• Biomolecules & Therapeutics
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• 제18권2호
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• pp.152-158
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• 2010

Melanin concentrating hormone is a neuropeptide highly expressed in the brain that regulates several physiological functions mediated by receptors in the G-protein coupled receptor family, especially plays an important role in the complex regulation of energy balance and body weight mediated by the melanin concentrating hormone receptor subtype 1 (MCH1). Compelling pharmacological evidence implicating MCH1 signaling in the regulation of food intake and energy expenditure has generated a great deal of interest by pharmaceutical companies as MCH1 antagonists may have potential therapeutic benefit in the treatment of obesity and metabolic syndrome. Although fluorescence-based calcium mobilization assay platform has been one of the most widely accepted tools for receptor research and drug discovery, fluorescence interference and shallow assay window limit their application in high throughput screening and have led to a growing interest in alternative, luminescence-based technologies. Herein, a luminescence-based functional assay system for the MCH1 receptor was developed and validated with the mitochondrial targeted aequorin. Aequorin based functional assay system for MCH1 presented excellent Z' factor (0.8983) and high signal-to-noise ratio (141.9). The nonpeptide MCH1 receptor antagonist, SNAP 7941 and GSK 803430, exhibited $IC_{50}$ values of 0.62 ${\pm}$ 0.11 and 12.29 ${\pm}$ 2.31 nM with excellent correlation coefficient. These results suggest that the aequorin based assay system for MCH1 is a strong alternative to the traditional GPCR related tools such as radioligand binding experiments and fluorescence functional determinations for the compound screening and receptor research.

• ETRI Journal
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• 제34권6호
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• pp.911-921
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• 2012

In high-speed wireless communications, an analysis of the propagation characteristics is an important process. Information on the propagation characteristics suitable for each environment significantly helps in the design of mobile communications. This paper presents the analysis results of radio propagation characteristics in outdoor environments for a new mobile wireless system at 781 MHz. To avoid the interference of Korean DTV broadcasting, we measure the channel characteristics in urban, suburban, and rural areas on Jeju Island, Republic of Korea, using a channel sounder and $4{\times}4$ antenna. The path loss (PL) measurement results differ from those of existing propagation models by more than 10 dB. To analyze the frequency characteristics for Korean propagation environments, we derive various propagation characteristic parameters: PL, delay spread, angular spread, and K-factor. Finally, we verify the validity of the measurement results by comparing them with the actual measurement results and 3D ray-tracing simulation results.

• The Korean Journal of Physiology and Pharmacology
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• 제21권4호
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• pp.397-405
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• 2017

MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-dependent manner. At a moderate concentration (${\sim}20{\mu}M$), MDL-12330A mainly induced apoptotic death whereas at concentrations greater than $20{\mu}M$, it increased non-apoptotic cell death. The induction of apoptosis was at least partially regulated by CHOP-mediated DR5 upregulation, as detected by immunoblotting and gene interference assays. More importantly, low concentrations of MDL-12330A effectively enhanced recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (rhTRAIL)-induced apoptosis and clonogenicity in these gastric cancer cells. This study demonstrates a possible role of MDL-12330A as a potential sensitizer to TRAIL, and suggests a novel therapeutic strategy targeting gastric cancer cells.

• The Transactions of the Korean Institute of Power Electronics
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• 제22권1호
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• pp.27-35
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• 2017

In this study, an integrated 2-in-1 transformer for a low-weight and low-cost light-emitting diode lighting power supply is proposed. In the transformer, a power factor correction (PFC) inductor and an LLC resonant transformer are placed and integrated on a single magnetic core. The amount of mutual interference, represented by the coupling coefficient, between magnetic fluxes generated from each magnetic source is minimized by using the new shape core of an integrated 2-in-1 transformer. The design consideration on critical conduction mode PFC converter and LLC resonant converter using the proposed 2-in-1 integrated transformer is described, and the overall performance of the 150 W LED PSU shown through the experiment.

• Journal of Families and Better Life
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• 제18권3호통권47호
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• pp.171-187
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• 2000

The purpose of this study is to research high school students' stressful life events, to examine effects of SES, psychological environments, stress coping methods on stress. Data were collected by 965 high school students in Cheon-buk. Data were analyzed with the frequency, percentage, factor analysis, reliability, ANOVA test, Multiple Regression in use of SPSS WIN 7.5 Program. The main results are as follow: 1. High school students; stressful life events are ① comparingㆍinterferenceㆍscolding ② having a bad at their study. ③ educational environments ④ ability ⑤ apearance. Peoples stressed me are ① her(him)self ② friend and ③ teacher. Stress coping behaviors are it's ① speak ill a person. ② listen to the music. ③ sleep. ④ be patient. ⑤ keep still or take breath deeply. 2. SES, Psychological Environments, Stress Coping Methods are related to stress. Especially hopeless in future, parental not affections and parental interference are related to stress highly. Also the stress by sex discrimination are related to gender intimately. 3. Effects of SES, Psychological Environments, Stress Coping Method on high school students' stress are very different. So it must to be differentiated the support on the high school students' stress.

• Journal of Korea Multimedia Society
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• 제7권2호
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• pp.204-210
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• 2004

This paper proposes a transmission probability control scheme and MAC protocol for packet data services in slotted CDMA system. In slotted CDMA system, multiple access interference is the major factor of unsuccessful packet transmissions. Therefore, in order to obtain the optimal system throughput, the number of simultaneously transmitted packets should be kept at a proper level. In the proposed protocol, the base station calculates the packet transmission probability of mobile stations according to the offered load and then broadcasts it. Mobile stations, which have a packet, attempt to transmit packet with the received probability. Numerical analysis and simulation results show that the proposed scheme can offer better system throughput than the conventional one, and guarantee a good fairness among all mobile stations regardless of the offered load.

• The Transactions of The Korean Institute of Electrical Engineers
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• 제59권9호
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• pp.1638-1643
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• 2010

HVDC is better economic method than HVAC in case of long distance transmission and it is possible to interconnect transmission lines regardless of difference of power frequency. The electrical environment problems of HVDC overhead transmission line are electric field, charged voltage, ion current and so on. For biopolar HVDC lines, most of the ions are directed toward the opposite polarity conductor, but a significant fraction is also directed toward the ground. These problems are major factor to design configuration of HVDC overhead transmission line. Therefore, It is necessary to test an environmental characteristics of HVDC overhead transmission line. In this paper, to assess the ion characteristic of HVDC transmission line, continuous measurements have been done on the biopolar single circuit line with ACSR 480mm2-6 bundle conductors of Gochang HVDC Test line. And then the ion characteristics were analyzed.

• International Journal of Precision Engineering and Manufacturing
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• 제1권1호
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• pp.62-70
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• 2000

The design of gear train is a kind of mixed problems which have to determine various types of design variables; i,e., continuous, discrete, and integer variables. Therefore, the most common practice of optimum design using the derivative of objective function has difficulty in solving those kinds of problems and the optimum solution also depends on initial guess because there are many sophisticated constrains. In this study, the Genetic Algorithm is introduced for the optimum design of gear trains to solve such problems and we propose a genetic algorithm based gear design system. This system is applied for the geometrical volume(size) minimization problem of the two-stage gear train and the simple planetary gear train to show that genetic algorithm is better than the conventional algorithm solving the problems that have continuous, discrete, and integer variables. In this system, each design factor such as strength, durability, interference, contact ratio, etc. is considered on the basis of AGMA standards to satisfy the required design specification and the performance with minimizing the geometrical volume(size) of gear trains

• Proceedings of the KOSOMBE Conference
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• 대한의용생체공학회 1995년도 추계학술대회
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• pp.18-21
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• 1995

When we inject drugstuffs to a patient for a long time, it is important to control proper injection amount and flow rate. Since inproper injection amount and a flow rate would cause bad a recovery a patient, the relience of sensors which detect injection amount is an important factor for whole injection systems' performance. In this research, we've compared the suitability of three sensors for injection pump monitoring system. The three types of sensors, piezo film sensor, photo transistor made up with three transmitting photodiodes and receving photodiode, and photo array, were selected for comparing. Using suggested data processing technique and photo amy sensors, we could minimize the effect of interference, disturbance, illumanation change, and sensitivity change caused by sensor's position. According to the experiments, the photo amy showed the higher reliance than any other the three types of sensors. The developed systems could be the foundation of beginning home production of infusion pump system and available for the base model of whole monitoring and control systems.

• Journal of international Conference on Electrical Machines and Systems
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• 제1권2호
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• pp.79-84
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• 2012

In this paper, a three-phase high-voltage converter (HVC), in which the main structure of each phase is composed of a cascaded PWM rectifier (CPR) and cascaded inverter (CI), is studied. A high-voltage grid is the input of the HVC. In order to ensure proper operation of the HVC, the control method should achieve output voltage sharing (OVS) among the rectifiers in the CPR, OVS among the inverters in the CI, and high power factor. Master-slave direct-current control (MDCC) is used to control the CPR. The ability of the control system to prevent interference is strong when using MDCC. The CI is controlled by three-loop control, which is composed of an outer common-output-voltage loop, inner current loops and voltage sharing loops. Simulation results show low total harmonic distortion (THD) in the HVC input currents and good OVS in both the CPR and CI.