• Molecules and Cells
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• v.45 no.12
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• pp.896-910
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• 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and potentially fatal virus. So far, most comprehensive analyses encompassing clinical and transcriptional manifestation have concentrated on the lungs. Here, we confirmed evident signs of viral infection in the lungs and spleen of SARS-CoV-2-infected K18-hACE2 mice, which replicate the phenotype and infection symptoms in hospitalized humans. Seven days post viral detection in organs, infected mice showed decreased vital signs, leading to death. Bronchopneumonia due to infiltration of leukocytes in the lungs and reduction in the spleen lymphocyte region were observed. Transcriptome profiling implicated the meticulous regulation of distress and recovery from cytokine-mediated immunity by distinct immune cell types in a time-dependent manner. In lungs, the chemokine-driven response to viral invasion was highly elevated at 2 days post infection (dpi). In late infection, diseased lungs, post the innate immune process, showed recovery signs. The spleen established an even more immediate line of defense than the lungs, and the cytokine expression profile dropped at 7 dpi. At 5 dpi, spleen samples diverged into two distinct groups with different transcriptome profile and pathophysiology. Inhibition of consecutive host cell viral entry and massive immunoglobulin production and proteolysis inhibition seemed that one group endeavored to survive, while the other group struggled with developmental regeneration against consistent viral intrusion through the replication cycle. Our results may contribute to improved understanding of the longitudinal response to viral infection and development of potential therapeutics for hospitalized patients affected by SARS-CoV-2.

• Journal of the Korean Association of Geographic Information Studies
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• v.9 no.2
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• pp.67-78
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• 2006

Local governments began to construct geographic information system to improve government productivity and performance. In support, central government organized a national commission for GIS. The master plan by NGIS has been the base for local government to participate in the construction of GIS at the local level in the under ground facilities management including water and sewers. The challenge faced by sewer facility managers includes controlling 'data accuracy'. The input for sewer data handling for efficient performance in local government requires accurate data. However data manipulation to get the 'good quality' data can be burdensome. Thus, the aim of this research is to provide the appropriate tool to guarantee the high quality of digital data in sewer facility management. It is helpful to pass the data examination by government as well as to insure confidence of decision and data analysis works in local government. In this research, error types of sewer data were classified and pointed the limitation of traditional examination methods. Thus this research suggested more improved method for finding and correcting errors in data input using sewer volume analysis and prediction model as immigrating sewer facility management work to Geographic Information System.

• Journal of Life Science
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• v.25 no.2
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• pp.237-242
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• 2015

The use of calcite-forming bacteria (CFB) in crack remediation and durability improvements in construction materials creates a permanent and environmentally-friendly material. Therefore, research into this type of application is stimulating interdisciplinary studies between microbiology and architectural engineering. However, the mechanisms giving rise to these materials are dependent on calcite precipitation by the metabolism of the CFB, which raises concerns about possible hazards to cement-based construction due to microbial metabolic acid production. The aim of this study was to determine target microorganisms that possibly can have bio-corrosive effects on cement mortar and to assess multi-functional CFBs for their safe application to cement structures. The chalky test was first used to evaluate the $CaCO_3$ solubilization feature of construction sites by fungi, yeast, bacterial strains. Not all bacterial strains are able to solubilize $CaCO_3$, but C. sphaerospermum KNUC253 or P. prolifica KNUC263 showed $CaCO_3$ solubilization activity. Therefore, these two strains were identified as target microorganisms that require control in cement structures. The registered patented strains Bacillus aryabhatti KNUC205, Arthrobacter nicotianae KNUC2100, B. thuringiensis KNUC2103 and Stenotrophomonas maltophilia KNUC2106, reported as multifunctional CFB (fungal growth inhibition, crack remediation, and water permeability reduction of cement surfaces) and isolated from Dokdo or construction site were unable to solubilize $CaCO_3$. Notably, B. aryabhatti KNUC205 and A. nicotianae KNUC2100 could not hydrolyze cellulose or protein, which can be the major constituent macromolecules of internal materials for buildings. These results show that several reported multi-functional CFB can be applied to cement structures or diverse building environments without corrosive or bio-deteriorative risks.

• Journal of Environmental Science International
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• v.26 no.5
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• pp.675-684
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• 2017

Provider-oriented weather information has been rapidly changing to become more customer-oriented and personalized. Given the increasing interest in wellness and health topics, the demand for health weather information, and biometeorology, also increased. However, research on changes in the human body according to weather conditions is still insufficient due to various constraints, and interdisciplinary research is also lacking. As part of an effort to change that, this study surveyed medical practitioners at an actual treatment site, using questionnaires, to investigate what kind of weather information they could utilize. Although there was a limit to the empirical awareness that medical staff had about weather information, most respondents noted that there is a correlation between disease and weather, with cardiovascular diseases (coronary artery disease (98.5%) and hypertension (95.9% ), skin diseases (atopic dermatitis (100%), sunburn (93.8%)) being the most common weather-sensitive ailments. Although there are subject-specific differences, most weather-sensitive diseases tend to be affected by temperature and humidity in general. Respiratory and skin diseases are affected by wind and solar radiation, respectively.

• Journal of the Korean Society for information Management
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• v.38 no.1
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• pp.53-69
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• 2021

This study aims to understand the research landscape of South Korea using the data of 2020 Google Scholar Metrics. To achieve the goal, we constructed and analyzed four types of networks including the university collaboration network, the keyword co-occurrence network, the journal citation network, and the discipline citation network. Through the analysis of the university collaboration network, we found major universities such as Seoul National University, Keimyung University, and Sungkyunkwan University that have led collaborative research. Job related keywords such as job change intention and job satisfaction have been frequently studied with other keywords. Through the analysis of the journal citation network, we found multiple journals such as The Journal of the Korea Contents Association, Korean Journal of Sociology, and Korean Journal of Culture and Social Issues that have been widely cited by the other journals and influenced them. Finally, Education, Business administration, and Social welfare were identified as the top influential disciplines that have influenced other disciplines through the knowledge diffusion. The study is the first of its kind to use the data of Google Scholar Metrics and conduct a stepwise network analysis (e.g., keyword, journal, and discipline) to broadly understand the research landscape of South Korea. Our results can be used by government agencies and universities to develop effective strategies of promoting university collaboration and interdisciplinary research.

• Tribology and Lubricants
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• v.27 no.5
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• pp.256-263
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• 2011

Bearings of marine engines are operated under severe conditions because of dynamic load and low sliding speed. This paper deals with lubrication analysis of a crank pin bearing for a marine diesel engine. Journal center locus and oil film thickness are compared of crank pin bearing. In the past researches, journal bearings have been studied only about the surface of bearing. In addition to this conventional research, this paper analyzes the effect of roundness error of a journal and a bearing on the minimum film thickness. Numerical analysis has been studied by using Reynolds equation and also Half-Sommerfeld condition is applied as boundary condition. Futhermore, this study investigates the effect of roundness error change on the minimum film thickness. The results demonstrate that the bigger amplitude of roundness error yields, the lower minimum oil film thickness is. In comparison to previous research considered a journal and a bearing individually, the results considering a journal and a bearing together show that amplitude of roundness error of journal has very little effect on the minimum oil film thickness.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2023.11a
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• pp.68-69
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• 2023

Recently, decarbonization has been emphasized worldwide to cope with climate change, and carbon neutrality by 2050 has emerged as a global agenda. The domestic port authorities have been participating in the global agenda in line with the government regulations. Since 2010, when decarbonization has been regarded as an important assignment in ports, container terminal efficiency considering undesirable outputs such as Carbon dioxide has been analyzed. However, most previous studies measured carbon dioxide emissions according to the Tier 1 and it is a first time to analyze container terminal efficiency based on the Tier 3 presented in the IPCC guidelines. 17 domestic container terminal operators were considered as decision making units and DEA-SBM Model was used. Subsequently, Undesirable outputs model was conducted to calculate the environmental efficiency.

• Journal of Navigation and Port Research
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• v.48 no.3
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• pp.171-180
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• 2024

Recently, there has been a global emphasis on decarbonization in order to address climate change and achieve carbon neutrality by 2050. In line with government regulations, domestic port authorities have also started participating in this global agenda. Since 2010, when decarbonization became an important task in ports, there have been studies analyzing the environmental efficiency of container terminals, taking into account undesirable outputs. However, most of these previous studies only measured carbon dioxide emissions based on Tier 1, whereas this study is the first to analyze the environmental efficiency of South Korea's container terminals based on Tier 3, as presented in the IPCC guidelines. The study considered 17 container terminal operators in South Korea as decision-making units and used the DEA-SBM Model. Subsequently, an Undesirable Outputs Model was conducted to calculate the environmental efficiency.

• Korean Journal of Food Science and Technology
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• v.49 no.6
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• pp.617-624
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• 2017

Chocolate, one of the most popular confectioneries in the world, is known for its aromatic flavor and high antioxidant activities. In this study, we investigated the effects of fermentation with commercially available lactic acid bacteria, ABT-5, on the flavor and antioxidant activities of dark chocolate. During 24 h fermentation, pH decreased from 5.52 to 3.97 and total acidity increased from 0.51 to 1.85%, whereas total polyphenol and flavonoid contents as well as DPPH and ABTS radical scavenging activities remained unchanged. Furthermore, compared with control HepG2 cells treated with unfermented dark chocolate, those treated with the fermented dark chocolate showed significantly lower levels of reactive oxygen species and higher viability under $H_2O_2-induced$ oxidative stress. Finally, GC-MS and headspace GC-MS analysis detected 4-hydroxy-2,5-dimethyl-3(2H)-furanone and 2-furanmethanol, known to enhance flavor, in the fermented dark chocolate. Collectively, these results suggest that ABT-5-fermented dark chocolate could be utilized for developing value-added dark chocolate products.

• The Journal of the Korea Contents Association
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• v.19 no.4
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• pp.218-226
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• 2019

As the shoes industry has been strengthened due to the contemporary fashion industry becoming segmented more and more, it is necessary to provide the basic data for the shoes industry through more in-depth research on the relevant fields. Accordingly, this study investigated the research trends related to shoes in Korea on the aspect of the publication methods, research contents and research methodologies for identifying the existing research status. In accordance with the analysis, the researches had been published since 2015 and presented by one author or two co-authors. The authors of researches were mostly affiliated to the colleges. Thus, it was identified that the professional research should be implemented in cooperation with the industry. For the research contents, the researches related to the shoes industry focused on the 21st century in the period field and marketing and design in the theme field. Then, it is required to investigate the converged interdisciplinary themes in wider areas in more diverse periods. Next, the case study accounted for the highest ratio in the methodology. Moreover, the methodology applied per theme showed the significant difference. Accordingly, the researches need to be conducted through more diverse viewpoints and methodologies. In case of the difference per research type, the significant difference was found only in the research approaches. Furthermore, the specific methodology was preferred per theme regardless of the research types. Then, it was found that the methodology played the significant role in the researches on the shoes industry.