics of the Hyangyak medicine in the early period of Chosun shown in "HyangyakBoncho(鄕藥本草)" in Vol. 76-85 of "Hyangyakjipseongbang(鄕藥集成方)" and "Sanghan section(傷寒門)" in Vol. 5-8 of "Hyangyakjipseongbang(鄕藥集成方)" was investigated. "Cough section(咳嗽門)" in "Various Diseases volume" of "Dongeuibogam(東醫寶鑑 雜病篇)" Vol. 5 and "Various Coughs section(諸咳門)" of "Hyangyakjipseongbang(鄕藥集成方)" Vol 24-25 which is a paragraph related to "Sanghan section(傷寒門)" was compared. The variety of the Hyangyak, processing methods and forms of the Hyangyak were shown by comparing each oriental medical botany(本草) used for treating cough(咳嗽) in "Dongeuibogam(東醫寶鑑)". Subsequently, the difference between each structure and medical theory was speculated. The facts revealed in this research is as follows. First, [Various Coughs section(諸咳門)] of "Hyangyakjipseongbang(鄕藥集成方)" uses only the Hyangyak, and no foreign medicines were used for treating cough(咳嗽) in "Dongeuibogam(東醫寶鑑)". Second, in [Various Coughs section(諸咳門)] of "Hyangyakjipseongbang(鄕藥集成方)", medicines related to diet and medicines taken raw were widely used, and various forms of medicine such as extracts, plasters, and gruels were used. Third, like other medical books in earlier periods, [Various Coughs section(諸咳門)] of "Hyangyakjipseongbang(鄕藥集成方)" describes the medical theory with conciseness, and keeps the structure of symptom classification focused on treatment and prescription. Fourth, as [Hyangyakboncho(鄕藥本草)] extensively uses the knowledge of oriental medical botany(本草) from two of Four Masters of GeumWon(金 元); JangWonSo(張元素) and LeeDongWon(李東垣), "Various Coughs section(諸咳門)" of "Hyangyakjipseongbang(鄕藥集成方)" quotes the books of JuDanGae but does not adopt the theory and prescriptions of 'replenishing yin and downbearing fire (滋陰降火)'. To find a more descriptive picture of the Hyangyak medicine for the treatment of 'cough(咳嗽)', a comparatitive study between the books written in the same period -"Euibangyuchui(醫方類聚)" and books compilated in China should be done, and there should be more profound researches done on individual medicines and prescriptions.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.7 no.1
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• pp.15-34
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• 1994

This is a literature Study on ophthalmologic disease remedies of the four famous physicians in Jin Yuan period. The results were as follows: 1. Yu Wan So regarded the cause of ophthalmologic disease as the wind and heat(風熱), the blood deficiency(血少), or the deficiency of vital function and essence ,of the kidney(腎氣虛). For each treatment he used the method to remove wind and heat(除風散熱), the tranquillizing and tonifying method to nourish the heart and to relieve mental strain due to dificiency of vital essence(養血安神). the method to nourish Yin in the kidney(補腎水). The important nature of the these medicines is bitter and cold. 2. Jang Jong Jeung regarded the cause of ophthalmologic disease as the blood excess(血太過). or the blood deficiency(血不及). or the fire and heat(火熱). For each treatment he used the method to extract blood(出血療法). the method to nourish the liver and the kidney(補肝腎療法). or the method of vomiting and diarrhea(吐不法). The medicines are usuallly classified into external treatment medicines(外用藥). medicines to disintegrate mass(破積聚藥). purgating medicines(攻下藥). 3. Lee Dong Won regarded the cause of ophthalmologic disease as the spleen and the stomach weakness(脾胃虛弱), excessive fire in the heart(心火太盛). For each treatment he used the method to tranquillize the spleen and the stomach (調理脾胃). the tranquillizing and tonifying method to nourish the heart and to relieve mental strain due to deficiency of vital essence(養血安神). 4. Ju Dan Gye regarded the cause of ophthalmologic disease as the wind and heat(風熱). the blood deficiency(血少). the mental exhaustion(神勞). the kidney weakness(腎弱). For each treatment he used the method to remove wind and heat(除風散熱), the method to nourish blood and yin water(養血補水), the method to relieve mental strain and to remove spiritual heat(安腎瀉神火). the method to nourish yin water(養陰水). These drugs are usually classified into the medicines to remove endogenous heat(淸熱藥). the medicines to nourish yin(補陰藥).

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.7 no.1
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• pp.53-84
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• 1994

The study has been carried out to investigate of the Allergic Rhinitis by referring to 87 literatures. The results were as follows; 1. In oriental medical science, Allergic Rhinitis is belong to the category of the 'BiGu'(鼻구) 'GuChe'(구체). The 'Gu'(구) of the BiGu means watery rhinorrhea, the 'Che'(체) of the GuChe means sneezing. 2. The cause of a disease summarize the weak of Lung, Spleen and Kidney, and invasion into the nasal cavity of PoongHan etc a wrong air. Sometimes the pathologial change appear PoongHan changeHwa(風寒化火), HwaYeol is hidden in the inside(火熱內伏). The contributing factors are found a season(spring, winter), an abnormal weather(運氣 : 少陰 少陽 陽明 司天, 歲金不及), an emotional stress, an external wound of the harmful air, a food allergens and fatigue, a contact of substances, a sunlight etc. 3. Predominant symptoms are watery rhinorrhea, sneezing and nasal obstruction. Sometimes accompanic symptoms are nasal bleeding, mucopurulent rhinorrhea, olfactory disturbance, nasal polyp, rhinolalia clausa, respiratory disfunction etc. 4. The treatment-methodes is as follows, OnBoPaeJang GeoPoongSanHan(溫補肺臟 祛風散寒), GeonBilkGi(健脾益氣), BoSinNabGi (補腎納氣). The treatmentherbs is as follows, OnBoJiLuDan GaGam(溫補止流丹 加減), OkByeongPoongSan plus ChangIJaSan GaGam(玉屛風散合 蒼耳子散 加減), BoJungIkGiTang GaGam plus SoCheongLyongTang(補中益氣湯加減 配合 小靑龍湯), SinGiHwan GaGam(腎氣丸加減), GaeJiTang(桂枝湯) etc. 5. The external treatment is as follows, JeokBi(滴鼻), ChuiBi(吹鼻), SaekBi(塞鼻), stick and herbs-injection on the acupuncture-point, pressure ear acupuncture-point, herbs-pillow etc. 6. The acupuncture-moxa treatment is as follows, the methodes of cure apply TongJoGyeongGi(通調經氣), SanTongBiGui(宣通鼻竅) etc. Predominent acupuncture-points are YoungHyang(迎香), InDang(印堂), BiTong(鼻通), SangSeong(上星), HabGok(合谷) and so on. As mentioned above, from now on, it's need to the oriental medical scientific study of the Immunity and Allergy and to the external treatment's application for the ascent of the treatment-effect of the allergic disease.

• Herbal Formula Science
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• v.19 no.2
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• pp.39-46
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• 2011

Objectives : The BangPungTongSungSan(BPTSS) has been used as a therapeutic agent for cerebrovascular disease, cerebral hemorrhage, hypertension, diabetes and obesity in oriental medicine. The present study designed to investigate the effect of BPTSS on behavioral change and neuronal activation induced by acute methamphetamine(METH, 2 mg/kg, i.p.) in C57BL/6 mice. Methods : Mice received the oral administration of BPTTS(25, 50 and 100 mg/kg) 1 h prior to saline or METH administration. Locomotor activity was measured for 90 min using videotractking method and c-Fos expression, as marker of neuronal activation, was identified in a separate groups of mice by immunohistochemistry. Results and conclusions : Methamphetamine injection significantly increased locomotor activity and c-Fos expression in the nucleus accumbens and striatum. Interestingly, BPTTS(100 mg/kg) significantly suppressed locomotor activity and c-Fos expression in the nucleus accumbens and striatum by acute exposure to METH. These results suggest that BangPungTongSungSan may be effective in suppressing the reinforcing effect of methamphetamine by modulation neuronal activity.

• Journal of Food Hygiene and Safety
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• v.24 no.1
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• pp.27-37
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• 2009

In an effort to evaluate the currents in pesticide residues, 3,020 agricultural products were tested by multiresidue method with 260 pesticides, obtained from the circulation market of in the Gangbuk province in 2007.20.4%(616/3020) of the products were determined to contain pesticides residues, but only 4.1%(124/3020) of these were deemed to be unsuitable by the korea Food Code. Unsuitably products were spinach(21.0%), perilla leaf(17.3%), ulgari(13.6%), leek(12.4%), crowndaisy(12.4%), asterscaber(12.4%), chard(11.1%). Detected pesticides were procymidone(3.9%), endosulfan(2.6%), chlorfenapyr(2.2%), bifenthrin(1.3%), cypermethrin(0.7%), metalaxyl(0.9%), azoxystrobin(0.3%) and chlorothalonil(0.7%). Sixty-four pesticides were detected and 11 pesticides were newly detected in 2007. Thirty-one pesticides in agricultural products exceeded their MRLs.

• Journal of Korean Medical classics
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• v.28 no.2
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• pp.147-162
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• 2015

Objectives : The purpose of this study is to investigate splenic constipation syndrome(脾約證) in Shanghanlun by comparing 179 & 247 provisions. Methods : Including Shanghanlun, several texts which contain Cheng Wu-ji, Wan Mi-zhai, Qian Huang, Zhu Gong, Fang You-zhi, Yu Jia-yan, Zhang Lu, Cheng Ying-mao, Zhang Xi-ju, Chen Xiu-yuan, Wu Qian, Xu Ling-tai, You Zai-jing, Zhu Dan-xi's opinion about the splenic constipation syndrome were chosen and comparative consideration was carried out. Results & Conclusions : The following conclusions could be drawn. 247 provisions in Shanghanlun is different from 179 provisions because the beginning of the each splenic constipation syndrome is different. The difference between 179 & 247 provisions are proved by comparing Mild Purgative Decoction which is used Taiyangyangming splenic constipation syndrome and Fructus Cannabis Pill which is used Dorsal pedal pulse splenic constipation syndrome. Cheng Wu-ji's opinion that 179 & 247 provisions is different is meaningful because he is first investigated the different beginning of the splenic constipation syndrome. Several annotator's opinion which oppose Cheng Wu-ji is majority and they set a high value on Jangbu(臟腑) factor. Several annotator's opinion which agree Cheng Wu-ji is minority and they set a high value on splenic constipation syndrome also begins from Taiyangbing. The concept of overlapping of Taiyangyangming is different from the concept of Taiyangyangming. Consequently 179 & 247 provisions has to be distinguished.

• Journal of Sasang Constitutional Medicine
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• v.21 no.2
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• pp.96-106
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• 2009

1. Objectives : The aim of this study was to survey the ordinary symptoms of TE type(Tae-eumin) and to compare the tendency of their symptoms according to the Exterior- or Interior- disease. 2. Methods : We recruited 659 TE type(Tae-eumin)-subjects in multi-oriental hospitals and researched their ordinary symptoms. Subjects were diagnosed by the Sasang Constitutional specialists in oriental hospitals, and had remarkable improvement in the chief complains after Sasang Constitutional Medication. Subjects were divided two groups. One group had the Exterior-cold disease and they took the prescription for the Exerior-cold disease(such as Taeumjowi-tang, Jowiseungcheong-tang, Nocyongdaebo-tang etc.). The other group had the Interior-febrile disease and they took the prescription for the Interior-febrile disease(such as Galgunhaegui-tang, Yeoldahanso-tang, Cheongsimyeonja-tang, Gongjinhugwon-dan etc.). All subjects answered the questionnaire about their symptoms. We found the differences of answers using the Chi-square test between-group comparisons. We analyzed using SPSS 12.0 for Korean. 3. Results and Conclusions : In symptoms, Quantity of meal(p=.009), Perspiration of head and face(p=.001), Aspect of Excrement(p=.027), Presence of pain after excrement(p=.001), Frequency of urination at night(p=.003), Clarity of urine(p=.041), Sleep during the day(p=.049), Warm or cold feeling on abdomen(p=.007), etc. are different according to the Exterior- or Interior- disease. We found the differences of symptoms between not only the constitutional types but also the types of disease.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.2 no.1
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• pp.65-82
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• 2007

This aim of study is to offer three way(the E-commerce operations site, electronic catalog site, the E- commerce function improvement, the off-line E-biz revitalization) for E-commerce revitalization of business incubator center's resident enterprise through interview with business incubator center's resident enterprise, business incubator center's manager and the operation company of the COBIAN as E-commerce site of business incubator center. Solutions presented by business incubator center are considered from various angles to improve law perception in the COBIAN and to exchange contact information among BI companies in the COBIAN. And The solution emphasize an efficiency as well as an absolute investment to present the solutions that are able to do better important function as business incubator center than any other. furthermore, a business incubator center presents solutions for solving problems with small and medium enterprises as well as the COBIAN, which is doing E-commerce operation.