• Journal of Animal Science and Technology
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• v.52 no.6
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• pp.521-527
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• 2010

Fibroblast growth factor receptor 1 (FGFR1) plays roles in angiogenesis, wound healing, and embryonic development via the regulation of cell proliferation, differentiation, and survival. It is well known that ectopic expression of FGFR1 is associated with cancer development. To characterize the function of FGFR1 in the normal and cancer cell lines DF-1 and DT40, respectively, we performed FGFR1 knockdown by RNA interference. In the DT40 cells, FGFR1 knockdown induced upregulation of FGFR2 and FGFR3 expression, downregulation of pro-apoptosis-related genes, and upregulation of anti-apoptosis-related genes. However, in DF-1 cells, FGFR1 knockdown induced upregulation of pro-apoptosis-related genes and downregulation of anti-apoptosis-related genes. Our data suggest that repression of FGFR1 induced upregulation of other FGF receptors and anti-apoptosis-related genes in cancer cells and pro-apoptosis-related genes in normal cells.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.11
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• pp.2168-2174
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• 2009

Electrical railway system consists of rolling stock, track, signal and streetcar line system. Track circuit system is a vital system due to checking the location of trains. Track circuits are divided by using frequency and isolated electrically. Currently, there is not a regulation for the distance between track circuits using identical frequency. In case of installing additional track circuits in large stations or marshalling yard, the problem which is that the signal is not exactly transmitted to the track circuit occurs due to the mutual interference. In other words, the track circuit properly is not operated on account of wrong induction current by the mutual inductance between track circuits. In this paper, we suggest the electrical model between track circuits and numerically calculate demanded parameters in electrical model. The distance between track circuits satisfying the mutual inductance which does not happen to the mutual interference phenomenon is presented about the distance of track circuit. It is proved by using Matlab and PSpice program as the amplitude of mutual induced current.

• Journal of Microbiology and Biotechnology
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• v.30 no.12
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• pp.1919-1926
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• 2020

CRISPR interference (CRISPRi) has been developed as a transcriptional control tool by inactivating the DNA cleavage ability of Cas9 nucleases to produce dCas9 (deactivated Cas9), and leaving dCas9 the ability to specifically bind to the target DNA sequence. CRISPR/Cas9 technology has limitations in designing target-specific single-guide RNA (sgRNA) due to the dependence of protospacer adjacent motif (PAM) (5'-NGG) for binding target DNAs. Reportedly, Cas9-NG recognizing 5'-NG as the PAM sequence has been constructed by removing the dependence on the last base G of PAM through protein engineering of Cas9. In this study, a dCas9-NG protein was engineered by introducing two active site mutations in Cas9-NG, and its ability to regulate transcription was evaluated in the gal promoter in E. coli. Analysis of cell growth rate, D-galactose consumption rate, and gal transcripts confirmed that dCas9-NG can completely repress the promoter by recognizing DNA targets with PAM of 5'-NGG, NGA, NGC, NGT, and NAG. Our study showed possible PAM sequences for dCas9-NG and provided information on target-specific sgRNA design for regulation of both gene expression and cellular metabolism.

• Journal of information and communication convergence engineering
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• v.9 no.5
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• pp.515-522
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• 2011

In this paper, we investigate cooperative diversity in a spectrum sharing environment where secondary users utilize primary users' spectrum only if the interference power received at the primary users is maintained below a predetermined level. The outage probability of a selective decode-and-forward (DF) based cooperative diversity scheme in the secondary network is derived to analyze the effects of spectrum sharing on cooperative diversity. Our analytical and simulation results show that the outage probability is saturated at a certain level of transmit power of secondary users due to interference regulation, and, hence, cooperative diversity gains are lost. Through asymptotic analysis, we also identify the critical value of transmit SNR beyond which the outage probability is saturated.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2003.11a
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• pp.604-608
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• 2003

In this paper, we studied the radiated electric field of power-line with DMT signal source in the frequency range of $1.7{\sim}30 MHz$. First, we made the midium voltage power-line communication model for PLC and calculated the current through the power-line using the impedance of the power-line model. Second, we calculated the radiated electric field in power range $-50{\sim}-30 dBm$ using the calculated current. Consequently, the calculated emissive electromagnetic field from the DMT signal is similar to the measured result. So this study is applicable to the standard regulation of electromagnetic interference for PLC.

• The Transactions of the Korean Institute of Power Electronics
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• v.9 no.1
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• pp.81-87
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• 2004

This paper describes a design method of electromagnetic interference (EMI) filter for pulse-width modulation (PWM) inverter-fed AC drives used for home appliances such as washing machine and air conditioner. The generating and coupling mechanisms of the conducted EMI for AC drives are first investigated. The design procedure of the EMI filter based on the EMI separation principle is then presented. Experiments we carried out for the PWM inverter-fed induction motor drive system and it is shown that the results satisfy the EN55014 EMI regulation.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.07b
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• pp.1121-1124
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• 2002

Currently, the regulation system on controlling EMI has been strengthened throughout the world and this system has emerged as another invisible barrier from the advanced countries. Such a regulation is likely to expand in many various ways depending on the objective and type, and there has to be a fundamental EMI measure to respond this movement. This study is aimed at learning the EMI technology of communication system through the shielding material. It introduces the selection of appropriate shielding material and method of use, and it introduces the cases that resolved the actual EMI problem of the system that is manufactured by the company.

• The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.13 no.2
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• pp.156-156
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• 1999

This paper describes the characteristics and the criteria of electrical environmental effects produced from power system especially transmission line. Audible noise radio and TV interference, electric and magnetic inductions which are main items for optimal conductor selection as well as major contributors to the community complaint of electrical environmental problem, are surveyed and studied comparing with the criteria or the environmental protection regulation of domestic and foreign countries. As a result a domestic criteria of electrical environmental on power system was suggested.

• Journal of Power Electronics
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• v.16 no.4
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• pp.1245-1255
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• 2016

The single resonant inverter is widely employed in typical inductive power transfer (IPT) systems to generate a high-frequency current in the primary side. However, the power capacity of a single resonant inverter is limited by the constraints of power electronic devices and the relevant cost. Consequently, IPT systems fail to meet high-power application requirements, such as those in rail applications. Total harmonic distortion (THD) may also violate the standard electromagnetic interference requirements with phase shift control under light load conditions. A power regulation approach with selective harmonic elimination is proposed on the basis of a parallel multi-inverter to upgrade the power levels of IPT systems and suppress THD under light load conditions by changing the output voltage pulse width and phase shift angle among parallel multi-inverters. The validity of the proposed control approach is verified by using a 1,412.3 W prototype system, which achieves a maximum transfer efficiency of 90.602%. Output power levels can be dramatically improved with the same semiconductor capacity, and distortion can be effectively suppressed under various load conditions.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.28 no.2
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• pp.113-119
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• 2017

In this paper, we have shown the performance analysis results of the LoRa low power wide area network under duty cycle local regulation in Korean RFID/USN frequency band. Especially, we analyzed uplink throughput and data transmission time of a single LoRa end device. From the analysis results, duty cycle regulation, in which a data transmission should be ended within 0.4 second, limits the performance of LoRa network. Therefore, it is necessary to revise Korea's duty cycle regulation referencing EU regulation in order to assess LoRa network in Korea.