• The Korean Journal of Physiology
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• 제8권1호
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• pp.15-22
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• 1974

The influence, upon male rat's mating behavior, of Korean Panax Ginseng administered for 3 and 5 days was investigated by direct behavioral observation and also by counting the number of copulation plugs the animals deposited. Four쇼-four male albino rats were used. Part of the animals received ginseng for 3 days (ginseng-3 day group, N= 12) or for 5 days(ginseng-5 day group, H=10), while the remaining animals received saline for 3 days (saline-3 day group, N=12) or for 5 days (saline-S day group, N=10). Each animal belonging to the 2 ginseng groups received subcutaneously 0.5 ml/100 g body weight of ginseng alcohol extract solution (4 mg of the ethyl alcohol extract in 1 ml of physiological saline), and each rat belonging to the 2 saline groups received the same amount of saline per day. During the dark period of the light-dark cycle on the next day following the last drug administration, a female rat in the artificial estrus was introduced to each male and the mating behavior was observed for 45 minutes. The observation session was divided into two parts and, in the early part which terminated with the first ejaculation and succeeding intromission, following behavioral measures were taken: mounting latency, intromission latency, inter-intromission period, ejaculatory latency(time from the first intromission until the first ejaculation), occurrence of mounting with intromission, occurrence of mounting without intromission, and postejaculatory interval. Behavioral measures taken in the later part of the session after the first ejaculation were: occurrence of mounting with intromission, occurrence of mounting without intromission, and occurrence of ejaculation. Immediately after the behavioral observation session the experiment turned to measure, for 10 days, the number of copulation plug which each pair of rats deposited. Following results were obtained: 1. After several mountings mounting with intromission, males of the 2 ginseng groups finished the first ejaculation significantly earlier than the corresponding 2 saline groups did. 2. The postejaculatory latency was significantly reduced in the ginseng-5 day group compare with the value of the saline-5 day group and also compared with the value of the ginseng-3 day group. 3. The 2 ginseng groups ejaculated significantly more often in 45 minutes' observation session than the corresponding 2 saline groups did. 4. The number of copulation plug deposited in 10 days by the animals of the 2 ginseng groups. significantly exceeded the number deposited by the corresponding 2 saline group animals. The animals of the ginseng-5 day group deposited copulation plugs significantly more than the animals of the ginseng-3 day group did. It is inferred from the above results that the ginseng facilitates mating behavior of male rats, and that the degree of facilitation may be influenced by the duration of drug administration.

• The Korean Journal of Physiology
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• 제6권1호
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• pp.33-37
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• 1972

유두체가 성 행동에 어떠한 영향을 미치는지를 알기 위하여 흰쥐 수컷 20마리를 두 무리로 나누어 한 무리에서는 유두체에 둔 전극을 거쳐 직류전류를 흘림으로써 유두체를 파괴하여 유두체군으로 하였으며, 다른 한 무리에서는 전류를 흘리기 전까지의 모든 조작을 유두체군에서와 마찬가지로하여 수술대조군으로 삼았다. 수술이 끝난 3주후 두 무리의 성 행동을 비교 관찰하였다. 실험결과는 다음과 같다. 1) 음부 압박을 하고 음경(陰莖)을 질내에 삽입하지 않은 오르기(mount)의 회수는 유두체군의 값이 수술대조군의 값보다 유의하게 적었다. 2) 질내 음경 삽입(intromission)을 동반한 오르기의 수효에 관해서는 두 무리 사이에 유의한 차이가 없었으나, 유두체군의 값이 수술대조군의 값에 비하여 다소 증가하는 경향이 있었다. 3) 질내 음경 삽입 유무를 가리지 않은 모든 오르기의 회수는 수술대조군에 비하여 유두체군에서 증가하는 경향은 있었으나 유의한 차이는 아니었다. 4) 첫 번째 질내 삽입에서부터 첫번째 사정시 까지의 시간 간격인 사정 지체시간(ejaculatory latency) 및 사정이 있은 때로부터 다음번 질내 음경 삽입 까지의 시간 간격인 사정-질내 삽입 시간 간격(postejaculatory interval)에 관하여는 두 무리 사이에 유의한 차이는 없었으나, 유두체군의 값이 수술대조군의 값에 비하여 다소 단축되는 경향이 있었다. 5) 그 밖에 관찰상자에 흰쥐 암컷을 넣은 다음 처음으로 질내 음경 삽입을 동반하거나 동반하지 않은 오르기를 하기 까지의 시간인 오르기 지체시간(mounting latency)과 관찰상자에 흰쥐 암컷을 넣은 후 처음으로 질내 음경 삽입을 하기까지의 시간인 질내 삽입 지체시간(intromission latency) 및 한 질내 삽입과 다음번 질내 삽입사이의 평균 시간인 질내 삽입 간 시간간격(interintromission period)에 관하여는 두 무리 사이에 유의한 차이가 없었다. 위의 결과로 미루어 유두체는 정상 동물에서 성 행동에 현저한 영향은 끼치지 않았으나 이 행동을 다소 억제하는 경향이 있는 것으로 추측된다. 그러나 이들 문제를 결정 짓기에 앞서 더 많은 연구가 요망된다.

• 동의생리병리학회지
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• 제18권5호
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• pp.1410-1417
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• 2004

To evaluate effect of Gamimajeonojahwan(GMOH) water extract on sexual functions, we orally administered GMOH exract(1,100㎎/㎏) for four weeks in male rats impaired by 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) and ketoconazole(KZ). And we investigated the sexual behaviors such as mount latency, mount frequency, intromission latency, intromission frequency, ejaculation period and ejaculation latency. Serum testosterone concentrations also are evaluated in GMOH-and/or vehicle-treated male rats. The results were obtained as follows: GMOH inhibited the increase of intromission latency by TCDD in male rats. GMOH inhibited the decrease of intromission frequency by TCDD in male rats. GMOH inhibited the increase of ejaculation latency by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by KZ in male rats. These results suggest that GMOH water extract is active in improving sexual functions and protecting a decrease of testosterone concentrations induced by TCDD and KZ in male rats.

• 대한한의학회지
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• 제20권1호
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• pp.22-29
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• 1999

To evaluate the effect of Choakwiyeum water extract on the male reproductive functions, experiments were performed on male rats. The results obtained were as follows: 1. Intromission frequency was increased significantly after the administration of Choakwiyeum water extract in male rats. 2. Intromission latency was increased significantly after the administration of Choakwiyeum water extract and ketoconazole in male rats. 3. Mount frequency was increased significantly after the administration of Cboakwiyeum water extract and TCDD in male rats. 4. Serum testosterone concentration was increased significantly after the administration of Choakwiyeum water extract in male rats. 5. Serum testosterone concentration was increased significantly after the administration of Choakwiyeum water extract and ketoconazole in male rats.

• Archives of Pharmacal Research
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• 제20권6호
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• pp.656-659
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• 1997

The Effects of Eurycoma longifolia Jack were studied on the sexual behaviour of male rats. Sexually normal male rats were treated twice daily with 500 mg $kg^{-1}$ / of different fractions of E.longifolia Jack for 10 days prior to test and were then observed for their copulatory behaviour with a receptive female in a copulation cage. Results showed that was a significant increase (p<0.05) in EL-1, EL-2, EL-3 but significant decrease (p<0.05) in both PEI-1 and PEI-2 in treated male rats as compared to the control male rats indicating that E. longifolia Jack increased the sexual performance of the treated male rats by extending the duration of coitus and decreasing the refractory period between the different series of copulation. Hence, this preliminary work supports the folk use of this plant as having aphrodisiac property.