• 대한두경부종양학회지
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• 제17권2호
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• pp.179-184
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• 2001

Objective: The role of chemotherapy in locally advanced head and neck cancer has been established in nasopharynx and larynx as definitive therapy and organ preserving therapy, respectively. Oral cavity cancers are relatively uncommon and local recurrence is the main cause of treatment failure. We planned this retrospective study to evaluate the role of neoadjuvant chemotherapy in locally advanced oral cavity cancer patients. Materials and Methods: From 1988 March to 2001 February, locally advanced, previously untreated oral cavity cancer patients who received neoadjuvant chemotherapy were examined. Chemotherapy had been done in the following patients: Histologically proven squamous cell or poorly differentiated carcinoma, stage 3 or 4, and performance state 0-2 patients. Chemotherapy regimen consisted of cisplatin and infusional 5-fluorouracil. Response was evaluated after 2 cycles and in case of no response, definitive local therapy was done; otherwise 3 cycles was done before local treatment. Results: 48 patients were treated and 47 patients were evaluable for responses. Complete response rate was 6.4%(3/47) and partial response 80.0%(38/47), scoring overall response rate of 87.2%. Median time to progression was 27.0 months (95% CI : 0-58months) and overall 5 year survival was 54.8%. 5-year disease-free survival in the patients in remission after local treatment was 51.9%. In multivariate analysis, contributing factor to the survival were response to neoadjuvant chemotherapy and local treatment modalities. Extensive surgery was done in 10 patients and 25 patents (52.1%) was followed up with preserved function. With median follow-up of 57.0 months, 19 recurrences were detected, most of which were local or regional type. Conclusion: Neoadjuvant chemotherapy followed by local treatment in oral cavity cancer showed high response rate and was thought to be effective therapeutic approach especially in view of organ preservation.

• 한국음향학회지
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• 제16권5호
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• pp.60-67
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• 1997

서기 771년(신라, 혜공왕 7년)에 주조된 성덕 대왕 신종은 지면으로부터 약 50cm 떨어지게 설치되어 있으며 지면에 울림통을 가지고 있다. 이 울림통은 일종의 공명기의 역할을 하여 종 내부와 함께 성덕 대왕 신종의 고유한 소리 특성에 영향을 줄 것이라 예측되어 왔다.[1, 2, 3]. 본 논문에서는 이를 규명하기 위한 내부 음장의 3차원 측정 실험을 소개하고 있으며 울림통이 종소리에 끼치는 영향을 단순하나 물리적 현상을 대표하는 모델을 이용하여 설명하고 있다. 이러한 해석 방법을 기초로 하여 새로운 울림통의 크기를 제안하고 있다.

• Restorative Dentistry and Endodontics
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• 제32권1호
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• pp.9-18
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• 2007

이 연구의 목적은 와동벽에서 다른 위치에서의 상아질 접착제의 두께를 평가하고, 이런 다양한 접착제의 두께와 미세 인장 강도 사이의 관계를 평가하기 위한 것이다. 여섯 개의 인간 대구치에 모든 상아질 면이 노출되도록 I급 와동을 형성하였다 3개의 치아는 filled adhesive ($Clearfil^{TM}$ SE bond)를 와동 내에 도포하였고, 다른 3개의 치아는 unfilled adhesives ($Scotchbond^{TM}$ Multi Purpose)를 도포하였다. 형광 현미경을 이용하여 접착층의 형태와 두께를 관찰하였다. 접착제의 두께는 수직 와동벽을 따라 와동 변연, 와동벽 1/2, 와동 내각의 세 지점에서 측정되었다. $Scotchbond^{TM}$ Multi Purpose와 $Clearfil^{TM}$ SE bond가 와동 변연과 와동벽 1/2, 와동 내각에서의 접착제의 두께를 재현하여 미세 인장 결합 강도를 측정하였다. 이 실험의 결과에서 두 가지 상아질 접착제 모두에서 와동 내각에서의 접착제의 두께가 와동 변연과 와동벽 1/2위치에서의 두께보다 두꺼웠으며, 와동 내각의 두꺼운 접착제의 미세 인장 결합 강도는 와동 변연과 와동벽 1/2에서의 얇은 접착제 두께의 미세 인장 결합 강도보다 유의성 있게 높게 나타났다.

• 전자공학회논문지D
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• 제36D권3호
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• pp.75-84
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• 1999

주입전류가 문턱전류 이상일 때 선폭증가계수, 구속계수, 내부손실과 레이저의 길이가 λ/4 위상천이 DFB레이저의 단일모드 이득차와 발진주파수의 변화에 미치는 영향에 대하여 체계적으로 연구하였다. 구속계수나 선폭증가계수와 구속계수의 곱으로 주어지는 변수보다 선폭증가계수가 단일모드 이득차 및 발진주파수에 미치는 영향이 크다. 내부손실이나 레이저 길이 각각의 값보다 내부손실과 레이저 길이의 곱으로 정의되는 정규화된 내부손실이 DFB 레이저의 단일모드 이득차 및 발진주파수의 변화에 미치는 영향이 크다. 정규화된 내부손실이 같은 경우에는 내부손실계수보다 레이저의 길이가 동작특성에 미치는 영향이 큼을 알 수 있었다. 또한 양자우물 레이저가 builk 레이저에 비하여 선폭증가계수가 작기 때문에 구속계수와 정규화된 내부손실 값의 변화에 따른 단일모드 이득차의 감소와 발진주파수의 변화가 작음을 보았다.

• Parasites, Hosts and Diseases
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• 제46권3호
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• pp.171-173
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• 2008

A 3-yr-old female mongrel dog was referred to the Veterinary Teaching Hospital of Chungnam National University in the Republic of Korea. An adult heartworm, Dirofilaria immitis, was found in the abdominal cavity of the dog during spaying. Dirofilariasis in this dog was also diagnosed by modified Knott's test, ELISA test, and PCR analysis. The present case is the first report on the migration of an adult dog heartworm to the abdominal cavity of a dog in the Republic of Korea.

• Journal of Yeungnam Medical Science
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• 제31권1호
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• pp.43-47
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• 2014

Extramedullary plasmacytoma (EMP) is a rare disease that occurs in 3% to 5% of patients with plasma cell disorder. It occurs most commonly in the upper respiratory tract and the oral cavity. Very few EMP cases have been reported in the central nervous system (CNS). We report herein an unusual case of EMP in the nasal cavity that recurred in the CNS without systemic involvement. A 67-year-old man visited our hospital due to a month-long bout with exophthalmos. He was diagnosed with EMP in the nasal cavity, paranasal sinus, and orbital cavity. He received radiotherapy to which he had complete responses. After 2 years, he visited our hospital because of a month-long headache. He was diagnosed with EMP recurrence in the CNS via brain magnetic resonance imaging and cerebrospinal fluid analysis. He was treated with whole brain radiotherapy and intrathecal chemotherapy with methotrexate, but he expired due to pneumonia.

• 한국토양비료학회지
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• 제25권2호
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• pp.175-180
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• 1992

홍삼(紅參)에서 내공발생(內空發生)은 품질저해요인(品質沮害要因)으로서 큰 비중을 자지하고 있다. 내공발생(內空發生)의 원인을 구명하고자 전국 주요산지의 재배환경 조건과, 그 산지에서 생산한 수삼(水蔘)을 각 포장별로 홍삼제조후 내공발생율(內空發生率)을 6개년간 조사하여 그 관계를 해석하고 여기서 얻은 주 요인들을 확인코자 몇개의 포장시험을 수행하여 확인한 결과를 요약하면 다음과 같다. 1. 홍삼에서 내공발생은 약 70%가 인삼동체의 주피부와 중심부 경계면에서 발현하므로 수삼의 주피부와 중심부간의 소질 차이에서 시인되는 것으로 보인다. 2. 홍삼에서 내공발생률이 27.5% 이상일 때는 천지삼율 저하와 밀접한 관계에 있지만 그 이하로 적게 발생할 때는 내공외의 다른 요인이 크게 작용하는 것으로 보였다. 3. 광(光)이 많이 들어가는 해가림구조(전후주고(前後柱高), 전후주(前後柱) 및 해가림 폭(幅)/후주고(後柱高) 비(比)가 큼)에서 내공발생율(內空發生率)이 높은 경향이나 유의성은 없었으며, 투광율(透光率) 15.9% 까지는 내공발생(內空發生)이 줄어들다가 그 이상으로 높아지면 다시 증가하였다. 4. 토양수분(土壤水分)과 내공발생율(內空發生率)과의 관계는 내공발생율(內空發生率)이 27.5% 이상으로 심할때는 부상관(負相關)이고 그 이하에서는 정상관(正相關)을 보여, 토양수분은 내공발생이 많을 때에는 내공(內空)요인으로 크게 기여하는 것으로 보이며, 토양공극율(土壤孔隙率)도 같은 경향이었다.

• Restorative Dentistry and Endodontics
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• 제19권1호
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• pp.231-254
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• 1994

Fracture of cusp, on posterior teeth, especially those carious or restored, is major cause of tooth loss. Inappropriate treatments, such as unnecessarily wide cavity preparations, increase the potential of further trauma and possible fracture of the remaining tooth structures. Fracture potential may be directly related to the stresses exerted upon the tooth during masticatory function. The purpose of this study is to evaluate the fracture resistance of tooth, restored with composite resin inlay. In this study, MOD inlay cavity prepared on maxillary first premolar and restored with composite resin inlay. Three dimensional finite element models with eight nodes isoparametric solid element, developed by serial grinding-photographing technique. These models have various occlusal isthmus and depth of cavity, 1/2, 1/3 and 1/4 of isthmus width and 0.7, 0.85 and 1.0 of depth of cavity. The magnitude of load was 474 N and 172 N as presented to maximal biting force and normal chewing force. These loads applied onto ridges of buccal and lingual cusp. These models analyzed with three dimensional finite element method. The results of this study were as follows : 1. There is no difference of displacement between width of occlusal isthmus and depth of cavity. 2. The stress concentrated at bucco-mesial comer, bucco-disal comer, pulpal line angle and the interface area between internal slopes of cusp and resin inlay. 3. The vector of stress direct to buccal and lingual side from center of cavity, to tooth surface going on to enamel. The magnitude of vector increase from occlusal surface to cervix. 4. The crack of tooth start interface area, between internal slop of buccal cusp and resin inlay. It progresses through buccopulpal line angle to cervix at buccomesial and buccodistal comer. 5. The influence with depth of cavity to fracture of tooth was more than width of isthmus. 6. It would be favorable to make the isthmus width narrower than a third of the intercuspal distance and depth of cavity is below 1 : 0.7.

• Wind and Structures
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• 제13권4호
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• pp.363-374
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• 2010

Appropriate scaling methods for wind tunnel modelling of building internal pressures induced through a dominant opening were investigated. In particular, model cavity volume distortion and geometric scaling of the opening details were studied. It was found that while model volume distortion may be used to scale down buildings for wind tunnel studies on internal pressure, the implementation of the added volume must be done with care so as not to create two cavity resonance systems. Incorrect scaling of opening details was also found to generate incorrect internal pressure characteristics. Furthermore, the effective air slug or jet was found to be longer when the opening was near a floor or sidewall as evidenced by somewhat lower Helmholtz frequencies. It is also shown that tangential flow excitation of Helmholtz resonance for off-centre openings in normal flow is also possible.

• 한국정밀공학회지
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• 제20권3호
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• pp.82-88
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• 2003

The nondestructive internal quality evaluation of agricultural products has been strongly required from the needs for individual inspection. Recently, the ultrasonic wave has been considered as a solution fur this problem, and an ultrasonic system was constructed for the ultrasonic NDE of fruits and vegetables in our previous work. In this paper, the practical applicability of our ultrasonic system is tested fur the inspection of internal defects (central cavity) in Atlantic potato. Sound speed and RMS of transmitted ultrasonic wave signal were measured and classification algorithm using 2 dimensional stochastic analysis. was presented. Experimental results showed greater value of sound speed and RMS (root mean square) of transmitted signal in normal samples than in abnormal samples with cavity. Also a stochastic method to distinguish normal and abnormal showed fault detection rate less than 5%.