• The Korean Journal of Physiology and Pharmacology
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• 제24권1호
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• pp.53-68
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• 2020

The purpose of this study was to characterize the genetic contribution to endothelial adaptation to exercise training. Vasoreactivity was assessed in aortas from four inbred mouse strains (129S1, B6, NON, and SJL) after 4 weeks of moderate intensity continuous exercise training (MOD), high intensity interval training (HIT) or in sedentary controls (SED). Intrinsic variations in endothelium-dependent vasorelaxation (EDR) to acetylcholine (ACh) as well as vasocontractile responses were observed across SED groups. For responses to exercise training, there was a significant interaction between mouse strain and training intensity on EDR. Exercise training had no effect on EDR in aortas from 129S1 and B6 mice. In NON, EDR was improved in aortas from MOD and HIT compared with respective SED, accompanied by diminished responses to PE in those groups. Interestingly, EDR was impaired in aorta from SJL HIT compared with SED. The transcriptional activation of endothelial genes was also influenced by the interaction between mouse strain and training intensity. The number of genes altered by HIT was greater than MOD, and there was little overlap between genes altered by HIT and MOD. HIT was associated with gene pathways for inflammatory responses. NON MOD genes showed enrichment for vessel growth pathways. These findings indicate that exercise training has non-uniform effects on endothelial function and transcriptional activation of endothelial genes depending on the interaction between genetic background and training intensity.

• 대한치매학회지
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• 제21권3호
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• pp.93-102
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• 2022

Background and Purpose: The effects of high-intensity interval training (HIIT) interventions on functional brain changes in older adults remain unclear. This preliminary study aimed to explore the effect of physical exercise intervention (PEI), including HIIT, on cognitive function, physical performance, and electroencephalogram patterns in Korean elderly people. Methods: We enrolled six non-dementia participants aged >65 years from a community health center. PEI was conducted at the community health center for 4 weeks, three times/week, and 50 min/day. PEI, including HIIT, involved aerobic exercise, resistance training (muscle strength), flexibility, and balance. Wilcoxon signed rank test was used for data analysis. Results: After the PEI, there was improvement in the 30-second sit-to-stand test result (16.2±7.0 times vs. 24.8±5.5 times, p=0.027), 2-minute stationary march result (98.3±27.2 times vs. 143.7±36.9 times, p=0.027), T-wall response time (104.2±55.8 seconds vs.71.0±19.4 seconds, p=0.028), memory score (89.6±21.6 vs. 111.0±19.1, p=0.028), executive function score (33.3±5.3 vs. 37.0±5.1, p=0.046), and total Literacy Independent Cognitive Assessment score (214.6±30.6 vs. 241.6±22.8, p=0.028). Electroencephalography demonstrated that the beta power in the frontal region was increased, while the theta power in the temporal region was decreased (all p<0.05). Conclusions: Our HIIT PEI program effectively improved cognitive function, physical fitness, and electroencephalographic markers in elderly individuals; thus, it could be beneficial for improving functional brain activity in this population.

• 국제물리치료학회지
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• 제12권2호
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• pp.2345-2353
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• 2021

Background: This study evaluated the effectiveness of upper thoracic manipulation (UTM) and proprioceptive training versus proprioceptive training alone on forward head posture (FHP) and cervicocephalic joint position sense (CJPS) in asymptomatic university students during a short interval of time. Objectives: To evaluate whether the suggested combination would provide greater benefit, and be superior to proprioceptive training alone in improving proprioceptive acuity and head posture. Design: A single-blind randomized controlled trial. Methods: Thirty-three university student volunteers with asymptomatic FHP were recruited. Subjects were randomly assigned to a manipulation group (n=16) receiving UTM combined with proprioceptive training or a proprioception group (n=17) receiving proprioceptive training only. The intervention period lasted 5 weeks in total, and consisted of one 15 to 20-minute session per week. FHP and CJPS were assessed before and after the intervention. Results: A significant pre- to post-intervention decrease in FHP and joint position error was identified in both groups (P<.05). Subjects in the manipulation group demonstrated greater improvements in CJPS and head posture compared to the proprioception group (P<.05). Conclusion: These findings support employing either intervention for treating asymptomatic students with FHP. However, the addition of UTM to proprioceptive training was more effective than proprioceptive training alone in reducing joint position errors and improving head posture.

• 생명과학회지
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• 제23권12호
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• pp.1436-1444
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• 2013

항산화 활성과 피로회복 기능성이 강화된 흑마늘 함유 음료를 개발하기 위하여 5% 흑마늘 추출물과 1%의 생약재 5종 혼합추출물(상황버섯, 황금, 단삼, 뽕잎, 작약)을 70:30(v/v)의 비로 혼합한 흑마늘 복합물(BHF)을 제조하였다. 흑마늘 복합물은 성인의 1일 섭취량을 고려하여 1일 100 ml 섭취 시(BHF1)와 300 ml 섭취 시(BHF2)를 기준으로 실험쥐의 식이에 5주간 혼합 급이하면서 간헐적 강제운동에 따른 체내 지질 성분 및 항산화 효소 활성을 분석하였다. 흑마늘 복합물의 총 페놀화합물 함량은 BHF2가 BHF1에 비해 유의적으로 높았으며, 항산화 활성은 총 페놀 함량에 의존적이었다. 혈중 총 단백질 함량은 운동대조군과 흑마늘 복합물 급이군 간에 유의차가 없었으나, 알부민 함량은 Ex-BHF2군이 유의적으로 높았다. AST 및 ALT 활성은 흑마늘 복합물 급이군이 운동대조군에 비해 유의적으로 감소되었다. 혈청 중성지방, 총 콜레스테롤, LDL-콜레스테롤 및 HTR 수준은 Ex-BHF2군에서 운동대조군에 비해 유의적으로 감소되었다. 간 조직의 총 지질 함량은 흑마늘 복합물 급이군과 운동 대조군간에 유의차가 없었다. 반면에 중성지방과 총 콜레스테롤 함량은 Ex-BHF2군이 타 실험군에 비해 유의적으로 낮았다. 흑마늘 복합물 급이에 따른 간 조직에서 catalase 활성은 Ex-BHF2군만 유의적으로 증가하였으나, SOD와 GSH-px 활성은 흑마늘 복합물의 농도가 많아짐에 따라 유의적으로 증가되었다. 간헐적인 강제운동을 한 흰쥐에서 흑마늘과 생약재 복합물의 급이는 체내 중성지방과 콜레스테롤 함량을 낮추고, 항산화 효소 활성을 증가시킴으로써 산화적 스트레스에 대한 생체 보호가 가능할 것으로 판단된다.

• 한국정보처리학회논문지
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• 제7권12호
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• pp.3821-3828
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• 2000

많은 소프트웨어 프로젝트는 시험이나 운영단계에서 고장 시간이나 고장 수 데이타 보다는 그룹 고장 데이타 (여러 고장 간격에서 또는 가변적인 시간 간격에서의 고장 들)가 수집된다. 본 논문은 그룹 고장 데이타에 대해 가변적인 미래의 시간에서 누적 고장 수를 예측할 수 있는 신경망 모델을 제시한다. 신경망의 입-출력으로 무엇을 선택하고 어떤 순서로 훈련을 수행하느냐에 따라 신경망의 예측력에 영향을 미친다. 따라서, 신경망의 입-출력에 대한 11개의 훈련제도가 고려되었으며, 모델의 성능을 평가하기 위해 다음 단계 평균 상대 예측 오차 (AE)와 정규화된 AE (NAE) 측도에 의해 최적의 훈련제도가 선택되고, 다른 잘 알려진 신경망 모델과 통계적 소프트웨어 신뢰성 성장 모델과 비교되었다. 실험 결과, 가변적인 미래의 시간 간격에서 누적 고장 수를 예측하기 위해서는 신경망 모델에 가변 시간간격 정보가 필요함을 보였다.

• 한국항공운항학회지
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• 제29권2호
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• pp.47-54
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• 2021

Recently, the issue of maintaining pilot competency has emerged as one of the major challenges in the aviation industry due to irregular schedules and flight intervals caused by the global COVID-19. Therefore, a survey was conducted on airline pilots to determine how stressed they would be when returning to their flights after experiencing irregular schedules or long-term furloughs. The level of stress that pilots receive due to flight intervals was divided into periods, and correlation with general characteristics was identified to see what emotional burdens exist as the lengths of flight interval increased. As a result, burdened flight intervals and the Pilot Flying(PF) intervals were identified as a statistically significant variables. In the case of the Pilot Flying interval, the level of stress was confirmed to be worse as the flying interval was elongated, and in the case of the burdened flying interval, the tendency of the stress index were lower as the period increased. Through this study, pilots who experienced reduced flight times were found to be accompanied by considerable amount of emotional burden proportionate to the length of the interval period.

• International Journal of Aeronautical and Space Sciences
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• 제16권4호
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• pp.510-519
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• 2015

Concerning the issue of high-dimensions, hybrid uncertainties of randomness and intervals including implicit and highly nonlinear limit state function, reliability analysis based on the hybrid uncertainty reliability mode combining with back propagation neural network (HU-BP neural network) is proposed in this paper. Random variables and interval variables are as input layer of the neural network, after the training and approximation of the neural network, the response variables are obtained through the output layer. Reliability index is calculated by solving the optimization model of the most probable point (MPP) searching in the limit state band. Two numerical cases are used to demonstrate the method proposed in this paper, and finally the method is employed to solving an engineering problem of the aerospace friction plate. For this high nonlinear, small failure probability problem with interval variables, this method could achieve a good analysis result.

• 대한인간공학회지
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• 제35권6호
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• pp.493-501
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• 2016

Objective: This study analyzes the effect of angle conditions of rehabilitation equipment used for supporting hemiplegic patients on their rehabilitation training for standing action. The study was performed by adjusting the rear angle of seat inclination through a motion analysis. Background: Owing to a loss of muscle rigidity and degradation of muscle control ability, hemiplegic stroke patients suffer from asymmetrical posture, abnormal body balance, and degraded balance abilities due to poor weight-shifting capacity. The ability to shift and maintain one's weight is extremely essential for mobility, which plays an important role in our daily life. Thus, to improve patients' ability to maintain weight evenly and move normally, they need to undergo orthostatic and ambulatory training. Method: Using a motion analysis system, knee movements on both hemiplegic side and non-hemiplegic side were measured and analyzed in five angles ($0^{\circ}$, $10^{\circ}$, $30^{\circ}$, $50^{\circ}$, $70^{\circ}$) while supported by the sit-to-stand rehabilitation equipment. Results: The knee movements on both sides increased as the angle increased in angle support interval to support a hemiplegic patient's standing up position. In standing up interval, a hemiplegic patient's knee movement deviations on both sides decreased, and the movement differences between hemiplegic and non-hemiplegic legs also decreased as the angle increased. Conclusion: The results of this study showed that the rehabilitation effectiveness increases as the angle increases, leading to a balanced standing posture through the decrease of movement difference between hemiplegic and non-hemiplegic sides and an improved standing up ability through the increase of knee movement on both sides. However, angles higher than $50^{\circ}$ didn't provide a significant effect. Therefore, a support angle under $50^{\circ}$ was proposed in this study. Application: The results of this study are expected to be applicable to the design of sit-to-stand support equipment to improve the effectiveness of the rehabilitation process of hemiplegic patients.

• 한국전문물리치료학회지
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• 제22권2호
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• pp.30-40
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• 2015

Robot-assisted rehabilitation therapy has been used to increase physical function in post-stroke patients. The aim of this meta-analysis was to identify whether robot-assisted gait training can improve patients' functional abilities. A comprehensive search was performed of PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Physiotherapy Evidence Database (PEDro), Academic Search Premier (ASP), ScienceDirect, Korean Studies Information Service System (KISS), Research Information Sharing Service (RISS), Korea National Library, and the Korean Medical Database up to April, 2014. Fifteen eligible studies researched the effects of robot-assisted gait training to a control group. All outcome measures were classified by International Classification of Functioning, Disability, and Health (ICF) domains (body function and structures, activity, and participation) and were pooled for calculating the effect size. The overall effect size of the robot-assisted gait training was .356 [95% confidence interval (CI): .186~.526]. When the effect was compared by the type of electromechanical robot, Gait Trainer (GT) (.471, 95% CI: .320~.621) showed more effective than Lokomat (.169, 95% CI: .063~.275). In addition, acute stroke patients showed more improvement than others. Although robot-assisted gait training may improve function, but there is no scientific evidence about the appropriate treatment time for one session or the appropriate duration of treatment. Additional researchers are needed to include more well-designed trials in order to resolve these uncertainties.

• 한국정보통신학회논문지
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• 제17권12호
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• pp.2818-2825
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• 2013

본 논문에서는 MIMO-OFDM 시스템에서 시간영역 훈련신호의 직교화를 통한 채널추정 방법을 제안하였다. 본 논문에서는 Jeon[8]이 제안한 방법을 그대로 송신 안테나 개수가 4개인 MIMO-OFDM 시스템으로 확장하였을 때 수신기에서 다중경로 지연신호로 인하여 훈련신호가 직교되는 않는 문제점이 있음을 보였다. 이러한 문제점에 대한 해결책으로 훈련신호 중앙에 보호구간을 삽입하는 새로운 훈련신호 발생 방법을 제안하였다. 제안한 방법은 훈련신호들이 서로 직교하기 때문에 수신기에서 Walsh decoding sum기법을 통하여 시간영역에서 채널응답을 추정할 수 있음을 보였다.