• Clinical and Experimental Pediatrics
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• v.49 no.5
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• pp.519-522
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• 2006

Purpose : Alagille syndrome is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region. The Jagged1(JAG1) gene, which encodes a ligand of Notch, has been found mutated in Alagille syndrome. The aim of the study was to investigate the mutation analysis of JAG1 gene in Korean patients with Alagille syndrome. Methods : Genomic DNA was extracted from peripheral leukocytes of 6 patients. The 26 exons of JAG1 gene were amplified and PCR products were directly sequenced. Results : Two novel frameshift mutations were found. 118delC in exon 2 was found in a patient who developed hepatocellular carcinoma at 4 years of age. 999-1000delTG was identified in exon 7. Conclusion : Mutations identified in this study are expected to give rise to truncated proteins.

• International Journal of Advanced Culture Technology
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• v.7 no.1
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• pp.237-242
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• 2019

Spark variance technique is melded the jagged spill-over-sonance status of the glitter-differentiation knowledge level (GDKL) on the spark knowledge gestalt. The knowledge level condition by the spark knowledge gestalt system is comprised with the spill-over-sonance system. As to search a spot of the glitter situation, we are obtained of the spark value with black-red dot by the spill-over upper structure. The concept of knowledge level is comprised the reference of glitter-differentiation level for variance signal by the spark sonance gestalt. Further presenting a jagged variance of the GDKL of the maximum in terms of the spill-over-sonance gestalt, and spark spot sonance that was the a spark value of the far variance of the Spa-kg-FA-${\rho}_{MAXN}$ with $17.68{\pm}2.22units$, that was the a spark value of the convenient variance of the Spa-kg-CO-${\rho}_{MAXN}$ with $7.55{\pm}0.59units$, that was the a spark value of the flank variance of the Spa-kg-FL-${\rho}_{MAX}$ with $2.70{\pm}0.48units$, that was the a spark value of the vicinage variance of the Spa-kg-VI-${\rho}_{MAX}$ with $0.48{\pm}0.05units$. The spill-over sonance will be to appraisal at the jagged ability of the spill-over-sonance gestalt with black-red dot by the spark knowledge level on the GDKL that is presented the glitter-differentiation gestalt by the knowledge level system. Spill-over knowledge system will be possible to restrain of a gestalt by the special signal and to employ a spark data of spill-over sonance level.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2005.11a
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• pp.185-188
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• 2005

DTV-to-DMB 비디오 변환을 위해서는 기본적으로 MPEG-2 MP@HL의 HDTV/SDTV급 영상을 MPEG-4 AVC BP@1.3의 QCIF/QVGA/WDF/CIF급 영상으로 변환하는 과정이 필요하다. 본 논문에서는 DTV-to-DMB 비디오 변환을 위해 DTV의 고해상도 영상을 DMB의 저해상도 영상으로 축소하는 방식을 제안하고 있다. DTV-to-DMB 비디오 변환은 실시간 변환이 고려되어야 하며, 실시간 변환을 위해서는 축소 방식의 시간 복잡도가 고려 되어야 한다. 일반적으로 낮은 시간 복잡도를 갖는 영상 축소 방식으로는 대상 영상의 하나의 픽셀을 참조 영상 내 대응하는 픽셀들 중 한 픽셀을 선택하여 결정하는 방식(Just Get A Pixel)이 있으며, 참조 영상의 대응하는 픽셀들의 평균값을 선택하는 방식 (Average Shrink)과 중간값을 선택하는 방식 (Median Shrink)이 있다. 한편, DTV 영상은 인터레이스 방식을사용하며 DMB의 프로그레시브 방식 영상으로 변환 처리 과정에서, 움직임이 큰 영상에 대해 사물의 윤곽선이 계단 모양으로 보이는 재그 에지 (Jagged Edge) 현상이 나타난다. 본 논문에서는 대상 영상의 한 픽셀을 참조 영상의 대응하는 픽셀들 중 중간 위치의 몇 개 픽셀들과 주변 인접 픽셀들을 선출하여 그것들의 평균값 (Average)을 구하여 결정하는 Center Average 축소 방식을 제안한다. 제안된 방식은 기본적인 축소 방식을 기반으로 하여 낮은 시간 복잡도를 갖으며, 재그 에지 (Jagged Edge) 현상을 줄여 준다.

• Animal Systematics, Evolution and Diversity
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• v.38 no.1
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• pp.46-49
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• 2022

This study newly records a deep-sea coral, Flabellum (Ulocyathus) deludens from Korea. The specimens were collected by trawling at a depth of 100 m off Jejudo Island in 2019. The newly recorded species is described and compared with the other similar consubgeneric species in detail based on morphological characteristics, including corallum size, calicular diameter, calicular edge, face angle, edge angle, and septal arrangement. Flabellum(Ulocyathus) deludens is characterized by its solitary, highly compressed, wedge-shaped corallite with a small cylindrical pedicel, radiating inverse chevron-patterned lateral stripes on thecal faces, highly jagged calicular edges, and hexameral septal arrangement in five cycles. As a result of this study, five species in the family Flabellidae have been recorded from Korea.

• Korean Journal of Pharmacognosy
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• v.49 no.4
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• pp.285-290
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• 2018

Harmine, a beta-carboline alkaloid isolated from the seeds of Peganum harmala has been reported as a promising drug candidate for cancer therapy. However, the effect of harmine on breast cancer remains still unclear. In this study, the effect of harmine on the cell proliferation, migration, and invasion of breast cancer MDA-MB231 cells and the underlying mechanism were investigated. The results indicated that harmine inhibited the proliferation MDA-MB231 cells in a dose-dependent manner and markedly suppressed migration and invasion of MDA-MB231 cells. The mechanism involved in part through Notch signaling. The Notch activity was significantly inhibited by harmine treatment and harmine suppressed the expression of Jagged1 which is a key ligand to activate Notch signaling. These findings suggest a novel mechanism of harmine on anti-cancer activity and harmine may act as a potential therapeutic drug for breast cancer treatment.

• Journal of the Korean Wood Science and Technology
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• v.30 no.1
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• pp.25-33
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• 2002

Improvement of density profile and sound absorption capability of particleboard was attempted. Three types of hot pressing methods examined ; flat-platen pressing method (A-type pressing), hot pressing in forming box (B-type pressing), and hot pressing set up jagged caul in forming box (C-type pressing). The raw materials were larch(Larix leptolepis (S, et. Z.) Gorden) shavings, phenol formaldehyde resin, and the particleboard perforated with stair type. The physical and mechanical properties such as specific gravity, bending strength (MOR), internal bonding strength (IB) and sound absorption coefficients were examined. The results are summarized as follows : 1) The MOR and internal bonding strength of the board pressed in forming box were higher than those of flat-platen pressed board. 2) The minimum density to average density ratio in thickness direction which pressed in forming box showed about 923%, in the case of 35 mm commercial particleboard and 50 mm flat-platen pressed board, its values showed about 66.4% and 865% respectively. 3) Sound absorption coefficients of the particleboard perforated with stair type were higher than those of flat-plated pressed board and commercial particleboard.

• Journal of Microbiology
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• v.44 no.2
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• pp.217-225
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• 2006

Kaposi's sarcoma-associated herpesvirus (KSHV) RTA transcription factor is recruited to its responsive elements through interaction with RBP-Jk that is a downstream transcription factor of the Notch signaling pathway that is important in development and cell fate determination. This suggests that KSHV RTA mimics cellular Notch signal transduction to activate viral lytic gene expression. Here, I demonstrated that unlike other B lymphoma cells, KSHV -infected primary effusion lymphoma BCBL1 cells displayed the constitutive activation of ligand-mediated Notch signal transduction, evidenced by the Jagged ligand expression and the complete proteolytic process of Notch receptor I. In order to investigate the effect of Notch signal transduction on KSHV gene expression, human Notch intracellular (hNIC) domain that constitutively activates RBP-Jk transcription factor activity was expressed in BCBL1 cells, TRExBCBL1-hNIC, in a tetracycline inducible manner. Gene expression profiling showed that like RTA, hNIC robustly induced expression of a number of viral genes including KS immune modulatory gene resulting in downregulation of MHC I and CD54 surface expression. Finally, the genetic analysis of KSHV genome demonstrated that the hNIC-mediated expression of KS during viral latency consequently conferred the downregulation of MHC I and CD54 surface expression. These results indicate that cellular. Notch signal transduction provides a novel expression profiling of KSHV immune deregulatory gene that consequently confers the escape of host immune surveillance during viral latency.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.6
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• pp.1534-1540
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• 2005

In order to testify the urate lowering effects of Daihwangmudan-tang(DMT), ICR mice were injected monosodium urate into the abdominal cavity and then DMT was administered on 2 and 4 days after Injection. Uric acid and triglyceride were measured as hematological indices of gout, and some genes related with this change were identified by ACP based GeneFishing PCR method and direct sequencing. From this experiment, DMT highly decreased the blood levels of uric acid and significantly suppressed and lowered the acute increment of triglyceride level. There were 11 differentially expressed genes(DEG) having relations with positive actions of DMT, and 4 major genes in the middle of DEGs were sequenced; Mfap 2, jagged 2, Hsd17b7, DkkI-1, These genes were supposed that several mechanisms through interleukin 1 and T-cell anergy, LDL cholesterol metabolism, wnt pathway would be related with the anti-inflammation effect against gout.

• Journal of Korea Game Society
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• v.3 no.1
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• pp.86-93
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• 2003

In this paper, we propose a new antialiasing method using filtering technique which is base on morphological pixel structure Aliasing occurs along the edge of lines and polygons. This undesirable effect happens because there are not enough pixels available on a typical monitor to properly display mathematically smooth lines and polygon edges. Aliasing can be very distracting. In a typical graphic scene, aliasing artifact will be visible along the edges of all objects that greatly diminish of realism. The proposed antialiasing method attempts to smooth extreme jagged contour lines and edges by properly handling pixel's structure, surface type and adjusting the pixel color according to the amount of pixel coverage. Next, we use filtering technique considering morphological pixel structure. Experimental results have shown that the propose algorithm achieves better performance in reducing noise for antialiasing. The method will be widely applied to basic antialiasing technique for computer graphic applications.

• Structural Engineering and Mechanics
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• v.51 no.5
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• pp.793-808
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• 2014

The goal of this study is to evaluate and design steel plates with optimal material distributions achieved through a specific material topology optimization by using a CCARAT (Computer Aided Research Analysis Tool) as an optimizer, topologically optimally updating node densities as design variables. In typical material topology optimization, optimal topology and layouts are described by distributing element densities (from almost 0 to 1), which are arithmetic means of node densities. The average element densities are employed as material properties of each element in finite element analysis. CCARAT may deal with material topology optimization to address the mean compliance problem of structural mechanical problems. This consists of three computational steps: finite element analysis, sensitivity analysis, and optimality criteria optimizer updating node densities. The present node density based design via CCARAT using node densities as design variables removes jagged optimal layouts and checkerboard patterns, which are disadvantages of classical material topology optimization using element densities as design variables. Numerical applications that topologically optimize reinforcement material distribution of steel plates of a cantilever type are studied to verify the numerical superiority of the present node density based design via CCARAT.