• Journal of Acupuncture Research
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• v.20 no.6
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• pp.128-139
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• 2003

Juglans sinensis Dode has been reported to have antioxidant activity. However, the effect of Juglans sinensis Dode aquacupuncture(JS) on reactive oxygen species(ROS)-induced alterations in membrane transport function in renal tubular cells. This study was performed to evaluate the effect of JS on the organic hydroperoxide t-butylhydroperoxide(tBHP)-induced inhibition of $Na^+$-dependent phosphate($Na^+$-Pi) uptake in opossum kidney (OK) cells, an established renal proximal epithelial cell line. tBHP inhibited $Na^+$-Pi uptake in a time-dependent manner. The inhibitory effect of tBHP was prevented by JS over concentration range of 0.05-1mg/100ml in a dose-dependent manner. Kinetic studies showed that tBHP caused an decrease in Vmax for $Na^+$-Pi uptake without any a significant change in Km. $Na^+$-dependent phosphonoformic acid binding, a irreversible inhibitor of renal $Na^+$-Pi uptake, was decreased by tBHP treatment. The reduction in Vmax and phosphonoformic acid binding by tBHP was prevented by JS. tBHP induced lipid peroxidation and its effect was completely inhibited by JS and antioxidant N,N'-diphenyl-p-phenylenediamine. These data suggest that the oxidant inhibits phosphate uptake by a reduction in the number of active carrier across the membrane. JS may prevent oxidant-induced inhibition of membrane transport function by a mechanism similar to antioxidants in renal epithelial cells. Although the precise constituents remain to be explored, JS may be employed as a useful candidate herb for drug development to prevent and treat oxidant-mediated renal failure.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.10a
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• pp.256-259
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• 2016

The growth of mobile devices in Internet of Things (IoT) leads to a number of intelligent buildings related IoT applications. For instance, home automation controlling system uses client system such web apps on smartphone or web service to access the home server by sending control commands. The home server receives the command, then controls for instance the light system. The gateway based RESTful technology responsible for handling clients' requests attests an internet latency in case a large number of clients' requests submit toward the gateway increases. In this paper, we propose the design tasks of the IoT gateway for handling concurrency events. In the procedure of designing tasks, concurrency is best understood by employing multiple levels of abstraction. The way that is eminently to accomplish concurrency is to build an object-oriented environment with support for messages passing between concurrent objects. We also investigate the performance of event-driven architecture for building IoT gateway using node.js on one side and communication protocol based message-oriented middleware known as XMPP to handle communications of intelligent building control devices connected to the gateway through a centralized hub. The Node.JS is 40% faster than the traditional web server side features thread-based approach. The use of Node.js server-side handles a large number of clients' requests, then therefore, reduces delay in performing predefined actions automatically in intelligent building IoT environment.

• The Journal of Dong Guk Oriental Medicine
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• v.6 no.1
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• pp.163-176
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• 1997

This study was undertaken to determine whether Juglandis Semen extraction(JS) has a protective effect against the lung cell injury caused by oxidant, t-butythydroperoxide(t-BHP) and $H_2O_2$ in rabbit lung slices. JS significantly prevented an increase in water content induced by t-BHP. Similarly, JS significantly prevented the lipid peroxidation induced by t-BHP. Cellular concentration of glutathione, and the activities of catalase and superoxide dismutase were significantly not altered by 5% JS. However, JS at 5% concentration significantly increased the glutathione peroxidase activity in oxidant-treated and control tissues. JS decreased directly the production of superoxide or hydroxyl radical. These results indicate that JS prevents the cell injury and lipid peroxidation induced by oxidants in the lung. Such an antioxidant effect is attributed to enhancement of major endogenous antioxidant defence systems such as glutathione peroxidase and direct inhibition of oxygen free radical production.

• Korean journal of applied entomology
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• v.19 no.3 s.44
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• pp.163-168
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• 1980

The antibiotic bacterium JS7901, one of the eighty three antibiotic microorganisms which have been is elated in the surburbs of CheongJu-city, showed the most effective antimicrobial activities against test organisms, both bacteria and fungi. Among the different culture media Soytone Sugar medium was the most effective for growth and activity of the JS7901 antibiotic bacterium a against both Escherichia coli and Staphyllococcus aureus by the cylinder plate method. The higher the sugar content, was, the greater the antibiotic amount of substances of JS7901 were produced in the soytone sugar media. The antibiotic bacterium, JS7901 appeared to have a broad activity spectrum showing inhibition in Vitro against gram positive and negative bacteria and plant disease fungi. In general, the active substances were not transferred into organic solvents. Only a small portion of the activity was transferred into ethyl ether and was also adsorbed to active carbon when the cultured broth was also adsorbed to active carbon when the cultured broth was at $pH\;2.0\~4.0$. On adjusting at pH 8.0, the activity disappeared. The crude active substances could be obtained by means of vacuum drying method and still shelved strong activity. The dried active rake was solved by solvents and crystallized into various shapes. The active substances were developed on the silica gel plate in the solvent system of n-butanol-acetic acid-water(3 : 1 : 1) and gave 5 pinkish colored spots when sprayed with $0.2\%$ ninhydrine in ethanol. The upper 5th spot, which was the result of using disc plate method with Escherichia coli was the strongest of these spots.

• 한국생물공학회:학술대회논문집
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• 2002.04a
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• pp.461-464
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• 2002

A Chemoautotroph identified as an Aeromonas sp. strain JS-1 was isolated from fresh water. Aeromonas sp. strain JS-1 used the $H_2$ and $CO_2$ as energy and carbon sources, respectively. Growth characteristics for improving the $CO_2$ fixation rate were examined in batch cultivation. Its results shown that the optimal growth appeared at culture conditions of $35^{\circ}C$, pH 7 and NaCl 0.1%(w/v). Some hydrogen-oxidizing bacteria were reported that the enzyme activity of ribulose 1,5-bisphosphate carboxylase- oxygenase (RubisCO-EC 4.1.1.39), in the key enzyme of the Calvin-Benson cycle. A RubisCO was purified from a chemoautotrophic bacterium, Aeromonas sp. strain JS-1. the enzyme was purified by ammonium sulfate precipitation, DEAE-sepharose CL-6B and gel filtration chromatography. The RubisCO showed that molecular mass was about 560KDa from gel filtration chromatography and nondenaturing PAGE, and the RubisCO was confirmed to consist of $L_8S_8$ enzyme structure by sodium dodecyl sulfate polyacrylamide gel electrophoresis. A large subunit was about 56KDa and small one was about 15kDa. The Km values of the enzyme for ribulose 1,5-bisphosphate(RUBP), $NaH^{14}CO_3$, and $Mg^{++}$ were estimated to be 0.25mM, 5.2mM, and 0.91mM, respectively. The optimum temperature for RubisCO enzymatic activity were $50^{\circ}C$, and the enzymatic activity was stable up to $45^{\circ}C$.

• Journal of Digital Convergence
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• v.15 no.7
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• pp.239-246
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• 2017

We study convergent influence on Job Satisfaction(JS) and its association with Self Efficacy(SE), Job Characteristics(JC) and Occupational Stress(OS) among Hospital Administrative Staff(HAS). The survey was administered to 221 staff from 11 general hospitals located in Jeonbuk area from Nov. 1st, 2016 to Jan. 31st, 2017. The structured self-administered questionaries were used. JS was positively correlated with SE and three sub-domains of JC, and it was negatively correlated with seven sub-domains of OS. With the analysis of covariance structure, OS was more influential on JS than SE and JC. The study found the higher SE and JC, and the lower OC tend to increase JS. The results indicate that the efforts, to increase SE and JC, and to decrease OS, are required to increase the JS of HAS. The results are expected to be useful for organization personnel management to increase the JS of HAS. In the following study, the analysis about convergent additional factors of influence on JS will be needed.

• International journal of advanced smart convergence
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• v.5 no.3
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• pp.32-39
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• 2016

With the help of a small wearable device, patients reside in an isolated village need constant monitoring which may increase access to care and decrease healthcare delivery cost. As the number of patients' requests increases in simultaneously manner, the web service gateway located in the village hall encounters limitations for performing them successfully and concurrently. The gateway based RESTful technology responsible for handling patients' requests attests an internet latency in case a large number of them submit toward the gateway increases. In this paper, we propose the design tasks of the web service gateway for handling concurrency events. In the procedure of designing tasks, concurrency is best understood by employing multiple levels of abstraction. The way that is eminently to accomplish concurrency is to build an object-oriented environment with support for messages passing between concurrent objects. We also investigate the performance of event-driven architecture for building web service gateway using node.js. The experiments results show that server-side JavaScript with Node.js and MongoDB as database is 40% faster than Apache Sling. With Node.js developers can build a high-performance, asynchronous, event-driven healthcare hub server to handle an increasing number of concurrent connections for Remote Healthcare Monitoring System in an isolated village with no access to local medical care.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.2
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• pp.766-783
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• 2012

Recently, many malicious users have attacked web browsers using JavaScript code that can execute dynamic actions within the browsers. By forcing the browser to execute malicious JavaScript code, the attackers can steal personal information stored in the system, allow malware program downloads in the client's system, and so on. In order to reduce damage, malicious web pages must be located prior to general users accessing the infected pages. In this paper, a novel framework (JsSandbox) that can monitor and analyze the behavior of malicious JavaScript code using internal function hooking (IFH) is proposed. IFH is defined as the hooking of all functions in the modules using the debug information and extracting the parameter values. The use of IFH enables the monitoring of functions that API hooking cannot. JsSandbox was implemented based on a debugger engine, and some features were applied to detect and analyze malicious JavaScript code: detection of obfuscation, deobfuscation of the obfuscated string, detection of URLs related to redirection, and detection of exploit codes. Then, the proposed framework was analyzed for specific features, and the results demonstrate that JsSandbox can be applied to the analysis of the behavior of malicious web pages.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.10a
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• pp.597-599
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• 2022

When IoT device performs on-device AI, the device is required to use various AI models selectively according to target service and surrounding environment. Also, AI model can be updated by additional training such as federated learning or adapting the improved technique. Hence, for successful on-device AI, IoT device should acquire various AI models selectively or update previous AI model to new one. In this paper, we propose AI model repository to tackle this issue. The repository supports AI model registration, searching, management, and deployment along with dashboard for practical usage. We implemented it using Node.js and Vue.js to verify it works well.

• Journal of Pharmacopuncture
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• v.4 no.3
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• pp.85-92
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• 2001

Objective : This study was purposed to investigate the acute. subacute toxicity of Herbal acupuncture with Juglandis Semen(JsD) in mice and rats. Methods & Results: Balb/c mice were injected intraperitoneally with JsD for $LD_{50}$ and acute toxicity test Sprague-Dawley rats were injected intraperitoneally with JsD for subacute toxicity test. Results: The results obtained were summarized as follows; 1. LD50 was uncountable as could not find the expired of treat group. 2. The clinical signs and body weight changes of mice treated with 0.2cc, 0.4cc JsD were not affected during the acute toxicity test. 3. In acute toxicity test of serum biochemical values of mice, total protein was increased in treat-l group, compared with normal group, and total cholesterol was increased in treat-2 group, compared with normal group.(P<0.05) 4. In subacute toxicity test, main toxic syndrome was not found. 5. The body weight was decreased in treat-2 group, compared with normal group and relative liver weight was decreased in treat-1, 2 group, compared with normal group in subacute toxicity test.(P<0.05) 6. In subacute toxicity test, WBC, MCH, MCHC were decreased in treat-2 group and RBC was increased in treat-2 group, compared with normal group in complete blood count test.(P<0.05) 7. In subacute toxicity test, treat groups were not changed serum biochemical values of rats, compared with normal group.(P<0.05) Conclusions: According to the results, Herbal-acupuncture with Juglandis Semen caused no toxicity.