• Title/Summary/Keyword: Isotope Production

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Shielding Calculations of Accelerator Facility for Medical Isotope Production using MCNPX Code (MCNPX 코드를 이용한 의료용 방사성동위원소 생산을 위한 가속기 시설의 방사선차폐 및 선량 계산)

  • Seo Kyu-Seok;Kim Chan-Hyeong
    • Progress in Medical Physics
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    • v.15 no.4
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    • pp.210-214
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    • 2004
  • Since production of radioactive isotope for using PET, a lot of neutrons were produced. The produced neutrons were mainly shielded by concrete facility. Secondary photons are generated and emitted from the concrete shielding wall of the PET cyclotron since the proton-generated neutrons are thermalized and absorbed in the concrete wall and emit secondary radiations, i.e., photons. This study calculated neutron dose and photon dose at outside of the accelerator facility using MCNPX code. As results of the calculation, total dose were calculated less than limited dose by law.

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The Evaluation of Performance of C-11 Radio Isotope Gas Target using Finite Element Method (FEM을 이용한 C-11 동위원소 기체표적의 성능평가)

  • Oh, Hwan-Sup;Hur, Min-Goo;Park, Sang-Pil;Jung, Hyo-Jin
    • Transactions of the Korean Society of Machine Tool Engineers
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    • v.15 no.3
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    • pp.24-31
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    • 2006
  • The energy degrader is the most fragile part of the security of a target, has been newly designed to improve the performance of the gas target. Also, the numerical analysis of the heat movement and mechanical movement during the operation of the target has been accomplished. The heat analysis and structure analysis which are using the cooling water flow and pressure in the energy degrader and the finite element analysis program, has been considered with the heat movement and mechanical movement according to the current capacity of proton beam which determines the production yield of the radioactive isotope. Also the possible use range has been determined and at the same time the most suitable running condition according to the current capacity of proton beam has been suggested.

STUDIES ON METHIONINE METABOLISM IN THE RUMEN BACTERIA OF GOATS

  • Muramatsu, T.;Numa, M.;Ueda, Y.;Furuse, M.;Okumura, J.;Samukawa, K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.7 no.2
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    • pp.223-229
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    • 1994
  • The metabolic fate of methionine in rumen bacteria was studied by intraruminal administration of $^{15}N$ and $1-^{13}C$ labeled methionine in goats. Time course changes in isotopic abundance of amino acids in the rumen bacteria were determined with a computer-controlled gas-chromatograph mass spectrometer. The results from the transition of peak isotopic abundance in amino acids indicated that in rumen bacteria the $^{15}N$ or $^{13}C$ isotope in the methionine molecule was transferred rapidly to into bacteria, methionine administered intraruminally may not be retained as it is, but would be converted quickly to other metabolites in the bacteria.

Nuclear Design Methodology of Fission Moly Target for Research Reactor

  • Cho, Dong-Keun;Kim, Myung-Hyun;Sohn, Dong-Seong
    • Nuclear Engineering and Technology
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    • v.31 no.4
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    • pp.365-374
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    • 1999
  • A nuclear design of fission moly production targets for a research reactor, HANARO was peformed. It was found that the use of MCNP-4A, ORIGEN-2 code was reliable for the analysis of production characteristics of $^{99}$ Mo in a target fuel at an irradiation holes. A parametric study was done for the optimization of target location, target dimension, target shape and fuel materials. It was shown that a fuel thickness was the most sensitive parameters and electro-deposited target gave the highest 99Mo yield ratio. A pellet target with vibro-compaction powder, however, showed the largest production capacity and better engineering feasibility even with less yield ratio. Ten kinds of optimized target design for both LEU and HEU satisfied all the given design constraints. The most favorable design was the HEU ring-shaped electro-deposited target, considered the safety limit, production yield, chemical process easiness, yield ratio, and amount of radioactive waste.

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Characteristice Study of Ancient Northeast Asian Lead Glass and Green Glaze Based on Analysis Results (분석자료를 기초한 고대 납유리와 녹유의 특성 연구)

  • Lee, Jihee;Kim, Hyunjeong
    • Conservation Science in Museum
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    • v.24
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    • pp.99-116
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    • 2020
  • This study examines the results of analyses of the lead isotope ratio and chemical composition of lead glass and green glaze from ancient Northeast Asia in order to suggest their production sites and reveal further characteristics. The comparison of the lead isotope ratio of lead glass and green glaze from two Baekje remains in Iksan-the Wanggung-ri Site and Mireuksa Temple Site-suggests that they were produced to the west of the South Gyeonggi Massif (Zone 4) using lead extracted from the same area. With a few exceptions, it has proved difficult to identify the production sites of most of the green-glazed roof tiles from Unified Silla-period Buddhist temples across Northeast Asia. The major component of the lead glass from Baekje, Silla, China, and Japan during the seventh century is PbO, SiO2, Al2O3, CuO, and Fe2O3, with a ratio of PbO and SiO2 of 70 and 30 wt.%, respectively. The green-glazed roof tiles excavated from a temple from the Unified Silla period have a high proportion of lead, ranging from 64 to 90 wt.%. Green-glazed lozenge tiles excavated from the Sacheonwangsa Temple site in Gyeongju were shown to contain PbO, SiO2, Al2O3, and CuO, a similar composition with lead glass. An experiment was conducted to reproduce a glaze according to the production method mentioned in the Zō hotokesho sakumotsu-chō (Buddhist statue workshop crop book) in the Shosoin Repository. In this experiment, an identical ratio of PbO was observed for Japanese green-glazed ceramics from the eighth to eleventh century as that found in Chinese lead-glazed ceramics excavated from kilns operated from the seventh to tenth century in Henan. This indicates that production methods for lead glass and glaze were shared across Northeast Asia.

Discrimination of the Origin of Ephedrine and Pseudoephedrine for Pharmaceutical Powder Materials by Carbon and Nitrogen Stable Isotope Ratio Analysis ($^{13}C$$^{15}N$ 안정성 동위원소 비율 분석에 의한 원료의약품에서 에페드린 및 슈도에페드린의 기원 판별)

  • Baeck, Seung-Kyung;Jang, Moon-Hee;Makino, Yukiko;Jeong, Jin-Il;Yang, Won-Kyang;Choi, Hwa-Kyung;Chung, Hee-Sun;Pyo, Myung-Yun;Nagano, Tetsuo
    • YAKHAK HOEJI
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    • v.53 no.5
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    • pp.293-297
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    • 2009
  • The abuse of methamphetamine (MA) is one of the most serious drug abuses in Asia. And, the prevention of precursor production for abuse drug is one of the most effective drug control system. Isotope ratio analysis at natural abundance levels have been used to establish the environmental source or the geographic origin of various biological and nonbiological materials. Ephedrine, the precursor of MA, is produced by one of three methods; extraction from Ephedra plants, full chemical synthesis or via a semi-synthetic process involving the fermentation of sugar, followed by amination. We investigated the origin of ephedrine and pseudoephedrine based on the carbon and nitrogen values for nineteen pharmaceutical powder materials (PPMs) obtained from pharmaceutical company in Korea by stable isotope ratio mass spectrometry coupled to an elemental analyser (EA-IRMS). The carbon delta values for the ephedrine and pseudoephedrine were -24.21~-22.72 (mean=-23.72) $^{\cir}/_{\circ\circ}$ and -23.79~-22.71 (mean=-23.48) $^{\cir}/_{\circ\circ}$. The nitrogen delta values were 3.51~5.55 (4.43) $^{\cir}/_{\circ\circ}$ and 2.24~8.22 (5.42) $^{\cir}/_{\circ\circ}$. These results indicate that PPMs are semi-synthetic products. Therefore the origins of ephedrine(natural, semi-synthetic or synthetic) could be discriminated by using carbon and nitrogen stable isotope ratios. we are sure tat this stable isotope ratio analysis can discriminate the origins of precursors of methamphetamine.

Lead Isotope Ratio Data Base for Metal Objects at the National Museum of Korea (I) (국립중앙박물관소장 금속유물의 납동위원소비 데이터베이스 구축(I))

  • Kang, Hyungtae;Ahn, Juyoung;Huh, Ilkwon
    • Conservation Science in Museum
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    • v.8
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    • pp.81-95
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    • 2007
  • The Conservation Science Team of National Museum of Korea has established the data base of lead isotope ratio as the scientific research of bronze patina, which was acquired from conservation process of metal objects, and based on this result, it intends to conduct the research related to the production places of raw material for the bronze objects. As the equipment for analysis of lead isotope ratio of the bronze patina, the thermal ionization mass spectrometer (TIMS) was used. As part of the research, in 2007, the 11 samples of the bronze Patina from the objects, believed to belong to of Nangnang(Lelang), the 6 items of bronze patina from the flower-shaped bronze dishes, belong to Unified Silla period and 4 items from the Goryeo bronze bell were acquired and analyzed the lead isotope ratio. Based on the data of the lead isotope ratio from the galena of Korea, China and Japan, the provenance raw materials were estimated through the comparison of their lead isotope ratios. In the future, the Conservation Science Team of the National Museum of Korea will collect as much bronze patina as possible from the process of conservation treatment of metal objects, and analyze them in order to conduct the study of provenance with the type, period and the region of the objects.

Analysis of Air Discharge and Disused Air Filters in Radioisotope Production Facility

  • Kim, Sung Ho;Lee, Bu Hyung;Kwon, Soo Il;Kim, Jae Seok;Kim, Gi-sub;Park, Min Seok;Jung, Haijo
    • Progress in Medical Physics
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    • v.27 no.3
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    • pp.156-161
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    • 2016
  • When air discharged from a radioisotope production facility is contaminated with radiation, the public may be exposed to radiation. The objective of this study is to manage such radiation exposure. We measured the airborne radioactivity concentration at a 30 MeV cyclotron radioisotope production facility to assess whether the exhaust gas was contaminated. Additionally, we investigted the radioactive contamination of the air filter for efficient air purification and radiation safety control. To measure the airborne radiation concentration, specimens were collected weekly for 4 h after the beginning of the radioisotope production. Regarding the air purifier, five specimens were collected at different positions of each filter-pre-filter, high-efficiency particulate air filter, and charcoal filter-installed in the cyclotron production room. The concentrations of F-18, I-123, I-131, and Tl-201 generated in the radioiodine production room were $13.5Bq/m^3$, $27.0Bq/m^3$, $0.10Bq/m^3$, and $11.5Bq/m^3$, respectively; the concentrations of F-18, I-123, and I-131 produced in the radioisotope production room were $0.05Bq/m^3$, $16.1Bq/m^3$, and $0.45Bq/m^3$, correspondingly; and those of F-18, I-123, I-131, and Tl-201 generated in the accelerator room were $2.07Bq/m^3$, $53.0Bq/m^3$, $0.37Bq/m^3$, and $0.15Bq/m^3$, respectively. The maximum radiation concentration of I-123 generated in the radioiodine production room was 1,820 Bq/g, which can be disposed after 2 days. The maximum radiation concentration of Tl-202 generated in the radioisotope production room was 205 Bq/g, and this isotope must be stored for 53 days. The I-123 generated in the radioiodine production room had a maximum concentration of 1,530 Bq/g and must be stored for 2 days. The maximum radiation concentration of Na-22 generated in the radioisotope production room was 0.18 Bq/g and this isotope must be disposed after 827 days. To manage the exhaust, the efficiency of air purification must be enhanced by selecting an air purifier with a long life and determining the appropriate replacement time by examining the differential pressure through systematic measurements of the airborne radiation contamination level.

Reconstruction of Nitrate Utilization Rate Change Based on Diatom-bound Nitrogen Isotope Values in the Central Slope Area of the Bering Sea during the Early Pleistocene (2.4-1.25 Ma) (플라이스토세 전기(2.4-1.25 Ma) 동안 베링해 중부 대륙사면 지역의 규조 골격내 유기물 질소동위원소 값에 의한 질산염 이용률의 변화 복원)

  • Kim, Sunghan;Khim, Boo-Keun
    • Ocean and Polar Research
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    • v.38 no.3
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    • pp.195-207
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    • 2016
  • Because the high latitude region in the North Pacific is characterized by high primary production in the surface water enriched with nutrients, it is important to understand the variation of surface water productivity and associated nutrient variability in terms of global carbon cycle. Surface water productivity change or its related nutrient utilization rate during the Northern Hemisphere Glaciation (NHG; ca. 2.73 Ma) has been reported, but little is known about such circumstances under gradual climate cooling since the NHG. Bulk nitrogen isotope (${\delta}^{15}N_{bulk}$) of sedimentary organic matter has been used for the reconstruction of nutrient utilization rate in the surface water. However, sedimentary organic matter experiences diagenesis incessantly during sinking through the water column and after burial within the sediments. Thus, in this study we examine the degree of nitrate utilization rate during the early Pleistocene (2.4-1.25 Ma) since the NHG, using the diatom-bound nitrogen isotope (${\delta}^{15}N_{db}$), which is known to be little influenced by diagenesis, from Site U1343 in the Bering slope area. ${\delta}^{15}N_{db}$ values range from ~0.5 to 5.5‰, which is lower than ${\delta}^{15}N_{bulk}$ values, but they vary with larger amplitude. Variation patterns between ${\delta}^{15}N_{db}$ values and biogenic opal concentration are generally consistent, which indicates that the nitrate utilization rate is closely related to opal productivity change in the surface water. A positive correlation between opal productivity and nitrate utilization rate was observed, which is different from the other high latitude regions in the North Pacific. The main reason for this contrasting relationship is that the primary production in the surface water at Site U1343 is influenced mostly by the degree of sea ice formation. Still, although concerns about diagenetic alteration have been avoided by using ${\delta}^{15}N_{db}$, the effects of the preservation state of biogenic opal and the species-dependent isotopic fractionation on ${\delta}^{15}N_{db}$ should be assessed in the future studies.

Stable Carbon and Nitrogen Isotopes of Sinking Particles in the Eastern Bransfield Strait (Antarctica)

  • Khim, Boo-Keun;Kim, Dong-Seon;Shin, Hyoung-Chul;Kim, Dong-Yup
    • Ocean Science Journal
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    • v.40 no.3
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    • pp.167-176
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    • 2005
  • A time-series sediment trap was deployed at 1,034 m water depth in the eastern Bransfield Strait for a complete year from December 25, 1998 to December 24, 1999. About 99% of total mass flux was trapped during an austral summer, showing distinct seasonal variation. Biogenic particles (biogenic opal, particulate organic carbon, and calcium carbonate) account for about two thirds of annual total mass flux $(49.2\;g\;m^{-2})$, among which biogenic opal flux is the most dominant (42% of the total flux). A positive relationship (except January) between biogenic opal and total organic carbon fluxes suggests that these two variables were coupled, due to the surface-water production (mainly diatoms). The relatively low $\delta^{13}C$ values of settling particles result from effects on C-fixation processes at low temperature and the high $CO_2$ availability to phytoplankton. The correspondingly low $\delta^{l5}N$ values are due to intense and steady input of nitrates into surface waters, reflecting an unlikely nitrate isotope fractionation by degree of surface-water production. The $\delta^{l5}N$ and $\delta^{l3}C$ values of sinking particles increased from the beginning to the end of a presumed phytoplankton bloom, except for anomalous $\delta^{l5}N$ values. Krill and the zooplankton fecal pellets, the most important carriers of sinking particles, may have contributed gradually to the increasing $\delta^{l3}C$ values towards the unproductive period through the biomodification of the $\delta^{l3}C$ values in the food web, respiring preferentially and selectively $^{12}C$ atoms. Correspondingly, the increasing $\delta^{l5}N$ values in the intermediate-water trap are likely associated with a switch in source from diatom aggregates to some remains of zooplankton, because organic matter dominated by diatom may be more liable and prone to remineralization, leading to greater isotopic alteration. In particular, the tendency for abnormally high $\delta^{l5}N$ values in February seems to be enigmatic. A specific species dominancy during the production may be suggested as a possible and speculative reason.