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Effects of Gamimajeonojahwan Extract on the Sexual Function in Male Rats  

Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim Bok Ryang (Department of Biochemistry, College of Medicine, Wonkwang University)
Hwang In Jin (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim Eun Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim Goo Hwan (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Ko Kwang Hak (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Choi Yeon Seong (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Zhang Geun Gook (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Ryo Seong Il (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University)
Han Dong Won (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University)
Cha Suk (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
Park Dae Young (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.5, 2004 , pp. 1410-1417 More about this Journal
Abstract
To evaluate effect of Gamimajeonojahwan(GMOH) water extract on sexual functions, we orally administered GMOH exract(1,100㎎/㎏) for four weeks in male rats impaired by 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) and ketoconazole(KZ). And we investigated the sexual behaviors such as mount latency, mount frequency, intromission latency, intromission frequency, ejaculation period and ejaculation latency. Serum testosterone concentrations also are evaluated in GMOH-and/or vehicle-treated male rats. The results were obtained as follows: GMOH inhibited the increase of intromission latency by TCDD in male rats. GMOH inhibited the decrease of intromission frequency by TCDD in male rats. GMOH inhibited the increase of ejaculation latency by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by KZ in male rats. These results suggest that GMOH water extract is active in improving sexual functions and protecting a decrease of testosterone concentrations induced by TCDD and KZ in male rats.
Keywords
Gamimajeonojahwan; 2,3,7,8-tetrachlorodibenzo-p-dioxin; ketoconazole; sexual behaviors; testosterone;
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