• The Korean Journal of Physiology
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• v.8 no.1
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• pp.15-22
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• 1974

The influence, upon male rat's mating behavior, of Korean Panax Ginseng administered for 3 and 5 days was investigated by direct behavioral observation and also by counting the number of copulation plugs the animals deposited. Four쇼-four male albino rats were used. Part of the animals received ginseng for 3 days (ginseng-3 day group, N= 12) or for 5 days(ginseng-5 day group, H=10), while the remaining animals received saline for 3 days (saline-3 day group, N=12) or for 5 days (saline-S day group, N=10). Each animal belonging to the 2 ginseng groups received subcutaneously 0.5 ml/100 g body weight of ginseng alcohol extract solution (4 mg of the ethyl alcohol extract in 1 ml of physiological saline), and each rat belonging to the 2 saline groups received the same amount of saline per day. During the dark period of the light-dark cycle on the next day following the last drug administration, a female rat in the artificial estrus was introduced to each male and the mating behavior was observed for 45 minutes. The observation session was divided into two parts and, in the early part which terminated with the first ejaculation and succeeding intromission, following behavioral measures were taken: mounting latency, intromission latency, inter-intromission period, ejaculatory latency(time from the first intromission until the first ejaculation), occurrence of mounting with intromission, occurrence of mounting without intromission, and postejaculatory interval. Behavioral measures taken in the later part of the session after the first ejaculation were: occurrence of mounting with intromission, occurrence of mounting without intromission, and occurrence of ejaculation. Immediately after the behavioral observation session the experiment turned to measure, for 10 days, the number of copulation plug which each pair of rats deposited. Following results were obtained: 1. After several mountings mounting with intromission, males of the 2 ginseng groups finished the first ejaculation significantly earlier than the corresponding 2 saline groups did. 2. The postejaculatory latency was significantly reduced in the ginseng-5 day group compare with the value of the saline-5 day group and also compared with the value of the ginseng-3 day group. 3. The 2 ginseng groups ejaculated significantly more often in 45 minutes' observation session than the corresponding 2 saline groups did. 4. The number of copulation plug deposited in 10 days by the animals of the 2 ginseng groups. significantly exceeded the number deposited by the corresponding 2 saline group animals. The animals of the ginseng-5 day group deposited copulation plugs significantly more than the animals of the ginseng-3 day group did. It is inferred from the above results that the ginseng facilitates mating behavior of male rats, and that the degree of facilitation may be influenced by the duration of drug administration.

• The Korean Journal of Physiology
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• v.6 no.1
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• pp.33-37
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• 1972

It was thought desirable to elucidate the influence of the mammillary bodies upon sexual behavior. Twenty male rats were used, of which 9 rats had their mammillary bodies damaged electrolytically through implanted electrodes (mammillary body group) and 11 rats received the same surgery short of electrolytic damage to the mammillary bodies (operated control group). Their sexual behavior was observed 3 weeks after surgery. Observation was discontinued when an ejaculation was followed by a successive intromission. 1. Mounting without intromission occurred significantly less often in the mammillary body group than in the operated control group. 2. No significant group difference existed with regard to the occurrence of mounting with intromission. However, the value tended to rise in the mammillary body group compared with the value of the operated control group. 3. Mountings with and without intromission tended to occure more often in the mammillary body group than in the operated control group, but the difference was nonsignificant. 4. The ejaculatory latency (time interval between the first intromission and the first ejaculation) and the postejaculatory interval (time interval between an ejaculatory act and the next intromission) tended to decrease in the mammillary body group compared with the values of the operated control group. However, again the difference did not reach significancy. 5. There existed no significant group differences with regard to the mounting latency (time interval between the first encounter with female and the first mounting with or without intromission), the intromission latency (time interval between the first encounter and the first intromission), and the interintromission period (mean time interval between two successive intromissions). From the above results, it may be inferred that the mammillary bodies tend to exert slight and nonsignificant inhibitory influence upon sexual behavior of male rats. However, further study is indicated before reaching final conclusion.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1410-1417
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• 2004

To evaluate effect of Gamimajeonojahwan(GMOH) water extract on sexual functions, we orally administered GMOH exract(1,100㎎/㎏) for four weeks in male rats impaired by 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) and ketoconazole(KZ). And we investigated the sexual behaviors such as mount latency, mount frequency, intromission latency, intromission frequency, ejaculation period and ejaculation latency. Serum testosterone concentrations also are evaluated in GMOH-and/or vehicle-treated male rats. The results were obtained as follows: GMOH inhibited the increase of intromission latency by TCDD in male rats. GMOH inhibited the decrease of intromission frequency by TCDD in male rats. GMOH inhibited the increase of ejaculation latency by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by KZ in male rats. These results suggest that GMOH water extract is active in improving sexual functions and protecting a decrease of testosterone concentrations induced by TCDD and KZ in male rats.

• The Journal of Korean Medicine
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• v.20 no.1 s.37
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• pp.22-29
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• 1999

To evaluate the effect of Choakwiyeum water extract on the male reproductive functions, experiments were performed on male rats. The results obtained were as follows: 1. Intromission frequency was increased significantly after the administration of Choakwiyeum water extract in male rats. 2. Intromission latency was increased significantly after the administration of Choakwiyeum water extract and ketoconazole in male rats. 3. Mount frequency was increased significantly after the administration of Cboakwiyeum water extract and TCDD in male rats. 4. Serum testosterone concentration was increased significantly after the administration of Choakwiyeum water extract in male rats. 5. Serum testosterone concentration was increased significantly after the administration of Choakwiyeum water extract and ketoconazole in male rats.

• Archives of Pharmacal Research
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• v.20 no.6
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• pp.656-659
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• 1997

The Effects of Eurycoma longifolia Jack were studied on the sexual behaviour of male rats. Sexually normal male rats were treated twice daily with 500 mg $kg^{-1}$ / of different fractions of E.longifolia Jack for 10 days prior to test and were then observed for their copulatory behaviour with a receptive female in a copulation cage. Results showed that was a significant increase (p<0.05) in EL-1, EL-2, EL-3 but significant decrease (p<0.05) in both PEI-1 and PEI-2 in treated male rats as compared to the control male rats indicating that E. longifolia Jack increased the sexual performance of the treated male rats by extending the duration of coitus and decreasing the refractory period between the different series of copulation. Hence, this preliminary work supports the folk use of this plant as having aphrodisiac property.