• Title/Summary/Keyword: Intrinsic product

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Product Characteristics as Factors of Process Parameters in Starch Phosphates Preparation by Twin-screw Extruder (이축압출성형기로 인산전분 제조시 Process Parameters에 따른 제품의 특성)

  • Kim, Chong-Tai;Kim, Dong-Chul;Kim, Chul-Jin;Kim, Hae-Sung
    • Korean Journal of Food Science and Technology
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    • v.23 no.2
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    • pp.235-240
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    • 1991
  • Starch phosphates were prepared from the corn starch mixed with 2% sodium tripolyphosphate by twin-screw extruder with a feed rate of 20 kg/hr and an extrusion temperature of $130^{\circ}C$, and the effects of extrusion variables on the physicochemical properties (target parameters) of starch phosphates were investigated. Interrelations of system parameters (specific mechanical energy and extrudate moisture) and rheological properities of starch was analyzed by using the response surface analysis. Degree of substitution (DS) was increased with increasing the feed moisture, and showed the maximum value at the screw of near 250 rpm, Degree of gelatinization was proportionally increased with increasing the screw speed and decreasing the feed moisture. Apparent viscosity of the paste was increased with increasing the feed moisture, but it was not significantly affected by the screw speed. It was found by scanning electron microscopy that the starch microgranules were much more degradaded, and as consequent result, the intrinsic viscosity was decreased, whereas, water solubility index was increased. The rate of retrogradation of the gels was retarded with increasing DS and decreasing viscosity.

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Anti-cancer Properties and Relevant Mechanisms of Cordycepin, an Active Ingredient of the Insect Fungus Cordyceps spp., (동충하초 유래 cordycepin의 항암 활성 기전 최근 연구 동향)

  • Jeong, Jin-Woo;Choi, Yung Hyun
    • Journal of Life Science
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    • v.25 no.5
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    • pp.607-614
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    • 2015
  • Cancers are the largest cause of mortality and morbidity all over the world. Cordycepin, an adenosine analog, is a major functional component of the Cordyceps species, which has been widely used in traditional Oriental medicine. Over the last decade, this compound has been reported to possess many pharmacological properties, such as an ability to enhance immune function, as well as anti-inflammatory, antioxidant and anti-cancer effects. Recently, numerous studies have reported interesting properties of cordycepin as a chemopreventive agent as well. There is an accumulating body of experimental evidences suggesting that cordycepin impedes cancer progression by promoting apoptosis, inducing cell cycle arrest, modulating intracellular signaling pathways, and inhibiting invasion and metastasis of cancer cells. In many cancer cell lines, cordycepin inhibits growth and cell cycle progression by inducing arrest of the G2/M phase, resulting from the inhibition of retinoblastoma protein phosphorylation and induction of cyclin-dependent kinase inhibitors. To induce apoptosis, cordycepin activates the extrinsic and intrinsic pathways, which promotes reactive oxygen species generation and the downstream activation of kinase cascades. Cordycepin also can activate alternative pathways to cell death such autophagy. In addition, cordycepin can inhibit the pro-metastatic processes of cancer cell detachment, migration, and invasion through a variety of mechanisms, including the nuclear factor-kappa B and activated protein-1 signaling pathways. In this review, we summarized the variety of action mechanisms by which cordycepin may mediate chemopreventive effects on cancer and discussed the potential of this natural product as a promising therapeutic inhibitor of cancer development.

Induction of Apoptosis by Pectenotoxin-2 Isolated from Marine Sponges in U937 Human Leukemic Cells (인체 혈구암세포 U937에서 해양해면동물에서 추출된 Pectenotoxin-2에 의한 Apoptosis의 유발에 관한 연구)

  • Shin, Dong Yeok;Kang, Ho Sung;Bae, Song-Ja;Jung, Jee H.;Choi, Yung Hyun
    • Journal of Marine Bioscience and Biotechnology
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    • v.1 no.2
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    • pp.63-70
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    • 2006
  • Natural product compounds are the source of numerous therapeutic agents. The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets including anticancer agents. Among these, pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, which depolymerizes actin filaments, was found to be highly effective and more potent to activate an intrinsic pathway of apoptosis in p53-deficient tumor cells compared to those with functional p53 both in vitro and in vivo. However, the anti-proliferative mechanism of the compound at non-cytotoxic concentrations has not yet been explored. In the current study, we sought to investigate anti-proliferation and apoptosis of PTX-2 against U937 human leukemic cells and its underlying molecular mechanism. Exposure of U937 cells to PTX-2 resulted in growth inhibition and induction of apoptosis in dose- and time-dependent manner as measured by MTT assay, fluorescent microscopy and flow cytometric analysis. The anti-proliferative effect of PTX-2 was associated with a marked increase in the expression of cyclin-dependent kinase p21 (WAF1/CIP1) mRNA which was tumor suppressor p53-independent. The increase in apoptosis was connected with a time-dependent down-regulation of anti-apoptotic Bcl-XL and inhibitor of apoptosis proteins (IAPs) family such as XIAP and cIAP-2. Though additional studies are needed, these findings suggested that PTX-2-induced inhibition of U937 cells was associated with the induction of apoptotic cell death and the results provided important new insights into the possible molecular mechanisms of the anti-cancer activity of PTX-2.

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Optimal Sampling Method of Censored Data for Optimizing Preventive Maintenance (예방정비 최적화를 위한 중도절단 자료의 최적 샘플링 방안)

  • Lee, In-Hyun;Oh, Sea-Hwa;Li, Chang-Long;Yang, Dong-In;Lee, Key-Seo
    • Journal of the Korean Society for Railway
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    • v.16 no.3
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    • pp.196-201
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    • 2013
  • As there is no failure data for the entire lifecycle of a product, when analyzing reliability measures based on early failure data only, there may be a significant error between the estimated mean life and the real one, because it can be underestimated, or on the other hand, it can be overestimated when analyzing reliability measures based on a large amount of censored data with the failure data. To resolve the issue, this study proposes an optimal sampling estimation procedure that selects the proportion of censored data to estimate the optimal distribution with the idea that the estimated distribution could be approximated as closely as the real life distribution. This would work if we sampled the optimal proportion on the censored data, because failure data has real intrinsic distribution in any situation. We validate the proposed procedure using an actual example. If the proposed method is applied to the maintenance policy of TWC (Train to Wayside Communication) system, then we can establish the optimal maintenance policy. Thus, we expect that it will be effective for improvement of reliability and cost savings.

The Realities and Practices in the UK's Community Archives Movement (영국 공동체 아카이브 운동의 전개와 실천적 함의)

  • Lee, Kyong Rae;Lee, Kwang-Suk
    • The Korean Journal of Archival Studies
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    • no.37
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    • pp.3-39
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    • 2013
  • The purpose of this study is to analyze the present stage of community archives movement in the UK. By doing so, it draws some implications of the UK case for the community archives movement in Korea. The UK's 'Independent' community archives as a part of grassroots movement are characterized by participation, autonomy, and self-help of community members. Along with the appearance of the concept of 'community', the UK has experienced the revitalization period of community archives in the social context of community-based urban regeneration project. Recently, the UK's community archives have transformed themselves into building a 'governance model' relying on the partnership with mainstream archives. In particular, the UK model of community archives is based 'on their own ways' with their autonomy as a product of intrinsic development initiated by communities themselves. The character of the model of this type is very analogous to the nature of maul' community archives movement in Korea. Since the early 2000s, however, the UK model of community archives has been evolving into a way of building governance through their appropriation of the skills and methodologies from mainstream archives without endangering the autonomous essences of community archives themselves. We need to note the point of local researchers' view in archival science who have tried to seek out the methodology for building maul community archives with regard to openness and collaboration. In this respect, a shift in archival principle in the UK would give significant implications in regenerating the locally based community model.

Induction of Apoptosis by Treatment of Human Prostate Cancer LNCaP Cells with Methanol Fractions from Prunus mume (매실(Prunus mume) 메탄올 분획물의 처리에 따른 인체 전립선암세포 LNCaP의 apoptosis 유도 효과)

  • Kim, Hwi-gon;Kim, Jeong-Ho;Heo, Ji-An;Won, Yeong-Seon;Seo, Kwon-Il
    • Journal of Life Science
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    • v.31 no.3
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    • pp.321-329
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    • 2021
  • This study examined the growth inhibitory effect of the methanol fraction of maesil (Prunus mume) extract (MMF) on LNCaP, PC-3, and RC-58T human prostate cancer cell lines. Among these cell lines, LNCaP was the most sensitive to the inhibitory effects of MMF. Observation of the morphology and apoptotic body formation in the LNCaP cells revealed morphological changes, nuclear damage, and condensation in response to MMF treatment. The suppressive effect of MMF was related to the intrinsic apoptosis pathway, as indicated by increased expression of the pro-apoptotic proteins Bax, capase-3, capase-9, and PARP and decreased expression of the anti-apoptotic protein Bcl-2. Combined treatment with MMF and the AIF inhibitor N-phenylmalemide (N-PM) indicated that MMF treatment alone had a significant growth suppression effect. The involvement of the extrinsic apoptosis pathway was also confirmed by increased expression of AIF and Endo G. The growth suppression effect of MMF was also significant when compared to the effects of a combination of the PI3K inhibitor LY294002 and MMF. The reduced expression of PI3K, p-Akt, and p-mTOR confirmed the involvement of the PI3K/Akt/ mTOR signaling pathway in regulating the anti-proliferative properties of MMF. In conclusion, the growth suppression effect of MMF in the LNCaP human prostate cancer cell line shows the possibility of using this natural product in functional foods.

A Data-Driven Approach and Network Analysis of Technological Innovation Resources in SMEs (데이터 기반 접근법을 활용한 중소기업 기술혁신자원의 네트워크 분석)

  • Kyung Min An;Young-Chan Lee
    • Knowledge Management Research
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    • v.24 no.4
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    • pp.103-129
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    • 2023
  • This study aims to analyze the network structure of technological innovation resources in SMEs, especially manufacturing firms, and reveal the differences between innovative and non-innovative firms. The study first analyzes connection centrality, flow-mediated centrality, and power centrality for all firms, and derives structural equivalence through CONCOR analysis. Then, the network structure of innovative and non-innovative firms was compared and analyzed according to innovation performance and creation. The results show that entrepreneurship and corporate innovation strategy have a significant impact on the analysis of technological innovation resources of all firms. According to the CONCOR analysis, the innovation resources of SMEs are organized into seven clusters, which can be defined as intrinsic product innovation resources, competitive advantage promotion resources, cooperative activities resources, information system resources, and innovation protection resources. The network analysis of innovative and non-innovative firms showed that innovative firms focused on enhancing competitiveness and improving quality, while non-innovative firms tended to focus more on existing products and customers. In addition, innovative firms had eight clusters, while non-innovative firms had six clusters, suggesting that innovative firms utilize resources diversely to pursue structural change and new value creation, while non-innovative firms operate technological innovation resources in a more stable form. This study emphasizes the importance of entrepreneurship and corporate innovation strategy in SMEs' technological innovation, and suggests that strong internal efforts are needed to increase innovativeness. These findings have important implications for strategy formulation and policy development for technological innovation in SMEs.

The Effect of Perceived Shopping Value Dimensions on Attitude toward Store, Emotional Response to Store Shopping, and Store Loyalty (지각된 쇼핑가치차원이 점포태도, 쇼핑과정에서의 정서적 경험, 점포충성도에 미치는 영향에 관한 연구)

  • Ahn Kwang Ho;Lee Ha Neol
    • Asia Marketing Journal
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    • v.12 no.4
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    • pp.137-164
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    • 2011
  • In the past, retailers secured customer loyalty by offering convenient locations, unique assortments of goods, better services than competitors, and good credit policy. All this has changed. Goods assortments among stores have become more alike as national-brand manufacturers place their goods in more and more retail stores. Service differentiation also has eroded. Many department stores have trimmed services, and many discount stores have increased theirs. Customers have become smarter shoppers. They don't pay more for identical brands, especially when service differences have diminished. In the face of increased competition from discount storess and specialty stores, department stores are waging a comeback war. Growth of intertype competition, competition between store-based and non-store-based retailing and growing investment in technology are changing the way consumers shop and retailers sell. Different types of stores-discount stores, catalog showrooms, department stores-all compete for the same consumers by carrying the same type of merchandise. The biggest winners are retailers that have helped shoppers to be economically cautious, simplified their increasingly busy and complicated lives, and provided an emotional connection. The growth of e-retailers has forced traditional brick-and-mortar retailers to respond. Basically brick-and-mortar retailers utilize their natural advantages, such as products that shoppers can actually see, touch, and test, real-life customer service, and no delivery lag time for small-sized purchases. They also provide a shopping experience as a strong differentiator. They are adopting practices as calling each shopper a "guest". The store atmosphere should match the basic motivations of the shopper. If target consumers are more likely to be in a task-oriented and functional mindset, then a simpler, more restrained in-store environment may be better. Consistent with this reasoning, some retailers of experiential products are creating in-store entertainment to attract customers who want fun and excitement. The retail experience must deliver value to turn a one-time visitor into a loyal customer. Retailers need a tool that measures the full range of components that define experience-based value. This study uses an experiential value scale(EVS) developed by Mathwick, Malhotra and Rigdon(2001) which reflects the benefits derived from perceptions of playfulness, aesthetics, customer "return on investment" and service excellence. EVS is useful to predict differences in shopping preferences and patronage behavior of customers. EVS consists of items measuring efficiency, economic value, visual appeal, entertainment value, service excellence, escapism, and intrinsic enjoyment, which are subscales of experiencial value. Efficiency, economic value, service excellence are linked to the utilitarian shopping value. And visual appeal, entertainment value, escapism and intrinsic enjoyment are linked to hedonic shopping value. It has been found that consumers value hedonic experiences activated from escapism and attractiveness of shopping environment as much as the product quality, price, and the convenient location. As a result, many department stores, discount stores, and other retailers are introducing differential marketing strategy based on emotional/hedonic values. Many researches suggest that consumers go shopping not only for buying products but also for various shopping experiences. In other words, they seek the practical, rational value as well as social, recreational values in the shopping process(Babin et al, 1994; Bloch et al, 1994). Retailers may enhance buyer's loyalty to store by providing excellent emotional/hedonic value such as the excitement from shopping, not just the practical value of buying good products efficiently. We investigate the effect of perceived shopping values on the emotional experience and store loyalty based on the EVS(Experiential Value Scales) developed by Holbrook(1994), Mathwick, Malhotra and Rigdon(2001). This study assumes that the relative effect of shopping value dimensions on the responses of shoppers will differ according to types of stores and analyzes the moderating effect of store type(department store VS. discount store) on the causal relationship between shopping value dimensions and store loyalty. Emprical results show that utilitarian values of shopping experience and hedonic value of shipping experience give the positive effect on the emotional response of consumers and store loyalty. We also found the moderating effect of store types. The effect of utilitarian shopping values on the attitude toward discount store is higher than the effect of utilitarian shopping values on the attitude toword department store. And the effect of hedonic shopping value on the emotional response to discount store is higher than on the emotional response to department store. The empirical results reflect on the recent trend that discount stores try to fulfill the hedonic needs of consumers as well as utilitarian needs(i.e, low price) that discount stores traditionally have focused on

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Determination of Preservatives in Raw Materials of Functional Foods by HPLC-PDA and GC-FID (HPLC 및 GC를 이용한 건강기능식품 원료 중 보존료 함유량 조사)

  • Kim, Jung-Bok;Kim, Myung-Chul;Song, Sung-Woan;Shin, Jae-Wook
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.46 no.3
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    • pp.358-367
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    • 2017
  • Preservatives, as food additives, are occasionally intrinsic to natural raw materials or sometimes generated during the fermentation process as reported in many research articles. Preservative compounds in raw food materials may persist in the final food product, which is not supposed to include such preservative compounds. In this study, we validated an analytical method for preservative compounds in raw materials of functional foods. Quantification of benzoic acid and sorbic acid was determined using HPLC-PDA analysis after distillation, whereas propionic acid was quantified with GC-FID. A significant set of validation data (accuracy, precision, linearity, recovery, etc) was acquired. A total of 212 samples were collected for analysis of naturally occurred preservatives, and preservatives were detected in 85 samples. Most of the detected samples showed less 10 mg/kg of preservatives. The results of this study provide fundamental data on naturally occurring preservatives in raw materials of functional foods. Moreover, building up a database of naturally occurring preservatives could solve problems in the current scientific data.

A Comparison between the Reference Evapotranspiration Products for Croplands in Korea: Case Study of 2016-2019 (우리나라 농지의 기준증발산 격자자료 비교평가: 2016-2019년의 사례연구)

  • Kim, Seoyeon;Jeong, Yemin;Cho, Subin;Youn, Youjeong;Kim, Nari;Lee, Yangwon
    • Korean Journal of Remote Sensing
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    • v.36 no.6_1
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    • pp.1465-1483
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    • 2020
  • Evapotranspiration is a concept that includes the evaporation from soil and the transpiration from the plant leaf. It is an essential factor for monitoring water balance, drought, crop growth, and climate change. Actual evapotranspiration (AET) corresponds to the consumption of water from the land surface and the necessary amount of water for the land surface. Because the AET is derived from multiplying the crop coefficient by the reference evapotranspiration (ET0), an accurate calculation of the ET0 is required for the AET. To date, many efforts have been made for gridded ET0 to provide multiple products now. This study presents a comparison between the ET0 products such as FAO56-PM, LDAPS, PKNU-NMSC, and MODIS to find out which one is more suitable for the local-scale hydrological and agricultural applications in Korea, where the heterogeneity of the land surface is critical. In the experiment for the period between 2016 and 2019, the daily and 8-day products were compared with the in-situ observations by KMA. The analyses according to the station, year, month, and time-series showed that the PKNU-NMSC product with a successful optimization for Korea was superior to the others, yielding stable accuracy irrespective of space and time. Also, this paper showed the intrinsic characteristics of the FAO56-PM, LDAPS, and MODIS ET0 products that could be informative for other researchers.