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http://dx.doi.org/10.14374/HFS.2011.19.2.039

Effect of BangPungTongSungSan(BPTSS, 防風通聖散) on acute methamphetamine-induced locomotor activity and c-Fos expression in mice  

Shin, Ji-Seob (College of Oriental Medicine, Dae-Gu Haany University)
Jang, Eun-Young (College of Oriental Medicine, Dae-Gu Haany University)
Kim, Dan-Hyo (College of Oriental Medicine, Dae-Gu Haany University)
Kim, Sang-Chan (College of Oriental Medicine, Dae-Gu Haany University)
Kim, Kwang-Joong (College of Oriental Medicine, Dae-Gu Haany University)
Yang, Chae-Ha (College of Oriental Medicine, Dae-Gu Haany University)
Publication Information
Herbal Formula Science / v.19, no.2, 2011 , pp. 39-46 More about this Journal
Abstract
Objectives : The BangPungTongSungSan(BPTSS) has been used as a therapeutic agent for cerebrovascular disease, cerebral hemorrhage, hypertension, diabetes and obesity in oriental medicine. The present study designed to investigate the effect of BPTSS on behavioral change and neuronal activation induced by acute methamphetamine(METH, 2 mg/kg, i.p.) in C57BL/6 mice. Methods : Mice received the oral administration of BPTTS(25, 50 and 100 mg/kg) 1 h prior to saline or METH administration. Locomotor activity was measured for 90 min using videotractking method and c-Fos expression, as marker of neuronal activation, was identified in a separate groups of mice by immunohistochemistry. Results and conclusions : Methamphetamine injection significantly increased locomotor activity and c-Fos expression in the nucleus accumbens and striatum. Interestingly, BPTTS(100 mg/kg) significantly suppressed locomotor activity and c-Fos expression in the nucleus accumbens and striatum by acute exposure to METH. These results suggest that BangPungTongSungSan may be effective in suppressing the reinforcing effect of methamphetamine by modulation neuronal activity.
Keywords
BangPungTongSeongSan; methamphetamine; locomotor activity; c-Fos;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 防風通聖散이 肥滿수준白鼠의 體重 및 脂質代謝에 미치는 影響. 경희의학. 1993;9(1):69-82.
2 이장천. 加味防風通星散이 고지방식이 급여 흰쥐의 체지질구성과 항산화능에 미치는 영향. 대한본초학회지. 2005;20(2):69-75.
3 Hendrickson RG, Horowitz BZ, Norton RL, NOtenboom H. "Prarchuting"meth: a novel delivery method for methamphetamine and delayed-onset toxicity from "body stuffing". Clin Toxicol(Phila). 2006;44:379-82.   DOI   ScienceOn
4 Richards JR, Johnson EB, Stark RW, Derlet RW:Methamphetamine abuse and rhabdomyolysis in the ED: a 5-year study. AM J Emerg MEd. 1999;17:681-5.   DOI   ScienceOn
5 Richards JR, Derlet RW, Duncan DDR: Chemical restraint for the agitated patient in the emergency department:lorazepam versus droperidol. J Emerg Med. 1998;16:567-73.   DOI
6 Dismukes K. Mulder AH. Effects of neuroleptics on release of 3H-dopamine from slices of rat corpus striatum. Naunyn Schmiedebergs Arcb Pharmacol. 1997;297(1):23-9.
7 Kreek MJ. Opiates, opioid and addiction. Mol Psychiatry. 1996;1(3):76-82.
8 Nestler EJ. Molecular basis of long-term plasticity underlying addition. Nat Rev Neurosci. 2001;2(2):119-28.   DOI
9 Koob GF, SannaPP, Bloom FE. Neuroscience of addiction. Neuron. 1998;21:467-76.   DOI   ScienceOn
10 Jang EY, Hwang M, Yoon SS, Lee JR, Kim KJ, Kim HC, Yang CH. Liquiritigenin decreases selective molecular and behavioral effects of cocaine in rodents. Curr Neuropharmacol. 2011;9(1):30-4.   DOI   ScienceOn
11 Kim KW, Kim HW, Li J, Kwon YB. Effect of bee venom acupuncture on methamphetamine-induced hyperactivity, hyperthermia and Fos expression in mice. Brain REs Bull. 2011;84(1): 61-8.   DOI   ScienceOn
12 Murray JB. Psychophysiological aspects of amphetamine-methamphetamine abuse. J Psychol. 1998;132:227-37.   DOI   ScienceOn
13 조은석, 김광준. 마약류 확산실태와 21세기 마약류통제정책의 방향. 한국형사정책연구원 연구보고서. 2001
14 Chung H, Park M, Hahn E, Choi H, Lim H. Recent trends of drug abuse and drug-associated deaths in Korea. Ann NY Acad Sci. 2004;1025:458-64.   DOI   ScienceOn
15 Nakajima A, Yamada K, He J, Zeng N, Nitta A, Nabeshima T. Anatomical substrates for the discriminative stimulus effects of methamphetamine in rats. J Neurochem. 2004;91(2):308-17.   DOI   ScienceOn
16 http://www.drugfree.or.kr
17 Barr AM, Panenka WJ, MacEwan GW, Thornton AE, Lang DJ, Honer WG, Lecomte T. The need for speed: an update on methamphetamine addiction. J Psychiatry Neurosci. 2006;31(5):301-13
18 Nora D.Volkow METHAMPHETAMINE Abuse and Addiction, NIH Publication Number 06-4210, 1988.
19 Zombeck JA, Lewicki AD, Patel K, Gupta T, Rhodes JS. Patterns of neural activity associated with differential acute locomotor stimulation to cocaine and methamphetamine in adolescent versus adult male C57BL/6J mice. Neuroscience. 2010;165(4):1087-99.   DOI   ScienceOn
20 Merchant KM, Hanson GR, Dorsa DM. Induction of neurotensin and c-fos mRNA in distinct subregions of rat neostriatum after acute methamphetamine: comparison with acute haloperidol effects. J Pharmacol Exp Ther. 1994;269(2):806-12.
21 Kim KW, Kim HW, Li J, Kwon YB. Effect of bee venom acupuncture on methamphetamine-induced hyperactivity, hyperthermia and Fos expression in mice. Brain Research Bulletin. 2011;84:61-8.   DOI   ScienceOn
22 하여태, 김동희. 가미방풍통성산의 항고혈압작용. 대전대학교 한의학 연구소 한의학 논문집. 2005;14(2):55-7.
23 防風通聖散이 高血壓.高脂血에 미치는 影響. 경희의학. 1991;7(1):101-9.