• Genomics & Informatics
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• 제9권2호
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• pp.69-73
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• 2011

The use of genomic information in genomic selection programs for dairy and beef cattle breeds has become a reality in recent years. In this investigation, we analyzed single-nucleotide polymorphisms (SNPs) for Hanwoo (n=50) and Holstein (n=50) breeds using the Illumina Bovine SNP50 BeadChip to facilitate genomic selection and utilization of the Hanwoo breed in Korea. Analysis of the entire genomes showed different spectra of SNP frequencies for Hanwoo and Holstein cattle. The study revealed a highly significant (p<0.001) difference between Hanwoo and Holstein cattle in minor allele frequency (MAF). The average MAFs were $0.19{\pm}0.16$ and $0.22{\pm}0.16$ for Hanwoo and Holstein, respectively. From the total of 52,337 SNPs that were successfully identified, about 72% and 79% were polymorphic in Hanwoos and Holsteins, respectively. Polymorphic and fixed SNPs were not distributed uniformly across the chromosomes within breeds or between the two breeds. The number of fixed SNPs on all chromosomes was higher in Hanwoo cattle, reflecting the genetic uniqueness of the Hanwoo breed. In general, the rate of polymorphisms detected in these two breeds suggests that the SNPs can be used for different applications, such as whole-genome association and comparative genetic studies, and are a helpful tool in developing breed identification genetic markers.

• 디지털콘텐츠학회 논문지
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• 제19권1호
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• pp.103-112
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• 2018

본 논문에서는 감정에 따라 변화하는 혈류량을 측정하는 PPG 센서를 사용하여 감정을 인식하는 방법을 제안한다. 기존의 PPG 신호로부터 전력스펙트럼밀도(PSD; Power Spectrum Density)를 통해 주파수 영역에서 긍정적인 감정과 부정적인 감정을 판단하는 방법을 활용한다. 제임스 러셀의 이차원 원형 모델에 기반을 두어 감정을 기쁨, 슬픔, 짜증, 평온으로 분류하여 주파수 영역에 따른 에너지의 크기와의 연관성을 살펴본다. 본 연구는 웨어러블 디바이스에서 사용되는 동일한 PPG 센서를 사용하여 상위 네 종류의 감정을 영상 실험을 통해 주파수 영역에서 측정하였다는 것에 의의가 있다. 설문 조사를 통해 정확도와 개인에 따른 몰입 정도와 감정 변화 및 영상에 대한 바이오피드백을 수집하였다. 제안하는 방법은 앞으로 PPG 센서를 사용하는 상용화된 웨어러블 디바이스와 기존에 사용하는 스마트폰의 상황정보와 융합되어 모바일 어플리케이션 예측 서비스 등 다양한 개발이 될 것으로 기대된다.

• Geomechanics and Engineering
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• 제11권5호
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• pp.625-638
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• 2016

This paper presents field study and numerical modeling results for a single-cell low-fill concrete box culvert under a flexible pavement subjected to traffic loading. The culvert in the field test was instrumented with displacement transducers to capture the deformations resulting from different combinations of static and traffic loads. A low-boy truck with a known axle configuration and loads was used to apply seven static load combinations and traffic loads at different speeds. Deflections under the culvert roof were measured during loading. Soil and pavement samples were obtained by drilling operation on the test site. The properties of the soil and pavement layers were determined in the laboratory. A 3-D numerical model of the culvert was developed using a finite difference program FLAC3D. Linear elastic models were used for the pavement layers and soil. The numerical results with the material properties determined in the laboratory were compared with the field test results. The observed deflections in the field test were generally smaller under moving loads than static loads. The maximum deflections measured during the static and traffic loads were 0.6 mm and 0.41 mm respectively. The deflections computed by the numerical method were in good agreement with those observed in the field test. The deflection profiles obtained from the field test and the numerical simulation suggest that the traffic load acted more like a concentrated load distributed over a limited area on the culvert. Elastic models for culverts, pavement layers, and surrounding soil are appropriate for numerical modeling of box culverts under loading for load rating purposes.

• Steel and Composite Structures
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• 제28권2호
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• pp.233-250
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• 2018

Back-to-back built-up cold-formed steel un-lipped channel sections are used in cold-formed steel structures; such as trusses, wall frames and portal frames. In such built-up columns, intermediate fasteners resist the buckling of individual channel-sections. No experimental tests or finite element analyses have been reported in the literature for back-to-back built-up cold-formed steel un-lipped channel sections and specially investigated the effect of screw spacing on axial strength of such columns. The issue is addressed in this paper. The results of 95 finite element analyses are presented covering stub to slender columns. The finite element model is validated against the experimental tests recently conducted by authors for back-to-back built-up cold-formed steel lipped channel sections. The verified finite element model is then used for the purposes of a parametric study to investigate the effect of screw spacing on axial strength of back-to-back built-up cold-formed steel un-lipped channel sections. Results are compared against the built-up lipped channel sections and it is shown that the axial strength of un-lipped built-up sections are 31% lesser on average than the built-up lipped channel sections. It was also found that the American Iron and Steel Institute (AISI) and the Australian and New Zealand Standards were over-conservative by around 15% for built-up columns failed through overall buckling, however AISI and AS/NZS were un-conservative by around 8% for built-up columns mainly failed by local buckling.

• 지구물리와물리탐사
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• 제10권4호
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• pp.345-352
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• 2007

호주 Century 광산 주변에서 2차원 MT 탐사를 수행하였다. 현장으로부터 약 80 km 떨어진 Gregory Downs(RR_GREG)에 원거리 기준점을 설치, 운영하고 이 자료를 이용하여 양질의 탐사자료의 획득이 가능하였다. 이와 동시에 현장으로부터 약 6,400 km 떨어진 일본 Esashi (RR_ESS)에서 측정된 수평 자기장 자료를 이용하여 원거리 기준 자료처리를 수행한 결과 자기장의 coherency가 낮아 원거리 기준점 자료로 사용하기에는 적합하지 않았다. Century 광산의 주변에서 수행된 측선 탐사자료의 2차원 및 3차원 역산 결과 연구지역의 전반적인 심부 지질구조를 잘 나타내었으며, 탐사의 주된 목표인 Termite Range Fault는 측선의 북쪽에 나타나는 저비저항층과 남쪽에 나타나는 고비저항층의 경계면을 이루면서 북동쪽으로 약간 경사진 것으로 해석되었다.

• Archives of Pharmacal Research
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• 제21권5호
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• pp.503-507
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• 1998

Percutaneous absorption and model membrane variations of melationin (MT) in aqueous-based propylene glycol and $2-hydroxypropyl-{\beta}-cyclodextrin $vehicles were investigatted. the excised hairless mouse skin (HMS) and two synthetic ethylene vinyl acetate (EVA) and microporous polyethylene (MPE) were selected as a model membrane. the solubility of MT was determined by phase equilibrium study. the vertical $Franz{\circledR}$ type cell was used for diffusion study. The concentration of MT was determined using reverse phse HPLC system. The MT solubility was the highest in a mixture of PG and $2-HP{\beta}CD$. The percutaneous absorption of MT through excised HMS increased as the solubility increased. However, the permeability coefficient decreased and then slightly increased in mixture of PG and $2-HP{\beta}CD$. On the other hand, both flux and permeability coefficient through EVA membrane decreased as the solubility increased. No MT was detected over 12 h after starting diffusion through MPE membrane. The flux of MT was dependent on the type of membrane selected. Flux of MT was greatest in excised HMS followed by EBA and MPE membrane. Flux of MT through EVA membrane was 5-20 times lower when compared to excised HMS. Interestingly, volumes of donor phase when MPE membrane was used, significantly increased during the study period. the HMS might be applicable to expect plasma concentration of MT in human subjects based on flux and pharmacokinetic parameters as studied previously. the current studies may be applied to deliver MT transdermally using aqueous-based vehicles and to fabricate MT dosage forms.

• Archives of Pharmacal Research
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• 제27권2호
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• pp.169-172
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• 2004

Activity-guided fractionation of the EtOAc-soluble extract of the stems of Couepia ulei, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells led to the isolation of two active compounds, a new natural product, erythro-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-1-o1 (1), and a known compound, evofolin-B (2), along with five inactive compounds all of known structure, viz., betulinic acid, oleanolic acid, pomolic acid, ($\pm$)-syringaresinol, and ursolic acid. These isolates were identified by analysis of physical and spectral data. Compounds 1 and 2 exhibited QR inducing activity, with observed CD (concentration required to double induction) values of 16.7 and 16.4 $\mu\textrm{M}$, respectively.

• 디지털융복합연구
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• 제18권4호
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• pp.149-161
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• 2020

본 논문은 신용카드 사용이 고착화되어 있는 한국의 환경이 핀테크 간편결제 수용의도에 영향을 미치는지에 관해 연구하였다. 의무수납제와 같은 신용카드 사용을 장려하는 제도는 신용카드 사용을 고착화시키고 인프라를 구축시켜 새로운 결제수단인 모바일 간편결제 수용에 영향을 미칠 수 있다. 따라서 본 연구는 기술수용모델을 바탕으로 신용카드의 용이성, 유용성에 접근성과 안정성 변수를 확장하여 검증을 시도했다. 신용카드의 고착도를 매개효과로 그리고 신용카드 의무수납제도를 조절효과로 설정하였다. 연구 결과 신용카드 사용의 인지된 용이성, 유용성, 접근성이 간편결제의 이용의도에 긍정적인 영향을 미치고 있는 것으로 나타났다. 또한, 신용카드사용의 유용성과 접근성이 소비자 고착도를 매개로 하여 모바일 간편결제 이용의도에 긍정적인 영향을 미치고 있는 것을 확인하였다.

• 천문학논총
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• 제30권2호
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• pp.119-120
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• 2015

We report results of the measurement of the trigonometric parallax of an $H_2O$ maser source in IRAS 22555+6213 with the VLBI Exploration of Radio Astrometry (VERA). The annual parallax was determined to be $0.278{\pm}0.019$ mas, corresponding to a distance of $3.66^{+0.30}_{-0.26}kpc$. Our results confirm that IRAS 22555+6213 is located in the Perseus arm. We computed the peculiar motion of IRAS 22555+6213 to be ($U_{src}$, $V_{src}$, $W_{src}$) = ($0{\pm}1$, $-32{\pm}1$, $9{\pm}1$) $km\;s^{-1}$, where $U_{src}$, $V_{src}$, and $W_{src}$ are directed toward the Galactic center, in the direction of Galactic rotation and toward the Galactic north pole, respectively. IRAS 22555+6213, NGC7538 and Cepheus A lie along the same line of sight, and are within $2^{\circ}$ on the sky. Their parallax distances, with which we derived their absolute position in the Milky Way, show that IRAS 22555+6213 and NGC7538 are associated with the Perseus arm, while Cepheus A is located in the Local arm. We compared the kinematic distances of IRAS 22555+6213 derived with flat and non-flat rotation curve with its parallax distance and found the kinematic distance derived from the non-flat rotation assumption ($-32km\;s^{-1}$ lag) to be consistent with the parallax distance.

• 한국전자거래학회:학술대회논문집
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• 한국전자거래학회 1999년도 학술대회지 vol.1
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• pp.215-231
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• 1999

CALS, Enterprise Integration, Virtual Enterprise 등을 구현하는데 있어서 BPR (business process re-engineering), ISP (Information Strategy Planning), Analysis/Design 등은 필수 적이다. 이러한 BPR, ISP, A/D 추진하는데 있어서 각 단계의 산출물은 유연하게 연계되지 못한다. 그 이유는 각 단계가 접근하는 초점이 다르고, 산출물의 성격이 다르며, 무엇보다도 각 단계의 전문가가 다르기 때문에 발생한다. 현재 기업이 각 단계를 추진할 때에는 반복적인 피드백을 통하여 정보를 공유하거나, 각 단계의 정보 연계가 제대로 이루어지지 않는다. 이러한 문제를 해결하기 위하여 BPR-ISP-A/D의 정보 연계를 유연하게 하기 위하여 PPO (Product-Process-Organization) 객체 진화에 의한 통합 방법론을 제안 하고자 한다. 그 과정은 1) Real world 정보를 PPO 객체로 정의하고, 2) PPO 객체를 기반으로 BPR을 수행하여 TO-BE model 을 만드는 동시에, 3) PPO TO-BE model과 함께 IT Architecture를 정의하며, 4) PPO 객체를 기반으로 Analysis and Design 과정을 통하여 Application system 객체 및 Data 객체를 정의한다. 이때 PPO 객체는 Real-world 객체에서 Application system 객체 및 Data 객체로 진화하게 되고 BPR-ISP-A/D의 seamless 통합이 이루어진다. 여기서, 단계 1) 과 2)는 System Engineering을 통하여 이루어진다. ARIS(Architecture of Integrated Information System, Dr. A-W. Scheer, 1998)개념을 도입하여 실세계를 정해진 규약에 따라 Model로 Mapping하고, 생성된 Model을 바탕으로 BPR을 수행하여 개선된 Model을 산출해 낸다. 단계 3)은, IE (Information Engineering, James Martine, 1990) 의 ISP가 도입되어, 설계업무를 지원하기위한 기본적인 시스템 구조를 구상하게 된다. 이와 함께 IT Model을 구성하게 되는데, 객체지향적 접근 방법으로 Model을 생성하고 UML(Unified Modeling Language)을 Tool로 사용한다. 단계 4)는 Software Engineering 관점으로 접근한다. 이는 최종산물이라고 볼 수 있는 설계업무 지원 시스템을 Design하는 과정으로, 시스템에 사용될 데이터를 Design하는 과정과, 데이터를 기반으로 한 기능을 Design하는 과정으로 나눈다. 이를 통해 생성된 Model에 따라 최종적으로 Coding을 통하여 실제 시스템을 구축하게 된다.