• Journal of Gastric Cancer
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• 제13권2호
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• pp.106-110
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• 2013

Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune disorder in 40 recently diagnosed gastric adenocarcinoma cases versus 80 healthy controls. The participants came from a region with high gastric cancer rate but sufficient iodine supply due to salt iodination. The investigation included urine iodine level, thyroid gland clinical and ultrasonographic examination, and thyroid function tests. Results: Goiter was detected more frequently in the case group (P=0.001); such a finding, however, was not true for lower than normal urine iodine levels. The free T3 mean level was significantly lower in the case group compared to the control group (P=0.005). Conclusions: The higher prevalence of goiter rather than low levels of urinary iodine in gastric adenocarcinoma cases suggests that goiter, perhaps due to protracted but currently adjusted iodine deficiency, is more likely to be associated with gastric adenocarcinoma compared to the existing iodine deficiency itself.

• Journal of Nutrition and Health
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• 제31권2호
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• pp.213-219
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• 1998

This study was conducted to compare and evaluate the iodide specific ion electrode method (ISE) and neutron activation analysis method (NAA) for determining iodine in human milk and cow milk. The neutron irradiation and counting operations were carried out at the TRIGA Mark-III reactor facility of the Korea Atomic Energy Research Institute. The mean concentrations of iodine in human milk samples by the ISE and the NAA were 1450$\mu\textrm{g}$/L and 1350$\mu\textrm{g}$/L, respectively. The levels were not significantly different. In cow milk samples , the mean concentrations of iodine by the ISE and the NAA were 250$\mu\textrm{g}$.L and 200$\mu\textrm{g}$/L, respectively. here, the ISE reading was significantly higher than the NAA. reading. The correlations of the two methods were 0.92(p<0.001) for human milk samples and 0.65 for cow milk samples . The coefficient of variation was 8.3% in the ISE and 4.9% in the NAA. Therefore, the iodide specific ion electrode method is sample and fast method, but probably not in processed milk since free sulfhydryl groups in milk are also detected by the iodide electrode. However, these also indicate that the ISE method may be applicable to human milk and pasteurized milk if the conventional pasteurization time-temperature relationship of standards is not exceeded. On the other hand, the NAA method , which is independent of chemical forms and matrix, can be used for determining iodine in all kinds of milk and foods.

• 한국콘텐츠학회논문지
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• 제14권3호
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• pp.337-345
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• 2014

중재적 시술 및 혈관조영검사에 사용되는 조영제의 요오드 함유량 차이에 따른 흡수도와 피폭선량을 알아보았다. 실험에 사용된 조영제는 요오드 함유량(I $mg/m{\ell}$)에 따라 240, 270, 300, 320, 350, 370, 400의 7종류를 사용하였으며, 그 결과 요오드 함유량이 많을수록 흡수도 및 피폭선량이 높아짐을 알 수 있었으며, TACE 검사에서도 조영제의 농도 270 I $mg/m{\ell}$에 비해 350 I $mg/m{\ell}$의 출력 선량이 8.5% 정도 증가하였다. 본 연구를 통해 조영제가 환자의 피폭선량에 영향을 주며 요오드 함유량이 많은 조영제일수록 환자의 피폭선량이 증가함을 알 수 있었다.

• 분석과학
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• 제12권6호
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• pp.528-533
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• 1999

유도결합 플라스마-질랑분석법을 이용하여 혈청, 생우유 및 사료첨가제 중 요오드를 정량하였다. 시료를 매트릭스 변형제인 $NH_4OH$(0.5% v/v)+$CH_3OH$(5% v/v) 혼합용액으로 25배 묽힌 다음, m/z=127에서 이온세기를 측정하였다. 이 방법에 대한 요오드의 검정곡선은 $0-100{\mu}g/L$ 범위에서 상관계수($R^2$)가 0.99인 직선관계를 나타내었으며, 검출한계는 $0.084{\mu}g/L$이었다. 최적 분석 및 기기 조건에서 분유 표준시료를 분석한 결과 상대오차는 2.30-4.73% 범위이었다. 또한 혈청, 생우유, 동물의 사료 첨가제 등과 같은 실제시료를 분석한 결과 요오드의 함유량은 각각 $12.4-40.2{\mu}g/L$, < 0.01-3.11 mg/L,< $10^{-7}-2.60g/kg$ 범위이었다.

• Asian-Australasian Journal of Animal Sciences
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• 제14권6호
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• pp.785-790
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• 2001

Twelve indigenous male goats, comprising of six intact and six castrated (2.5-3 years; $24.4{\pm}0.62kg$) were assigned evenly into two dietary treatments, viz. $I_0$ and $I_{100}$ and were used to study the effect of supplementation of iodine on the nutrient utilization when their diet contained Leucaena leaf meal. They were offered a conventional concentrate mixture along with Leucaena leucocephala leaf meal, the latter to meet 50% of their crude protein (CP) requirements, and supplemented with either no iodine ($I_0$) or 0.1 mg of iodine ($I_{100}$)/day/animal as potassium iodide for a period of 105 days. Wheat straw given ad libitum was the sole source of roughage. A metabolism trial of 8 days duration was conducted after 90 days of experimental feeding. It was observed that the overall dry matter (DM) intake during experimental period was higher (p<0.05) in $I_{100}$ group as compared to $I_0$ group (508.6 vs. $443.7g\;d^{-1}$). The intake of CP, digestible crude protein (DCP) and metabolisable energy (ME), although non-significant, tended to be higher in the iodine supplemented group, $I_{100}$. Digestibility of dry matter, organic matter (OM), CP, ether extract and crude fiber (CF) did not differ (p>0.05) between the treatments. However, nitrogen retention was higher (p<0.01) in $I_{100}$ than $I_0$ with the values being 2.63 and $1.70g\;d^{-1}$, respectively. No difference (p>0.05) was evident in the retention of calcium and phosphorus between the two groups. The castrated animal exhibited lower DM intake concurrent with higher digestibility of DM and crude fibre (p<0.05), and organic matter and total carbohydrates (p<0.01) when compared to intact ones. It was concluded that supplementation of iodine to leucaena based ration may help in improving the DM intake and nitrogen utilization by goats.

• Asian-Australasian Journal of Animal Sciences
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• 제13권9호
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• pp.1245-1248
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• 2000

In order to ascertain the influence of supplemental iodine on nutrient utilisation by goats fed a leucaena leucocephala leaf meal containing diet, 8 adult male goats (2 years; $22.3{\pm}1.73kg$) were randomly allocated into two groups, viz. control and experimental. Both the groups were fed a diet comprising of wheat bran, leucaena leaf meal and wheat straw ad lib. In addition, the experimental animals were given extra iodine at 0.04 mg/head/day (as KI soln.). A metabolism trial of 6 days duration conducted after 13 weeks of experimental feeding revealed that the daily DM intake $(g/W^{0.75})$ increased significantly due to iodine supplementation. Similar was the case with the intakes of DCP and ME. The digestibility of CP and EE showed significant improvement in the experimental group while that of DM, OM and total carbohydrates did not vary significantly between the two groups. The animals of control group were in negative nitrogen balance, which improved significantly and become positive in the experimental group. Moreover, the control animals lose weight apparently in contrast to the experimental animals, who maintained their weights. While iodine supplementation tended to enhance phosphorus retention that of calcium exhibited significant improvement. Conclusively, provision of extra iodine to Leucaena containing diet may prove beneficial in augmenting the nutrient utilization of this protein rich tropical forage.

• 한국수소및신에너지학회논문집
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• 제24권1호
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• pp.61-69
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• 2013

Polymer exchange membrane (PEM) fuel cells have multifunctional properties, and bipolar plates are one of the key components in these fuel cells. Generally, a bipolar plate has a gas flow path for hydrogen and oxygen liberated at the anode and cathode, respectively. In this study, the influence of iodine applied to a bipolar plate was investigated. Accordingly, we compared bipolar plates with and without iodine coating, and the performances of these plates were evaluated under operating conditions of $75^{\circ}C$ and 100% relative humidity. The membrane and platinum-carbon layer were affected by the iodine-coated bipolar plate. Bipolar plates coated with iodine and a membrane-electrode assembly (MEA) were investigated by electron probe microanalyzer (EPMA) and energy-dispersive x-ray spectroscopy (EDS) analysis. Polarization curves showed that the performance of a coated bipolar plate is approximately 19% higher than that of a plate without coating. Moreover, electrochemical impedance spectroscopy (EIS) analysis revealed that charge transfer resistance and membrane resistance decreased with the influence of the iodine charge transfer complex for fuel cells on the performance.

• 한국임상수의학회지
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• 제24권3호
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• pp.337-341
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• 2007

This study determined the effect of postpartum intrauterine infusion of povidone-iodine solution on the subsequent reproductive performance in dairy cows. Six hundred and fifty-eight dairy cows that were around week 4 postpartum were randomly divided into two groups: (1) Cows in treated group received an intrauterine infusion of 100 to 150 ml 2% povidone-iodine solution (treated group, n=269), or (2) Cows that received no treatment were served as the controls (control group, n=389). The cows were bred at observed estrus more than 50 days after calving. Artificial insemination (AI) was done according to the a.m.-p.m. rule. The conception to AI was determined per rectum 60 days after AI by both ultrasonographical observation and manual palpation. The intervals from calving to first service and conception ($94.2{\pm}2.7$ and $144.1{\pm}4.1$ days vs. $88.0{\pm,}2.1$ and $143.5{\pm}4.6$ days, respectively), number of services per conception ($2.0{\pm}0.1$ vs. $2.1{\pm}0.1$), and cumulative pregnancy rates within 90 and 150 days postpartum (31.9 and 61.7% vs. 29.7 and 62.1%) did not differ between the control and treated groups (P>0.05), while conception rate at first service was lower (P<0.05) in the treated group (40.5%) than in the control group (49.4%). Additionally, we could not find any effect of intrauterine infusion of povidone-iodine solution according to cow parity or calving season on the reproductive performance. These results indicate that intrauterine infusion of povidone-iodine solution at week 4 postpartum does not affect the subsequent reproductive performance in dairy cows.

• Korean Journal of Radiology
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• 제19권6호
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• pp.1077-1088
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• 2018

Objective: To correlate CT parameters on detector-based dual-energy CT enterography (DECTE) with Crohn's disease activity index (CDAI) and externally validate quantitative CT parameters. Materials and Methods: Thirty-nine patients with CD were retrospectively enrolled. Two radiologists reviewed DECTE images by consensus for qualitative and quantitative CT features. CT attenuation and iodine concentration for the diseased bowel were also measured. Univariate statistical tests were used to evaluate whether there was a significant difference in CTE features between remission and active groups, on the basis of the CDAI score. Pearson's correlation test and multiple linear regression analyses were used to assess the correlation between quantitative CT parameters and CDAI. For external validation, an additional 33 consecutive patients were recruited. The correlation and concordance rate were calculated between real and estimated CDAI. Results: There were significant differences between remission and active groups in the bowel enhancement pattern, subjective degree of enhancement, mesenteric fat infiltration, comb sign, and obstruction (p < 0.05). Significant correlations were found between CDAI and quantitative CT parameters, including number of lesions (correlation coefficient, r = 0.573), bowel wall thickness (r = 0.477), iodine concentration (r = 0.744), and relative degree of enhancement (r = 0.541; p < 0.05). Iodine concentration remained the sole independent variable associated with CDAI in multivariate analysis (p = 0.001). The linear regression equation for CDAI (y) and iodine concentration (x) was y = 53.549x + 55.111. For validation patients, a significant correlation (r = 0.925; p < 0.001) and high concordance rate (87.9%, 29/33) were observed between real and estimated CDAIs. Conclusion: Iodine concentration, measured on detector-based DECTE, represents a convenient and reproducible biomarker to monitor disease activity in CD.

• Journal of Radiation Protection and Research
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• 제46권4호
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• pp.170-177
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• 2021

Background: The International Commission on Radiological Protection is preparing to provide reference dose coefficients for environmental radioiodine intake based on newly developed age-specific biokinetic models. However, the biokinetics of iodine has been reported to be strongly dependent on the dietary intake of stable iodine; for example, the thyroidal uptake of iodine may be substantially lower in iodine-rich regions than in iodine-deficient regions. Therefore, this study attempted to establish a system of age-specific thyroid dose estimation for South Koreans, whose daily iodine intakes are significantly higher than that of the world population. Materials and Methods: Korean age-specific biokinetic parameters and thyroid masses were derived based on the previously developed Korean adult model and the Korean anatomical reference data for adults, respectively. This study complied with the principles used in the development of age-specific biokinetic models for world population and used the ratios of baseline values for each age group relative to the value for adults to derive age-specific values. Results and Discussion: Biokinetic model predictions based on the Korean age-specific parameters showed significant differences in iodine behaviors in the body compared to those predicted using the model for the world population. In particular, the Korean age-specific thyroid dose coefficients for ¹²⁹I and ¹³¹I were considerably lower than those calculated for the world population (25%-76% of the values for the world population). Conclusion: These differences stress the need for Korean-specific internal dose assessments for infants and children, which can be achieved by using the data calculated in this study.